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Chad G. Pearson

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Cell and Devopmental Bio
Phone303/724-5742

    Collapse Research 
    Collapse research activities and funding
    R35GM140813     (PEARSON, CHAD G)Jun 1, 2021 - Mar 31, 2026
    NIH
    Centriole assembly and function for centrosome and cilia biology
    Role: Principal Investigator
    R01GM138415     (PEARSON, CHAD G)Aug 14, 2020 - Jul 31, 2024
    NIH
    Centrosome regulation of trafficking, ciliogenesis and cilia-dependent signaling
    Role: Principal Investigator
    R01GM099820     (PEARSON, CHAD G)Sep 24, 2012 - Jul 31, 2021
    NIH
    Mechanisms of basal body assembly, stability and positioning
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Leggere JC, Hibbard JVK, Papoulas O, Lee C, Pearson CG, Marcotte EM, Wallingford JB. Label-free proteomic comparison reveals ciliary and nonciliary phenotypes of IFT-A mutants. Mol Biol Cell. 2024 Mar 01; 35(3):ar39. PMID: 38170584.
      View in: PubMed
    2. Ruehle MD, Li S, Agard DA, Pearson CG. Poc1 is a basal body inner junction protein that promotes triplet microtubule integrity and interconnections. bioRxiv. 2023 Nov 28. PMID: 38014135.
      View in: PubMed
    3. Leggere JC, Hibbard JVK, Papoulas O, Lee C, Pearson CG, Marcotte EM, Wallingford JB. Label-free proteomic comparison reveals ciliary and non-ciliary phenotypes of IFT-A mutants. bioRxiv. 2023 Mar 09. PMID: 36945534.
      View in: PubMed
    4. Jewett CE, McCurdy BL, O'Toole ET, Stemm-Wolf AJ, Given KS, Lin CH, Olsen V, Martin W, Reinholdt L, Espinosa JM, Sullivan KD, Macklin WB, Prekeris R, Pearson CG. Trisomy 21 induces pericentrosomal crowding delaying primary ciliogenesis and mouse cerebellar development. Elife. 2023 01 19; 12. PMID: 36656118.
      View in: PubMed
    5. Sun H, Soh AWJ, Mitchell LE, Pearson CG, Murphy RF. Basal body organization and cell geometry during the cell cycle in Tetrahymena thermophila. Mol Biol Cell. 2023 05 15; 34(6):ar53. PMID: 36630324.
      View in: PubMed
    6. Junker AD, Woodhams LG, Soh AWJ, O'Toole ET, Bayly PV, Pearson CG. Basal bodies bend in response to ciliary forces. Mol Biol Cell. 2022 12 01; 33(14):ar146. PMID: 36287828.
      View in: PubMed
    7. Soh AWJ, Woodhams LG, Junker AD, Enloe CM, Noren BE, Harned A, Westlake CJ, Narayan K, Oakey JS, Bayly PV, Pearson CG. Intracellular connections between basal bodies promote the coordinated behavior of motile cilia. Mol Biol Cell. 2022 09 15; 33(11):br18. PMID: 35767367.
      View in: PubMed
    8. McCurdy BL, Jewett CE, Stemm-Wolf AJ, Duc HN, Joshi M, Espinosa JM, Prekeris R, Pearson CG. Trisomy 21 increases microtubules and disrupts centriolar satellite localization. Mol Biol Cell. 2022 07 01; 33(8). PMID: 35476505.
      View in: PubMed
    9. Soh AWJ, Pearson CG. Ciliate cortical organization and dynamics for cell motility: Comparing ciliates and vertebrates. J Eukaryot Microbiol. 2022 09; 69(5):e12880. PMID: 34897878.
      View in: PubMed
    10. Stemm-Wolf AJ, O'Toole ET, Sheridan RM, Morgan JT, Pearson CG. The SON RNA splicing factor is required for intracellular trafficking structures that promote centriole assembly and ciliogenesis. Mol Biol Cell. 2021 10 01; 32(20):ar4. PMID: 34406792.
