 Solute Carrier Family 12, Member 1
"Solute Carrier Family 12, Member 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Na-K-Cl transporter in the ASCENDING LIMB OF LOOP OF HENLE. It mediates active reabsorption of sodium chloride and is inhibited by LOOP DIURETICS such as FUROSEMIDE; and BUMETANIDE. Mutations in the gene encoding SLC12A1 are associated with a BARTTER SYNDROME.
| Descriptor ID |
D064466
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| MeSH Number(s) |
D12.776.157.530.450.625.750.500 D12.776.157.530.937.750.500 D12.776.543.585.450.625.750.500 D12.776.543.585.937.875.500
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| Concept/Terms |
Solute Carrier Family 12, Member 1- Solute Carrier Family 12, Member 1
- Kidney-Specific Na-K-Cl Symporter
- Kidney Specific Na K Cl Symporter
- Na-K-Cl Symporter, Kidney-Specific
- Symporter, Kidney-Specific Na-K-Cl
- BSC1 Transport Protein
- Protein, BSC1 Transport
- Transport Protein, BSC1
- NKCC2 Protein
- Protein, NKCC2
- NKCC2 Cotransporter
- Cotransporter, NKCC2
- SLC12A1 Cotransporter
- Cotransporter, SLC12A1
- Bumetanide-Sensitive Sodium-(Potassium)-Chloride Cotransporter 2
- SLC12A1 Protein
- Protein, SLC12A1
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Below are MeSH descriptors whose meaning is more general than "Solute Carrier Family 12, Member 1".
Below are MeSH descriptors whose meaning is more specific than "Solute Carrier Family 12, Member 1".
This graph shows the total number of publications written about "Solute Carrier Family 12, Member 1" by people in this website by year, and whether "Solute Carrier Family 12, Member 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 | | 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Solute Carrier Family 12, Member 1" by people in Profiles.
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Otterpohl KL, Busselman BW, Ratnayake I, Hart RG, Hart KR, Evans CM, Phillips CL, Beach JR, Ahrenkiel P, Molitoris BA, Surendran K, Chandrasekar I. Conditional Myh9 and Myh10 inactivation in adult mouse renal epithelium results in progressive kidney disease. JCI Insight. 2020 11 05; 5(21).
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Ibla JC, Khoury J, Kong T, Robinson A, Colgan SP. Transcriptional repression of Na-K-2Cl cotransporter NKCC1 by hypoxia-inducible factor-1. Am J Physiol Cell Physiol. 2006 Aug; 291(2):C282-9.
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