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Melanie G. Cree

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
Phone720/777-5743
Email
ORCID ORCID Icon0000-0003-1593-1695 Additional info

    Collapse Biography 
    Collapse education and training
    Bryn Mawr College, Bryn Mawr, PABA1999Biology & Chemistry
    University of Texas Medical Branch, Galveston, TXPhD5/2007Clinical Investigations
    University of Texas Medical Branch, Galveston, TXMD6/2007
    University of Colorado, Anschutz, Aurora, CO6/2011Pediatric Residency
    University of Colorado, Anschutz, Aurora, CO6/2014Pediatric Endocrinology
    Collapse awards and honors
    2023Selected CU faculty, AAMC Mid-Career Women’s Faculty Leadership Seminar , CU Anschutz
    2023Henry Friesen Lectureship, Canadian Diabetes Association
    2022Article selected for Endocrine Society issue on Women’s Health. JES February 2022. PMID: 336446, Endocrine Society
    2021“Article of the Week” JES March 2021. PMID: 33644620, Journal of the Endocrine Society
    20212021 Mentor of the year award nominee, Nutrition and Obesity Research Core, CU Anschutz
    2019“Best of Women’s Health articles” JCEM 2019. PMID:30888398, Journal of Clinical Endocrinology and Metabolism
    2018High Patient Satisfaction Award, Children’s Hospital Colorado
    2017Highest Patient Satisfaction Award, Children's Hospital Colorado
    2017Best of 2017 Journal of the Endocrine Society Article, Endocrine Society
    20161st annual Carmel Prize for Academic Excellence, Western Section American Federation for Medical Research
    2016Early Investigators Award, Endocrine Society
    2015Junior Faculty Outstanding Abstract Award, Endocrine Society

    Collapse Overview 
    Collapse overview
    I am interested in how insulin resistance affects the reproductive axis, risk for diabetes and liver health. As an MD, PhD with clinical training in pediatric endocrinology and research training in human physiology, I perform translational work in youth with endocrine disorders using stable isotope tracers, magnetic resonance spectroscopy and mathematical modeling. In particular, I am challenged by the extent of insulin resistance-related co-morbidities in girls with polycystic ovary syndrome, including a 21 fold increased risk of type 2 diabetes, common pre-diabetes and >50% with elevated liver fat. My overall goal is to improve the long term health for adolescents with polycystic ovary syndrome or type 2 diabetes and to perform work to inform clinical trials for new therapeutic strategies.

    Collapse Research 
    Collapse research activities and funding
    DK135312-01     (Wolfe Robert R)Oct 1, 2023 - Jul 31, 2025
    NIH NIDDK Small Buisiness Grant
    Amino Acids and Pediatric Hepatic Steatosis
    Role Description: 3-month placebo controlled randomized trial of EAA to reduce liver fat in adolescents with NAFLD
    Role: CO-Primary Investigator
    R01HD108340     (CREE, MELANIE G)Aug 15, 2023 - Jul 31, 2028
    NIH
    Role of semaglutide in restoring ovulation in youth and adults with polycystic ovary syndrome
    Role: Principle Investigator
    R21HD109488     (CREE, MELANIE G)Jun 5, 2023 - May 31, 2025
    NIH
    The presentation and medical course of PCOS in adolescents across the United States
    Role: Principle Investigator
    5R01HL165433-02     (NADEAU, KRISTEN JANE)Jul 27, 2022 - Jun 30, 2026
    NIH
    Type 1 Diabetes Impacts of Semaglutide on Cardiovascular Outcomes (T1-DISCO)
    Role: Co-Investigator
    R01DK120612     (CREE GREEN, MELANIE C)Aug 1, 2019 - Jul 31, 2024
    NIH
    Impact of GLP-1 on Hepatic Fat and Energy Utilization in Obese Girls with Polycystic Ovarian Syndrome
    Role: Principle Investigator
    R01DK118149     (BERGMAN, BRYAN C)Aug 1, 2018 - Jul 31, 2023
    NIH
    Intermuscular adipose tissue (IMAT): protagonist in sarcopenia and insulin resistance in humans
    Role: Co-Investigator
    CDSA     (CREE-GREEN, MELANIE)Jul 1, 2018 - Jun 20, 2021
    Doris Duke Foundation
    Use of essential amino acid supplementation to decrease metabolic disease in high risk obese girls with PCOS
    Role: Principal Investigator
    Pilot, UL1 TR002535     (CREE-GREEN, MELANIE)Apr 1, 2018 - Mar 31, 2019
    Colorado CTSI, NIH/NCATS
    Do alterations in serum testosterone mediate systemic insulin sensitivity and hepatic health via the gut microbiota
    Role: Pilot Principal Investigator
    Multi-Center Pilot     (CREE-GREEN, MELANIE)Mar 1, 2018 - Feb 28, 2020
    Nutrition and Obesity Research Center
    Comparison of in-vivo and ex-vivo measures of mitochondrial flux in non-alcoholic fatty liver disease across the lifespan
    Role: Principal Investigator
    Pilot     (CREE-GREEN, MELANIE)Oct 2, 2017 - Oct 31, 2019
    GI & Liver Innate Immune Program
    Do alterations in testosterone concentrations mediate improvements in insulin sensitivity and hepatic health via microbiota taxa abundance changes?
