 Botulinum Toxins
"Botulinum Toxins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.
| Descriptor ID |
D001905
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| MeSH Number(s) |
D08.811.277.656.300.480.153 D08.811.277.656.675.374.153 D12.776.097.156 D23.946.123.179
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| Concept/Terms |
Botulinum Toxins- Botulinum Toxins
- Toxins, Botulinum
- Botulinum Toxin
- Toxin, Botulinum
- Clostridium botulinum Toxins
- Toxins, Clostridium botulinum
- Botulin
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Below are MeSH descriptors whose meaning is more general than "Botulinum Toxins".
Below are MeSH descriptors whose meaning is more specific than "Botulinum Toxins".
This graph shows the total number of publications written about "Botulinum Toxins" by people in this website by year, and whether "Botulinum Toxins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 | | 1996 | 1 | 0 | 1 | | 1997 | 2 | 0 | 2 | | 2000 | 1 | 0 | 1 | | 2007 | 1 | 0 | 1 | | 2008 | 4 | 0 | 4 | | 2009 | 4 | 0 | 4 | | 2010 | 2 | 0 | 2 | | 2012 | 0 | 1 | 1 | | 2014 | 3 | 0 | 3 | | 2016 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2018 | 2 | 0 | 2 | | 2019 | 2 | 1 | 3 | | 2020 | 1 | 0 | 1 | | 2021 | 2 | 0 | 2 | | 2022 | 1 | 0 | 1 | | 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Botulinum Toxins" by people in Profiles.
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Mehner L, Ng SM, Singh J. Interventions for infantile esotropia. Cochrane Database Syst Rev. 2023 01 16; 1:CD004917.
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Montminy T, Belkind-Gerson J, Kilgore A, Tran P, Mark JA. Evaluating the Accuracy of Anal Botulinum Toxin Injection in Children With Constipation Using Endoscopic Ultrasound. J Pediatr Gastroenterol Nutr. 2022 04 01; 74(4):e98.
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Gosain A, Goldstein AM. Invited commentary on Ahmad et?al.: Routine botulinum toxin injection one month after a Swenson pull-through does not change the incidence of Hirschsprung associated enterocolitis. J Pediatr Surg. 2022 08; 57(8):1458-1459.
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Zakin E, Simpson DM. Botulinum Toxin Therapy in Writer's Cramp and Musician's Dystonia. Toxins (Basel). 2021 12 14; 13(12).
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Oleszek JL, Kanallakan AS, Powell AJ. Out of the spasticity box: Off-label uses of botulinum toxin in children. J Pediatr Rehabil Med. 2020; 13(2):205-207.
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Khashab MA, Vela MF, Thosani N, Agrawal D, Buxbaum JL, Abbas Fehmi SM, Fishman DS, Gurudu SR, Jamil LH, Jue TL, Kannadath BS, Law JK, Lee JK, Naveed M, Qumseya BJ, Sawhney MS, Yang J, Wani S. ASGE guideline on the management of achalasia. Gastrointest Endosc. 2020 02; 91(2):213-227.e6.
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Wilhour D, Ceriani CEJ, Nahas SJ. Nummular Headache. Curr Neurol Neurosci Rep. 2019 04 17; 19(6):26.
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Liu Q, Sinnen BL, Boxer EE, Schneider MW, Grybko MJ, Buchta WC, Gibson ES, Wysoczynski CL, Ford CP, Gottschalk A, Aoto J, Tucker CL, Kennedy MJ. A Photoactivatable Botulinum Neurotoxin for Inducible Control of Neurotransmission. Neuron. 2019 03 06; 101(5):863-875.e6.
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Zakin E, Simpson D. Evidence on botulinum toxin in selected disorders. Toxicon. 2018 Jun 01; 147:134-140.
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Ozzello DJ, Giacometti JN. Botulinum Toxins for Treating Essential Blepharospasm and Hemifacial Spasm. Int Ophthalmol Clin. 2018; 58(1):49-61.
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