 Tetanus Toxin
"Tetanus Toxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.
| Descriptor ID |
D013744
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| MeSH Number(s) |
D12.776.097.872 D23.946.123.893
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| Concept/Terms |
Tetanus Toxin- Tetanus Toxin
- Toxin, Tetanus
- Clostridium tetani Toxin
- Toxin, Clostridium tetani
- Tetanus Toxins
- Toxins, Tetanus
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Below are MeSH descriptors whose meaning is more general than "Tetanus Toxin".
Below are MeSH descriptors whose meaning is more specific than "Tetanus Toxin".
This graph shows the total number of publications written about "Tetanus Toxin" by people in this website by year, and whether "Tetanus Toxin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 | | 2004 | 1 | 0 | 1 | | 2008 | 0 | 1 | 1 | | 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Tetanus Toxin" by people in Profiles.
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He YG, Pappworth IY, Rossbach A, Paulin J, Mavimba T, Hayes C, Kulik L, Holers VM, Knight AM, Marchbank KJ. A novel C3d-containing oligomeric vaccine provides insight into the viability of testing human C3d-based vaccines in mice. Immunobiology. 2018 01; 223(1):125-134.
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Davis MW, Morton JJ, Carroll D, Jorgensen EM. Gene activation using FLP recombinase in C. elegans. PLoS Genet. 2008 Mar 21; 4(3):e1000028.
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Benke TA, Swann J. The tetanus toxin model of chronic epilepsy. Adv Exp Med Biol. 2004; 548:226-38.
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Schloot NC, Meierhoff G, Karlsson Faresj? M, Ott P, Putnam A, Lehmann P, Gottlieb P, Roep BO, Peakman M, Tree T. Comparison of cytokine ELISpot assay formats for the detection of islet antigen autoreactive T cells. Report of the third immunology of diabetes society T-cell workshop. J Autoimmun. 2003 Dec; 21(4):365-76.
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