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Claudia S Mickael

TitleAsst Professor-Research
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

    Collapse Biography 
    Collapse education and training
    Universidade Federal de Goias, Goiania, BrazilBachelors in Science03/1992
    Universidade Federal de Goias, Goiania, BrazilMasters06/2000Tropical Medicine and Public Health
    The Ohio State University, Columbus, OHPhD06/2005Virology

    Collapse Research 
    Collapse research activities and funding
    K01HL161024     (MICKAEL, CLAUDIA SILVA)Sep 1, 2022 - Aug 31, 2027
    NIH
    Novel Role of Classical Dendritic Cells in the pathogenesis of Hypoxia-Induced Pulmonary Hypertension
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Kumar R, Chanana N, Sharma K, Palmo T, Lee MH, Mishra A, Nolan K, Fonseca Balladares DC, Mickael C, Gupta MD, Thinlas T, Pasha Q, Graham BB. Dexamethasone prophylaxis protects from acute high-altitude illness by modifying the peripheral blood mononuclear cell inflammatory transcriptome. Biosci Rep. 2023 11 30; 43(11). PMID: 37975243.
      View in: PubMed
    2. Graham BB, Hilton JF, Lee MH, Kumar R, Balladares DF, Rahaghi FN, Est?par RSJ, Mickael C, Lima RLB, Loureiro CMC, Lucena J, Oliveira RKF, Corr?a RA. Is pulmonary arterial hypertension associated with schistosomiasis distinct from pulmonary arterial hypertension associated with portal hypertension? JHLT Open. 2023 Oct; 1. PMID: 38050478.
      View in: PubMed
    3. Kumar R, Lee MH, Kassa B, Fonseca Balladares DC, Mickael C, Sanders L, Andruska A, Kumar M, Spiekerkoetter E, Bandeira A, Stenmark KR, Tuder RM, Graham BB. Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension. Clin Sci (Lond). 2023 04 26; 137(8):617-631. PMID: 37014925.
      View in: PubMed
    4. Mickael C, Lee MH, Graham BB. The COVID-19 pandemic and pulmonary arterial hypertension in Italy: adaptation, outcomes and valuable lessons learned. Eur Respir J. 2022 10; 60(4). PMID: 36202406.
      View in: PubMed
    5. Gu S, Mickael C, Kumar R, Lee MH, Sanders L, Kassa B, Harral J, Williams J, Hansen KC, Stenmark KR, Tuder RM, Graham BB. The role of macrophages in right ventricular remodeling in experimental pulmonary hypertension. Pulm Circ. 2022 Jul; 12(3):e12105. PMID: 35874852.
      View in: PubMed
    6. Lee MH, Sanders L, Kumar R, Hernandez-Saavedra D, Yun X, Ford JA, Perez MJ, Mickael C, Gandjeva A, Koyanagi DE, Harral JW, Irwin DC, Kassa B, Eckel RH, Shimoda LA, Graham BB, Tuder RM. Contribution of fatty acid oxidation to the pathogenesis of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2022 09 01; 323(3):L355-L371. PMID: 35763400.
      View in: PubMed
    7. Campbell NV, Mickael C, Kumar S, Zhang H, Campbell IL, Gillen AE, Trentin CO, Diener K, Gao B, Kheyfets VO, Gu S, Kumar R, Phang T, Brown RD, Graham BB, Stenmark KR. Single-cell RNA sequencing and binary hierarchical clustering define lung interstitial macrophage heterogeneity in response to hypoxia. Am J Physiol Lung Cell Mol Physiol. 2022 07 01; 323(1):L58-L68. PMID: 35608266.
      View in: PubMed
    8. Mickael C, Kheyfets VO, Langou?t-Astri? C, Lee MH, Sanders LA, Trentin CO, Sweatt AJ, Zamanian RT, Bull TM, Stenmark K, Graham BB, Tuder RM. Peripheral Blood Inflammation Profile of Patients with Pulmonary Arterial Hypertension Using the High-Throughput Olink Proteomics Platform. Am J Respir Cell Mol Biol. 2022 05; 66(5):580-581. PMID: 35486078.
      View in: PubMed
    9. Kassa B, Lee MH, Kumar R, Mickael C, Sanders L, Tuder RM, Mentink-Kane M, Graham BB. Experimental Schistosoma japonicum-induced pulmonary hypertension. PLoS Negl Trop Dis. 2022 04; 16(4):e0010343. PMID: 35417453.
      View in: PubMed
    10. Lee MH, Mickael C, Graham BB. Two Birds with One Stone: Helping the Pulmonary Arteries and the Right Ventricle by Targeting BMPR2 Signaling. Am J Respir Cell Mol Biol. 2021 09; 65(3):233-235. PMID: 34029508.
      View in: PubMed
    11. Kassa B, Kumar R, Mickael C, Sanders L, Vohwinkel C, Lee MH, Gu S, Poth JM, Stenmark KR, Zhao YY, Tuder RM, Graham BB. Endothelial cell PHD2-HIF1a-PFKFB3 contributes to right ventricle vascular adaptation in pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2021 10 01; 321(4):L675-L685. PMID: 34346780.