    Role: Principal Investigator
    R01DK111559     (BERGMAN, BRYAN C)Feb 1, 2017 - Jan 31, 2022
    NIH
    Skeletal muscle diacylglycerol and sphingolipids: Impact of localization and species on insulin resistance in humans
    Role: Co-Investigator
    Pilot/Feasibility Grant     (BURANT, C)Jul 1, 2016 - Jun 30, 2017
    University of Michigan MRC2
    The role of branched chain amino acid metabolism in muscle insulin resistance in youth with obesity and Polycystic ovarian syndrome
    Role: Pilot Principal Investigator
    Caregivers Fellowship 2015212     (REGENSTEINER, JUDY)May 1, 2016 - Apr 30, 2018
    Doris Duke Foundation
    Role: Recipient
    K23DK107871     (CREE GREEN, MELANIE C)Sep 21, 2015 - Aug 31, 2019
    NIH
    Influence of peripheral insulin resistance and hepatic lipogenesis on liver fat in obese PCOS girls
    Role: Principal Investigator
    Biomedical Research Award     (CREE-GREEN, MELANIE)Jul 1, 2015 - Jun 30, 2018
    Boettcher Webb-Waring Foundation
    Non-invasive assessment of liver glucose metabolism in obese girls
    Role: Principal Investigator
    Pilot Award     (CREE-GREEN, MELANIE)Jan 1, 2015 - Dec 31, 2015
    Children’s Hospital Colorado Research Institute
    Role of hepatic de novo lipogenesis in development of hepatic steatosis in obese girls with PCOS
    Role: Principal Investigator
    Pilot Grant, P30 DK048520     (CREE-GREEN, MELANIE)Sep 1, 2014 - Sep 30, 2016
    University of Colorado Nutrition and Obesity Research Core
    Modeling hepatic and adipose insulin sensitivity with stable isotope tracers during an oral glucose load
    Role: Principal Investigator
    Collaborative Pilot Award     (CREE-GREEN, MELANIE)Jun 1, 2014 - May 31, 2015
    Children's Hospital Colorado/Colorado School of the Mines
    Modeling Hepatic and Adipose IR with stable isotopes during an oral glucose tolerance test
    Role: Principal Investigator
    K12HD057022     (REGENSTEINER, JUDY)Apr 1, 2014
    NIH
    Building Interdisciplinary Careers in Women's Health
    Role: Trainee Scholar
    Research Fellowship Award     (CREE-GREEN, MELANIE)Jun 1, 2013 - May 31, 2014
    Pediatric Endocrine Society
    Impact of obesity and androgens on CV function and organ specific IR in youth with PCOS
    Role: Principal Investigator
    Clinical Research Fellowship in Women’s Health     (CREE-GREEN, MELANIE)Jun 1, 2013 - Mar 31, 2014
    Endocrine Society
    Impact of obesity and androgens on serum lipoproteins in youth with PCOS
    Role: Principal Investigator
    13CRP14120015     (CREE-GREEN, MELANIE)Jan 1, 2013 - Dec 31, 2014
    American Heart Association
    Impact of obesity and androgens on CV function and organ specific IR in youth with PCOS
    Role: Principal Investigator
    Pilot Award     (CREE-GREEN, MELANIE)Oct 1, 2012 - Dec 1, 2013
    Center for Women's Health Research
    Impact of obesity and androgens on CV function and organ specific IR in youth with PCOS
    Role: Principal Investogator
    T32 DK063687     (KLINGENSMITH, G)Jul 1, 2011 - Aug 31, 2012
    NIH NIDDK
    Fellowship Training Grant in Pediatric Diabetes
    Role: Trainee
    Mentored Pilot, TL1 RR025778     (CREE-GREEN, MELANIE)Jun 1, 2011 - Mar 1, 2013
    University of Colorado CTSI
    Role of androgens and obesity in insulin resistance and cardiovascular disease in PCOS
    Role: Principal Investigator
    Mentored Pilot Award     (CREE-GREEN, MELANIE)Jan 1, 2011 - Dec 31, 2012
    Thrasher Pediatric Foundation
    Mechanism of insulin resistance in girls with polycystic ovary disease
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Nokoff NJ, Nemkov T, Bothwell S, Cree MG, Fuller KNZ, Keller AC, Kelsey MM, Nadeau KJ, Moreau KL. Differences in cardiorespiratory fitness by gonadotropin-releasing hormone agonist treatment before and after testosterone in transgender adolescents. J Appl Physiol (1985). 2024 Nov 01; 137(5):1470-1483. PMID: 39417821.
      View in: PubMed
    2. Gottlieb D, Abushamat LA, Nadeau KJ, Regensteiner JG, Reusch JEB, Tommerdahl KL, Rice J, Knaub LA, Monaco CMF, Hawke TJ, Perry CGR, Cree MG, Schauer IE. Muscle mitochondrial function is impaired in adults with type 1 diabetes. J Diabetes Complications. 2024 Aug; 38(8):108798. PMID: 38991492.
      View in: PubMed
    3. Nokoff NJ, Bothwell S, Rice JD, Cree MG, Kelsey MM, Moreau KL, Zeitler P, Nadeau KJ. Insulin sensitivity, body composition and bone mineral density after testosterone treatment in transgender youth with and without prior GnRH agonist therapy. J Clin Transl Endocrinol. 2024 Jun; 36:100356. PMID: 38948245.
      View in: PubMed
    4. Tas E, Sundararajan D, Lo JS, Morelli N, Garcia-Reyes Y, Ware MA, Rahat H, Ou X, Na X, Sundaram S, Severn C, Pyle LL, B?rsheim E, Vajravelu ME, Muzumdar R, Dranoff JA, Cree MG. Diagnostic Accuracy of Transient Elastography in Hepatosteatosis in Youth With Obesity. J Endocr Soc. 2024 May 23; 8(7):bvae110. PMID: 38895640.
      View in: PubMed
    5. Rydin AA, Severn C, Pyle L, Morelli N, Shoemaker AH, Chung ST, Yanovski JA, Han JC, Higgins JA, Nadeau KJ, Fox C, Kelly AS, Cree MG. Prediction of resting energy expenditure for adolescents with severe obesity: A multi-centre analysis. Pediatr Obes. 2024 Jul; 19(7):e13123. PMID: 38658523.
      View in: PubMed
    6. Simon SL, Phimphasone-Brady P, McKenney KM, Gulley LD, Bonny AE, Moore JM, Torres-Zegarra C, Cree MG. Comprehensive transition of care for polycystic ovary syndrome from adolescence to adulthood. Lancet Child Adolesc Health. 2024 Jun; 8(6):443-455. PMID: 38552655.
      View in: PubMed
    7. Fordham TM, Morelli NS, Garcia-Reyes Y, Ware MA, Rahat H, Sundararajan D, Fuller KNZ, Severn C, Pyle L, Malloy CR, Jin ES, Parks EJ, Wolfe RR, Cree MG. Metabolic effects of an essential amino acid supplement in adolescents with PCOS and obesity. Obesity (Silver Spring). 2024 04; 32(4):678-690. PMID: 38439205.
      View in: PubMed
    8. Chen-Patterson A, Bernier A, Burgert T, Davis V, Khan T, Geller D, Paprocki E, Shah R, Witchel SF, Pereira-Eshraghi C, Sopher AB, Cree MG, Torchen LC. Distinct Reproductive Phenotypes Segregate With Differences in Body Weight in Adolescent Polycystic Ovary Syndrome. J Endocr Soc. 2024 Jan 05; 8(2):bvad169. PMID: 38213910.
      View in: PubMed
    9. Ha J, Chung ST, Springer M, Kim JY, Chen P, Chhabra A, Cree MG, Diniz Behn C, Sumner AE, Arslanian SA, Sherman AS. Estimating insulin sensitivity and ?-cell function from the oral glucose tolerance test: validation of a new insulin sensitivity and secretion (ISS) model. Am J Physiol Endocrinol Metab. 2024 Apr 01; 326(4):E454-E471. PMID: 38054972.
      View in: PubMed
    10. Tjaden AH, Edelstein SL, Arslanian S, Barengolts E, Caprio S, Cree-Green M, Lteif A, Mather KJ, Savoye M, Xiang AH, Kahn SE. Reproducibility of Glycemic Measures Among Dysglycemic Youth and Adults in the RISE Study. J Clin Endocrinol Metab. 2023 09 18; 108(10):e1125-e1133. PMID: 36938582.
      View in: PubMed
    11. Roy MK, Wilkerson RB, Alexander K, Nokoff NJ, Cree-Green M, D'Alessandro A. Longitudinal metabolic study of red blood cells from patients undergoing gender-affirming testosterone therapy. Blood Adv. 2023 08 22; 7(16):4269-4277. PMID: 36001490.
      View in: PubMed
    12. Ha J, Chung ST, Springer M, Kim JY, Chen P, Cree MG, Behn CD, Sumner AE, Arslanian S, Sherman AS. Estimating Insulin Sensitivity and Beta-Cell Function from the Oral Glucose Tolerance Test: Validation of a new Insulin Sensitivity and Secretion (ISS) Model. bioRxiv. 2023 Jun 21. PMID: 37503271.
