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David E. Clouthier

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSDM-Craniofacial Biology
Phone303/724-4565
    Other Positions
    TitleChair
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSDM-Craniofacial Biology


    Collapse Research 
    Collapse research activities and funding
    R01DE033098     (CLOUTHIER, DAVID E.)Mar 1, 2024 - Jan 31, 2029
    NIH
    The role of GATA3 in hemifacial microsomia
    Role: Principal Investigator
    R01DE029091     (CLOUTHIER, DAVID E.)Aug 1, 2020 - Jul 31, 2024
    NIH
    Gene Regulatory Networks that Establish Mandible and Maxilla Patterning
    Role: Principal Investigator
    R01HL149836     (SCHWARTZ, DAVID ALBERT)Jun 1, 2020 - May 31, 2025
    NIH
    Genes and Transcripts that Interact with MUC5B in Pulmonary Fibrosis
    Role: Co-Principal Investigator
    R56DE029091     (CLOUTHIER, DAVID E.)Aug 1, 2019 - Jul 31, 2020
    NIH
    Gene regulatory networks that establish mandible and maxilla patterning
    Role: Principal Investigator
    R01HD081562     (WILLIAMS, TREVOR J)Sep 20, 2014 - Jun 30, 2019
    NIH
    Phenotyping Embryonic Lethal Knockout mice with neural crest and neural defects
    Role: Co-Principal Investigator
    R01DE023050     (CLOUTHIER, DAVID E.)Jul 1, 2014 - Mar 31, 2020
    NIH
    Defining an Integrated Signaling Network That Patterns the Craniofacial Skeleton
    Role: Principal Investigator
    U01DE020076     (CLOUTHIER, DAVID E.)Sep 21, 2009 - Apr 30, 2015
    NIH
    Idenfication of miRNAs involved midfacial development and clefting
    Role: Principal Investigator
    R01DE018899     (CLOUTHIER, DAVID E.)Jul 20, 2009 - Jun 30, 2019
    NIH
    Hand2 Function and Regulation During Craniofacial Development
    Role: Principal Investigator
    K02DE014765     (CLOUTHIER, DAVID E.)Aug 1, 2002 - May 31, 2007
    NIH
    Endothelin A Signaling in Craniofacial Development
    Role: Principal Investigator
    R01DE014181     (CLOUTHIER, DAVID E.)Jul 1, 2001 - May 31, 2014
    NIH
    ENDOTHELIN-A SIGNALING IN CRANIOFACIAL DEVELOPMENT
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kanai SM, Clouthier DE. Endothelin signaling in development. Development. 2023 Dec 15; 150(24). PMID: 38078652.
      View in: PubMed
    2. Baxi A, Jourdeuil K, Cox TC, Clouthier DE, Tavares ALP. Transcriptomic analysis reveals the role of SIX1 in mouse cranial neural crest patterning and bone development. Dev Dyn. 2023 Oct; 252(10):1303-1315. PMID: 37183792.
      View in: PubMed
    3. Stottmann RW, Harris MP, Saint-Jeannet JP, Merrill AE, Clouthier DE. The Society for Craniofacial Genetics and Developmental Biology 45th Annual Meeting. Am J Med Genet A. 2023 07; 191(7):1994-2002. PMID: 37040531.
      View in: PubMed
    4. Micke KC, Elfman HM, Fantauzzo KA, McGrath PS, Clouthier DE, McCandless SE, Larson A, Putra M, Cuneo BF, Reynolds RM, Zaretsky MV. Piloting a multidisciplinary approach to improve outcomes of fetal whole exome sequencing: An overview of workflow and case example. Prenat Diagn. 2023 04; 43(4):544-552. PMID: 36759743.
      View in: PubMed
    5. Kanai SM, Heffner C, Cox TC, Cunningham ML, Perez FA, Bauer AM, Reigan P, Carter C, Murray SA, Clouthier DE. Auriculocondylar syndrome 2 results from the dominant-negative action of PLCB4 variants. Dis Model Mech. 2022 04 01; 15(4). PMID: 35284927.
      View in: PubMed
    6. Prummel KD, Crowell HL, Nieuwenhuize S, Brombacher EC, Daetwyler S, Soneson C, Kresoja-Rakic J, Kocere A, Ronner M, Ernst A, Labbaf Z, Clouthier DE, Firulli AB, S?nchez-Iranzo H, Naganathan SR, O'Rourke R, Raz E, Mercader N, Burger A, Felley-Bosco E, Huisken J, Robinson MD, Mosimann C. Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma. Nat Commun. 2022 03 30; 13(1):1677. PMID: 35354817.
