 Baclofen
"Baclofen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPASTICITY, especially that due to SPINAL CORD INJURIES. Its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission.
| Descriptor ID |
D001418
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| MeSH Number(s) |
D02.241.081.114.500.350.100
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| Concept/Terms |
Baclofen- Baclofen
- Baclophen
- PCP-GABA
- beta-(Aminomethyl)-4-chlorobenzenepropanoic Acid
- Chlorophenyl GABA
- GABA, Chlorophenyl
- beta-(p-Chlorophenyl)-gamma-aminobutyric Acid
Ba-34,647- Ba-34,647
- Ba34,647
- Ba-34647
- Ba34647
- CIBA-34,647-BA
- CIBA34,647BA
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Below are MeSH descriptors whose meaning is more general than "Baclofen".
Below are MeSH descriptors whose meaning is more specific than "Baclofen".
This graph shows the total number of publications written about "Baclofen" by people in this website by year, and whether "Baclofen" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 2 | 2 | | 2002 | 0 | 1 | 1 | | 2003 | 2 | 0 | 2 | | 2006 | 0 | 1 | 1 | | 2009 | 1 | 0 | 1 | | 2010 | 0 | 1 | 1 | | 2014 | 1 | 0 | 1 | | 2018 | 0 | 1 | 1 | | 2020 | 0 | 1 | 1 | | 2021 | 1 | 1 | 2 | | 2022 | 0 | 1 | 1 | | 2023 | 1 | 0 | 1 | | 2024 | 2 | 0 | 2 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Baclofen" by people in Profiles.
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Ryan MV, Blasco S, Olson KE, Sawyer K, Oleszek J, Sundar S, LeBeau S, Wilkinson CC. Cyclic Hypertonia and Hypotonia Associated with Intrathecal Baclofen Pumps: Findings and Treatments. Pediatr Neurosurg. 2025; 60(3):51-63.
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Ryan MV, Freeman LM, Blasco S, Sawyer K, Graber S, Tong S, Oleszek J, Wilkinson C. Complications of intrathecal baclofen therapy in children and young adults. J Neurosurg Pediatr. 2024 Dec 01; 34(6):659-670.
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Kondrad E, Bonner A, Sandhu S, Seitz K, Weldon S. Baclofen for Alcohol Use Disorder. Am Fam Physician. 2024 05; 109(5):463-464.
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Killam-Worrall L, Brand R, Castro JR, Patel DS, Huynh K, Lindley B, Torres BP. Baclofen and Tizanidine Adverse Effects Observed Among Community-Dwelling Adults Above the Age of 50 Years: A Systematic Review. Ann Pharmacother. 2024 May; 58(5):523-532.
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Xu AL, Marrache M, Hardesty CK, Groves ML, Erickson MA, Murphy RF, Thompson GH, Sponseller PD. Baclofen Pump Use: Complications After Growth-friendly Instrumentation for Early-onset Scoliosis. J Pediatr Orthop. 2022 Feb 01; 42(2):77-82.
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Bouchet CA, McPherson KB, Li MH, Traynor JR, Ingram SL. Mice Expressing Regulators of G protein Signaling-insensitive Gao Define Roles of µ Opioid Receptor Gao and Gai Subunit Coupling in Inhibition of Presynaptic GABA Release. Mol Pharmacol. 2021 09; 100(3):217-223.
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Shao L, Elujoba-Bridenstine A, Zink KE, Sanchez LM, Cox BJ, Pollok KE, Sinn AL, Bailey BJ, Sims EC, Cooper SH, Broxmeyer HE, Pajcini KV, Tamplin OJ. The neurotransmitter receptor Gabbr1 regulates proliferation and function of hematopoietic stem and progenitor cells. Blood. 2021 02 11; 137(6):775-787.
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Mohon RT, Sawyer K, Pickett K, Bothwell S, Brinton JT, Sobremonte-King M, DelRosso LM. Sleep-related breathing disorders associated with intrathecal baclofen therapy to treat patients with cerebral palsy: A cohort study and discussion. NeuroRehabilitation. 2021; 48(4):481-491.
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Mohon RT, Khan E, DelRosso LM. Increasingly Familiar Breathing Pattern in an Unfamiliar Population. Sleep-related Breathing Disorders in High-Risk Patients. Ann Am Thorac Soc. 2020 07; 17(7):895-898.
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McPherson KB, Leff ER, Li MH, Meurice C, Tai S, Traynor JR, Ingram SL. Regulators of G-Protein Signaling (RGS) Proteins Promote Receptor Coupling to G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channels. J Neurosci. 2018 10 10; 38(41):8737-8744.
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