 Periaqueductal Gray
"Periaqueductal Gray" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Central gray matter surrounding the CEREBRAL AQUEDUCT in the MESENCEPHALON. Physiologically it is probably involved in RAGE reactions, the LORDOSIS REFLEX; FEEDING responses, bladder tonus, and pain.
| Descriptor ID |
D010487
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| MeSH Number(s) |
A08.186.211.132.659.413.875.595
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| Concept/Terms |
Periaqueductal Gray- Periaqueductal Gray
- Central Gray Substance of Midbrain
- Griseum Centrale
- Griseum Centrale Mesencephali
- Griseum Centrale Mesencephalus
- Periaqueductal Gray Matter
- Gray Matter, Periaqueductal
- Central Periaqueductal Gray
- Gray, Central Periaqueductal
- Periaqueductal Grays, Central
- Mesencephalic Central Gray
- Central Gray, Mesencephalic
- Midbrain Central Gray
- Central Gray, Midbrain
- Substantia Grisea Centralis
- Substantia Grisea Centralis Mesencephali
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Below are MeSH descriptors whose meaning is more general than "Periaqueductal Gray".
Below are MeSH descriptors whose meaning is more specific than "Periaqueductal Gray".
This graph shows the total number of publications written about "Periaqueductal Gray" by people in this website by year, and whether "Periaqueductal Gray" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 2 | 0 | 2 | | 1998 | 1 | 0 | 1 | | 1999 | 0 | 1 | 1 | | 2000 | 1 | 0 | 1 | | 2004 | 2 | 0 | 2 | | 2005 | 1 | 0 | 1 | | 2006 | 1 | 1 | 2 | | 2007 | 2 | 1 | 3 | | 2008 | 1 | 0 | 1 | | 2009 | 5 | 0 | 5 | | 2010 | 2 | 1 | 3 | | 2012 | 4 | 0 | 4 | | 2013 | 2 | 1 | 3 | | 2014 | 1 | 1 | 2 | | 2015 | 0 | 1 | 1 | | 2016 | 1 | 1 | 2 | | 2017 | 0 | 2 | 2 | | 2018 | 1 | 0 | 1 | | 2019 | 2 | 0 | 2 | | 2020 | 0 | 2 | 2 | | 2021 | 1 | 0 | 1 | | 2023 | 1 | 0 | 1 | | 2024 | 1 | 0 | 1 | | 2025 | 2 | 0 | 2 |
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Below are the most recent publications written about "Periaqueductal Gray" by people in Profiles.
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Crawford LS, Tinoco Mendoza FA, Robertson RV, Meylakh N, Macey PM, Bannister K, Wager TD, Macefield VG, Keay KA, Henderson LA. Somatotopic organization of brainstem analgesic circuitry. Science. 2025 Aug 28; 389(6763):eadu8846.
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Coutens B, Bouchet CA, Patti LC, McPherson KB, Boston BS, Jewett DC, Ingram SL. Corticosterone stimulates synthesis of 2-arachidonoylglycerol via putative membrane-bound glucocorticoid receptors and inhibits GABA release via CB1 cannabinoid receptors in the ventrolateral periaqueductal gray. Mol Pharmacol. 2025 Aug; 107(8):100058.
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Fischbach AK, Satpute AB, Quigley K, Kragel PA, Chen D, Bianciardi M, Wald L, Wager TD, Choi JK, Zhang J, Barrett LF, Theriault JE. Seven Tesla Evidence for Columnar and Rostral-Caudal Organization of the Human Periaqueductal Gray Response in the Absence of Threat: A Working Memory Study. J Neurosci. 2024 Jun 26; 44(26).
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McPherson KB, Bouchet CA, Coutens B, Ingram SL. Persistent inflammation selectively activates opioid-sensitive phasic-firing neurons within the vlPAG. J Neurophysiol. 2023 05 01; 129(5):1237-1248.
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Wang W, Schuette PJ, La-Vu MQ, Torossian A, Tobias BC, Ceko M, Kragel PA, Reis FM, Ji S, Sehgal M, Maesta-Pereira S, Chakerian M, Silva AJ, Canteras NS, Wager T, Kao JC, Adhikari A. Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats. Elife. 2021 09 01; 10.
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Bagley EE, Ingram SL. Endogenous opioid peptides in the descending pain modulatory circuit. Neuropharmacology. 2020 08 15; 173:108131.
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Bouchet CA, Ingram SL. Cannabinoids in the descending pain modulatory circuit: Role in inflammation. Pharmacol Ther. 2020 05; 209:107495.
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Kragel PA, Bianciardi M, Hartley L, Matthewson G, Choi JK, Quigley KS, Wald LL, Wager TD, Feldman Barrett L, Satpute AB. Functional Involvement of Human Periaqueductal Gray and Other Midbrain Nuclei in Cognitive Control. J Neurosci. 2019 07 31; 39(31):6180-6189.
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Bobeck EN, Schoo SM, Ingram SL, Morgan MM. Lack of Antinociceptive Cross-Tolerance With Co-Administration of Morphine and Fentanyl Into the Periaqueductal Gray of Male Sprague-Dawley Rats. J Pain. 2019 09; 20(9):1040-1047.
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McPherson KB, Leff ER, Li MH, Meurice C, Tai S, Traynor JR, Ingram SL. Regulators of G-Protein Signaling (RGS) Proteins Promote Receptor Coupling to G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channels. J Neurosci. 2018 10 10; 38(41):8737-8744.
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