 Sphingomyelin Phosphodiesterase
"Sphingomyelin Phosphodiesterase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide (N-acylsphingosine) plus choline phosphate. A defect in this enzyme leads to NIEMANN-PICK DISEASE. EC 3.1.4.12.
| Descriptor ID |
D013108
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| MeSH Number(s) |
D08.811.277.352.640.750
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| Concept/Terms |
Sphingomyelin Phosphodiesterase- Sphingomyelin Phosphodiesterase
- Sphingomyelin Cleaving Enzyme
- Sphingomyelinase C
- Sphingomyelinase
- Sphingomyelin Cholinephosphohydrolase
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Below are MeSH descriptors whose meaning is more general than "Sphingomyelin Phosphodiesterase".
Below are MeSH descriptors whose meaning is more specific than "Sphingomyelin Phosphodiesterase".
This graph shows the total number of publications written about "Sphingomyelin Phosphodiesterase" by people in this website by year, and whether "Sphingomyelin Phosphodiesterase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 2 | 0 | 2 | | 2008 | 0 | 3 | 3 | | 2010 | 1 | 0 | 1 | | 2011 | 0 | 1 | 1 | | 2016 | 1 | 0 | 1 | | 2018 | 1 | 1 | 2 | | 2019 | 0 | 1 | 1 | | 2021 | 1 | 1 | 2 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Sphingomyelin Phosphodiesterase" by people in Profiles.
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Staquicini DI, Card?-Vila M, Rotolo JA, Staquicini FI, Tang FHF, Smith TL, Ganju A, Schiavone C, Dogra P, Wang Z, Cristini V, Giordano RJ, Ozawa MG, Driessen WHP, Proneth B, Souza GR, Brinker LM, Noureddine A, Snider AJ, Canals D, Gelovani JG, Petrache I, Tuder RM, Obeid LM, Hannun YA, Kolesnick RN, Brinker CJ, Pasqualini R, Arap W. Ceramide as an endothelial cell surface receptor and a lung-specific lipid vascular target for circulating ligands. Proc Natl Acad Sci U S A. 2023 08 22; 120(34):e2220269120.
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Piccolo BD, Graham JL, Kang P, Randolph CE, Shankar K, Yeruva L, Fox R, Robeson MS, Moody B, LeRoith T, Stanhope KL, Adams SH, Havel PJ. Progression of diabetes is associated with changes in the ileal transcriptome and ileal-colon morphology in the UC Davis Type 2 Diabetes Mellitus rat. Physiol Rep. 2021 11; 9(22):e15102.
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Mondal K, Takahashi H, Cole J, Del Mar NA, Li C, Stephenson DJ, Allegood J, Cowart LA, Chalfant CE, Reiner A, Mandal N. Systemic Elevation of n-3 Polyunsaturated Fatty Acids (n-3-PUFA) Is Associated with Protection against Visual, Motor, and Emotional Deficits in Mice following Closed-Head Mild Traumatic Brain Injury. Mol Neurobiol. 2021 Nov; 58(11):5564-5580.
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Poczobutt JM, Mikosz AM, Poirier C, Beatman EL, Serban KA, Gally F, Cao D, McCubbrey AL, Cornell CF, Schweitzer KS, Berdyshev EV, Bronova IA, Paris F, Petrache I. Altered Macrophage Function Associated with Crystalline Lung Inflammation in Acid Sphingomyelinase Deficiency. Am J Respir Cell Mol Biol. 2021 05; 64(5):629-640.
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Mandell EW, Savani RC. Ceramides, Autophagy, and Apoptosis Mechanisms of Ventilator-induced Lung Injury and Potential Therapeutic Targets. Am J Respir Crit Care Med. 2019 Mar 15; 199(6):687-689.
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Julien C, Tomberlin C, Roberts CM, Akram A, Stein GH, Silverman MA, Link CD. In vivo induction of membrane damage by ?-amyloid peptide oligomers. Acta Neuropathol Commun. 2018 11 29; 6(1):131.
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Justice MJ, Bronova I, Schweitzer KS, Poirier C, Blum JS, Berdyshev EV, Petrache I. Inhibition of acid sphingomyelinase disrupts LYNUS signaling and triggers autophagy. J Lipid Res. 2018 04; 59(4):596-606.
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Herrera A, Vu BG, Stach CS, Merriman JA, Horswill AR, Salgado-Pab?n W, Schlievert PM. Staphylococcus aureus ?-Toxin Mutants Are Defective in Biofilm Ligase and Sphingomyelinase Activity, and Causation of Infective Endocarditis and Sepsis. Biochemistry. 2016 05 03; 55(17):2510-7.
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Lane L, McCoppin HH, Dyer J. Acute generalized exanthematous pustulosis and Coombs-positive hemolytic anemia in a child following Loxosceles reclusa envenomation. Pediatr Dermatol. 2011 Nov-Dec; 28(6):685-688.
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Filosto S, Castillo S, Danielson A, Franzi L, Khan E, Kenyon N, Last J, Pinkerton K, Tuder R, Goldkorn T. Neutral sphingomyelinase 2: a novel target in cigarette smoke-induced apoptosis and lung injury. Am J Respir Cell Mol Biol. 2011 Mar; 44(3):350-60.
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