 alpha 1-Antitrypsin Deficiency
"alpha 1-Antitrypsin Deficiency" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Deficiency of the protease inhibitor ALPHA 1-ANTITRYPSIN that manifests primarily as PULMONARY EMPHYSEMA and LIVER CIRRHOSIS.
| Descriptor ID |
D019896
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| MeSH Number(s) |
C06.552.074 C08.381.112 C16.320.060 C23.550.325.500.500
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| Concept/Terms |
alpha 1-Antitrypsin Deficiency- alpha 1-Antitrypsin Deficiency
- Deficiencies, alpha 1-Antitrypsin
- Deficiency, alpha 1-Antitrypsin
- alpha 1 Antitrypsin Deficiency
- alpha 1-Antitrypsin Deficiencies
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Below are MeSH descriptors whose meaning is more general than "alpha 1-Antitrypsin Deficiency".
Below are MeSH descriptors whose meaning is more specific than "alpha 1-Antitrypsin Deficiency".
This graph shows the total number of publications written about "alpha 1-Antitrypsin Deficiency" by people in this website by year, and whether "alpha 1-Antitrypsin Deficiency" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 2 | 2 | | 2004 | 0 | 2 | 2 | | 2005 | 0 | 1 | 1 | | 2006 | 2 | 1 | 3 | | 2007 | 3 | 1 | 4 | | 2008 | 3 | 0 | 3 | | 2009 | 1 | 1 | 2 | | 2010 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 1 | 1 | 2 | | 2013 | 5 | 1 | 6 | | 2015 | 4 | 1 | 5 | | 2016 | 2 | 1 | 3 | | 2017 | 1 | 0 | 1 | | 2018 | 2 | 0 | 2 | | 2019 | 2 | 1 | 3 | | 2020 | 1 | 0 | 1 | | 2022 | 3 | 1 | 4 | | 2023 | 3 | 0 | 3 | | 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "alpha 1-Antitrypsin Deficiency" by people in Profiles.
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Chan ED. Identification of Alpha-1 Antitrypsin-Deficient Subjects with Normal Spirometry Who May Benefit from Alpha-1 Antitrypsin Replacement. Am J Respir Crit Care Med. 2024 04 15; 209(8):1033-1034.
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Teckman J, Rosenthal P, Ignacio RV, Spino C, Bass LM, Horslen S, Wang K, Magee JC, Karpen S, Asai A, Molleston JP, Squires RH, Kamath BM, Guthery SL, Loomes KM, Shneider BL, Sokol RJ. Neonatal cholestasis in children with Alpha-1-AT deficiency is a risk for earlier severe liver disease with male predominance. Hepatol Commun. 2023 12 01; 7(12).
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Crapo JD, Gupta A, Lynch DA, Turner AM, Mroz RM, Janssens W, Ludwig-Sengpiel A, Koegler H, Eleftheraki A, Risse F, Diefenbach C. Baseline characteristics from a 3-year longitudinal study to phenotype subjects with COPD: the FOOTPRINTS study. Respir Res. 2023 Nov 17; 24(1):290.
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Bai X, Schountz T, Buckle AM, Talbert JL, Sandhaus RA, Chan ED. Alpha-1-antitrypsin antagonizes COVID-19: a review of the epidemiology, molecular mechanisms, and clinical evidence. Biochem Soc Trans. 2023 06 28; 51(3):1361-1375.
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Bai X, Bai A, Tomasicchio M, Hagman JR, Buckle AM, Gupta A, Kadiyala V, Bevers S, Serban KA, Kim K, Feng Z, Spendier K, Hagen G, Fornis L, Griffith DE, Dzieciatkowska M, Sandhaus RA, Gerber AN, Chan ED. a1-Antitrypsin Binds to the Glucocorticoid Receptor with Anti-Inflammatory and Antimycobacterial Significance in Macrophages. J Immunol. 2022 11 01; 209(9):1746-1759.
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Serban KA, Pratte KA, Strange C, Sandhaus RA, Turner AM, Beiko T, Spittle DA, Maier L, Hamzeh N, Silverman EK, Hobbs BD, Hersh CP, DeMeo DL, Cho MH, Bowler RP. Unique and shared systemic biomarkers for emphysema in Alpha-1 Antitrypsin deficiency and chronic obstructive pulmonary disease. EBioMedicine. 2022 Oct; 84:104262.
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Cruz MA, Bohinc D, Andraska EA, Alvikas J, Raghunathan S, Masters NA, van Kleef ND, Bane KL, Hart K, Medrow K, Sun M, Liu H, Haldeman S, Banerjee A, Lessieur EM, Hageman K, Gandhi A, de la Fuente M, Nieman MT, Kern TS, Maas C, de Maat S, Neeves KB, Neal MD, Sen Gupta A, Stavrou EX. Nanomedicine platform for targeting activated neutrophils and neutrophil-platelet complexes using an a1-antitrypsin-derived peptide motif. Nat Nanotechnol. 2022 09; 17(9):1004-1014.
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Ryan SM, Mroz MM, Herzog EL, Ryu C, Fingerlin TE, Maier LA, Gulati M. Occupational and environmental exposures in the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) study. Respir Med. 2022 Aug-Sep; 200:106923.
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Abu Rmilah A, Fencl R, Watt K, Krowka M, Wiesner R, Murray D, Nyberg S, Leise M. Association of a 1 Antitrypsin Phenotype and Development of Advanced Liver Disease and Pulmonary Complications Before and After Liver Transplantation. Transplantation. 2021 07 01; 105(7):1576-1584.
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Murray JD, Willrich MA, Krowka MJ, Bobr A, Murray DL, Halling KC, Graham RP, Snyder MR. Liquid Chromatography-Tandem Mass Spectrometry-Based a1-Antitrypsin (AAT) Testing. Am J Clin Pathol. 2021 03 15; 155(4):547-552.
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