Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Jacob L Houghton

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-RADONC General Operations
    Other Positions
    TitleAssoc Chair
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-RADONC General Operations


    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Delaney S, Grimaldi C, Houghton JL, Zeglis BM. MIB Guides: Measuring the Immunoreactivity of Radioimmunoconjugates. Mol Imaging Biol. 2024 Apr; 26(2):213-221. PMID: 38446323.
      View in: PubMed
    2. Jallinoja VIJ, Abbriano CH, Bhatt K, Kaur A, Schlyer DJ, Yazaki PJ, Carney BD, Houghton JL. Pretargeting with Cucurbituril-Adamantane Host-Guest Pair in Xenograft Models. J Nucl Med. 2023 08; 64(8):1203-1209. PMID: 37024305.
      View in: PubMed
    3. Wen X, Ou L, Cutshaw G, Uthaman S, Ou YC, Zhu T, Szakas S, Carney B, Houghton J, Gundlach-Graham A, Rafat M, Yang K, Bardhan R. Physicochemical Properties and Route of Systemic Delivery Control the In Vivo Dynamics and Breakdown of Radiolabeled Gold Nanostars. Small. 2023 07; 19(29):e2204293. PMID: 36965074.
      View in: PubMed
    4. Jallinoja VIJ, Carney BD, Bhatt K, Abbriano CH, Schlyer DJ, Yazaki PJ, Houghton JL. Investigation of Copper-64-Based Host-Guest Chemistry Pretargeted Positron Emission Tomography. Mol Pharm. 2022 07 04; 19(7):2268-2278. PMID: 35700402.
      View in: PubMed
    5. Jallinoja VIJ, Carney BD, Zhu M, Bhatt K, Yazaki PJ, Houghton JL. Cucurbituril-Ferrocene: Host-Guest Based Pretargeted Positron Emission Tomography in a Xenograft Model. Bioconjug Chem. 2021 08 18; 32(8):1554-1558. PMID: 34156824.
      View in: PubMed
    6. Jallinoja VIJ, Houghton JL. Current Landscape in Clinical Pretargeted Radioimmunoimaging and Therapy. J Nucl Med. 2021 Sep 01; 62(9):1200-1206. PMID: 34016727.
      View in: PubMed
    7. Escorcia FE, Houghton JL, Abdel-Atti D, Pereira PR, Cho A, Gutsche NT, Baidoo KE, Lewis JS. ImmunoPET Predicts Response to Met-targeted Radioligand Therapy in Models of Pancreatic Cancer Resistant to Met Kinase Inhibitors. Theranostics. 2020; 10(1):151-165. PMID: 31903112.
      View in: PubMed
    8. Jae Huh W, Niitsu H, Carney B, McKinley ET, Houghton JL, Coffey RJ. Identification and Characterization of Unique Neutralizing Antibodies to Mouse EGF Receptor. Gastroenterology. 2020 04; 158(5):1500-1502. PMID: 31866246.
      View in: PubMed
    9. Escorcia FE, Steckler JM, Abdel-Atti D, Price EW, Carlin SD, Scholz WW, Lewis JS, Houghton JL. Tumor-Specific Zr-89 Immuno-PET Imaging in a Human Bladder Cancer Model. Mol Imaging Biol. 2018 10; 20(5):808-815. PMID: 29508263.
      View in: PubMed
    10. Brand C, Sadique A, Houghton JL, Gangangari K, Ponte JF, Lewis JS, Pillarsetty NVK, Konner JA, Reiner T. Leveraging PET to image folate receptor a therapy of an antibody-drug conjugate. EJNMMI Res. 2018 Aug 28; 8(1):87. PMID: 30155674.
      View in: PubMed
    11. Houghton JL, Abdel-Atti D, Scholz WW, Lewis JS. Preloading with Unlabeled CA19.9 Targeted Human Monoclonal Antibody Leads to Improved PET Imaging with 89Zr-5B1. Mol Pharm. 2017 03 06; 14(3):908-915. PMID: 28191976.
      View in: PubMed
    12. Houghton JL, Membreno R, Abdel-Atti D, Cunanan KM, Carlin S, Scholz WW, Zanzonico PB, Lewis JS, Zeglis BM. Establishment of the In Vivo Efficacy of Pretargeted Radioimmunotherapy Utilizing Inverse Electron Demand Diels-Alder Click Chemistry. Mol Cancer Ther. 2017 01; 16(1):124-133. PMID: 28062708.
      View in: PubMed
    13. Zhang H, Desai P, Koike Y, Houghton J, Carlin S, Tandon N, Touijer K, Weber WA. Dual-Modality Imaging of Prostate Cancer with a Fluorescent and Radiogallium-Labeled Gastrin-Releasing Peptide Receptor Antagonist. J Nucl Med. 2017 Jan; 58(1):29-35. PMID: 27516447.
