 Tetrahydrofolate Dehydrogenase
"Tetrahydrofolate Dehydrogenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.
| Descriptor ID |
D013762
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| MeSH Number(s) |
D08.811.682.662.825
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| Concept/Terms |
Tetrahydrofolate Dehydrogenase- Tetrahydrofolate Dehydrogenase
- Dehydrogenase, Tetrahydrofolate
- Folic Acid Reductase
- Acid Reductase, Folic
- Reductase, Folic Acid
- Dihydrofolate Dehydrogenase
- Dehydrogenase, Dihydrofolate
- Dihydrofolate Reductase
- Reductase, Dihydrofolate
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Below are MeSH descriptors whose meaning is more general than "Tetrahydrofolate Dehydrogenase".
Below are MeSH descriptors whose meaning is more specific than "Tetrahydrofolate Dehydrogenase".
This graph shows the total number of publications written about "Tetrahydrofolate Dehydrogenase" by people in this website by year, and whether "Tetrahydrofolate Dehydrogenase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 1 | 2 | | 1997 | 1 | 0 | 1 | | 2004 | 1 | 0 | 1 | | 2005 | 0 | 1 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2016 | 0 | 1 | 1 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tetrahydrofolate Dehydrogenase" by people in Profiles.
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Bourke AM, Schwartz SL, Bowen AB, Kleinjan MS, Winborn CS, Kareemo DJ, Gutnick A, Schwarz TL, Kennedy MJ. zapERtrap: A light-regulated ER release system reveals unexpected neuronal trafficking pathways. J Cell Biol. 2021 09 06; 220(9).
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Sheridan RM, Bentley DL. Selectable one-step PCR-mediated integration of a degron for rapid depletion of endogenous human proteins. Biotechniques. 2016 Feb; 60(2):69-74.
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Tu??n I, Laage D, Hynes JT. Are there dynamical effects in enzyme catalysis? Some thoughts concerning the enzymatic chemical step. Arch Biochem Biophys. 2015 Sep 15; 582:42-55.
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Renn JP, Junker M, Besingi RN, Braselmann E, Clark PL. ATP-independent control of autotransporter virulence protein transport via the folding properties of the secreted protein. Chem Biol. 2012 Feb 24; 19(2):287-96.
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Oyeyemi OA, Sours KM, Lee T, Kohen A, Resing KA, Ahn NG, Klinman JP. Comparative hydrogen-deuterium exchange for a mesophilic vs thermophilic dihydrofolate reductase at 25 ?C: identification of a single active site region with enhanced flexibility in the mesophilic protein. Biochemistry. 2011 Sep 27; 50(38):8251-60.
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Oyeyemi OA, Sours KM, Lee T, Resing KA, Ahn NG, Klinman JP. Temperature dependence of protein motions in a thermophilic dihydrofolate reductase and its relationship to catalytic efficiency. Proc Natl Acad Sci U S A. 2010 Jun 01; 107(22):10074-9.
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Gray SJ, Liu G, Altman AL, Small LE, Fanning E. Discrete functional elements required for initiation activity of the Chinese hamster dihydrofolate reductase origin beta at ectopic chromosomal sites. Exp Cell Res. 2007 Jan 01; 313(1):109-20.
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Powell MS, Barnes NC, Bradford TM, Musgrave IF, Wines BD, Cambier JC, Hogarth PM. Alteration of the Fc gamma RIIa dimer interface affects receptor signaling but not ligand binding. J Immunol. 2006 Jun 15; 176(12):7489-94.
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Xiao YD, Clauset A, Harris R, Bayram E, Santago P, Schmitt JD. Supervised self-organizing maps in drug discovery. 1. Robust behavior with overdetermined data sets. J Chem Inf Model. 2005 Nov-Dec; 45(6):1749-58.
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Saraf MC, Horswill AR, Benkovic SJ, Maranas CD. FamClash: a method for ranking the activity of engineered enzymes. Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12):4142-7.
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