      View in: PubMed
    13. Jin ES, Malloy CR, Sharma G, Finn E, Fuller KNZ, Reyes YG, Lovell MA, Derderian SC, Schoen JA, Inge TH, Cree MG. Glycerol as a precursor for hepatic de novo glutathione synthesis in human liver. Redox Biol. 2023 07; 63:102749. PMID: 37224695.
      View in: PubMed
    14. Ha J, Cree-Green M, Chung ST, Diniz Behn C. Editorial: Metabolic estimates during glucose challenge tests and continuous glucose monitoring-Innovative and broad approaches to assessing glucose and insulin metabolism in diverse populations. Front Physiol. 2022; 13:1112502. PMID: 36589464.
      View in: PubMed
    15. Breslow E, Taylor A, Chan CL, Severn C, Pyle L, Torchen L, Sisk R, Legro R, Turcu AF, Auchus RJ, Dunaif A, Kelsey MM, Cree-Green M. 11-Oxygenated Androgen Metabolite Concentrations Are Affected by Pubertal Progression and Obesity. Horm Res Paediatr. 2023; 96(4):412-422. PMID: 36446347.
      View in: PubMed
    16. Bjornstad P, Chao LC, Cree-Green M, Dart AB, King M, Looker HC, Magliano DJ, Nadeau KJ, Pinhas-Hamiel O, Shah AS, van Raalte DH, Pavkov ME, Nelson RG. Youth-onset type 2 diabetes mellitus: an urgent challenge. Nat Rev Nephrol. 2023 03; 19(3):168-184. PMID: 36316388.
      View in: PubMed
    17. Hampton GS, Bartlette K, Nadeau KJ, Cree-Green M, Diniz Behn C. Mathematical modeling reveals differential dynamics of insulin action models on glycerol and glucose in adolescent girls with obesity. Front Physiol. 2022; 13:895118. PMID: 35991189.
      View in: PubMed
    18. Kahn D, Macias E, Zarini S, Garfield A, Zemski Berry K, Gerszten R, Schoen J, Cree-Green M, Bergman BC. Quantifying the inflammatory secretome of human intermuscular adipose tissue. Physiol Rep. 2022 08; 10(16):e15424. PMID: 35980018.
      View in: PubMed
    19. Tayachew B, Vanden Brink H, Garcia-Reyes Y, Rahat H, D'Alessandro A, Frank DN, Robertson CE, Silveira L, Kelsey M, Pyle L, Cree-Green M. Combined Oral Contraceptive Treatment Does Not Alter the Gut Microbiome but Affects Amino Acid Metabolism in Sera of Obese Girls With Polycystic Ovary Syndrome. Front Physiol. 2022; 13:887077. PMID: 35800349.
      View in: PubMed
    20. Taylor AE, Ware MA, Breslow E, Pyle L, Severn C, Nadeau KJ, Chan CL, Kelsey MM, Cree-Green M. 11-Oxyandrogens in Adolescents With Polycystic Ovary Syndrome. J Endocr Soc. 2022 Jul 01; 6(7):bvac037. PMID: 35611324.
      View in: PubMed
    21. Ware MA, Kaar JL, Diniz Behn C, Bartlette K, Carreau AM, Lopez-Paniagua D, Scherzinger A, Xie D, Rahat H, Garcia-Reyes Y, Nadeau KJ, Cree-Green M. Pancreatic fat relates to fasting insulin and postprandial lipids but not polycystic ovary syndrome in adolescents with obesity. Obesity (Silver Spring). 2022 01; 30(1):191-200. PMID: 34932884.
      View in: PubMed
    22. Cung S, Pyle L, Nadeau K, Dabelea D, Cree-Green M, Davis SM. In-vivo skeletal muscle mitochondrial function in Klinefelter syndrome. J Investig Med. 2022 01; 70(1):104-107. PMID: 34493629.
      View in: PubMed
    23. Utzschneider KM, Tripputi MT, Kozedub A, Barengolts E, Caprio S, Cree-Green M, Edelstein SL, El Ghormli L, Hannon TS, Mather KJ, Palmer J, Nadeau KJ. Differential loss of ?-cell function in youth vs. adults following treatment withdrawal in the Restoring Insulin Secretion (RISE) study. Diabetes Res Clin Pract. 2021 Aug; 178:108948. PMID: 34274407.
      View in: PubMed
    24. Moore JM, Waldrop SW, Cree-Green M. Weight Management in Adolescents with Polycystic Ovary Syndrome. Curr Obes Rep. 2021 Sep; 10(3):311-321. PMID: 34043216.
      View in: PubMed
    25. Xiang AH, Martinez MP, Trigo E, Utzschneider KM, Cree-Green M, Arslanian SA, Ehrmann DA, Caprio S, Mohamed PHIH, Hwang DH, Katkhouda N, Nayak KS, Buchanan TA. Liver Fat Reduction After Gastric Banding and Associations with Changes in Insulin Sensitivity and ?-Cell Function. Obesity (Silver Spring). 2021 07; 29(7):1155-1163. PMID: 34038037.
      View in: PubMed
    26. Hudnut-Beumler J, Kaar JL, Taylor A, Kelsey MM, Nadeau KJ, Zeitler P, Snell-Bergeon J, Pyle L, Cree-Green M. Development of type 2 diabetes in adolescent girls with polycystic ovary syndrome and obesity. Pediatr Diabetes. 2021 08; 22(5):699-706. PMID: 33870630.
      View in: PubMed
    27. Torres-Zegarra C, Sundararajan D, Benson J, Seagle H, Witten M, Walders-Abramson N, Simon SL, Huguelet P, Nokoff NJ, Cree-Green M. Care for Adolescents With Polycystic Ovary Syndrome: Development and Prescribing Patterns of a Multidisciplinary Clinic. J Pediatr Adolesc Gynecol. 2021 Oct; 34(5):617-625. PMID: 33794340.
      View in: PubMed
    28. Scalzo RL, Schauer IE, Rafferty D, Knaub LA, Kvaratskhelia N, Johnson TK, Pott GB, Abushamat LA, Whipple MO, Huebschmann AG, Cree-Green M, Reusch JEB, Regensteiner JG. Single-leg exercise training augments in vivo skeletal muscle oxidative flux and vascular content and function in adults with type 2 diabetes. J Physiol. 2022 02; 600(4):963-978. PMID: 33569797.
      View in: PubMed
    29. Mather KJ, Tjaden AH, Hoehn A, Nadeau KJ, Buchanan TA, Kahn SE, Arslanian SA, Caprio S, Atkinson KM, Cree-Green M, Utzschneider KM, Edelstein SL. Precision and accuracy of hyperglycemic clamps in a multicenter study. Am J Physiol Endocrinol Metab. 2021 04 01; 320(4):E797-E807. PMID: 33645253.
      View in: PubMed
    30. Pyle L, Carreau AM, Rahat H, Garcia-Reyes Y, Bergman BC, Nadeau KJ, Cree-Green M. Fasting plasma metabolomic profiles are altered by three days of standardized diet and restricted physical activity. Metabol Open. 2021 Mar; 9:100085. PMID: 33665598.
