Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Last Name
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Lays Martin Sobral

TitleResearch Associate
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
Phone303/724-4299

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. McCann TS, Parrish JK, Hsieh J, Sechler M, Sobral LM, Self C, Jones KL, Goodspeed A, Costello JC, Jedlicka P. KDM5A and PHF2 positively control expression of pro-metastatic genes repressed by EWS/Fli1, and promote growth and metastatic properties in Ewing sarcoma. Oncotarget. 2020 Oct 27; 11(43):3818-3831. PMID: 33196691.
      View in: PubMed
    2. Sobral LM, Hicks HM, Parrish JK, McCann TS, Hsieh J, Goodspeed A, Costello JC, Black JC, Jedlicka P. KDM3A/Ets1 epigenetic axis contributes to PAX3/FOXO1-driven and independent disease-promoting gene expression in fusion-positive Rhabdomyosarcoma. Mol Oncol. 2020 10; 14(10):2471-2486. PMID: 32697014.
      View in: PubMed
    3. Thom? CH, Ferreira GA, Pereira-Martins DA, Dos Santos GA, Ortiz CA, de Souza LEB, Sobral LM, Silva CLA, Scheucher PS, Gil CD, Leopoldino AM, Silveira DRA, Coelho-Silva JL, Traina F, Koury LC, Melo RAM, Bittencourt R, Pagnano K, Pasquini R, Nunes EC, Fagundes EM, Gloria ABF, Kerbauy FR, Chauffaille ML, Keating A, Tallman MS, Ribeiro RC, Dillon R, Ganser A, L?wenberg B, Valk P, Lo-Coco F, Sanz MA, Berliner N, Fa?a VM, Rego EM. NTAL is associated with treatment outcome, cell proliferation and differentiation in acute promyelocytic leukemia. Sci Rep. 2020 06 25; 10(1):10315. PMID: 32587277.
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    4. Goto RN, Sobral LM, Stringhetta-Padovani K, Garcia CB, da Silva G, Vitek MP, Leopoldino AM. Synergic effect of OP449 and FTY720 on oral squamous cell carcinoma. Eur J Pharmacol. 2020 Sep 05; 882:173268. PMID: 32569675.
      View in: PubMed
    5. Sousa LO, Sobral LM, de Almeida LO, Garcia CB, Greene LJ, Leopoldino AM. SET protein modulates H4 histone methylation status and regulates miR-137 level in oral squamous cell carcinoma. Epigenomics. 2020 03; 12(6):475-485. PMID: 32267167.
      View in: PubMed
    6. Sobral LM, Sechler M, Parrish JK, McCann TS, Jones KL, Black JC, Jedlicka P. KDM3A/Ets1/MCAM axis promotes growth and metastatic properties in Rhabdomyosarcoma. Genes Cancer. 2020; 11(1-2):53-65. PMID: 32577157.
      View in: PubMed
    7. McCann TS, Sobral LM, Self C, Hsieh J, Sechler M, Jedlicka P. Biology and targeting of the Jumonji-domain histone demethylase family in childhood neoplasia: a preclinical overview. Expert Opin Ther Targets. 2019 04; 23(4):267-280. PMID: 30759030.
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    8. Parrish JK, McCann TS, Sechler M, Sobral LM, Ren W, Jones KL, Tan AC, Jedlicka P. The Jumonji-domain histone demethylase inhibitor JIB-04 deregulates oncogenic programs and increases DNA damage in Ewing Sarcoma, resulting in impaired cell proliferation and survival, and reduced tumor growth. Oncotarget. 2018 Sep 04; 9(69):33110-33123. PMID: 30237855.
      View in: PubMed
    9. Goto RN, Sobral LM, Sousa LO, Garcia CB, Lopes NP, Mar?n-Prida J, Ochoa-Rodr?guez E, Verdecia-Reyes Y, Pardo-Andreu GL, Curti C, Leopoldino AM. Anti-cancer activity of a new dihydropyridine derivative, VdiE-2N, in head and neck squamous cell carcinoma. Eur J Pharmacol. 2018 Jan 15; 819:198-206. PMID: 29221949.
