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Wayne Oliver Hemphill

TitleResearch Associate
InstitutionUniversity of Colorado Boulder
DepartmentBiochemistry

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    F32GM147934     (HEMPHILL, WAYNE OLIVER)Sep 1, 2022 - Aug 31, 2025
    NIH
    Biophysical interrogation of the RNA-mediated mechanisms regulating Polycomb Repressive Complex 2 activity
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Song J, Yao L, Gooding AR, Thron V, Hemphill WO, Goodrich KJ, Erbse AH, Kasinath V, Cech TR. RNA-induced PRC2 inhibition depends on the sequence of bound RNA. Nat Commun. 2026 Apr 23; 17(1). PMID: 42020439.
      View in: PubMed
    2. Song J, Yao L, Gooding AR, Thron V, Hemphill WO, Goodrich KJ, Kasinath V, Cech TR. RNA-induced PRC2 inhibition depends on the sequence of bound RNA. Res Sq. 2025 Nov 20. PMID: 41333429.
      View in: PubMed
    3. Song J, Yao L, Gooding AR, Thron V, Hemphill WO, Goodrich K, Kasinath V, Cech TR. RNA-induced PRC2 inhibition depends on the sequence of bound RNA. bioRxiv. 2025 Sep 15. PMID: 39257770.
      View in: PubMed
    4. Hemphill WO, Steiner HR, Kominsky JR, Wuttke DS, Cech TR. Transcription factors ERa and Sox2 have differing multiphasic DNA- and RNA-binding mechanisms. RNA. 2024 07 16; 30(8):1089-1105. PMID: 38760076.
      View in: PubMed
    5. Hemphill WO, Steiner HR, Kominsky JR, Wuttke DS, Cech TR. Transcription factors ERa and Sox2 have differing multiphasic DNA and RNA binding mechanisms. bioRxiv. 2024 Mar 19. PMID: 38562825.
      View in: PubMed
    6. Song J, Gooding AR, Hemphill WO, Love BD, Robertson A, Yao L, Zon LI, North TE, Kasinath V, Cech TR. Structural basis for inactivation of PRC2 by G-quadruplex RNA. Science. 2023 09 22; 381(6664):1331-1337. PMID: 37733873.
      View in: PubMed
    7. Hemphill WO, Voong CK, Fenske R, Goodrich JA, Cech TR. Multiple RNA- and DNA-binding proteins exhibit direct transfer of polynucleotides with implications for target-site search. Proc Natl Acad Sci U S A. 2023 06 27; 120(26):e2220537120. PMID: 37339225.
      View in: PubMed
    8. Hemphill WO, Fenske R, Gooding AR, Cech TR. PRC2 direct transfer from G-quadruplex RNA to dsDNA has implications for RNA-binding chromatin modifiers. Proc Natl Acad Sci U S A. 2023 06 06; 120(23):e2220528120. PMID: 37252986.
      View in: PubMed
    9. Song J, Gooding AR, Hemphill WO, Kasinath V, Cech TR. Structural basis for inactivation of PRC2 by G-quadruplex RNA. bioRxiv. 2023 Feb 06. PMID: 36798278.
      View in: PubMed
    10. Amico G, Hemphill WO, Severino M, Moratti C, Pascarella R, Bertamino M, Napoli F, Volpi S, Rosamilia F, Signa S, Perrino F, Zedde M, Ceccherini I. Genotype-Phenotype Correlation and Functional Insights for Two Monoallelic TREX1 Missense Variants Affecting the Catalytic Core. Genes (Basel). 2022 06 30; 13(7). PMID: 35885962.
      View in: PubMed
    11. Batalis S, Rogers LC, Hemphill WO, Mauney CH, Ornelles DA, Hollis T. SAMHD1 Phosphorylation at T592 Regulates Cellular Localization and S-phase Progression. Front Mol Biosci. 2021; 8:724870. PMID: 34513928.
      View in: PubMed
    12. Hemphill WO, Simpson SR, Liu M, Salsbury FR, Hollis T, Grayson JM, Perrino FW. TREX1 as a Novel Immunotherapeutic Target. Front Immunol. 2021; 12:660184. PMID: 33868310.
      View in: PubMed
    13. Simpson SR, Hemphill WO, Hudson T, Perrino FW. TREX1 - Apex predator of cytosolic DNA metabolism. DNA Repair (Amst). 2020 10; 94:102894. PMID: 32615442.
      View in: PubMed
    14. Simpson SR, Rego SL, Harvey SE, Liu M, Hemphill WO, Venkatadri R, Sharma R, Grayson JM, Perrino FW. T Cells Produce IFN-a in the TREX1 D18N Model of Lupus-like Autoimmunity. J Immunol. 2020 01 15; 204(2):348-359. PMID: 31826941.
      View in: PubMed
    15. Hemphill WO, Perrino FW. Measuring TREX1 and TREX2 exonuclease activities. Methods Enzymol. 2019; 625:109-133. PMID: 31455522.
      View in: PubMed
    16. Rego SL, Harvey S, Simpson SR, Hemphill WO, McIver ZA, Grayson JM, Perrino FW. TREX1 D18N mice fail to process erythroblast DNA resulting in inflammation and dysfunctional erythropoiesis. Autoimmunity. 2018 Nov; 51(7):333-344. PMID: 30422000.
      View in: PubMed
    17. Patel D, Xu C, Nagarajan S, Liu Z, Hemphill WO, Shi R, Uversky VN, Caldwell GA, Caldwell KA, Witt SN. Alpha-synuclein inhibits Snx3-retromer-mediated retrograde recycling of iron transporters in S. cerevisiae and C. elegans models of Parkinson's disease. Hum Mol Genet. 2018 05 01; 27(9):1514-1532. PMID: 29452354.
      View in: PubMed
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