      View in: PubMed
    31. Mokhlesi B, Tjaden AH, Temple KA, Edelstein SL, Sam S, Nadeau KJ, Hannon TS, Manchanda S, Mather KJ, Kahn SE, Ehrmann DA, Van Cauter E. Obstructive Sleep Apnea, Glucose Tolerance, and ?-Cell Function in Adults With Prediabetes or Untreated Type 2 Diabetes in the Restoring Insulin Secretion (RISE) Study. Diabetes Care. 2021 04; 44(4):993-1001. PMID: 33547205.
      View in: PubMed
    32. Andrisse S, Garcia-Reyes Y, Pyle L, Kelsey MM, Nadeau KJ, Cree-Green M. Racial and Ethnic Differences in Metabolic Disease in Adolescents With Obesity and Polycystic Ovary Syndrome. J Endocr Soc. 2021 Apr 01; 5(4):bvab008. PMID: 33644620.
      View in: PubMed
    33. Jobira B, Frank DN, Silveira LJ, Pyle L, Kelsey MM, Garcia-Reyes Y, Robertson CE, Ir D, Nadeau KJ, Cree-Green M. Hepatic steatosis relates to gastrointestinal microbiota changes in obese girls with polycystic ovary syndrome. PLoS One. 2021; 16(1):e0245219. PMID: 33465100.
      View in: PubMed
    34. Bartlette K, Carreau AM, Xie D, Garcia-Reyes Y, Rahat H, Pyle L, Nadeau KJ, Cree-Green M, Diniz Behn C. Oral minimal model-based estimates of insulin sensitivity in obese youth depend on oral glucose tolerance test protocol duration. Metabol Open. 2021 Mar; 9:100078. PMID: 33511337.
      View in: PubMed
    35. Tommerdahl KL, Baumgartner K, Sch?fer M, Bjornstad P, Melena I, Hegemann S, Baumgartner AD, Pyle L, Cree-Green M, Truong U, Browne L, Regensteiner JG, Reusch JEB, Nadeau KJ. Impact of Obesity on Measures of Cardiovascular and Kidney Health in Youth With Type 1 Diabetes as Compared With Youth With Type 2 Diabetes. Diabetes Care. 2021 03; 44(3):795-803. PMID: 33402367.
      View in: PubMed
    36. Maier S, Wieland A, Cree-Green M, Nadeau K, Sullivan S, Lanaspa MA, Johnson RJ, Jensen T. Lean NAFLD: an underrecognized and challenging disorder in medicine. Rev Endocr Metab Disord. 2021 06; 22(2):351-366. PMID: 33389543.
      View in: PubMed
    37. Tommerdahl KL, Bjornstad P, Kendrick J, Cree-Green M, Baumgartner AD, Pyle L, Reusch JEB, Nadeau KJ. Results from the Effects of MEtformin on cardiovasculaR function in AdoLescents with type 1 Diabetes (EMERALD) study: A brief report of kidney and inflammatory outcomes. Diabetes Obes Metab. 2021 03; 23(3):844-849. PMID: 33236509.
      View in: PubMed
    38. Utzschneider KM, Tripputi MT, Kozedub A, Mather KJ, Nadeau KJ, Edelstein SL, Hannon TS, Arslanian SA, Cree-Green M, Buchanan TA, Caprio S, Mari A. ?-cells in youth with impaired glucose tolerance or early type 2 diabetes secrete more insulin and are more responsive than in adults. Pediatr Diabetes. 2020 12; 21(8):1421-1429. PMID: 32902875.
      View in: PubMed
    39. Tommerdahl KL, Brinton JT, Vigers T, Cree-Green M, Zeitler PS, Nadeau KJ, Chan CL. Delayed glucose peak and elevated 1-hour glucose on the oral glucose tolerance test identify youth with cystic fibrosis with lower oral disposition index. J Cyst Fibros. 2021 03; 20(2):339-345. PMID: 32928701.
      View in: PubMed
    40. Buyers E, Sass AE, Severn CD, Pyle L, Cree-Green M. Twelve-month Continuation of the Etonogestrel Implant in Adolescents With Polycystic Ovary Syndrome. J Pediatr Adolesc Gynecol. 2021 Feb; 34(1):33-39. PMID: 32919086.
      View in: PubMed
    41. Huguelet PS, Olson E, Sass A, Bartz S, Hsu S, Cree-Green M. Application of a Standard Cross-Specialty Workup for Diagnosis and Metabolic Screening of Obese Adolescents With Polycystic Ovary Syndrome. J Adolesc Health. 2021 03; 68(3):589-595. PMID: 32819830.
      View in: PubMed
    42. Carreau AM, Xie D, Garcia-Reyes Y, Rahat H, Bartlette K, Behn CD, Pyle L, Nadeau KJ, Cree-Green M. Good agreement between hyperinsulinemic-euglycemic clamp and 2 hours oral minimal model assessed insulin sensitivity in adolescents. Pediatr Diabetes. 2020 11; 21(7):1159-1168. PMID: 32592269.
      View in: PubMed
    43. Cree-Green M, Carreau AM, Davis SM, Frohnert BI, Kaar JL, Ma NS, Nokoff NJ, Reusch JEB, Simon SL, Nadeau KJ. Peer mentoring for professional and personal growth in academic medicine. J Investig Med. 2020 08; 68(6):1128-1134. PMID: 32641352.
      View in: PubMed
    44. Davis SM, Soares K, Howell S, Cree-Green M, Buyers E, Johnson J, Tartaglia NR. Diminished Ovarian Reserve in Girls and Adolescents with Trisomy X Syndrome. Reprod Sci. 2020 11; 27(11):1985-1991. PMID: 32578162.
      View in: PubMed
    45. Benson J, Severn C, Hudnut-Beumler J, Simon SL, Abramson N, Shomaker LB, Gulley LD, Taylor A, Kelsey MM, Nadeau KJ, Zeitler PS, Pyle L, Cree-Green M. Depression in Girls With Obesity and Polycystic Ovary Syndrome and/or Type 2 Diabetes. Can J Diabetes. 2020 Aug; 44(6):507-513. PMID: 32792104.
      View in: PubMed
    46. Jobira B, Frank DN, Pyle L, Silveira LJ, Kelsey MM, Garcia-Reyes Y, Robertson CE, Ir D, Nadeau KJ, Cree-Green M. Obese Adolescents With PCOS Have Altered Biodiversity and Relative Abundance in Gastrointestinal Microbiota. J Clin Endocrinol Metab. 2020 06 01; 105(6). PMID: 31970418.
      View in: PubMed
    47. Pereira-Eshraghi CF, Chiuzan C, Zhang Y, Tao RH, McCann M, Neugut YD, Printz A, Fennoy I, Cree-Green M, Oberfield SE, Sopher AB. Obesity and Insulin Resistance, Not Polycystic Ovary Syndrome, Are Independent Predictors of Bone Mineral Density in Adolescents and Young Women. Horm Res Paediatr. 2019; 92(6):365-371. PMID: 32348991.
      View in: PubMed
    48. Simon S, Rahat H, Carreau AM, Garcia-Reyes Y, Halbower A, Pyle L, Nadeau KJ, Cree-Green M. Poor Sleep Is Related to Metabolic Syndrome Severity in Adolescents With PCOS and Obesity. J Clin Endocrinol Metab. 2020 04 01; 105(4). PMID: 31901092.
