Phosphodiesterase I
"Phosphodiesterase I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phosphoric diester hydrolase that removes 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated OLIGONUCLEOTIDES. It has low activity towards POLYNUCLEOTIDES and the presence of 3'-phosphate terminus on the substrate may inhibit hydrolysis.
| Descriptor ID |
D043264
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| MeSH Number(s) |
D08.811.277.352.640.430
|
| Concept/Terms |
Phosphodiesterase I- Phosphodiesterase I
- Orthophosphoric Diester Phosphohydrolase
- Diester Phosphohydrolase, Orthophosphoric
- Phosphohydrolase, Orthophosphoric Diester
- Alkaline Phosphodiesterase I
- Phosphodiesterase I, Alkaline
- 5'-Nucleotidephosphodiesterase
- 5' Nucleotidephosphodiesterase
- Alkaline Phosphodiesterase
- Phosphodiesterase, Alkaline
- Oligonucleate 5'-Nucleotidohydrolase
- Oligonucleate 5' Nucleotidohydrolase
- 5'-Exonuclease
- 5' Exonuclease
|
Below are MeSH descriptors whose meaning is more general than "Phosphodiesterase I".
Below are MeSH descriptors whose meaning is more specific than "Phosphodiesterase I".
This graph shows the total number of publications written about "Phosphodiesterase I" by people in this website by year, and whether "Phosphodiesterase I" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
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Below are the most recent publications written about "Phosphodiesterase I" by people in Profiles.
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Janssen W, Ghofrani HA, Weissmann N, Grimminger F, Schermuly RT. [Update: Preclinical developments for the treatment of pulmonary arterial hypertension]. Dtsch Med Wochenschr. 2009 Aug; 134 Suppl 5:S157-9.
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Fox MA, Colello RJ, Macklin WB, Fuss B. Phosphodiesterase-Ialpha/autotaxin: a counteradhesive protein expressed by oligodendrocytes during onset of myelination. Mol Cell Neurosci. 2003 Jul; 23(3):507-19.
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Fuss B, Baba H, Phan T, Tuohy VK, Macklin WB. Phosphodiesterase I, a novel adhesion molecule and/or cytokine involved in oligodendrocyte function. J Neurosci. 1997 Dec 01; 17(23):9095-103.