 Lysine Acetyltransferase 5
"Lysine Acetyltransferase 5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A catalytic subunit of the NuA4 histone acetyltransferase complex that functions in transcriptional activation of genes by acetylation of nucleosomal HISTONES H4 and H2A, altering nucleosome-DNA interactions and interaction of the modified histones with other activating transcription factors. It may control gene expression changes associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest; CELL AGING; APOPTOSIS; and DNA REPAIR. It is polyubiquitinated and degraded during HIV-1 infection through its interaction with the viral TAT PROTEIN.
| Descriptor ID |
D000074443
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| MeSH Number(s) |
D08.811.913.050.134.415.500.062
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| Concept/Terms |
Lysine Acetyltransferase 5- Lysine Acetyltransferase 5
- KAT5 (TIP60) Protein
- HIV-1-Tat Interactive Protein Tip60
- HIV 1 Tat Interactive Protein Tip60
- HTATIP
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Below are MeSH descriptors whose meaning is more general than "Lysine Acetyltransferase 5".
Below are MeSH descriptors whose meaning is more specific than "Lysine Acetyltransferase 5".
This graph shows the total number of publications written about "Lysine Acetyltransferase 5" by people in this website by year, and whether "Lysine Acetyltransferase 5" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 1 | 0 | 1 | | 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Lysine Acetyltransferase 5" by people in Profiles.
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Manickavinayaham S, V?lez-Cruz R, Biswas AK, Bedford E, Klein BJ, Kutateladze TG, Liu B, Bedford MT, Johnson DG. E2F1 acetylation directs p300/CBP-mediated histone acetylation at DNA double-strand breaks to facilitate repair. Nat Commun. 2019 10 30; 10(1):4951.
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Perez-Perri JI, Dengler VL, Audetat KA, Pandey A, Bonner EA, Urh M, Mendez J, Daniels DL, Wappner P, Galbraith MD, Espinosa JM. The TIP60 Complex Is a Conserved Coactivator of HIF1A. Cell Rep. 2016 06 28; 16(1):37-47.
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