 Group IV Phospholipases A2
"Group IV Phospholipases A2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cytosolic phospholipase A2 group that plays an important role in the release of free ARACHIDONIC ACID, which in turn is metabolized to PROSTAGLANDINS by the CYCLOOXYGENASE pathway and to LEUKOTRIENES by the 5-LIPOXYGENASE pathway.
| Descriptor ID |
D054513
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| MeSH Number(s) |
D08.811.277.352.100.680.750.937.625.249
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| Concept/Terms |
Group IV Phospholipases A2- Group IV Phospholipases A2
- PLA2-IV
- Phospholipases A2, Group IV
- PLA(2)-IV
- Group IV Cytosolic Phospholipase A2
- Phospholipase A2 IV
Group IVB Phospholipase A2- Group IVB Phospholipase A2
- Phospholipase A2-beta
- Phospholipase A2 beta
- Phospholipase A2, Group IVB
- Cytosolic Phospholipase A2 beta
- Group IVB Phospholipases A2
Group IVC Phospholipase A2- Group IVC Phospholipase A2
- Phospholipase A2, Group IVC
- Cytosolic Phospholipase A2 gamma
- cPLA2-gamma
- cPLA2 gamma
- Group IVC Phospholipases A2
- Phospholipase A2-gamma
- Phospholipase A2 gamma
Group IVE Phospholipase A2- Group IVE Phospholipase A2
- Group IVE Phospholipases A2
- Phospholipase A2, Group IVE
- Cytosolic Phospholipase A2 epsilon
Group IVA Phospholipase A2- Group IVA Phospholipase A2
- Cytosolic Phospholipase A2 alpha
- Phospholipase A2-alpha
- Phospholipase A2 alpha
- Phospholipase A(2)alpha
- Phospholipase A2 Group IVA
- cPLA2-alpha
- cPLA2 alpha
- Group IVA Phospholipases A2
Group IVD Phospholipase A2- Group IVD Phospholipase A2
- Group IVD Phospholipases A2
- Phospholipase A2, Group IVD
- Cytosolic Phospholipase A2 delta
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Below are MeSH descriptors whose meaning is more general than "Group IV Phospholipases A2".
Below are MeSH descriptors whose meaning is more specific than "Group IV Phospholipases A2".
This graph shows the total number of publications written about "Group IV Phospholipases A2" by people in this website by year, and whether "Group IV Phospholipases A2" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 2 | 2 | | 2006 | 0 | 3 | 3 | | 2007 | 1 | 2 | 3 | | 2009 | 1 | 1 | 2 | | 2011 | 1 | 1 | 2 | | 2013 | 1 | 2 | 3 | | 2014 | 0 | 1 | 1 | | 2016 | 1 | 0 | 1 | | 2017 | 1 | 1 | 2 | | 2019 | 3 | 1 | 4 | | 2020 | 0 | 1 | 1 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Group IV Phospholipases A2" by people in Profiles.
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Maus KD, Stephenson DJ, Macknight HP, Vu NT, Hoeferlin LA, Kim M, Diegelmann RF, Xie X, Chalfant CE. Skewing cPLA2a activity toward oxoeicosanoid production promotes neutrophil N2 polarization, wound healing, and the response to sepsis. Sci Signal. 2023 07 11; 16(793):eadd6527.
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Nelson AJ, Stephenson DJ, Bone RN, Cardona CL, Park MA, Tusing YG, Lei X, Kokotos G, Graves CL, Mathews CE, Kramer J, Hessner MJ, Chalfant CE, Ramanadham S. Lipid mediators and biomarkers associated with type 1 diabetes development. JCI Insight. 2020 08 20; 5(16).
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Nelson AJ, Stephenson DJ, Cardona CL, Lei X, Almutairi A, White TD, Tusing YG, Park MA, Barbour SE, Chalfant CE, Ramanadham S. Macrophage polarization is linked to Ca2+-independent phospholipase A2?-derived lipids and cross-cell signaling in mice. J Lipid Res. 2020 02; 61(2):143-158.
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MacKnight HP, Stephenson DJ, Hoeferlin LA, Benusa SD, DeLigio JT, Maus KD, Ali AN, Wayne JS, Park MA, Hinchcliffe EH, Brown RE, Ryan JJ, Diegelmann RF, Chalfant CE. The interaction of ceramide 1-phosphate with group IVA cytosolic phospholipase A2 coordinates acute wound healing and repair. Sci Signal. 2019 12 03; 12(610).
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Hirano Y, Gao YG, Stephenson DJ, Vu NT, Malinina L, Simanshu DK, Chalfant CE, Patel DJ, Brown RE. Structural basis of phosphatidylcholine recognition by the C2-domain of cytosolic phospholipase A2a. Elife. 2019 05 03; 8.
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Siegrist KJ, Romo D, Upham BL, Armstrong M, Quinn K, Vanderlinden L, Osgood RS, Velmurugan K, Elie M, Manke J, Reinhold D, Reisdorph N, Saba L, Bauer AK. Early Mechanistic Events Induced by Low Molecular Weight Polycyclic Aromatic Hydrocarbons in Mouse Lung Epithelial Cells: A Role for Eicosanoid Signaling. Toxicol Sci. 2019 05 01; 169(1):180-193.
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Montford JR, Lehman AMB, Bauer CD, Klawitter J, Klawitter J, Poczobutt JM, Scobey M, Weiser-Evans M, Nemenoff RA, Furgeson SB. Bone marrow-derived cPLA2a contributes to renal fibrosis progression. J Lipid Res. 2018 02; 59(2):380-390.
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Yun B, Lee H, Powell R, Reisdorph N, Ewing H, Gelb MH, Hsu KL, Cravatt BF, Leslie CC. Regulation of calcium release from the endoplasmic reticulum by the serine hydrolase ABHD2. Biochem Biophys Res Commun. 2017 09 02; 490(4):1226-1231.
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Yun B, Lee H, Ewing H, Gelb MH, Leslie CC. Off-target effect of the cPLA2a inhibitor pyrrophenone: Inhibition of calcium release from the endoplasmic reticulum. Biochem Biophys Res Commun. 2016 10 07; 479(1):61-6.
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Montford JR, Lehman AM, Scobey MS, Weiser-Evans MC, Nemenoff RA, Furgeson SB. Cytosolic phospholipase A2a increases proliferation and de-differentiation of human renal tubular epithelial cells. Prostaglandins Other Lipid Mediat. 2016 11; 126:1-8.
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