      View in: PubMed
    49. Cree-Green M, Cree J, Urban K, Bunik M, Sass AE, Rosenberg A. A Structured Neonatal Parenting Elective: An Approach for Parenting Leave During Residency. Acad Pediatr. 2020 07; 20(5):595-599. PMID: 32045680.
      View in: PubMed
    50. McGarry L, Messer R, Cree-Green M, Ray K, Knupp K. Incidence of Hypertension Among Children Treated With Adrenocorticotropic Hormone (ACTH) or Prednisolone for Infantile Spasms. J Child Neurol. 2020 03; 35(3):215-220. PMID: 31769329.
      View in: PubMed
    51. Cree-Green M, Wiromrat P, Stuppy JJ, Thurston J, Bergman BC, Baumgartner AD, Bacon S, Scherzinger A, Pyle L, Nadeau KJ. Muscle Insulin Resistance in Youth with Obesity and Normoglycemia is Associated with Altered Fat Metabolism. Obesity (Silver Spring). 2019 12; 27(12):2046-2054. PMID: 31659873.
      View in: PubMed
    52. Diniz Behn C, Jin ES, Bubar K, Malloy C, Parks EJ, Cree-Green M. Advances in stable isotope tracer methodology part 1: hepatic metabolism via isotopomer analysis and postprandial lipolysis modeling. J Investig Med. 2020 01; 68(1):3-10. PMID: 31554675.
      View in: PubMed
    53. Cree-Green M. Editoral commentary: Understanding cardiovascular disease risk in women with polycystic ovary syndrome. Trends Cardiovasc Med. 2020 10; 30(7):405-406. PMID: 31607636.
      View in: PubMed
    54. Carreau AM, Pyle L, Garcia-Reyes Y, Rahat H, Vigers T, Jensen T, Scherzinger A, Nadeau KJ, Cree-Green M. Clinical prediction score of nonalcoholic fatty liver disease in adolescent girls with polycystic ovary syndrome (PCOS-HS index). Clin Endocrinol (Oxf). 2019 10; 91(4):544-552. PMID: 31301251.
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    55. Simon SL, McWhirter L, Diniz Behn C, Bubar KM, Kaar JL, Pyle L, Rahat H, Garcia-Reyes Y, Carreau AM, Wright KP, Nadeau KJ, Cree-Green M. Morning Circadian Misalignment Is Associated With Insulin Resistance in Girls With Obesity and Polycystic Ovarian Syndrome. J Clin Endocrinol Metab. 2019 08 01; 104(8):3525-3534. PMID: 30888398.
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    56. Cree-Green M, Bergman BC, Cengiz E, Fox LA, Hannon TS, Miller K, Nathan B, Pyle L, Kahn D, Tansey M, Tichy E, Tsalikian E, Libman I, Nadeau KJ. Metformin Improves Peripheral Insulin Sensitivity in Youth With Type 1 Diabetes. J Clin Endocrinol Metab. 2019 08 01; 104(8):3265-3278. PMID: 30938764.
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    57. Obesity and insulin sensitivity effects on cardiovascular risk factors: Comparisons of obese dysglycemic youth and adults. Pediatr Diabetes. 2019 11; 20(7):849-860. PMID: 31301210.
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    58. Simon SL, Diniz Behn C, Laikin A, Kaar JL, Rahat H, Cree-Green M, Wright KP, Nadeau KJ. Sleep & Circadian Health are Associated with Mood & Behavior in Adolescents with Overweight/Obesity. Behav Sleep Med. 2020 Jul-Aug; 18(4):550-559. PMID: 31218887.
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    59. Effects of Treatment of Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes With Metformin Alone or in Combination With Insulin Glargine on ?-Cell Function: Comparison of Responses In Youth And Adults. Diabetes. 2019 08; 68(8):1670-1680. PMID: 31178433.
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    60. Lack of Durable Improvements in ?-Cell Function Following Withdrawal of Pharmacological Interventions in Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes. Diabetes Care. 2019 09; 42(9):1742-1751. PMID: 31178434.
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    61. Cree-Green M, Ravi S, Carreau AM, Sewell R, Baumgartner A, Coe G, Bergman BC, Scherzinger A, Jensen T, Pyle L, Nadeau KJ. Nonalcoholic fatty liver disease in obese adolescent females is associated with multi-tissue insulin resistance and visceral adiposity markers. Metabol Open. 2019 Jun; 2:100011. PMID: 32812939.
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    62. Scalzo RL, Rafferty D, Schauer I, Huebschmann AG, Cree-Green M, Reusch JEB, Regensteiner JG. Sitagliptin improves diastolic cardiac function but not cardiorespiratory fitness in adults with type 2 diabetes. J Diabetes Complications. 2019 08; 33(8):561-566. PMID: 31182338.
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    63. Mokhlesi B, Temple KA, Tjaden AH, Edelstein SL, Utzschneider KM, Nadeau KJ, Hannon TS, Sam S, Barengolts E, Manchanda S, Ehrmann DA, Van Cauter E. Association of Self-Reported Sleep and Circadian Measures With Glycemia in Adults With Prediabetes or Recently Diagnosed Untreated Type 2 Diabetes. Diabetes Care. 2019 07; 42(7):1326-1332. PMID: 31048411.
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    64. Carreau AM, Jin ES, Garcia-Reyes Y, Rahat H, Nadeau KJ, Malloy CR, Cree-Green M. A simple method to monitor hepatic gluconeogenesis and triglyceride synthesis following oral sugar tolerance test in obese adolescents. Am J Physiol Regul Integr Comp Physiol. 2019 07 01; 317(1):R134-R142. PMID: 31042400.
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    65. Wiromrat P, Bjornstad P, Roncal C, Cree-Green M, Baumgartner A, Coe G, Reyes YG, Sch?fer M, Truong U, Pyle L, Johnson RJ, Nadeau KJ. Serum uromodulin inversely associates with aortic stiffness in youth with type 1 diabetes: A brief report from EMERALD study. J Diabetes Complications. 2019 06; 33(6):434-436. PMID: 31003921.
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    66. Cree-Green M, Carreau AM, Rahat H, Garcia-Reyes Y, Bergman BC, Pyle L, Nadeau KJ. Amino acid and fatty acid metabolomic profile during fasting and hyperinsulinemia in girls with polycystic ovarian syndrome. Am J Physiol Endocrinol Metab. 2019 05 01; 316(5):E707-E718. PMID: 30753112.
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    67. Cree-Green M. Postglucose Hyperinsulinemia in Black Women Is Not What We Thought. J Clin Endocrinol Metab. 2019 02 01; 104(2):266-268. PMID: 30371868.
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    68. Ravi SJ, Cree-Green M. Use of Successive Pharmacologic Hormone Suppression Testing for a Severe Presentation of Adolescent Polycystic Ovarian Syndrome: A Case Report. J Investig Med High Impact Case Rep. 2019 Jan-Dec; 7:2324709619850215. PMID: 31113263.
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    69. Cree-Green M, Wiromrat P, Stuppy JJ, Thurston J, Bergman BC, Baumgartner AD, Bacon S, Scherzinger A, Pyle L, Nadeau KJ. Youth with type 2 diabetes have hepatic, peripheral, and adipose insulin resistance. Am J Physiol Endocrinol Metab. 2019 02 01; 316(2):E186-E195. PMID: 30562061.