      View in: PubMed
    7. Brugmann SA, Merrill AE, Saint-Jeannet JP, Stottmann RW, Clouthier DE. The Society for Craniofacial Genetics and Developmental Biology 44th Annual Meeting. Am J Med Genet A. 2022 07; 188(7):2258-2266. PMID: 35352468.
      View in: PubMed
    8. Abe M, Cox TC, Firulli AB, Kanai SM, Dahlka J, Lim KC, Engel JD, Clouthier DE. GATA3 is essential for separating patterning domains during facial morphogenesis. Development. 2021 09 01; 148(17). PMID: 34383890.
      View in: PubMed
    9. Brugmann S, Clouthier DE, Saint-Jeannet JP, Taneyhill LA, Moody SA. The society for craniofacial genetics and developmental biology 43rd annual meeting. Am J Med Genet A. 2021 06; 185(6):1932-1939. PMID: 33660912.
      View in: PubMed
    10. Eisenhoffer GT, Clouthier D, Cox T, Saint-Jeannet JP, Taneyhill LA, Trainor PA, Moody SA. The Society for Craniofacial Genetics and Developmental Biology 42nd Annual Meeting. Am J Med Genet A. 2020 07; 182(7):1555-1561. PMID: 32352199.
      View in: PubMed
    11. Vincentz JW, Clouthier DE, Firulli AB. Mis-Expression of a Cranial Neural Crest Cell-Specific Gene Program in Cardiac Neural Crest Cells Modulates HAND Factor Expression, Causing Cardiac Outflow Tract Phenotypes. J Cardiovasc Dev Dis. 2020 Apr 20; 7(2). PMID: 32325975.
      View in: PubMed
    12. Pritchard AB, Kanai SM, Krock B, Schindewolf E, Oliver-Krasinski J, Khalek N, Okashah N, Lambert NA, Tavares ALP, Zackai E, Clouthier DE. Loss-of-function of Endothelin receptor type A results in Oro-Oto-Cardiac syndrome. Am J Med Genet A. 2020 05; 182(5):1104-1116. PMID: 32133772.
      View in: PubMed
    13. Sottnik JL, Mallaredy V, Chauca-Diaz A, Ritterson Lew C, Owens C, Dancik GM, Pagliarani S, Lucchiari S, Moggio M, Ripolone M, Comi GP, Frierson HF, Clouthier D, Theodorescu D. Elucidating the role of Agl in bladder carcinogenesis by generation and characterization of genetically engineered mice. Carcinogenesis. 2019 03 12; 40(1):194-201. PMID: 30403777.
      View in: PubMed
    14. Xu J, Liu H, Lan Y, Adam M, Clouthier DE, Potter S, Jiang R. Hedgehog signaling patterns the oral-aboral axis of the mandibular arch. Elife. 2019 01 14; 8. PMID: 30638444.
      View in: PubMed
    15. Sharma PP, MacLean AL, Meinecke L, Clouthier DE, Nie Q, Schilling TF. Transcriptomics reveals complex kinetics of dorsal-ventral patterning gene expression in the mandibular arch. Genesis. 2019 01; 57(1):e23275. PMID: 30561090.
      View in: PubMed
    16. Tavares ALP, Cox TC, Maxson RM, Ford HL, Clouthier DE. Negative regulation of endothelin signaling by SIX1 is required for proper maxillary development. Development. 2017 06 01; 144(11):2021-2031. PMID: 28455376.
      View in: PubMed
    17. Ikl? JM, Tavares AL, King M, Ding H, Colombo S, Firulli BA, Firulli AB, Targoff KL, Yelon D, Clouthier DE. Nkx2.5 regulates endothelin converting enzyme-1 during pharyngeal arch patterning. Genesis. 2017 03; 55(3). PMID: 28109039.
      View in: PubMed
    18. Ding HL, Hooper JE, Batzel P, Eames BF, Postlethwait JH, Artinger KB, Clouthier DE. MicroRNA Profiling during Craniofacial Development: Potential Roles for Mir23b and Mir133b. Front Physiol. 2016; 7:281. PMID: 27471470.
      View in: PubMed
    19. Vincentz JW, Casasnovas JJ, Barnes RM, Que J, Clouthier DE, Wang J, Firulli AB. Exclusion of Dlx5/6 expression from the distal-most mandibular arches enables BMP-mediated specification of the distal cap. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):7563-8. PMID: 27335460.
