 Solute Carrier Family 12, Member 2
"Solute Carrier Family 12, Member 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Na-K-Cl transporter ubiquitously expressed. It plays a key role in salt secretion in epithelial cells and cell volume regulation in nonepithelial cells.
| Descriptor ID |
D064506
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| MeSH Number(s) |
D12.776.157.530.450.625.750.625 D12.776.157.530.937.750.625 D12.776.543.585.450.625.750.625 D12.776.543.585.937.875.625
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| Concept/Terms |
Solute Carrier Family 12, Member 2- Solute Carrier Family 12, Member 2
- Bumetanide-Sensitive Sodium Potassium Chloride Cotransporter 2
- Bumetanide Sensitive Sodium Potassium Chloride Cotransporter 2
- Sodium-Potassium-Chloride Cotransporter 1 Protein
- Sodium Potassium Chloride Cotransporter 1 Protein
- BSC2 Protein
- Protein, BSC2
- BSC2 Transport Protein
- Protein, BSC2 Transport
- Transport Protein, BSC2
- Bumetanide-Sensitive Cotransporter 2
- Bumetanide Sensitive Cotransporter 2
- Cotransporter 2, Bumetanide-Sensitive
- NKCC1 Protein
- Protein, NKCC1
- SLC12A2 Cotransporter
- Cotransporter, SLC12A2
- Solute Carrier Family 12 (Sodium Potassium Chloride Transporters), Member 2
- SLC12A2 Protein
- Protein, SLC12A2
- SLC12A2 Transporter
- Transporter, SLC12A2
- NKCC1 Cotransporter
- Cotransporter, NKCC1
- NKCC1 Transport Protein
- Protein, NKCC1 Transport
- Transport Protein, NKCC1
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Below are MeSH descriptors whose meaning is more general than "Solute Carrier Family 12, Member 2".
Below are MeSH descriptors whose meaning is more specific than "Solute Carrier Family 12, Member 2".
This graph shows the total number of publications written about "Solute Carrier Family 12, Member 2" by people in this website by year, and whether "Solute Carrier Family 12, Member 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 2 | 2 | | 2008 | 0 | 2 | 2 | | 2009 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Solute Carrier Family 12, Member 2" by people in Profiles.
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Cabrera OH, Tesic V, Tat QL, Chastain S, Quillinan N, Jevtovic-Todorovic V. Sevoflurane-Induced Dysregulation of Cation-Chloride Cotransporters NKCC1 and KCC2 in Neonatal Mouse Brain. Mol Neurobiol. 2020 Jan; 57(1):1-10.
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Gonz?lez MI. Regulation of the cell surface expression of chloride transporters during epileptogenesis. Neurosci Lett. 2016 08 15; 628:213-8.
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Morita Y, Callicott JH, Testa LR, Mighdoll MI, Dickinson D, Chen Q, Tao R, Lipska BK, Kolachana B, Law AJ, Ye T, Straub RE, Weinberger DR, Kleinman JE, Hyde TM. Characteristics of the cation cotransporter NKCC1 in human brain: alternate transcripts, expression in development, and potential relationships to brain function and schizophrenia. J Neurosci. 2014 Apr 02; 34(14):4929-40.
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Hyde TM, Lipska BK, Ali T, Mathew SV, Law AJ, Metitiri OE, Straub RE, Ye T, Colantuoni C, Herman MM, Bigelow LB, Weinberger DR, Kleinman JE. Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophrenia. J Neurosci. 2011 Jul 27; 31(30):11088-95.
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Tang J, Bouyer P, Mykoniatis A, Buschmann M, Matlin KS, Matthews JB. Activated PKC{delta} and PKC{epsilon} inhibit epithelial chloride secretion response to cAMP via inducing internalization of the Na+-K+-2Cl- cotransporter NKCC1. J Biol Chem. 2010 Oct 29; 285(44):34072-85.
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Mykoniatis A, Shen L, Fedor-Chaiken M, Tang J, Tang X, Worrell RT, Delpire E, Turner JR, Matlin KS, Bouyer P, Matthews JB. Phorbol 12-myristate 13-acetate-induced endocytosis of the Na-K-2Cl cotransporter in MDCK cells is associated with a clathrin-dependent pathway. Am J Physiol Cell Physiol. 2010 Jan; 298(1):C85-97.
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Bragin DE, Sanderson JL, Peterson S, Connor JA, M?ller WS. Development of epileptiform excitability in the deep entorhinal cortex after status epilepticus. Eur J Neurosci. 2009 Aug; 30(4):611-24.
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Sanderson JL, Donald Partridge L, Valenzuela CF. Modulation of GABAergic and glutamatergic transmission by ethanol in the developing neocortex: an in vitro test of the excessive inhibition hypothesis of fetal alcohol spectrum disorder. Neuropharmacology. 2009 Feb; 56(2):541-55.
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Zheng W, Kuhlicke J, J?ckel K, Eltzschig HK, Singh A, Sj?blom M, Riederer B, Weinhold C, Seidler U, Colgan SP, Karhausen J. Hypoxia inducible factor-1 (HIF-1)-mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium. FASEB J. 2009 Jan; 23(1):204-13.
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Dzhala VI, Talos DM, Sdrulla DA, Brumback AC, Mathews GC, Benke TA, Delpire E, Jensen FE, Staley KJ. NKCC1 transporter facilitates seizures in the developing brain. Nat Med. 2005 Nov; 11(11):1205-13.
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