 Connective Tissue Growth Factor
"Connective Tissue Growth Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It is found in hypertrophic CHONDROCYTES where it may play a role in CHONDROGENESIS and endochondral ossification.
| Descriptor ID |
D055513
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| MeSH Number(s) |
D12.644.276.200.100 D12.776.467.200.100 D12.776.860.300.200.100 D23.529.237.100
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| Concept/Terms |
Connective Tissue Growth Factor- Connective Tissue Growth Factor
- Hypertrophic Chondrocyte-Specific Protein 24
- Hypertrophic Chondrocyte Specific Protein 24
- IGF-Binding Protein-Related Protein-2
- IGF Binding Protein Related Protein 2
- IGFBP-rP2
- Insulin-Like Growth Factor Binding Protein 8
- Insulin Like Growth Factor Binding Protein 8
- CCN2 Protein
- IGFBP-8
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Below are MeSH descriptors whose meaning is more general than "Connective Tissue Growth Factor".
Below are MeSH descriptors whose meaning is more specific than "Connective Tissue Growth Factor".
This graph shows the total number of publications written about "Connective Tissue Growth Factor" by people in this website by year, and whether "Connective Tissue Growth Factor" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2007 | 0 | 2 | 2 | | 2010 | 1 | 1 | 2 | | 2011 | 1 | 0 | 1 | | 2012 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2017 | 1 | 2 | 3 |
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Below are the most recent publications written about "Connective Tissue Growth Factor" by people in Profiles.
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Montford JR, Furgeson SB. A new CTGF target in renal?fibrosis. Kidney Int. 2017 10; 92(4):784-786.
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Jiang L, Sun L, Edwards G, Manley M, Wallace DP, Septer S, Manohar C, Pritchard MT, Apte U. Increased YAP Activation Is Associated With Hepatic Cyst Epithelial Cell Proliferation in ARPKD/CHF. Gene Expr. 2017 11 27; 17(4):313-326.
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Cardin LT, Sonehara NM, Mimura KK, Ramos Dinarte Dos Santos A, da Silva WA, Sobral LM, Leopoldino AM, da Cunha BR, Tajara EH, Oliani SM, Rodrigues-Lisoni FC. ANXA1Ac2-26 peptide, a possible therapeutic approach in inflammatory ocular diseases. Gene. 2017 May 30; 614:26-36.
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Raghu G, Scholand MB, de Andrade J, Lancaster L, Mageto Y, Goldin J, Brown KK, Flaherty KR, Wencel M, Wanger J, Neff T, Valone F, Stauffer J, Porter S. FG-3019 anti-connective tissue growth factor monoclonal antibody: results of an open-label clinical trial in idiopathic pulmonary fibrosis. Eur Respir J. 2016 05; 47(5):1481-91.
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Bagchi RA, Mozolevska V, Abrenica B, Czubryt MP. Development of a high throughput luciferase reporter gene system for screening activators and repressors of human collagen Ia2 gene expression. Can J Physiol Pharmacol. 2015 Oct; 93(10):887-92.
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Hendesi H, Barbe MF, Safadi FF, Monroy MA, Popoff SN. Integrin mediated adhesion of osteoblasts to connective tissue growth factor (CTGF/CCN2) induces cytoskeleton reorganization and cell differentiation. PLoS One. 2015; 10(2):e0115325.
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Whitson RJ, Lucia MS, Lambert JR. Growth differentiation factor-15 (GDF-15) suppresses in vitro angiogenesis through a novel interaction with connective tissue growth factor (CCN2). J Cell Biochem. 2013 Jun; 114(6):1424-33.
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Wang H, Haeger SM, Kloxin AM, Leinwand LA, Anseth KS. Redirecting valvular myofibroblasts into dormant fibroblasts through light-mediated reduction in substrate modulus. PLoS One. 2012; 7(7):e39969.
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Guney MA, Petersen CP, Boustani A, Duncan MR, Gunasekaran U, Menon R, Warfield C, Grotendorst GR, Means AL, Economides AN, Gannon M. Connective tissue growth factor acts within both endothelial cells and beta cells to promote proliferation of developing beta cells. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15242-7.
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Arnott JA, Lambi AG, Mundy C, Hendesi H, Pixley RA, Owen TA, Safadi FF, Popoff SN. The role of connective tissue growth factor (CTGF/CCN2) in skeletogenesis. Crit Rev Eukaryot Gene Expr. 2011; 21(1):43-69.
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