      View in: PubMed
    10. Souza LEB, Beckenkamp LR, Sobral LM, Fantacini DMC, Melo FUF, Borges JS, Leopoldino AM, Kashima S, Covas DT. Pre-culture in endothelial growth medium enhances the angiogenic properties of adipose-derived stem/stromal cells. Angiogenesis. 2018 02; 21(1):15-22. PMID: 28988272.
      View in: PubMed
    11. Sobral LM, Coletta RD, Alberici LC, Curti C, Leopoldino AM. SET/I2PP2A overexpression induces phenotypic, molecular, and metabolic alterations in an oral keratinocyte cell line. FEBS J. 2017 09; 284(17):2774-2785. PMID: 28636114.
      View in: PubMed
    12. da Silva JM, Moreira Dos Santos TP, Sobral LM, Queiroz-Junior CM, Rachid MA, Proudfoot AEI, Garlet GP, Batista AC, Teixeira MM, Leopoldino AM, Russo RC, Silva TA. Relevance of CCL3/CCR5 axis in oral carcinogenesis. Oncotarget. 2017 Aug 01; 8(31):51024-51036. PMID: 28881626.
      View in: PubMed
    13. Cardin LT, Sonehara NM, Mimura KK, Ramos Dinarte Dos Santos A, da Silva WA, Sobral LM, Leopoldino AM, da Cunha BR, Tajara EH, Oliani SM, Rodrigues-Lisoni FC. ANXA1Ac2-26 peptide, a possible therapeutic approach in inflammatory ocular diseases. Gene. 2017 May 30; 614:26-36. PMID: 28257834.
      View in: PubMed
    14. Sousa LO, Sobral LM, Matsumoto CS, Saggioro FP, L?pez RV, Panepucci RA, Curti C, Silva WA, Greene LJ, Leopoldino AM. Lymph node or perineural invasion is associated with low miR-15a, miR-34c and miR-199b levels in head and neck squamous cell carcinoma. BBA Clin. 2016 Dec; 6:159-164. PMID: 27896137.
      View in: PubMed
    15. Huber LA, Pereira TA, Ramos DN, Rezende LC, Emery FS, Sobral LM, Leopoldino AM, Lopez RF. Topical Skin Cancer Therapy Using Doxorubicin-Loaded Cationic Lipid Nanoparticles and lontophoresis. J Biomed Nanotechnol. 2015 Nov; 11(11):1975-88. PMID: 26554156.
      View in: PubMed
    16. Bufalino A, Cervigne NK, de Oliveira CE, Fonseca FP, Rodrigues PC, Macedo CC, Sobral LM, Miguel MC, Lopes MA, Paes Leme AF, Lambert DW, Salo TA, Kowalski LP, Graner E, Coletta RD. Low miR-143/miR-145 Cluster Levels Induce Activin A Overexpression in Oral Squamous Cell Carcinomas, Which Contributes to Poor Prognosis. PLoS One. 2015; 10(8):e0136599. PMID: 26317418.
      View in: PubMed
    17. Sobral LM, Sousa LO, Coletta RD, Cabral H, Greene LJ, Tajara EH, Gutkind JS, Curti C, Leopoldino AM. Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models. Mol Cancer. 2014 Feb 20; 13:32. PMID: 24555657.
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    18. Polachini GM, Sobral LM, Mercante AM, Paes-Leme AF, Xavier FC, Henrique T, Guimar?es DM, Vidotto A, Fukuyama EE, G?is-Filho JF, Cury PM, Curioni OA, Michaluart P, Silva AM, W?nsch-Filho V, Nunes FD, Leopoldino AM, Tajara EH. Proteomic approaches identify members of cofilin pathway involved in oral tumorigenesis. PLoS One. 2012; 7(12):e50517. PMID: 23227181.
