 Spermine
"Spermine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. It is found as a polycation at all pH values. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure.
| Descriptor ID |
D013096
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| MeSH Number(s) |
D02.092.211.415.701.801.821 D02.092.782.802
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Spermine".
Below are MeSH descriptors whose meaning is more specific than "Spermine".
This graph shows the total number of publications written about "Spermine" by people in this website by year, and whether "Spermine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 2 | 2 | | 2001 | 1 | 1 | 2 | | 2002 | 0 | 2 | 2 | | 2005 | 1 | 2 | 3 | | 2006 | 1 | 0 | 1 | | 2008 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 0 | 1 | 1 | | 2021 | 0 | 1 | 1 | | 2022 | 0 | 2 | 2 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Spermine" by people in Profiles.
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Embi PJ, Levy ME, Patel P, DeSilva MB, Gaglani M, Dascomb K, Dunne MM, Klein NP, Ong TC, Grannis SJ, Natarajan K, Yang DH, Stenehjem E, Zerbo O, McEvoy C, Rao S, Thompson MG, Konatham D, Irving SA, Dixon BE, Han J, Schrader KE, Grisel N, Lewis N, Kharbanda AB, Barron MA, Reynolds S, Liao IC, Fadel WF, Rowley EA, Arndorfer J, Goddard K, Murthy K, Valvi NR, Weber ZA, Fireman B, Reese SE, Ball SW, Naleway AL. Effectiveness of COVID-19 vaccines at preventing emergency department or urgent care encounters and hospitalizations among immunocompromised adults: An observational study of real-world data across 10 US states from August-December 2021. Vaccine. 2023 08 23; 41(37):5424-5434.
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Sil D, Panja S, Jogdeo CM, Kumar R, Yu A, Holbert CE, Ding L, Foley JR, Stewart TM, Casero RA, Oupický D. Self-Assembled Alkylated Polyamine Analogs as Supramolecular Anticancer Agents. Molecules. 2022 Apr 10; 27(8).
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McCubbrey AL, McManus SA, McClendon JD, Thomas SM, Chatwin HB, Reisz JA, D'Alessandro A, Mould KJ, Bratton DL, Henson PM, Janssen WJ. Polyamine import and accumulation causes immunomodulation in macrophages engulfing apoptotic cells. Cell Rep. 2022 01 11; 38(2):110222.
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Sanderson JL, Freund RK, Gorski JA, Dell'Acqua ML. ß-Amyloid disruption of LTP/LTD balance is mediated by AKAP150-anchored PKA and Calcineurin regulation of Ca2+-permeable AMPA receptors. Cell Rep. 2021 10 05; 37(1):109786.
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Mattison HA, Bagal AA, Mohammadi M, Pulimood NS, Reich CG, Alger BE, Kao JP, Thompson SM. Evidence of calcium-permeable AMPA receptors in dendritic spines of CA1 pyramidal neurons. J Neurophysiol. 2014 Jul 15; 112(2):263-75.
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Jones-Carson J, Laughlin JR, Stewart AL, Voskuil MI, Vázquez-Torres A. Nitric oxide-dependent killing of aerobic, anaerobic and persistent Burkholderia pseudomallei. Nitric Oxide. 2012 Jun 30; 27(1):25-31.
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Russo BC, Horzempa J, O'Dee DM, Schmitt DM, Brown MJ, Carlson PE, Xavier RJ, Nau GJ. A Francisella tularensis locus required for spermine responsiveness is necessary for virulence. Infect Immun. 2011 Sep; 79(9):3665-76.
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Matsushita K, Fukumoto M, Kobayashi T, Kobayashi M, Ishizaki E, Minami M, Katsumura K, Liao SD, Wu DM, Zhang T, Puro DG. Diabetes-induced inhibition of voltage-dependent calcium channels in the retinal microvasculature: role of spermine. Invest Ophthalmol Vis Sci. 2010 Nov; 51(11):5979-90.
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Serkova NJ, Gamito EJ, Jones RH, O'Donnell C, Brown JL, Green S, Sullivan H, Hedlund T, Crawford ED. The metabolites citrate, myo-inositol, and spermine are potential age-independent markers of prostate cancer in human expressed prostatic secretions. Prostate. 2008 May 01; 68(6):620-8.
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Patel MM, Anchordoquy TJ. Ability of spermine to differentiate between DNA sequences--preferential stabilization of A-tracts. Biophys Chem. 2006 Jun 20; 122(1):5-15.
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