 Ribonuclease P
"Ribonuclease P" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An RNA-containing enzyme that plays an essential role in tRNA processing by catalyzing the endonucleolytic cleavage of TRANSFER RNA precursors. It removes the extra 5'-nucleotides from tRNA precursors to generate mature tRNA molecules.
| Descriptor ID |
D043262
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| MeSH Number(s) |
D08.811.277.352.700.350.711 D08.811.797.500 D12.776.157.725.500.625 D12.776.664.962.500.625
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Ribonuclease P".
Below are MeSH descriptors whose meaning is more specific than "Ribonuclease P".
This graph shows the total number of publications written about "Ribonuclease P" by people in this website by year, and whether "Ribonuclease P" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 | | 1995 | 0 | 1 | 1 | | 1996 | 0 | 2 | 2 | | 1997 | 0 | 1 | 1 | | 1998 | 0 | 2 | 2 | | 1999 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2005 | 1 | 0 | 1 | | 2006 | 2 | 1 | 3 | | 2012 | 1 | 0 | 1 | | 2013 | 0 | 1 | 1 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Ribonuclease P" by people in Profiles.
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Lounsbury N, Eidem T, Colquhoun J, Mateo G, Abou-Gharbia M, Dunman PM, Childers WE. Novel inhibitors of Staphylococcus aureus RnpA that synergize with mupirocin. Bioorg Med Chem Lett. 2018 04 01; 28(6):1127-1131.
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Chen TH, Tanimoto A, Shkriabai N, Kvaratskhelia M, Wysocki V, Gopalan V. Use of chemical modification and mass spectrometry to identify substrate-contacting sites in proteinaceous RNase P, a tRNA processing enzyme. Nucleic Acids Res. 2016 06 20; 44(11):5344-55.
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Eidem TM, Lounsbury N, Emery JF, Bulger J, Smith A, Abou-Gharbia M, Childers W, Dunman PM. Small-molecule inhibitors of Staphylococcus aureus RnpA-mediated RNA turnover and tRNA processing. Antimicrob Agents Chemother. 2015 Apr; 59(4):2016-28.
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Goldfarb KC, Cech TR. 3' terminal diversity of MRP RNA and other human noncoding RNAs revealed by deep sequencing. BMC Mol Biol. 2013 Sep 21; 14:23.
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Goldfarb KC, Borah S, Cech TR. RNase P branches out from RNP to protein: organelle-triggered diversification? Genes Dev. 2012 May 15; 26(10):1005-9.
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Marquez SM, Chen JL, Evans D, Pace NR. Structure and function of eukaryotic Ribonuclease P RNA. Mol Cell. 2006 Nov 03; 24(3):445-56.
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Evans D, Marquez SM, Pace NR. RNase P: interface of the RNA and protein worlds. Trends Biochem Sci. 2006 Jun; 31(6):333-41.
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Guo F, Gooding AR, Cech TR. Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme. RNA. 2006 Mar; 12(3):387-95.
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Buck AH, Kazantsev AV, Dalby AB, Pace NR. Structural perspective on the activation of RNAse P RNA by protein. Nat Struct Mol Biol. 2005 Nov; 12(11):958-64.
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Buck AH, Dalby AB, Poole AW, Kazantsev AV, Pace NR. Protein activation of a ribozyme: the role of bacterial RNase P protein. EMBO J. 2005 Oct 05; 24(19):3360-8.
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