 Extracellular Matrix Proteins
"Extracellular Matrix Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).
| Descriptor ID |
D016326
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| MeSH Number(s) |
D12.776.860.300
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Extracellular Matrix Proteins".
Below are MeSH descriptors whose meaning is more specific than "Extracellular Matrix Proteins".
This graph shows the total number of publications written about "Extracellular Matrix Proteins" by people in this website by year, and whether "Extracellular Matrix Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1995 | 0 | 1 | 1 | | 1996 | 1 | 0 | 1 | | 1997 | 0 | 1 | 1 | | 1998 | 3 | 0 | 3 | | 2000 | 0 | 2 | 2 | | 2001 | 0 | 1 | 1 | | 2002 | 1 | 1 | 2 | | 2003 | 1 | 1 | 2 | | 2004 | 1 | 2 | 3 | | 2005 | 1 | 1 | 2 | | 2006 | 2 | 2 | 4 | | 2007 | 1 | 2 | 3 | | 2008 | 0 | 3 | 3 | | 2009 | 5 | 1 | 6 | | 2010 | 1 | 6 | 7 | | 2011 | 4 | 4 | 8 | | 2012 | 1 | 2 | 3 | | 2013 | 3 | 3 | 6 | | 2014 | 2 | 1 | 3 | | 2015 | 3 | 2 | 5 | | 2016 | 2 | 3 | 5 | | 2017 | 2 | 3 | 5 | | 2018 | 2 | 7 | 9 | | 2019 | 1 | 3 | 4 | | 2021 | 1 | 1 | 2 | | 2022 | 0 | 1 | 1 | | 2023 | 2 | 5 | 7 | | 2024 | 1 | 3 | 4 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Extracellular Matrix Proteins" by people in Profiles.
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Dube CT, Gilbert HTJ, Rabbitte N, Baird P, Patel S, Herrera JA, Baricevic-Jones I, Unwin RD, Chan D, Gnanalingham K, Hoyland JA, Richardson SM. Proteomic profiling of human plasma and intervertebral disc tissue reveals matrisomal, but not plasma, biomarkers of disc degeneration. Arthritis Res Ther. 2025 Feb 10; 27(1):28.
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Jespersen KE, Xiong W, Santhanam L, Terrin M, Matsumura J, Curci JA, Blackwelder W, Brown CH, Martinez Yus M, Baxter BT. Hyperglycemia inhibits AAA expansion: examining the role of lysyl oxidase. Am J Physiol Heart Circ Physiol. 2025 Feb 01; 328(2):H247-H259.
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Williams J, Iheagwam FN, Maroney SP, Schmitt LR, Brown RD, Krafsur GM, Frid MG, McCabe MC, Gandjeva A, Williams KJ, Luyendyk JP, Saviola AJ, Tuder RM, Stenmark K, Hansen KC. A bovine model of hypoxia-induced pulmonary hypertension reveals a gradient of immune and matrisome response with a complement signature found in circulation. Am J Physiol Cell Physiol. 2024 Dec 01; 327(6):C1666-C1680.
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Hong J, Medzikovic L, Sun W, Wong B, Ruffenach G, Rhodes CJ, Brownstein A, Liang LL, Aryan L, Li M, Vadgama A, Kurt Z, Schwantes-An TH, Mickler EA, Gr?f S, Eyries M, Lutz KA, Pauciulo MW, Trembath RC, Perros F, Montani D, Morrell NW, Soubrier F, Wilkins MR, Nichols WC, Aldred MA, Desai AA, Tr?gou?t DA, Umar S, Saggar R, Channick R, Tuder RM, Geraci MW, Stearman RS, Yang X, Eghbali M. Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension. Circulation. 2024 Oct 15; 150(16):1268-1287.
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Bhattacharya M, Horswill AR. The role of human extracellular matrix proteins in defining Staphylococcus aureus biofilm infections. FEMS Microbiol Rev. 2024 Jan 12; 48(1).
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Oshima K, Siddiqui N, Orfila JE, Carter D, Laing J, Han X, Zakharevich I, Iozzo RV, Ghasabyan A, Moore H, Zhang F, Linhardt RJ, Moore EE, Quillinan N, Schmidt EP, Herson PS, Hippensteel JA. A role for decorin in improving motor deficits after traumatic brain injury. Matrix Biol. 2024 Jan; 125:88-99.
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Samadzadeh S, Olesen MN, Wirenfeldt M, M?ller S, Misu T, Soelberg K, Frederiksen JL, Heegaard S, Mariotto S, Fujihara K, Ruprecht K, Andersen TL, Marignier R, Lillevang ST, Flanagan EP, Pittock SJ, Kim HJ, Bennett JL, Paul F, Sorensen GL, Weinshenker BG, Lassmann H, Asgari N. Microfibrillar-associated protein 4 as a potential marker of acute relapse in inflammatory demyelinating diseases of the central nervous system: Pathological and clinical aspects. Mult Scler. 2023 Dec; 29(14):1721-1735.
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Frank BS, Nandy D, Khailova L, Mitchell MB, Morgan GJ, Twite M, DiMaria MV, Davidson JA. Circulating biomarkers of extracellular matrix dysregulation are associated with adverse post-stage 2 outcomes in infants with single ventricle heart disease. Sci Rep. 2023 09 28; 13(1):16318.
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Sayres L, Flockton AR, Ji S, Rey Diaz C, Gumina DL, Su EJ. Angiogenic Function of Human Placental Endothelial Cells in Severe Fetal Growth Restriction Is Not Rescued by Individual Extracellular Matrix Proteins. Cells. 2023 09 23; 12(19).
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Sumalde AAM, Scholes MA, Kalmanson OA, Terhune EA, Frejo L, Wethey CI, Roman-Naranjo P, Carry PM, Gubbels SP, Lopez-Escamez JA, Hadley-Miller N, Santos-Cortez RLP. Rare Coding Variants in Patients with Non-Syndromic Vestibular Dysfunction. Genes (Basel). 2023 03 30; 14(4).
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