      View in: PubMed
    11. Junker AD, Jacob S, Philippe H, Legrand D, Pearson CG. Plastic cell morphology changes during dispersal. iScience. 2021 Aug 20; 24(8):102915. PMID: 34430806.
      View in: PubMed
    12. Jewett CE, Pearson CG. Cancer biology: Messages in extracellular vesicles depend on centrosome number. Curr Biol. 2021 04 12; 31(7):R337-R340. PMID: 33848487.
      View in: PubMed
    13. Jewett CE, Soh AWJ, Lin CH, Lu Q, Lencer E, Westlake CJ, Pearson CG, Prekeris R. RAB19 Directs Cortical Remodeling and Membrane Growth for Primary Ciliogenesis. Dev Cell. 2021 02 08; 56(3):325-340.e8. PMID: 33561422.
      View in: PubMed
    14. Ruehle MD, Stemm-Wolf AJ, Pearson CG. Sas4 links basal bodies to cell division via Hippo signaling. J Cell Biol. 2020 08 03; 219(8). PMID: 32435796.
      View in: PubMed
    15. Sankaran DG, Stemm-Wolf AJ, McCurdy BL, Hariharan B, Pearson CG. A semi-automated machine learning-aided approach to quantitative analysis of centrosomes and microtubule organization. J Cell Sci. 2020 07 30; 133(14). PMID: 32591487.
      View in: PubMed
    16. Soh AWJ, van Dam TJP, Stemm-Wolf AJ, Pham AT, Morgan GP, O'Toole ET, Pearson CG. Ciliary force-responsive striated fibers promote basal body connections and cortical interactions. J Cell Biol. 2020 01 06; 219(1). PMID: 31740506.
      View in: PubMed
    17. Junker AD, Soh AWJ, O'Toole ET, Meehl JB, Guha M, Winey M, Honts JE, Gaertig J, Pearson CG. Microtubule glycylation promotes attachment of basal bodies to the cell cortex. J Cell Sci. 2019 08 07; 132(15). PMID: 31243050.
      View in: PubMed
    18. Ganapathi Sankaran D, Stemm-Wolf AJ, Pearson CG. CEP135 isoform dysregulation promotes centrosome amplification in breast cancer cells. Mol Biol Cell. 2019 05 01; 30(10):1230-1244. PMID: 30811267.
      View in: PubMed
    19. Han KJ, Wu Z, Pearson CG, Peng J, Song K, Liu CW. Deubiquitylase USP9X maintains centriolar satellite integrity by stabilizing pericentriolar material 1 protein. J Cell Sci. 2019 01 22; 132(2). PMID: 30584065.
      View in: PubMed
    20. Louka P, Vasudevan KK, Guha M, Joachimiak E, Wloga D, Tomasi RF, Baroud CN, Dupuis-Williams P, Galati DF, Pearson CG, Rice LM, Moresco JJ, Yates JR, Jiang YY, Lechtreck K, Dentler W, Gaertig J. Proteins that control the geometry of microtubules at the ends of cilia. J Cell Biol. 2018 12 03; 217(12):4298-4313. PMID: 30217954.
      View in: PubMed
    21. Galati DF, Sullivan KD, Pham AT, Espinosa JM, Pearson CG. Trisomy 21 Represses Cilia Formation and Function. Dev Cell. 2018 09 10; 46(5):641-650.e6. PMID: 30100262.
      View in: PubMed
    22. Baschal EE, Terhune EA, Wethey CI, Baschal RM, Robinson KD, Cuevas MT, Pradhan S, Sutphin BS, Taylor MRG, Gowan K, Pearson CG, Niswander LA, Jones KL, Miller NH. Idiopathic Scoliosis Families Highlight Actin-Based and Microtubule-Based Cellular Projections and Extracellular Matrix in Disease Etiology. G3 (Bethesda). 2018 07 31; 8(8):2663-2672. PMID: 29930198.