      View in: PubMed
    20. Van Otterloo E, Feng W, Jones KL, Hynes NE, Clouthier DE, Niswander L, Williams T. MEMO1 drives cranial endochondral ossification and palatogenesis. Dev Biol. 2016 07 15; 415(2):278-295. PMID: 26746790.
      View in: PubMed
    21. Glidewell SC, Miyamoto SD, Grossfeld PD, Clouthier DE, Coldren CD, Stearman RS, Geraci MW. Transcriptional Impact of Rare and Private Copy Number Variants in Hypoplastic Left Heart Syndrome. Clin Transl Sci. 2015 Dec; 8(6):682-9. PMID: 26534787.
      View in: PubMed
    22. Tavares AL, Artinger KB, Clouthier DE. Regulating Craniofacial Development at the 3' End: MicroRNAs and Their Function in Facial Morphogenesis. Curr Top Dev Biol. 2015; 115:335-75. PMID: 26589932.
      View in: PubMed
    23. Van Laarhoven PM, Neitzel LR, Quintana AM, Geiger EA, Zackai EH, Clouthier DE, Artinger KB, Ming JE, Shaikh TH. Kabuki syndrome genes KMT2D and KDM6A: functional analyses demonstrate critical roles in craniofacial, heart and brain development. Hum Mol Genet. 2015 Aug 01; 24(15):4443-53. PMID: 25972376.
      View in: PubMed
    24. Gordon CT, Weaver KN, Zechi-Ceide RM, Madsen EC, Tavares AL, Oufadem M, Kurihara Y, Adameyko I, Picard A, Breton S, Pierrot S, Biosse-Duplan M, Voisin N, Masson C, Bole-Feysot C, Nitschk? P, Delrue MA, Lacombe D, Guion-Almeida ML, Moura PP, Garib DG, Munnich A, Ernfors P, Hufnagel RB, Hopkin RJ, Kurihara H, Saal HM, Weaver DD, Katsanis N, Lyonnet S, Golzio C, Clouthier DE, Amiel J. Mutations in the endothelin receptor type A cause mandibulofacial dysostosis with alopecia. Am J Hum Genet. 2015 Apr 02; 96(4):519-31. PMID: 25772936.
      View in: PubMed
    25. Tavares AL, Clouthier DE. Cre recombinase-regulated Endothelin1 transgenic mouse lines: novel tools for analysis of embryonic and adult disorders. Dev Biol. 2015 Apr 15; 400(2):191-201. PMID: 25725491.
      View in: PubMed
    26. Firulli BA, Fuchs RK, Vincentz JW, Clouthier DE, Firulli AB. Hand1 phosphoregulation within the distal arch neural crest is essential for craniofacial morphogenesis. Development. 2014 Aug; 141(15):3050-61. PMID: 25053435.
      View in: PubMed
    27. Clouthier DE, Passos-Bueno MR, Tavares AL, Lyonnet S, Amiel J, Gordon CT. Understanding the basis of auriculocondylar syndrome: Insights from human, mouse and zebrafish genetic studies. Am J Med Genet C Semin Med Genet. 2013 Nov; 163C(4):306-17. PMID: 24123988.
      View in: PubMed
    28. Feng W, Choi I, Clouthier DE, Niswander L, Williams T. The Ptch1(DL) mouse: a new model to study lambdoid craniosynostosis and basal cell nevus syndrome-associated skeletal defects. Genesis. 2013 Oct; 51(10):677-89. PMID: 23897749.
      View in: PubMed
    29. Ding HL, Clouthier DE, Artinger KB. Redundant roles of PRDM family members in zebrafish craniofacial development. Dev Dyn. 2013 Jan; 242(1):67-79. PMID: 23109401.
      View in: PubMed
    30. Tavares AL, Garcia EL, Kuhn K, Woods CM, Williams T, Clouthier DE. Ectodermal-derived Endothelin1 is required for patterning the distal and intermediate domains of the mouse mandibular arch. Dev Biol. 2012 Nov 01; 371(1):47-56. PMID: 22902530.
      View in: PubMed
    31. Ikl? JM, Artinger KB, Clouthier DE. Identification and characterization of the zebrafish pharyngeal arch-specific enhancer for the basic helix-loop-helix transcription factor Hand2. Dev Biol. 2012 Aug 01; 368(1):118-26. PMID: 22595513.
      View in: PubMed
    32. Barron F, Woods C, Kuhn K, Bishop J, Howard MJ, Clouthier DE. Downregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesis. Development. 2011 Jun; 138(11):2249-59. PMID: 21558373.
