 Selegiline
"Selegiline" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual, 1994, p385) The compound without isomeric designation is Deprenyl.
| Descriptor ID |
D012642
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| MeSH Number(s) |
D02.092.471.683.915
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| Concept/Terms |
Selegiline- Selegiline
- Selegiline, (R)-Isomer
- Selegyline
- L-Deprenyl
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Below are MeSH descriptors whose meaning is more general than "Selegiline".
Below are MeSH descriptors whose meaning is more specific than "Selegiline".
This graph shows the total number of publications written about "Selegiline" by people in this website by year, and whether "Selegiline" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 2 | 0 | 2 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Selegiline" by people in Profiles.
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Hoffman GR, Olson MG, Schoffstall AM, Est?vez RF, Van den Eynde V, Gillman PK, Stabio ME. Classics in Chemical Neuroscience: Selegiline, Isocarboxazid, Phenelzine, and Tranylcypromine. ACS Chem Neurosci. 2023 12 06; 14(23):4064-4075.
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Evans SR, Yeh TM, Sacktor N, Clifford DB, Simpson D, Miller EN, Ellis RJ, Valcour V, Marra CM, Millar L, Schifitto G. Selegiline transdermal system (STS) for HIV-associated cognitive impairment: open-label report of ACTG 5090. HIV Clin Trials. 2007 Nov-Dec; 8(6):437-46.
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Schifitto G, Zhang J, Evans SR, Sacktor N, Simpson D, Millar LL, Hung VL, Miller EN, Smith E, Ellis RJ, Valcour V, Singer E, Marra CM, Kolson D, Weihe J, Remmel R, Katzenstein D, Clifford DB. A multicenter trial of selegiline transdermal system for HIV-associated cognitive impairment. Neurology. 2007 Sep 25; 69(13):1314-21.
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Lew MF, Pahwa R, Leehey M, Bertoni J, Kricorian G. Safety and efficacy of newly formulated selegiline orally disintegrating tablets as an adjunct to levodopa in the management of 'off' episodes in patients with Parkinson's disease. Curr Med Res Opin. 2007 Apr; 23(4):741-50.
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