      View in: PubMed
    12. Rahaghi FN, Hilton JF, Corr?a RA, Loureiro C, Ota-Arakaki JS, Verrastro CGY, Lee MH, Mickael C, Nardelli P, Systrom DA, Waxman AB, Washko GR, San Jos? Est?par R, Graham BB, Oliveira RKF. Arterial vascular volume changes with haemodynamics in schistosomiasis-associated pulmonary arterial hypertension. Eur Respir J. 2021 05; 57(5). PMID: 33446601.
      View in: PubMed
    13. Sibomana JP, Campeche A, Carvalho-Filho RJ, Correa RA, Duani H, Pacheco Guimaraes V, Hilton JF, Kassa B, Kumar R, Lee MH, Loureiro CMC, Mazimba S, Mickael C, Oliveira RKF, Ota-Arakaki JS, Rezende CF, Silva LCS, Sinkala E, Ahmed HY, Graham BB. Schistosomiasis Pulmonary Arterial Hypertension. Front Immunol. 2020; 11:608883. PMID: 33362796.
      View in: PubMed
    14. Kumar R, Lee MH, Mickael C, Kassa B, Pasha Q, Tuder R, Graham B. Pathophysiology and potential future therapeutic targets using preclinical models of COVID-19. ERJ Open Res. 2020 Oct; 6(4). PMID: 33313306.
      View in: PubMed
    15. Kumar R, Mickael C, Kassa B, Sanders L, Hernandez-Saavedra D, Koyanagi DE, Kumar S, Pugliese SC, Thomas S, McClendon J, Maloney JP, Janssen WJ, Stenmark KR, Tuder RM, Graham BB. Interstitial macrophage-derived thrombospondin-1 contributes to hypoxia-induced pulmonary hypertension. Cardiovasc Res. 2020 10 01; 116(12):2021-2030. PMID: 31710666.
      View in: PubMed
    16. Hernandez-Saavedra D, Sanders L, Freeman S, Reisz JA, Lee MH, Mickael C, Kumar R, Kassa B, Gu S, D' Alessandro A, Stenmark KR, Tuder RM, Graham BB. Publisher Correction: Stable isotope metabolomics of pulmonary artery smooth muscle and endothelial cells in pulmonary hypertension and with TGF-beta treatment. Sci Rep. 2020 Mar 04; 10(1):4349. PMID: 32132567.
      View in: PubMed
    17. Hernandez-Saavedra D, Sanders L, Freeman S, Reisz JA, Lee MH, Mickael C, Kumar R, Kassa B, Gu S, D' Alessandro A, Stenmark KR, Tuder RM, Graham BB. Stable isotope metabolomics of pulmonary artery smooth muscle and endothelial cells in pulmonary hypertension and with TGF-beta treatment. Sci Rep. 2020 01 15; 10(1):413. PMID: 31942023.
      View in: PubMed
    18. Kumar R, Mickael C, Kassa B, Sanders L, Koyanagi D, Hernandez-Saavedra D, Freeman S, Morales-Cano D, Cogolludo A, McKee AS, Fontenot AP, Butrous G, Tuder RM, Graham BB. Th2 CD4+ T Cells Are Necessary and Sufficient for Schistosoma-Pulmonary Hypertension. J Am Heart Assoc. 2019 08 06; 8(15):e013111. PMID: 31339057.
      View in: PubMed
    19. Botoni FA, Marinho CC, Carvalho VT, Mickael CS, Graham BB. A retrospective study of schistosomiasis-associated pulmonary hypertension from an endemic area in Brazil. Int J Cardiol Heart Vasc. 2019 Sep; 24:100387. PMID: 31334331.
      View in: PubMed
    20. Mickael C, Kumar R, Hernandez-Saavedra D, Kassa B, Sanders L, Koyanagi D, Gu S, Lee MH, Tuder RM, Graham BB. IL-6Ra in Smooth Muscle Cells Protects against Schistosoma- and Hypoxia-induced Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2019 07; 61(1):123-126. PMID: 31259624.
      View in: PubMed
    21. Mickael C, Lee MH, Gu S, Graham BB. Comparing pulmonary hypertension severity between rat strains suggests right ventricle NK cells are protective. Cardiovasc Res. 2019 03 15; 115(4):699-700. PMID: 30517607.
      View in: PubMed
    22. Mickael CS, Graham BB. The Role of Type 2 Inflammation in Schistosoma-Induced Pulmonary Hypertension. Front Immunol. 2019; 10:27. PMID: 30733718.
      View in: PubMed
    23. Gu S, Kumar R, Lee MH, Mickael C, Graham BB. Common genetic variants in pulmonary arterial hypertension. Lancet Respir Med. 2019 03; 7(3):190-191. PMID: 30527955.