      View in: PubMed
    33. Hochheiser H, Aronow BJ, Artinger K, Beaty TH, Brinkley JF, Chai Y, Clouthier D, Cunningham ML, Dixon M, Donahue LR, Fraser SE, Hallgrimsson B, Iwata J, Klein O, Marazita ML, Murray JC, Murray S, de Villena FP, Postlethwait J, Potter S, Shapiro L, Spritz R, Visel A, Weinberg SM, Trainor PA. The FaceBase Consortium: a comprehensive program to facilitate craniofacial research. Dev Biol. 2011 Jul 15; 355(2):175-82. PMID: 21458441.
      View in: PubMed
    34. Clouthier DE, Garcia E, Schilling TF. Regulation of facial morphogenesis by endothelin signaling: insights from mice and fish. Am J Med Genet A. 2010 Dec; 152A(12):2962-73. PMID: 20684004.
      View in: PubMed
    35. Ruest LB, Clouthier DE. Elucidating timing and function of endothelin-A receptor signaling during craniofacial development using neural crest cell-specific gene deletion and receptor antagonism. Dev Biol. 2009 Apr 01; 328(1):94-108. PMID: 19185569.
      View in: PubMed
    36. Clouthier DE, Gray J, Artinger KB. Micromanaging Palate Development. Perspect Speech Sci Orofac Disord. 2008 Oct 01; 18(2):62-72. PMID: 20016765.
      View in: PubMed
    37. Hendershot TJ, Liu H, Clouthier DE, Shepherd IT, Coppola E, Studer M, Firulli AB, Pittman DL, Howard MJ. Conditional deletion of Hand2 reveals critical functions in neurogenesis and cell type-specific gene expression for development of neural crest-derived noradrenergic sympathetic ganglion neurons. Dev Biol. 2008 Jul 15; 319(2):179-91. PMID: 18501887.
      View in: PubMed
    38. Clouthier DE. MicroRNAs in facial development. Nat Genet. 2008 Mar; 40(3):268-9. PMID: 18305475.
      View in: PubMed
    39. Hendershot TJ, Liu H, Sarkar AA, Giovannucci DR, Clouthier DE, Abe M, Howard MJ. Expression of Hand2 is sufficient for neurogenesis and cell type-specific gene expression in the enteric nervous system. Dev Dyn. 2007 Jan; 236(1):93-105. PMID: 17075884.
      View in: PubMed
    40. Abe M, Ruest LB, Clouthier DE. Fate of cranial neural crest cells during craniofacial development in endothelin-A receptor-deficient mice. Int J Dev Biol. 2007; 51(2):97-105. PMID: 17294360.
      View in: PubMed
    41. Kanzaki-Kato N, Tamakoshi T, Fu Y, Chandra A, Itakura T, Uezato T, Tanaka T, Clouthier DE, Sugiyama T, Yanagisawa M, Miura N. Roles of forkhead transcription factor Foxc2 (MFH-1) and endothelin receptor A in cardiovascular morphogenesis. Cardiovasc Res. 2005 Feb 15; 65(3):711-8. PMID: 15664398.
      View in: PubMed
    42. Ruest LB, Kedzierski R, Yanagisawa M, Clouthier DE. Deletion of the endothelin-A receptor gene within the developing mandible. Cell Tissue Res. 2005 Mar; 319(3):447-53. PMID: 15647918.
      View in: PubMed
    43. Maurer M, Wedemeyer J, Metz M, Piliponsky AM, Weller K, Chatterjea D, Clouthier DE, Yanagisawa MM, Tsai M, Galli SJ. Mast cells promote homeostasis by limiting endothelin-1-induced toxicity. Nature. 2004 Nov 25; 432(7016):512-6. PMID: 15543132.
      View in: PubMed
    44. Ruest LB, Xiang X, Lim KC, Levi G, Clouthier DE. Endothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identity. Development. 2004 Sep; 131(18):4413-23. PMID: 15306564.
      View in: PubMed
    45. Clouthier DE, Schilling TF. Understanding endothelin-1 function during craniofacial development in the mouse and zebrafish. Birth Defects Res C Embryo Today. 2004 Jun; 72(2):190-9. PMID: 15269892.
      View in: PubMed
    46. Ruest LB, Hammer RE, Yanagisawa M, Clouthier DE. Dlx5/6-enhancer directed expression of Cre recombinase in the pharyngeal arches and brain. Genesis. 2003 Dec; 37(4):188-94. PMID: 14666512.
      View in: PubMed
    47. Clouthier DE, Williams SC, Hammer RE, Richardson JA, Yanagisawa M. Cell-autonomous and nonautonomous actions of endothelin-A receptor signaling in craniofacial and cardiovascular development. Dev Biol. 2003 Sep 15; 261(2):506-19. PMID: 14499656.
