 Fenfluramine
"Fenfluramine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
| Descriptor ID |
D005277
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| MeSH Number(s) |
D02.092.471.683.467
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Fenfluramine".
Below are MeSH descriptors whose meaning is more specific than "Fenfluramine".
This graph shows the total number of publications written about "Fenfluramine" by people in this website by year, and whether "Fenfluramine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 | | 1999 | 1 | 0 | 1 | | 2004 | 0 | 1 | 1 | | 2009 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 | | 2020 | 1 | 0 | 1 | | 2021 | 0 | 2 | 2 | | 2022 | 0 | 4 | 4 |
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Below are the most recent publications written about "Fenfluramine" by people in Profiles.
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Bishop KI, Isquith PK, Gioia GA, Knupp KG, Scheffer IE, Nabbout R, Specchio N, Sullivan J, Auvin S, Helen Cross J, Guerrini R, Farfel G, Galer BS, Gammaitoni AR. Fenfluramine treatment is associated with improvement in everyday executive function in preschool-aged children (<5 years) with Dravet syndrome: A critical period for early neurodevelopment. Epilepsy Behav. 2023 01; 138:108994.
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Knupp KG, Scheffer IE, Ceulemans B, Sullivan J, Nickels KC, Lagae L, Guerrini R, Zuberi SM, Nabbout R, Riney K, Agarwal A, Lock M, Dai D, Farfel GM, Galer BS, Gammaitoni AR, Polega S, Davis R, Gil-Nagel A. Fenfluramine provides clinically meaningful reduction in frequency of drop seizures in patients with Lennox-Gastaut syndrome: Interim analysis of an open-label extension study. Epilepsia. 2023 01; 64(1):139-151.
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Lopez JC, Pare JR, Blackmer AB, Orth LE. Treatment-Refractory Dravet Syndrome: Considerations for Novel Medications. J Pediatr Health Care. 2022 Sep-Oct; 36(5):479-488.
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Knupp KG, Scheffer IE, Ceulemans B, Sullivan JE, Nickels KC, Lagae L, Guerrini R, Zuberi SM, Nabbout R, Riney K, Shore S, Agarwal A, Lock M, Farfel GM, Galer BS, Gammaitoni AR, Davis R, Gil-Nagel A. Efficacy and Safety of Fenfluramine for the Treatment of Seizures Associated With Lennox-Gastaut Syndrome: A Randomized Clinical Trial. JAMA Neurol. 2022 06 01; 79(6):554-564.
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Andrade DM, Berg AT, Hood V, Knupp KG, Koh S, Laux L, Meskis MA, Miller I, Perry MS, Scheffer IE, Sullivan J, Villas N, Wirrell E. Dravet syndrome: A quick transition guide for the adult neurologist. Epilepsy Res. 2021 Nov; 177:106743.
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Gil-Nagel A, Sullivan J, Ceulemans B, Wirrell E, Devinsky O, Nabbout R, Knupp KG, Scott Perry M, Polster T, Davis R, Lock M, Cortes RM, Gammaiton AR, Farfel G, Galer BS, Agarwal A. Treatment with fenfluramine in patients with Dravet syndrome has no long-term effects on weight and growth. Epilepsy Behav. 2021 09; 122:108212.
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Nabbout R, Mistry A, Zuberi S, Villeneuve N, Gil-Nagel A, Sanchez-Carpintero R, Stephani U, Laux L, Wirrell E, Knupp K, Chiron C, Farfel G, Galer BS, Morrison G, Lock M, Agarwal A, Auvin S. Fenfluramine for Treatment-Resistant Seizures in Patients With Dravet Syndrome Receiving Stiripentol-Inclusive Regimens: A Randomized Clinical Trial. JAMA Neurol. 2020 03 01; 77(3):300-308.
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Lagae L, Sullivan J, Knupp K, Laux L, Polster T, Nikanorova M, Devinsky O, Cross JH, Guerrini R, Talwar D, Miller I, Farfel G, Galer BS, Gammaitoni A, Mistry A, Morrison G, Lock M, Agarwal A, Lai WW, Ceulemans B. Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial. Lancet. 2019 12 21; 394(10216):2243-2254.
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Feng N, Telefont M, Kelly KJ, Orchinik M, Forster GL, Renner KJ, Lowry CA. Local perfusion of corticosterone in the rat medial hypothalamus potentiates D-fenfluramine-induced elevations of extracellular 5-HT concentrations. Horm Behav. 2009 Jun; 56(1):149-57.
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Horton MR, Tuder RM. Primary pulmonary arterial hypertension presenting as diffuse micronodules on CT. Crit Rev Comput Tomogr. 2004; 45(5-6):335-41.
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