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    19. Leopoldino AM, Squarize CH, Garcia CB, Almeida LO, Pestana CR, Sobral LM, Uyemura SA, Tajara EH, Silvio Gutkind J, Curti C. SET protein accumulates in HNSCC and contributes to cell survival: antioxidant defense, Akt phosphorylation and AVOs acidification. Oral Oncol. 2012 Nov; 48(11):1106-13. PMID: 22739068.
      View in: PubMed
    20. Sobral LM, Aseredo F, Agostini M, Bufalino A, Pereira MC, Graner E, Coletta RD. Molecular events associated with ciclosporin A-induced gingival overgrowth are attenuated by Smad7 overexpression in fibroblasts. J Periodontal Res. 2012 Apr; 47(2):149-58. PMID: 21883230.
      View in: PubMed
    21. Sobral LM, Bufalino A, Lopes MA, Graner E, Salo T, Coletta RD. Myofibroblasts in the stroma of oral cancer promote tumorigenesis via secretion of activin A. Oral Oncol. 2011 Sep; 47(9):840-6. PMID: 21727023.
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    22. Sobral LM, Zecchin KG, Nascimento de Aquino S, Lopes MA, Graner E, Coletta RD. Isolation and characterization of myofibroblast cell lines from oral squamous cell carcinoma. Oncol Rep. 2011 Apr; 25(4):1013-20. PMID: 21271223.
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    23. Sobral LM, Montan PF, Zecchin KG, Martelli-Junior H, Vargas PA, Graner E, Coletta RD. Smad7 blocks transforming growth factor-?1-induced gingival fibroblast-myofibroblast transition via inhibitory regulation of Smad2 and connective tissue growth factor. J Periodontol. 2011 Apr; 82(4):642-51. PMID: 21054221.
      View in: PubMed
    24. Sobral LM, Kellermann MG, Graner E, Martelli-Junior H, Coletta RD. Cyclosporin A-induced gingival overgrowth is not associated with myofibroblast transdifferentiation. Braz Oral Res. 2010 Apr-Jun; 24(2):182-8. PMID: 20658037.
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    25. Fregnani ER, Sobral LM, Alves FA, Soares FA, Kowalski LP, Coletta RD. Presence of myofibroblasts and expression of matrix metalloproteinase-2 (MMP-2) in ameloblastomas correlate with rupture of the osseous cortical. Pathol Oncol Res. 2009 Jun; 15(2):231-40. PMID: 19096916.
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    26. Kellermann MG, Sobral LM, da Silva SD, Zecchin KG, Graner E, Lopes MA, Nishimoto I, Kowalski LP, Coletta RD. Myofibroblasts in the stroma of oral squamous cell carcinoma are associated with poor prognosis. Histopathology. 2007 Dec; 51(6):849-53. PMID: 18042073.
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    27. Kellermann MG, Sobral LM, da Silva SD, Zecchin KG, Graner E, Lopes MA, Kowalski LP, Coletta RD. Mutual paracrine effects of oral squamous cell carcinoma cells and normal oral fibroblasts: induction of fibroblast to myofibroblast transdifferentiation and modulation of tumor cell proliferation. Oral Oncol. 2008 May; 44(5):509-17. PMID: 17826300.
      View in: PubMed
    28. Sobral LM, Montan PF, Martelli-Junior H, Graner E, Coletta RD. Opposite effects of TGF-beta1 and IFN-gamma on transdifferentiation of myofibroblast in human gingival cell cultures. J Clin Periodontol. 2007 May; 34(5):397-406. PMID: 17403017.
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    29. Bitu CC, Sobral LM, Kellermann MG, Martelli-Junior H, Zecchin KG, Graner E, Coletta RD. Heterogeneous presence of myofibroblasts in hereditary gingival fibromatosis. J Clin Periodontol. 2006 Jun; 33(6):393-400. PMID: 16677327.
      View in: PubMed
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