 Collectins
"Collectins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of C-type lectins that target the carbohydrate structures found on invading pathogens. Binding of collectins to microorganisms results in their agglutination and enhanced clearance. Collectins form trimers that may assemble into larger oligomers. Each collectin polypeptide chain consists of four regions: a relatively short N-terminal region, a collagen-like region, an alpha-helical coiled-coil region, and carbohydrate-binding region.
| Descriptor ID |
D037222
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| MeSH Number(s) |
D12.776.503.280.249
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| Concept/Terms |
Collectins- Collectins
- Collagenous Lectins
- Lectins, Collagenous
- Collectin
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Below are MeSH descriptors whose meaning is more general than "Collectins".
Below are MeSH descriptors whose meaning is more specific than "Collectins".
This graph shows the total number of publications written about "Collectins" by people in this website by year, and whether "Collectins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 | | 2003 | 1 | 0 | 1 | | 2006 | 1 | 1 | 2 | | 2012 | 1 | 0 | 1 | | 2017 | 0 | 1 | 1 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Collectins" by people in Profiles.
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Wang N, Wu W, Qiang C, Ma N, Wu K, Liu D, Wang JX, Yang X, Xue L, Diao TY, Liu JY, Li A, Zhang B, Li ZF, Farrar CA, Banda NK, Bayarri-Olmos R, Garred P, Zhou W, Li K. Protective Role of Collectin 11 in a Mouse Model of Rheumatoid Arthritis. Arthritis Rheumatol. 2021 08; 73(8):1430-1440.
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Banda NK, Acharya S, Scheinman RI, Mehta G, Takahashi M, Endo Y, Zhou W, Farrar CA, Sacks SH, Fujita T, Sekine H, Holers VM. Deconstructing the Lectin Pathway in the Pathogenesis of Experimental Inflammatory Arthritis: Essential Role of the Lectin Ficolin B and Mannose-Binding Protein-Associated Serine Protease 2. J Immunol. 2017 09 01; 199(5):1835-1845.
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McCubbrey AL, Sonstein J, Ames TM, Freeman CM, Curtis JL. Glucocorticoids relieve collectin-driven suppression of apoptotic cell uptake in murine alveolar macrophages through downregulation of SIRPa. J Immunol. 2012 Jul 01; 189(1):112-9.
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Gardai SJ, Bratton DL, Ogden CA, Henson PM. Recognition ligands on apoptotic cells: a perspective. J Leukoc Biol. 2006 May; 79(5):896-903.
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Stuart LM, Henson PM, Vandivier RW. Collectins: opsonins for apoptotic cells and regulators of inflammation. Curr Dir Autoimmun. 2006; 9:143-61.
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Kudo K, Sano H, Takahashi H, Kuronuma K, Yokota S, Fujii N, Shimada K, Yano I, Kumazawa Y, Voelker DR, Abe S, Kuroki Y. Pulmonary collectins enhance phagocytosis of Mycobacterium avium through increased activity of mannose receptor. J Immunol. 2004 Jun 15; 172(12):7592-602.
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Gardai SJ, Xiao YQ, Dickinson M, Nick JA, Voelker DR, Greene KE, Henson PM. By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation. Cell. 2003 Oct 03; 115(1):13-23.
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Ogden CA, deCathelineau A, Hoffmann PR, Bratton D, Ghebrehiwet B, Fadok VA, Henson PM. C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. J Exp Med. 2001 Sep 17; 194(6):781-95.
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