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    70. Bjornstad P, Sch?fer M, Truong U, Cree-Green M, Pyle L, Baumgartner A, Garcia Reyes Y, Maniatis A, Nayak S, Wadwa RP, Browne LP, Reusch JEB, Nadeau KJ. Metformin Improves Insulin Sensitivity and Vascular Health in Youth With Type 1 Diabetes Mellitus. Circulation. 2018 12 18; 138(25):2895-2907. PMID: 30566007.
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    71. Jensen T, Wieland A, Cree-Green M, Nadeau K, Sullivan S. Clinical workup of fatty liver for the primary care provider. Postgrad Med. 2019 Jan; 131(1):19-30. PMID: 30496690.
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    72. Simon SL, Behn CD, Cree-Green M, Kaar JL, Pyle L, Hawkins SMM, Rahat H, Garcia-Reyes Y, Wright KP, Nadeau KJ. Too Late and Not Enough: School Year Sleep Duration, Timing, and Circadian Misalignment Are Associated with Reduced Insulin Sensitivity in Adolescents with Overweight/Obesity. J Pediatr. 2019 02; 205:257-264.e1. PMID: 30497764.
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    73. Cree-Green M, Cai N, Thurston JE, Coe GV, Newnes L, Garcia-Reyes Y, Baumgartner AD, Pyle L, Nadeau KJ. Using simple clinical measures to predict insulin resistance or hyperglycemia in girls with polycystic ovarian syndrome. Pediatr Diabetes. 2018 12; 19(8):1370-1378. PMID: 30246333.
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    74. Xiang AH, Trigo E, Martinez M, Katkhouda N, Beale E, Wang X, Wu J, Chow T, Montgomery C, Nayak KS, Hendee F, Buchanan TA. Impact of Gastric Banding Versus Metformin on ?-Cell Function in Adults With Impaired Glucose Tolerance or Mild Type 2 Diabetes. Diabetes Care. 2018 12; 41(12):2544-2551. PMID: 30282699.
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    75. Cree-Green M, Stuppy JJ, Thurston J, Bergman BC, Coe GV, Baumgartner AD, Bacon S, Scherzinger A, Pyle L, Nadeau KJ. Youth With Type 1 Diabetes Have Adipose, Hepatic, and Peripheral Insulin Resistance. J Clin Endocrinol Metab. 2018 10 01; 103(10):3647-3657. PMID: 30020457.
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    76. Impact of Insulin and Metformin Versus Metformin Alone on ?-Cell Function in Youth With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes. Diabetes Care. 2018 08; 41(8):1717-1725. PMID: 29941500.
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    77. Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: I. Observations Using the Hyperglycemic Clamp. Diabetes Care. 2018 08; 41(8):1696-1706. PMID: 29941497.
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    78. Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: II. Observations Using the Oral Glucose Tolerance Test. Diabetes Care. 2018 08; 41(8):1707-1716. PMID: 29941498.
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    79. Cree-Green M, Xie D, Rahat H, Garcia-Reyes Y, Bergman BC, Scherzinger A, Diniz Behn C, Chan CL, Kelsey MM, Pyle L, Nadeau KJ. Oral Glucose Tolerance Test Glucose Peak Time Is Most Predictive of Prediabetes and Hepatic Steatosis in Obese Girls. J Endocr Soc. 2018 Jun 01; 2(6):547-562. PMID: 29942919.
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    80. Cree-Green M, Scalzo RL, Harrall K, Newcomer BR, Schauer IE, Huebschmann AG, McMillin S, Brown MS, Orlicky D, Knaub L, Nadeau KJ, McClatchey PM, Bauer TA, Regensteiner JG, Reusch JEB. Supplemental Oxygen Improves In Vivo Mitochondrial Oxidative Phosphorylation Flux in Sedentary Obese Adults With Type 2 Diabetes. Diabetes. 2018 07; 67(7):1369-1379. PMID: 29643061.
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    81. Bjornstad P, Cree-Green M, Baumgartner A, Coe G, Reyes YG, Sch?fer M, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Achieving ADA/ISPAD clinical guideline goals is associated with higher insulin sensitivity and cardiopulmonary fitness in adolescents with type 1 diabetes: Results from RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) and Effects of MEtformin on CardiovasculaR Function in AdoLescents with Type 1 Diabetes (EMERALD) Studies. Pediatr Diabetes. 2018 05; 19(3):436-442. PMID: 29082640.
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    82. Rozance PJ, Zastoupil L, Wesolowski SR, Goldstrohm DA, Strahan B, Cree-Green M, Sheffield-Moore M, Meschia G, Hay WW, Wilkening RB, Brown LD. Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep. J Physiol. 2018 01 01; 596(1):67-82. PMID: 28940557.
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    83. Cree-Green M, Rahat H, Newcomer BR, Bergman BC, Brown MS, Coe GV, Newnes L, Garcia-Reyes Y, Bacon S, Thurston JE, Pyle L, Scherzinger A, Nadeau KJ. Insulin Resistance, Hyperinsulinemia, and Mitochondria Dysfunction in Nonobese Girls With Polycystic Ovarian Syndrome. J Endocr Soc. 2017 Jul 01; 1(7):931-944. PMID: 29264544.
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    84. Cree-Green M, Cai N, Pyle L, Ringham B, Brown MS, Newcomer BR, Nadeau KJ, Dabelea D. Insulin Resistance in Youth Without Diabetes Is Not Related to Muscle Mitochondrial Dysfunction. J Clin Endocrinol Metab. 2017 05 01; 102(5):1652-1660. PMID: 28204552.
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    85. Bjornstad P, Cree-Green M, Baumgartner A, Coe G, Reyes YG, Schafer M, Pyle L, Regensteiner JG, Reusch JEB, Nadeau KJ. Leptin is associated with cardiopulmonary fitness independent of body-mass index and insulin sensitivity in adolescents with type 1 diabetes: a brief report from the EMERALD study. J Diabetes Complications. 2017 May; 31(5):850-853. PMID: 28336216.
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    86. Cree-Green M. Worldwide Dissatisfaction With the Diagnostic Process and Initial Treatment of PCOS. J Clin Endocrinol Metab. 2017 02 01; 102(2):375-378. PMID: 28359108.
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    87. Patel SS, Truong U, King M, Ferland A, Moreau KL, Dorosz J, Hokanson JE, Wang H, Kinney GL, Maahs DM, Eckel RH, Nadeau KJ, Cree-Green M. Obese adolescents with polycystic ovarian syndrome have elevated cardiovascular disease risk markers. Vasc Med. 2017 04; 22(2):85-95. PMID: 28095749.
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    88. Cree-Green M, Bergman BC, Coe GV, Newnes L, Baumgartner AD, Bacon S, Sherzinger A, Pyle L, Nadeau KJ. Hepatic Steatosis is Common in Adolescents with Obesity and PCOS and Relates to De Novo Lipogenesis but not Insulin Resistance. Obesity (Silver Spring). 2016 11; 24(11):2399-2406. PMID: 27804265.
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    89. Cree-Green M, Gupta A, Coe GV, Baumgartner AD, Pyle L, Reusch JE, Brown MS, Newcomer BR, Nadeau KJ. Insulin resistance in type 2 diabetes youth relates to serum free fatty acids and muscle mitochondrial dysfunction. J Diabetes Complications. 2017 01; 31(1):141-148. PMID: 27839922.
