Shwartzman Phenomenon
"Shwartzman Phenomenon" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Hemorrhagic necrosis that was first demonstrated in rabbits with a two-step reaction, an initial local (intradermal) or general (intravenous) injection of a priming endotoxin (ENDOTOXINS) followed by a second intravenous endotoxin injection (provoking agent) 24 h later. The acute inflammation damages the small blood vessels. The following intravascular coagulation leads to capillary and venous THROMBOSIS and NECROSIS. Shwartzman phenomenon can also occur in other species with a single injection of a provoking agent, and during infections or pregnancy. Its susceptibility depends on the status of IMMUNE SYSTEM, coagulation, FIBRINOLYSIS, and blood flow.
| Descriptor ID |
D012790
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| MeSH Number(s) |
C14.907.454.810 C14.907.940.890 C15.378.463.515.810
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| Concept/Terms |
Shwartzman Phenomenon- Shwartzman Phenomenon
- Phenomenon, Shwartzman
- Schwartzman Reaction
- Schwartzman Reactions
- Shwartzman Reaction
- Schwartzman Phenomenon
- Phenomenon, Schwartzman
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Below are MeSH descriptors whose meaning is more general than "Shwartzman Phenomenon".
Below are MeSH descriptors whose meaning is more specific than "Shwartzman Phenomenon".
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Below are the most recent publications written about "Shwartzman Phenomenon" by people in Profiles.
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Dinarello CA, Ward SB, Wolff SM. Pyrogenic properties of bleomycin (NSC-125066). Cancer Chemother Rep. 1973 Nov-Dec; 57(4):393-8.