      View in: PubMed
    23. Kendrick AA, Schafer J, Dzieciatkowska M, Nemkov T, D'Alessandro A, Neelakantan D, Ford HL, Pearson CG, Weekes CD, Hansen KC, Eisenmesser EZ. CD147: a small molecule transporter ancillary protein at the crossroad of multiple hallmarks of cancer and metabolic reprogramming. Oncotarget. 2017 Jan 24; 8(4):6742-6762. PMID: 28039486.
      View in: PubMed
    24. Galati DF, Mitchell BJ, Pearson CG. Subdistal Appendages Stabilize the Ups and Downs of Ciliary Life. Dev Cell. 2016 11 21; 39(4):387-389. PMID: 27875681.
      View in: PubMed
    25. Bayless BA, Galati DF, Junker AD, Backer CB, Gaertig J, Pearson CG. Asymmetrically localized proteins stabilize basal bodies against ciliary beating forces. J Cell Biol. 2016 Nov 21; 215(4):457-466. PMID: 27807131.
      View in: PubMed
    26. Wall KP, Pagratis M, Armstrong G, Balsbaugh JL, Verbeke E, Pearson CG, Hough LE. Molecular Determinants of Tubulin's C-Terminal Tail Conformational Ensemble. ACS Chem Biol. 2016 11 18; 11(11):2981-2990. PMID: 27541566.
      View in: PubMed
    27. Ruehle MD, Orias E, Pearson CG. Tetrahymena as a Unicellular Model Eukaryote: Genetic and Genomic Tools. Genetics. 2016 06; 203(2):649-65. PMID: 27270699.
      View in: PubMed
    28. Meehl JB, Bayless BA, Giddings TH, Pearson CG, Winey M. Tetrahymena Poc1 ensures proper intertriplet microtubule linkages to maintain basal body integrity. Mol Biol Cell. 2016 08 01; 27(15):2394-403. PMID: 27251062.
      View in: PubMed
    29. Hudish LI, Galati DF, Ravanelli AM, Pearson CG, Huang P, Appel B. miR-219 regulates neural progenitors by dampening apical Par protein-dependent Hedgehog signaling. Development. 2016 07 01; 143(13):2292-304. PMID: 27226318.
      View in: PubMed
    30. Garcia G, Finnigan GC, Heasley LR, Sterling SM, Aggarwal A, Pearson CG, Nogales E, McMurray MA, Thorner J. Assembly, molecular organization, and membrane-binding properties of development-specific septins. J Cell Biol. 2016 Feb 29; 212(5):515-29. PMID: 26929450.
      View in: PubMed
    31. Bayless BA, Galati DF, Pearson CG. Tetrahymena basal bodies. Cilia. 2015; 5:1. PMID: 26793300.
      View in: PubMed
    32. Galati DF, Abuin DS, Tauber GA, Pham AT, Pearson CG. Automated image analysis reveals the dynamic 3-dimensional organization of multi-ciliary arrays. Biol Open. 2015 Dec 23; 5(1):20-31. PMID: 26700722.
      View in: PubMed
    33. Dahl KD, Sankaran DG, Bayless BA, Pinter ME, Galati DF, Heasley LR, Giddings TH, Pearson CG. A Short CEP135 Splice Isoform Controls Centriole Duplication. Curr Biol. 2015 Oct 05; 25(19):2591-6. PMID: 26412126.
      View in: PubMed
    34. Galati DF, Bonney S, Kronenberg Z, Clarissa C, Yandell M, Elde NC, Jerka-Dziadosz M, Giddings TH, Frankel J, Pearson CG. DisAp-dependent striated fiber elongation is required to organize ciliary arrays. J Cell Biol. 2014 Dec 22; 207(6):705-15. PMID: 25533842.
      View in: PubMed
    35. Pearson CG. Choosing sides--asymmetric centriole and basal body assembly. J Cell Sci. 2014 Jul 01; 127(Pt 13):2803-10. PMID: 24895399.