      View in: PubMed
    48. Ruest LB, Dager M, Yanagisawa H, Charit? J, Hammer RE, Olson EN, Yanagisawa M, Clouthier DE. dHAND-Cre transgenic mice reveal specific potential functions of dHAND during craniofacial development. Dev Biol. 2003 May 15; 257(2):263-77. PMID: 12729557.
      View in: PubMed
    49. Comerford SA, Clouthier DE, Hinnant EA, Hammer RE. Induction of hepatocyte proliferation and death by modulation of T-Antigen expression. Oncogene. 2003 Apr 24; 22(16):2515-30. PMID: 12717428.
      View in: PubMed
    50. Yanagisawa H, Clouthier DE, Richardson JA, Charit? J, Olson EN. Targeted deletion of a branchial arch-specific enhancer reveals a role of dHAND in craniofacial development. Development. 2003 Mar; 130(6):1069-78. PMID: 12571099.
      View in: PubMed
    51. Charit? J, McFadden DG, Merlo G, Levi G, Clouthier DE, Yanagisawa M, Richardson JA, Olson EN. Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer. Genes Dev. 2001 Nov 15; 15(22):3039-49. PMID: 11711438.
      View in: PubMed
    52. Yanagisawa H, Hammer RE, Richardson JA, Emoto N, Williams SC, Takeda Si, Clouthier DE, Yanagisawa M. Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development. J Clin Invest. 2000 May; 105(10):1373-82. PMID: 10811845.
      View in: PubMed
    53. Clouthier DE, Williams SC, Yanagisawa H, Wieduwilt M, Richardson JA, Yanagisawa M. Signaling pathways crucial for craniofacial development revealed by endothelin-A receptor-deficient mice. Dev Biol. 2000 Jan 01; 217(1):10-24. PMID: 10625532.
      View in: PubMed
    54. Devine JH, Eubank DW, Clouthier DE, Tontonoz P, Spiegelman BM, Hammer RE, Beale EG. Adipose expression of the phosphoenolpyruvate carboxykinase promoter requires peroxisome proliferator-activated receptor gamma and 9-cis-retinoic acid receptor binding to an adipocyte-specific enhancer in vivo. J Biol Chem. 1999 May 07; 274(19):13604-12. PMID: 10224131.
      View in: PubMed
    55. Yanagisawa H, Hammer RE, Richardson JA, Williams SC, Clouthier DE, Yanagisawa M. Role of Endothelin-1/Endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice. J Clin Invest. 1998 Jul 01; 102(1):22-33. PMID: 9649553.
      View in: PubMed
    56. Clouthier DE, Hosoda K, Richardson JA, Williams SC, Yanagisawa H, Kuwaki T, Kumada M, Hammer RE, Yanagisawa M. Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice. Development. 1998 Mar; 125(5):813-24. PMID: 9449664.
      View in: PubMed
    57. Yanagisawa H, Yanagisawa M, Kapur RP, Richardson JA, Williams SC, Clouthier DE, de Wit D, Emoto N, Hammer RE. Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene. Development. 1998 Mar; 125(5):825-36. PMID: 9449665.
      View in: PubMed
    58. Clouthier DE, Comerford SA, Hammer RE. Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-beta1 transgenic mice. J Clin Invest. 1997 Dec 01; 100(11):2697-713. PMID: 9389733.
      View in: PubMed
    59. Clouthier DE, Avarbock MR, Maika SD, Hammer RE, Brinster RL. Rat spermatogenesis in mouse testis. Nature. 1996 May 30; 381(6581):418-21. PMID: 8632797.
      View in: PubMed
    60. Beale EG, Clouthier DE, Hammer RE. Cell-specific expression of cytosolic phosphoenolpyruvate carboxykinase in transgenic mice. FASEB J. 1992 Dec; 6(15):3330-7. PMID: 1281456.
      View in: PubMed
    61. Herz J, Clouthier DE, Hammer RE. LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation. Cell. 1992 Oct 30; 71(3):411-21. PMID: 1423604.
      View in: PubMed
    62. Short MK, Clouthier DE, Schaefer IM, Hammer RE, Magnuson MA, Beale EG. Tissue-specific, developmental, hormonal, and dietary regulation of rat phosphoenolpyruvate carboxykinase-human growth hormone fusion genes in transgenic mice. Mol Cell Biol. 1992 Mar; 12(3):1007-20. PMID: 1545785.
      View in: PubMed
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