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    90. Ohman-Hanson RA, Cree-Green M, Kelsey MM, Bessesen DH, Sharp TA, Pyle L, Pereira RI, Nadeau KJ. Ethnic and Sex Differences in Adiponectin: From Childhood to Adulthood. J Clin Endocrinol Metab. 2016 12; 101(12):4808-4815. PMID: 27603898.
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    91. Chan CL, Pyle L, Morehead R, Baumgartner A, Cree-Green M, Nadeau KJ. The role of glycemia in insulin resistance in youth with type 1 and type 2 diabetes. Pediatr Diabetes. 2017 Sep; 18(6):470-477. PMID: 27503277.
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    92. Poppy A, Retamal-Munoz C, Cree-Green M, Wood C, Davis S, Clements SA, Majidi S, Steck AK, Alonso GT, Chambers C, Rewers A. Reduction of Insulin Related Preventable Severe Hypoglycemic Events in Hospitalized Children. Pediatrics. 2016 07; 138(1). PMID: 27317577.
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    93. Bjornstad P, Truong U, Pyle L, Dorosz JL, Cree-Green M, Baumgartner A, Coe G, Regensteiner JG, Reusch JE, Nadeau KJ. Youth with type 1 diabetes have worse strain and less pronounced sex differences in early echocardiographic markers of diabetic cardiomyopathy compared to their normoglycemic peers: A RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) Study. J Diabetes Complications. 2016 08; 30(6):1103-10. PMID: 27133451.
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    94. Bjornstad P, Truong U, Dorosz JL, Cree-Green M, Baumgartner A, Coe G, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Cardiopulmonary Dysfunction and Adiponectin in Adolescents With Type 2 Diabetes. J Am Heart Assoc. 2016 Mar 18; 5(3):e002804. PMID: 26994128.
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    95. Pyle L, Bergman BC, Nadeau KJ, Cree-Green M. Modeling changes in glucose and glycerol rates of appearance when true basal rates of appearance cannot be readily determined. Am J Physiol Endocrinol Metab. 2016 Mar 01; 310(5):E323-31. PMID: 26714848.
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    96. Cree-Green M, Maahs DM, Ferland A, Hokanson JE, Wang H, Pyle L, Kinney GL, King M, Eckel RH, Nadeau KJ. Lipoprotein subfraction cholesterol distribution is more atherogenic in insulin resistant adolescents with type 1 diabetes. Pediatr Diabetes. 2016 06; 17(4):257-65. PMID: 26080650.
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    97. Cree-Green M, Newcomer BR, Coe G, Newnes L, Baumgartner A, Brown MS, Pyle L, Reusch JE, Nadeau KJ. Peripheral insulin resistance in obese girls with hyperandrogenism is related to oxidative phosphorylation and elevated serum free fatty acids. Am J Physiol Endocrinol Metab. 2015 May 01; 308(9):E726-33. PMID: 25714677.
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    98. Bjornstad P, Cree-Green M, Baumgartner A, Maahs DM, Cherney DZ, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Renal function is associated with peak exercise capacity in adolescents with type 1 diabetes. Diabetes Care. 2015 Jan; 38(1):126-31. PMID: 25414156.
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    99. Cree-Green M, Newcomer BR, Brown M, Hull A, West AD, Singel D, Reusch JE, McFann K, Regensteiner JG, Nadeau KJ. Method for controlled mitochondrial perturbation during phosphorus MRS in children. Med Sci Sports Exerc. 2014 Oct; 46(10):2030-6. PMID: 24576856.
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    100. Cree-Green M, Newcomer BR, Brown MS, Baumgartner AD, Bergman B, Drew B, Regensteiner JG, Pyle L, Reusch JE, Nadeau KJ. Delayed skeletal muscle mitochondrial ADP recovery in youth with type 1 diabetes relates to muscle insulin resistance. Diabetes. 2015 Feb; 64(2):383-92. PMID: 25157095.
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    101. Bjornstad P, Maahs DM, Cherney DZ, Cree-Green M, West A, Pyle L, Nadeau KJ. Insulin sensitivity is an important determinant of renal health in adolescents with type 2 diabetes. Diabetes Care. 2014 Nov; 37(11):3033-9. PMID: 25071077.
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    102. Geary K, Knaub LA, Schauer IE, Keller AC, Watson PA, Miller MW, Garat CV, Nadeau KJ, Cree-Green M, Pugazhenthi S, Regensteiner JG, Klemm DJ, Reusch JE. Targeting mitochondria to restore failed adaptation to exercise in diabetes. Biochem Soc Trans. 2014 Apr; 42(2):231-8. PMID: 24646223.
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    103. Lindquist KA, Chow K, West A, Pyle L, Isbell TS, Cree-Green M, Nadeau KJ. The StatStrip glucose monitor is suitable for use during hyperinsulinemic euglycemic clamps in a pediatric population. Diabetes Technol Ther. 2014 May; 16(5):298-302. PMID: 24471560.
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    104. Messacar K, Cree-Green M, Lovell M, Anderson MS, Dominguez SR. Severe Neuroinvasive West Nile Virus Infection in a Child with Undiagnosed Addison's Disease. IDCases. 2014; 1(3):29-31. PMID: 25133095.
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    105. Cree-Green M, Triolo TM, Nadeau KJ. Etiology of insulin resistance in youth with type 2 diabetes. Curr Diab Rep. 2013 Feb; 13(1):81-8. PMID: 23135953.
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    106. Brumbaugh DE, Tearse P, Cree-Green M, Fenton LZ, Brown M, Scherzinger A, Reynolds R, Alston M, Hoffman C, Pan Z, Friedman JE, Barbour LA. Intrahepatic fat is increased in the neonatal offspring of obese women with gestational diabetes. J Pediatr. 2013 May; 162(5):930-6.e1. PMID: 23260099.
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    107. Mizokami-Stout K, Cree-Green M, Nadeau KJ. Insulin resistance in type 2 diabetic youth. Curr Opin Endocrinol Diabetes Obes. 2012 Aug; 19(4):255-62. PMID: 22732484.
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    108. Nokoff NJ, Rewers M, Cree Green M. The interplay of autoimmunity and insulin resistance in type 1 diabetes. Discov Med. 2012 Feb; 13(69):115-22. PMID: 22369970.
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    109. Fram RY, Cree MG, Wolfe RR, Barr D, Herndon DN. Impaired glucose tolerance in pediatric burn patients at discharge from the acute hospital stay. J Burn Care Res. 2010 Sep-Oct; 31(5):728-33. PMID: 20634704.
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    110. Fram RY, Cree MG, Wolfe RR, Mlcak RP, Qian T, Chinkes DL, Herndon DN. Intensive insulin therapy improves insulin sensitivity and mitochondrial function in severely burned children. Crit Care Med. 2010 Jun; 38(6):1475-83. PMID: 20400899.
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    111. Thyfault JP, Cree MG, Tapscott EB, Bell JA, Koves TR, Ilkayeva O, Wolfe RR, Dohm GL, Muoio DM. Metabolic profiling of muscle contraction in lean compared with obese rodents. Am J Physiol Regul Integr Comp Physiol. 2010 Sep; 299(3):R926-34. PMID: 20504904.