      View in: PubMed
    36. Redzic JS, Kendrick AA, Bahmed K, Dahl KD, Pearson CG, Robinson WA, Robinson SE, Graner MW, Eisenmesser EZ. Extracellular vesicles secreted from cancer cell lines stimulate secretion of MMP-9, IL-6, TGF-?1 and EMMPRIN. PLoS One. 2013; 8(8):e71225. PMID: 23936495.
      View in: PubMed
    37. Bayless BA, Giddings TH, Winey M, Pearson CG. Bld10/Cep135 stabilizes basal bodies to resist cilia-generated forces. Mol Biol Cell. 2012 Dec; 23(24):4820-32. PMID: 23115304.
      View in: PubMed
    38. Backer CB, Gutzman JH, Pearson CG, Cheeseman IM. CSAP localizes to polyglutamylated microtubules and promotes proper cilia function and zebrafish development. Mol Biol Cell. 2012 Jun; 23(11):2122-30. PMID: 22493317.
      View in: PubMed
    39. Winey M, Stemm-Wolf AJ, Giddings TH, Pearson CG. Cytological analysis of Tetrahymena thermophila. Methods Cell Biol. 2012; 109:357-78. PMID: 22444152.
      View in: PubMed
    40. Coyne RS, Hannick L, Shanmugam D, Hostetler JB, Brami D, Joardar VS, Johnson J, Radune D, Singh I, Badger JH, Kumar U, Saier M, Wang Y, Cai H, Gu J, Mather MW, Vaidya AB, Wilkes DE, Rajagopalan V, Asai DJ, Pearson CG, Findly RC, Dickerson HW, Wu M, Martens C, Van de Peer Y, Roos DS, Cassidy-Hanley DM, Clark TG. Comparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free-living relatives and a host species provide insights into adoption of a parasitic lifestyle and prospects for disease control. Genome Biol. 2011 Oct 17; 12(10):R100. PMID: 22004680.
      View in: PubMed
    41. Pearson CG. A kinesin in command of primary ciliogenesis. Cell. 2011 Jun 10; 145(6):817-9. PMID: 21663786.
      View in: PubMed
    42. Pearson CG, Winey M. Plk4/SAK/ZYG-1 in the regulation of centriole duplication. F1000 Biol Rep. 2010 Aug 09; 2:58. PMID: 21173875.
      View in: PubMed
    43. Gardner MK, Sprague BL, Pearson CG, Cosgrove BD, Bicek AD, Bloom K, Salmon ED, Odde DJ. Model Convolution: A Computational Approach to Digital Image Interpretation. Cell Mol Bioeng. 2010 Jun; 3(2):163-170. PMID: 20461132.
      View in: PubMed
    44. Giddings TH, Meehl JB, Pearson CG, Winey M. Electron tomography and immuno-labeling of Tetrahymena thermophila basal bodies. Methods Cell Biol. 2010; 96:117-41. PMID: 20869521.
      View in: PubMed
    45. Pearson CG, Osborn DP, Giddings TH, Beales PL, Winey M. Basal body stability and ciliogenesis requires the conserved component Poc1. J Cell Biol. 2009 Dec 14; 187(6):905-20. PMID: 20008567.
      View in: PubMed
    46. Pearson CG, Winey M. Basal body assembly in ciliates: the power of numbers. Traffic. 2009 May; 10(5):461-71. PMID: 19192246.
      View in: PubMed
    47. Pearson CG, Giddings TH, Winey M. Basal body components exhibit differential protein dynamics during nascent basal body assembly. Mol Biol Cell. 2009 Feb; 20(3):904-14. PMID: 19056680.
      View in: PubMed
    48. Kilburn CL, Pearson CG, Romijn EP, Meehl JB, Giddings TH, Culver BP, Yates JR, Winey M. New Tetrahymena basal body protein components identify basal body domain structure. J Cell Biol. 2007 Sep 10; 178(6):905-12. PMID: 17785518.
      View in: PubMed
    49. Pearson CG, Culver BP, Winey M. Centrioles want to move out and make cilia. Dev Cell. 2007 Sep; 13(3):319-21. PMID: 17765674.
