 Inositol Polyphosphate 5-Phosphatases
"Inositol Polyphosphate 5-Phosphatases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Phosphoinositide phosphatases that catalyze the removal of the 5' phosphate from INOSITOL 1,4,5-TRISPHOSPHATE or myo-inositol 1,3,4,5-tetrakisphosphate, resulting in inositol 1,4-bisphosphate and phosphate. They have important functions in the metabolism of INOSITOL PHOSPHATES and inositol 1,4,5-trisphosphate signaling pathways such as CALCIUM SIGNALING.
| Descriptor ID |
D000072181
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| MeSH Number(s) |
D08.811.277.352.650.624.500
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| Concept/Terms |
Inositol Polyphosphate 5-Phosphatases- Inositol Polyphosphate 5-Phosphatases
- Inositol Polyphosphate 5 Phosphatases
- Inositol 5-Phosphatase
- Inositol 5 Phosphatase
- Inositol Triphosphate 5-Phosphatase
- Inositol Triphosphate 5 Phosphatase
- Inositol-Polyphosphate 5-Phosphatase
- Inositol Polyphosphate 5 Phosphatase
- Inositol Polyphosphate 5-Phosphatase
1,4,5-Triphosphate-1,2,4,5-Tetrakisphosphate 5-Phosphatase- 1,4,5-Triphosphate-1,2,4,5-Tetrakisphosphate 5-Phosphatase
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Below are MeSH descriptors whose meaning is more general than "Inositol Polyphosphate 5-Phosphatases".
Below are MeSH descriptors whose meaning is more specific than "Inositol Polyphosphate 5-Phosphatases".
This graph shows the total number of publications written about "Inositol Polyphosphate 5-Phosphatases" by people in this website by year, and whether "Inositol Polyphosphate 5-Phosphatases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Inositol Polyphosphate 5-Phosphatases" by people in Profiles.
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Akerlund J, Getahun A, Cambier JC. B cell expression of the SH2-containing inositol 5-phosphatase (SHIP-1) is required to establish anergy to high affinity, proteinacious autoantigens. J Autoimmun. 2015 Aug; 62:45-54.
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Khalil AM, Cambier JC, Shlomchik MJ. B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity. Science. 2012 Jun 01; 336(6085):1178-81.
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Waterman PM, Marschner S, Brandl E, Cambier JC. The inositol 5-phosphatase SHIP-1 and adaptors Dok-1 and 2 play central roles in CD4-mediated inhibitory signaling. Immunol Lett. 2012 Mar 30; 143(1):122-30.
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O'Neill SK, Getahun A, Gauld SB, Merrell KT, Tamir I, Smith MJ, Dal Porto JM, Li QZ, Cambier JC. Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy. Immunity. 2011 Nov 23; 35(5):746-56.
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Zhang H, He J, Kutateladze TG, Sakai T, Sasaki T, Markadieu N, Erneux C, Prestwich GD. 5-Stabilized phosphatidylinositol 3,4,5-trisphosphate analogues bind Grp1 PH, inhibit phosphoinositide phosphatases, and block neutrophil migration. Chembiochem. 2010 Feb 15; 11(3):388-95.
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Crowley JE, Stadanlick JE, Cambier JC, Cancro MP. FcgammaRIIB signals inhibit BLyS signaling and BCR-mediated BLyS receptor up-regulation. Blood. 2009 Feb 12; 113(7):1464-73.
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Cady CT, Rice JS, Ott VL, Cambier JC. Regulation of hematopoietic cell function by inhibitory immunoglobulin G receptors and their inositol lipid phosphatase effectors. Immunol Rev. 2008 Aug; 224:44-57.
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Rider DA, Havenith CE, de Ridder R, Schuurman J, Favre C, Cooper JC, Walker S, Baadsgaard O, Marschner S, vandeWinkel JG, Cambier J, Parren PW, Alexander DR. A human CD4 monoclonal antibody for the treatment of T-cell lymphoma combines inhibition of T-cell signaling by a dual mechanism with potent Fc-dependent effector activity. Cancer Res. 2007 Oct 15; 67(20):9945-53.
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Brauweiler A, Merrell K, Gauld SB, Cambier JC. Cutting Edge: Acute and chronic exposure of immature B cells to antigen leads to impaired homing and SHIP1-dependent reduction in stromal cell-derived factor-1 responsiveness. J Immunol. 2007 Mar 15; 178(6):3353-7.
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Isnardi I, Lesourne R, Bruhns P, Fridman WH, Cambier JC, Da?ron M. Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap. J Biol Chem. 2004 Dec 10; 279(50):51931-8.
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