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    112. Cree MG, Paddon-Jones D, Newcomer BR, Ronsen O, Aarsland A, Wolfe RR, Ferrando A. Twenty-eight-day bed rest with hypercortisolemia induces peripheral insulin resistance and increases intramuscular triglycerides. Metabolism. 2010 May; 59(5):703-10. PMID: 19919871.
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    113. Katsanos CS, Aarsland A, Cree MG, Wolfe RR. Muscle protein synthesis and balance responsiveness to essential amino acids ingestion in the presence of elevated plasma free fatty acid concentrations. J Clin Endocrinol Metab. 2009 Aug; 94(8):2984-90. PMID: 19454587.
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    114. B?rsheim E, Bui QU, Tissier S, Cree MG, R?nsen O, Morio B, Ferrando AA, Kobayashi H, Newcomer BR, Wolfe RR. Amino acid supplementation decreases plasma and liver triacylglycerols in elderly. Nutrition. 2009 Mar; 25(3):281-8. PMID: 19041223.
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    115. Cree MG, Fram RY, Herndon DN, Qian T, Angel C, Green JM, Mlcak R, Aarsland A, Wolfe RR. Human mitochondrial oxidative capacity is acutely impaired after burn trauma. Am J Surg. 2008 Aug; 196(2):234-9. PMID: 18639661.
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    116. Cree MG, Fram RY, Barr D, Chinkes D, Wolfe RR, Herndon DN. Insulin resistance, secretion and breakdown are increased 9 months following severe burn injury. Burns. 2009 Feb; 35(1):63-9. PMID: 18672331.
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    117. Cree MG, Zwetsloot JJ, Herndon DN, Newcomer BR, Fram RY, Angel C, Green JM, Dohm GL, Sun D, Aarsland A, Wolfe RR. Insulin sensitivity is related to fat oxidation and protein kinase C activity in children with acute burn injury. J Burn Care Res. 2008 Jul-Aug; 29(4):585-94. PMID: 18535477.
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    118. Cree MG, Wolfe RR. Postburn trauma insulin resistance and fat metabolism. Am J Physiol Endocrinol Metab. 2008 Jan; 294(1):E1-9. PMID: 17957035.
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    119. Fram RY, Cree MG, Chinkes DL, Herndon DN, Wolfe RR. Recovery of labeled CO2 from acetate in severely burned children. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1726-9. PMID: 17895286.
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    120. Cree MG, Aarsland A, Herndon DN, Wolfe RR. Role of fat metabolism in burn trauma-induced skeletal muscle insulin resistance. Crit Care Med. 2007 Sep; 35(9 Suppl):S476-83. PMID: 17713396.
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    121. Cree MG, Newcomer BR, Read LK, Sheffield-Moore M, Paddon-Jones D, Chinkes D, Aarsland A, Wolfe RR. Plasma triglycerides are not related to tissue lipids and insulin sensitivity in elderly following PPAR-alpha agonist treatment. Mech Ageing Dev. 2007 Oct; 128(10):558-65. PMID: 17904198.
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    122. Cree MG, Newcomer BR, Herndon DN, Qian T, Sun D, Morio B, Zwetsloot JJ, Dohm GL, Fram RY, Mlcak RP, Aarsland A, Wolfe RR. PPAR-alpha agonism improves whole body and muscle mitochondrial fat oxidation, but does not alter intracellular fat concentrations in burn trauma children in a randomized controlled trial. Nutr Metab (Lond). 2007 Apr 23; 4:9. PMID: 17451602.
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    123. Cree MG, Zwetsloot JJ, Herndon DN, Qian T, Morio B, Fram R, Sanford AP, Aarsland A, Wolfe RR. Insulin sensitivity and mitochondrial function are improved in children with burn injury during a randomized controlled trial of fenofibrate. Ann Surg. 2007 Feb; 245(2):214-21. PMID: 17245174.
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    124. Thyfault JP, Cree MG, Zheng D, Zwetsloot JJ, Tapscott EB, Koves TR, Ilkayeva O, Wolfe RR, Muoio DM, Dohm GL. Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism. Am J Physiol Cell Physiol. 2007 Feb; 292(2):C729-39. PMID: 17050616.
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    125. Paddon-Jones D, Sheffield-Moore M, Cree MG, Hewlings SJ, Aarsland A, Wolfe RR, Ferrando AA. Atrophy and impaired muscle protein synthesis during prolonged inactivity and stress. J Clin Endocrinol Metab. 2006 Dec; 91(12):4836-41. PMID: 16984982.
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    126. Tipton KD, Elliott TA, Cree MG, Aarsland AA, Sanford AP, Wolfe RR. Stimulation of net muscle protein synthesis by whey protein ingestion before and after exercise. Am J Physiol Endocrinol Metab. 2007 Jan; 292(1):E71-6. PMID: 16896166.
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    127. Elliot TA, Cree MG, Sanford AP, Wolfe RR, Tipton KD. Milk ingestion stimulates net muscle protein synthesis following resistance exercise. Med Sci Sports Exerc. 2006 Apr; 38(4):667-74. PMID: 16679981.
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    128. Sun D, Cree MG, Zhang XJ, B?ersheim E, Wolfe RR. Measurement of stable isotopic enrichment and concentration of long-chain fatty acyl-carnitines in tissue by HPLC-MS. J Lipid Res. 2006 Feb; 47(2):431-9. PMID: 16301738.
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    129. Sun D, Cree MG, Wolfe RR. Quantification of the concentration and 13C tracer enrichment of long-chain fatty acyl-coenzyme A in muscle by liquid chromatography/mass spectrometry. Anal Biochem. 2006 Feb 01; 349(1):87-95. PMID: 16307720.
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    130. Sheffield-Moore M, Paddon-Jones D, Sanford AP, Rosenblatt JI, Matlock AG, Cree MG, Wolfe RR. Mixed muscle and hepatic derived plasma protein metabolism is differentially regulated in older and younger men following resistance exercise. Am J Physiol Endocrinol Metab. 2005 May; 288(5):E922-9. PMID: 15644460.
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    131. Tipton KD, Elliott TA, Cree MG, Wolf SE, Sanford AP, Wolfe RR. Ingestion of casein and whey proteins result in muscle anabolism after resistance exercise. Med Sci Sports Exerc. 2004 Dec; 36(12):2073-81. PMID: 15570142.
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    132. Cree MG, Newcomer BR, Katsanos CS, Sheffield-Moore M, Chinkes D, Aarsland A, Urban R, Wolfe RR. Intramuscular and liver triglycerides are increased in the elderly. J Clin Endocrinol Metab. 2004 Aug; 89(8):3864-71. PMID: 15292319.
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    133. B?rsheim E, Cree MG, Tipton KD, Elliott TA, Aarsland A, Wolfe RR. Effect of carbohydrate intake on net muscle protein synthesis during recovery from resistance exercise. J Appl Physiol (1985). 2004 Feb; 96(2):674-8. PMID: 14594866.
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    134. Lu LJ, Cree M, Josyula S, Nagamani M, Grady JJ, Anderson KE. Increased urinary excretion of 2-hydroxyestrone but not 16alpha-hydroxyestrone in premenopausal women during a soya diet containing isoflavones. Cancer Res. 2000 Mar 01; 60(5):1299-305. PMID: 10728690.
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