      View in: PubMed
    50. Beales PL, Bland E, Tobin JL, Bacchelli C, Tuysuz B, Hill J, Rix S, Pearson CG, Kai M, Hartley J, Johnson C, Irving M, Elcioglu N, Winey M, Tada M, Scambler PJ. IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy. Nat Genet. 2007 Jun; 39(6):727-9. PMID: 17468754.
      View in: PubMed
    51. Pearson CG, Gardner MK, Paliulis LV, Salmon ED, Odde DJ, Bloom K. Measuring nanometer scale gradients in spindle microtubule dynamics using model convolution microscopy. Mol Biol Cell. 2006 Sep; 17(9):4069-79. PMID: 16807354.
      View in: PubMed
    52. Gardner MK, Pearson CG, Sprague BL, Zarzar TR, Bloom K, Salmon ED, Odde DJ. Tension-dependent regulation of microtubule dynamics at kinetochores can explain metaphase congression in yeast. Mol Biol Cell. 2005 Aug; 16(8):3764-75. PMID: 15930123.
      View in: PubMed
    53. De Antoni A, Pearson CG, Cimini D, Canman JC, Sala V, Nezi L, Mapelli M, Sironi L, Faretta M, Salmon ED, Musacchio A. The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint. Curr Biol. 2005 Feb 08; 15(3):214-25. PMID: 15694304.
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    54. Jones MH, Huneycutt BJ, Pearson CG, Zhang C, Morgan G, Shokat K, Bloom K, Winey M. Chemical genetics reveals a role for Mps1 kinase in kinetochore attachment during mitosis. Curr Biol. 2005 Jan 26; 15(2):160-5. PMID: 15668173.
      View in: PubMed
    55. Pearson CG, Yeh E, Gardner M, Odde D, Salmon ED, Bloom K. Stable kinetochore-microtubule attachment constrains centromere positioning in metaphase. Curr Biol. 2004 Nov 09; 14(21):1962-7. PMID: 15530400.
      View in: PubMed
    56. Pearson CG, Bloom K. Dynamic microtubules lead the way for spindle positioning. Nat Rev Mol Cell Biol. 2004 Jun; 5(6):481-92. PMID: 15173827.
      View in: PubMed
    57. Pearson CG, Maddox PS, Zarzar TR, Salmon ED, Bloom K. Yeast kinetochores do not stabilize Stu2p-dependent spindle microtubule dynamics. Mol Biol Cell. 2003 Oct; 14(10):4181-95. PMID: 14517328.
      View in: PubMed
    58. Sprague BL, Pearson CG, Maddox PS, Bloom KS, Salmon ED, Odde DJ. Mechanisms of microtubule-based kinetochore positioning in the yeast metaphase spindle. Biophys J. 2003 Jun; 84(6):3529-46. PMID: 12770865.
      View in: PubMed
    59. Yoder TJ, Pearson CG, Bloom K, Davis TN. The Saccharomyces cerevisiae spindle pole body is a dynamic structure. Mol Biol Cell. 2003 Aug; 14(8):3494-505. PMID: 12925780.
      View in: PubMed
    60. Kosco KA, Pearson CG, Maddox PS, Wang PJ, Adams IR, Salmon ED, Bloom K, Huffaker TC. Control of microtubule dynamics by Stu2p is essential for spindle orientation and metaphase chromosome alignment in yeast. Mol Biol Cell. 2001 Sep; 12(9):2870-80. PMID: 11553724.
      View in: PubMed
    61. Hoffman DB, Pearson CG, Yen TJ, Howell BJ, Salmon ED. Microtubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochores. Mol Biol Cell. 2001 Jul; 12(7):1995-2009. PMID: 11451998.
      View in: PubMed
    62. Pearson CG, Maddox PS, Salmon ED, Bloom K. Budding yeast chromosome structure and dynamics during mitosis. J Cell Biol. 2001 Mar 19; 152(6):1255-66. PMID: 11257125.
      View in: PubMed
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