      View in: PubMed
    14. Houghton JL, Zeglis BM, Abdel-Atti D, Aggeler R, Sawada R, Agnew BJ, Scholz WW, Lewis JS. Site-specifically labeled CA19.9-targeted immunoconjugates for the PET, NIRF, and multimodal PET/NIRF imaging of pancreatic cancer. Proc Natl Acad Sci U S A. 2015 Dec 29; 112(52):15850-5. PMID: 26668398.
      View in: PubMed
    15. Meyer JP, Houghton JL, Kozlowski P, Abdel-Atti D, Reiner T, Pillarsetty NV, Scholz WW, Zeglis BM, Lewis JS. (18)F-Based Pretargeted PET Imaging Based on Bioorthogonal Diels-Alder Click Chemistry. Bioconjug Chem. 2016 Feb 17; 27(2):298-301. PMID: 26479967.
      View in: PubMed
    16. Houghton JL, Zeglis BM, Abdel-Atti D, Sawada R, Scholz WW, Lewis JS. Pretargeted Immuno-PET of Pancreatic Cancer: Overcoming Circulating Antigen and Internalized Antibody to Reduce Radiation Doses. J Nucl Med. 2016 Mar; 57(3):453-9. PMID: 26471693.
      View in: PubMed
    17. Thamban Chandrika N, Green KD, Houghton JL, Garneau-Tsodikova S. Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides. ACS Med Chem Lett. 2015 Nov 12; 6(11):1134-9. PMID: 26617967.
      View in: PubMed
    18. Dimastromatteo J, Houghton JL, Lewis JS, Kelly KA. Challenges of Pancreatic Cancer. Cancer J. 2015 May-Jun; 21(3):188-93. PMID: 26049698.
      View in: PubMed
    19. Zeglis BM, Houghton JL, Evans MJ, Viola-Villegas N, Lewis JS. Underscoring the influence of inorganic chemistry on nuclear imaging with radiometals. Inorg Chem. 2014 Feb 17; 53(4):1880-99. PMID: 24313747.
      View in: PubMed
    20. Houghton JL, Biswas T, Chen W, Tsodikov OV, Garneau-Tsodikova S. Chemical and structural insights into the regioversatility of the aminoglycoside acetyltransferase Eis. Chembiochem. 2013 Nov 04; 14(16):2127-35. PMID: 24106131.
      View in: PubMed
    21. Houghton JL, Green KD, Pricer RE, Mayhoub AS, Garneau-Tsodikova S. Unexpected N-acetylation of capreomycin by mycobacterial Eis enzymes. J Antimicrob Chemother. 2013 Apr; 68(4):800-5. PMID: 23233486.
      View in: PubMed
    22. Pinkosky SL, Filippov S, Srivastava RA, Hanselman JC, Bradshaw CD, Hurley TR, Cramer CT, Spahr MA, Brant AF, Houghton JL, Baker C, Naples M, Adeli K, Newton RS. AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism. J Lipid Res. 2013 Jan; 54(1):134-51. PMID: 23118444.
      View in: PubMed
    23. Pricer RE, Houghton JL, Green KD, Mayhoub AS, Garneau-Tsodikova S. Biochemical and structural analysis of aminoglycoside acetyltransferase Eis from Anabaena variabilis. Mol Biosyst. 2012 Oct 30; 8(12):3305-13. PMID: 23090428.
      View in: PubMed
    24. Biswas T, Houghton JL, Garneau-Tsodikova S, Tsodikov OV. The structural basis for substrate versatility of chloramphenicol acetyltransferase CATI. Protein Sci. 2012 Apr; 21(4):520-30. PMID: 22294317.
      View in: PubMed
    25. Porter VR, Green KD, Zolova OE, Houghton JL, Garneau-Tsodikova S. Dissecting the cosubstrate structure requirements of the Staphylococcus aureus aminoglycoside resistance enzyme ANT(4'). Biochem Biophys Res Commun. 2010 Dec 03; 403(1):85-90. PMID: 21040710.
      View in: PubMed
    26. Houghton JL, Green KD, Chen W, Garneau-Tsodikova S. The future of aminoglycosides: the end or renaissance? Chembiochem. 2010 May 03; 11(7):880-902. PMID: 20397253.
      View in: PubMed
    27. Green KD, Chen W, Houghton JL, Fridman M, Garneau-Tsodikova S. Exploring the substrate promiscuity of drug-modifying enzymes for the chemoenzymatic generation of N-acylated aminoglycosides. Chembiochem. 2010 Jan 04; 11(1):119-26. PMID: 19899089.
      View in: PubMed
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