 T-Lymphoma Invasion and Metastasis-inducing Protein 1
"T-Lymphoma Invasion and Metastasis-inducing Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A Rho guanine nucleotide exchange factor that consists of two pleckstrin homology domains flanking central Ras-binding, Dbl-homology (DH) and PDZ domains. It stimulates GTP-GDP exchange of rho-like GTPases such as RAC1 PROTEIN; CDC42 PROTEIN; and RHOA PROTEIN, and functions to link extracellular signals to remodeling of the CYTOSKELETON for CELL ADHESION and CELL MOVEMENT.
| Descriptor ID |
D000075684
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| MeSH Number(s) |
D12.644.360.325.300.850 D12.776.476.325.300.850
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "T-Lymphoma Invasion and Metastasis-inducing Protein 1".
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This graph shows the total number of publications written about "T-Lymphoma Invasion and Metastasis-inducing Protein 1" by people in this website by year, and whether "T-Lymphoma Invasion and Metastasis-inducing Protein 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "T-Lymphoma Invasion and Metastasis-inducing Protein 1" by people in Profiles.
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Liu X, Golden LC, Lopez JA, Shepherd TR, Yu L, Fuentes EJ. Conformational Dynamics and Cooperativity Drive the Specificity of a Protein-Ligand Interaction. Biophys J. 2019 06 18; 116(12):2314-2330.
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Smith KR, Rajgor D, Hanley JG. Differential regulation of the Rac1 GTPase-activating protein (GAP) BCR during oxygen/glucose deprivation in hippocampal and cortical neurons. J Biol Chem. 2017 12 08; 292(49):20173-20183.
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Ahmed MM, Dhanasekaran AR, Tong S, Wiseman FK, Fisher EM, Tybulewicz VL, Gardiner KJ. Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain. Hum Mol Genet. 2013 May 01; 22(9):1709-24.
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Liu C, Morishima M, Yu T, Matsui S, Zhang L, Fu D, Pao A, Costa AC, Gardiner KJ, Cowell JK, Nowak NJ, Nowak NJ, Parmacek MS, Liang P, Baldini A, Yu YE. Genetic analysis of Down syndrome-associated heart defects in mice. Hum Genet. 2011 Nov; 130(5):623-32.
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Abell AN, DeCathelineau AM, Weed SA, Ambruso DR, Riches DW, Johnson GL. Rac2D57N, a dominant inhibitory Rac2 mutant that inhibits p38 kinase signaling and prevents surface ruffling in bone-marrow-derived macrophages. J Cell Sci. 2004 Jan 15; 117(Pt 2):243-55.
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