      View in: PubMed
    24. Kassa B, Mickael C, Kumar R, Sanders L, Koyanagi D, Hernandez-Saavedra D, Tuder RM, Graham BB. Paclitaxel blocks Th2-mediated TGF-? activation in Schistosoma mansoni-induced pulmonary hypertension. Pulm Circ. 2019 Jan-Mar; 9(1):2045894018820813. PMID: 30511588.
      View in: PubMed
    25. Graham BB, Kumar R, Mickael C, Kassa B, Koyanagi D, Sanders L, Zhang L, Perez M, Hernandez-Saavedra D, Valencia C, Dixon K, Harral J, Loomis Z, Irwin D, Nemkov T, D'Alessandro A, Stenmark KR, Tuder RM. Vascular Adaptation of the Right Ventricle in Experimental Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2018 10; 59(4):479-489. PMID: 29851508.
      View in: PubMed
    26. Kumar R, Mickael C, Kassa B, Gebreab L, Robinson JC, Koyanagi DE, Sanders L, Barthel L, Meadows C, Fox D, Irwin D, Li M, McKeon BA, Riddle S, Dale Brown R, Morgan LE, Evans CM, Hernandez-Saavedra D, Bandeira A, Maloney JP, Bull TM, Janssen WJ, Stenmark KR, Tuder RM, Graham BB. TGF-? activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension. Nat Commun. 2017 05 30; 8:15494. PMID: 28555642.
      View in: PubMed
    27. Kumar R, Mickael C, Chabon J, Gebreab L, Rutebemberwa A, Garcia AR, Koyanagi DE, Sanders L, Gandjeva A, Kearns MT, Barthel L, Janssen WJ, Mauad T, Bandeira A, Schmidt E, Tuder RM, Graham BB. The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension. Am J Respir Crit Care Med. 2015 Oct 15; 192(8):998-1008. PMID: 26192556.
      View in: PubMed
    28. Graham BB, Kumar R, Mickael C, Sanders L, Gebreab L, Huber KM, Perez M, Smith-Jones P, Serkova NJ, Tuder RM. Severe pulmonary hypertension is associated with altered right ventricle metabolic substrate uptake. Am J Physiol Lung Cell Mol Physiol. 2015 Sep 01; 309(5):L435-40. PMID: 26115672.
      View in: PubMed
    29. Wisner AL, Desin TS, Lam PK, Berberov E, Mickael CS, Townsend HG, Potter AA, K?ster W. Immunization of chickens with Salmonella enterica subspecies enterica serovar Enteritidis pathogenicity island-2 proteins. Vet Microbiol. 2011 Dec 15; 153(3-4):274-84. PMID: 21684090.
      View in: PubMed
    30. Desin TS, Wisner AL, Lam PK, Berberov E, Mickael CS, Potter AA, K?ster W. Evaluation of Salmonella enterica serovar Enteritidis pathogenicity island-1 proteins as vaccine candidates against S. Enteritidis challenge in chickens. Vet Microbiol. 2011 Mar 24; 148(2-4):298-307. PMID: 20888713.
      View in: PubMed
    31. Desin TS, Mickael CS, Lam PK, Potter AA, K?ster W. Protection of epithelial cells from Salmonella enterica serovar Enteritidis invasion by antibodies against the SPI-1 type III secretion system. Can J Microbiol. 2010 Jun; 56(6):522-6. PMID: 20657623.
      View in: PubMed
    32. Mickael CS, Lam PK, Berberov EM, Allan B, Potter AA, K?ster W. Salmonella enterica serovar Enteritidis tatB and tatC mutants are impaired in Caco-2 cell invasion in vitro and show reduced systemic spread in chickens. Infect Immun. 2010 Aug; 78(8):3493-505. PMID: 20498258.
      View in: PubMed
    33. Wisner ALS, Desin TS, Koch B, Lam PS, Berberov EM, Mickael CS, Potter AA, K?ster W. Salmonella enterica subspecies enterica serovar Enteritidis Salmonella pathogenicity island 2 type III secretion system: role in intestinal colonization of chickens and systemic spread. Microbiology (Reading). 2010 Sep; 156(Pt 9):2770-2781. PMID: 20488876.
      View in: PubMed
    34. Desin TS, Lam PK, Koch B, Mickael C, Berberov E, Wisner AL, Townsend HG, Potter AA, K?ster W. Salmonella enterica serovar enteritidis pathogenicity island 1 is not essential for but facilitates rapid systemic spread in chickens. Infect Immun. 2009 Jul; 77(7):2866-75. PMID: 19364835.
      View in: PubMed
    35. Subler KA, Mickael CS, Jackwood DJ. Infectious bursal disease virus-induced immunosuppression exacerbates Campylobacter jejuni colonization and shedding in chickens. Avian Dis. 2006 Jun; 50(2):179-84. PMID: 16863064.
      View in: PubMed
    36. Mickael CS, Jackwood DJ. Real-time RT-PCR analysis of two epitope regions encoded by the VP2 gene of infectious bursal disease viruses. J Virol Methods. 2005 Sep; 128(1-2):37-46. PMID: 16023522.
      View in: PubMed
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