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Jeffrey Kyle Moore

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Cell and Devopmental Bio
Phone303/724-6198

    Collapse Research 
    Collapse research activities and funding
    R03NS135453     (MOORE, JEFFREY KYLE)Sep 15, 2023 - Aug 31, 2025
    NIH
    Tools for mapping the tubulin landscape
    Role: Principal Investigator
    T32GM141742     (MOORE, JEFFREY KYLE)Jul 1, 2021 - Jun 30, 2026
    NIH
    Predoctoral Training in the Genetics of Development, Disease and Regeneration
    Role: Principal Investigator
    R35GM136253     (MOORE, JEFFREY KYLE)May 15, 2020 - Apr 30, 2025
    NIH
    Beyond the tubulin code: Understanding how subunit diversity regulates the formation and function of microtubules
    Role: Principal Investigator
    R01GM112893     (MOORE, JEFFREY KYLE)Aug 1, 2015 - Jan 31, 2021
    NIH
    Regulation of Microtubule Function by Tubulin Carboxy-terminal Tails
    Role: Principal Investigator
    R00GM092968     (MOORE, JEFFREY KYLE)Feb 1, 2011 - May 31, 2015
    NIH
    Role of tubulin CTTs in the activity of microtubule motors
    Role: Principal Investigator
    K99GM092968     (MOORE, JEFFREY KYLE)Feb 1, 2011 - Jan 31, 2012
    NIH
    ROLE OF THE TUBULIN E-HOOK IN THE ACTIVITY OF MICROTUBULE MOTORS
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Thomas EC, Moore JK. Selective regulation of kinesin-5 function by ?-tubulin carboxy-terminal tails. J Cell Biol. 2025 Mar 03; 224(3). PMID: 39688542.
      View in: PubMed
    2. Lo J, Vaeth KF, Bhardwaj G, Mukherjee N, Russ HA, Moore JK, Taliaferro JM. The RNA binding protein HNRNPA2B1 regulates RNA abundance and motor protein activity in neurites. bioRxiv. 2024 Aug 26. PMID: 39253515.
      View in: PubMed
    3. Wood LM, Moore JK. ?3 accelerates microtubule plus end maturation through a divergent lateral interface. bioRxiv. 2024 Jul 18. PMID: 39071388.
      View in: PubMed
    4. Ceglowski J, Hoffman HK, Neumann AJ, Hoff KJ, McCurdy BL, Moore JK, Prekeris R. TTLL12 is required for primary ciliary axoneme formation in polarized epithelial cells. EMBO Rep. 2024 Jan; 25(1):198-227. PMID: 38177908.
      View in: PubMed
    5. Wethekam LC, Moore JK. a-tubulin regulation by 5' introns in Saccharomyces cerevisiae. Genetics. 2023 12 06; 225(4). PMID: 37675603.
      View in: PubMed
    6. Ansari S, Gergely ZR, Flynn P, Li G, Moore JK, Betterton MD. Quantifying Yeast Microtubules and Spindles Using the Toolkit for Automated Microtubule Tracking (TAMiT). Biomolecules. 2023 06 04; 13(6). PMID: 37371519.
      View in: PubMed
    7. Wethekam LC, Moore JK. Tubulin isotype regulation maintains asymmetric requirement for a-tubulin over ?-tubulin. J Cell Biol. 2023 03 06; 222(3). PMID: 36719400.
      View in: PubMed
    8. Hoff KJ, Neumann AJ, Moore JK. The molecular biology of tubulinopathies: Understanding the impact of variants on tubulin structure and microtubule regulation. Front Cell Neurosci. 2022; 16:1023267. PMID: 36406756.
      View in: PubMed
    9. Wethekam LC, Moore JK. Microtubule cytoskeleton: Revealing new readers of?the tubulin code. Curr Biol. 2022 09 26; 32(18):R960-R962. PMID: 36167046.
      View in: PubMed
    10. Hoff KJ, Aiken JE, Gutierrez MA, Franco SJ, Moore JK. TUBA1A tubulinopathy mutants disrupt neuron morphogenesis and override XMAP215/Stu2 regulation of microtubule dynamics. Elife. 2022 05 05; 11. PMID: 35511030.
      View in: PubMed
    11. Park K, Hoff KJ, Wethekam L, Stence N, Saenz M, Moore JK. Kinetically Stabilizing Mutations in Beta Tubulins Create Isotype-Specific Brain Malformations. Front Cell Dev Biol. 2021; 9:765992. PMID: 34869359.
      View in: PubMed
    12. Moore JK, Wethekam L. Specialist a-tubulins for pluralist microtubules. J Cell Biol. 2021 12 06; 220(12). PMID: 34762120.
      View in: PubMed
    13. Thomas EC, Ismael A, Moore JK. Ase1 domains dynamically slow anaphase spindle elongation and recruit Bim1 to the midzone. Mol Biol Cell. 2020 11 15; 31(24):2733-2747. PMID: 32997572.
      View in: PubMed
    14. Buscaglia G, Northington KR, Moore JK, Bates EA. Reduced TUBA1A Tubulin Causes Defects in Trafficking and Impaired Adult Motor Behavior. eNeuro. 2020 Mar/Apr; 7(2). PMID: 32184299.
      View in: PubMed
    15. Li G, Moore JK. Microtubule dynamics at low temperature: evidence that tubulin recycling limits assembly. Mol Biol Cell. 2020 05 15; 31(11):1154-1166. PMID: 32213119.
      View in: PubMed
    16. Aiken J, Buscaglia G, Aiken AS, Moore JK, Bates EA. Tubulin mutations in brain development disorders: Why haploinsufficiency does not explain TUBA1A tubulinopathies. Cytoskeleton (Hoboken). 2020 03; 77(3-4):40-54. PMID: 31574570.
      View in: PubMed
    17. Estrem C, Moore JK. Astral microtubule forces alter nuclear organization and inhibit DNA repair in budding yeast. Mol Biol Cell. 2019 07 22; 30(16):2000-2013. PMID: 31067146.
      View in: PubMed
    18. Fees CP, Moore JK. A unified model for microtubule rescue. Mol Biol Cell. 2019 03 15; 30(6):753-765. PMID: 30672721.
      View in: PubMed
    19. Fees CP, Moore JK. Regulation of microtubule dynamic instability by the carboxy-terminal tail of ?-tubulin. Life Sci Alliance. 2018 May; 1(2). PMID: 29963657.
      View in: PubMed
    20. Aiken J, Buscaglia G, Bates EA, Moore JK. The a-Tubulin gene TUBA1A in Brain Development: A Key Ingredient in the Neuronal Isotype Blend. J Dev Biol. 2017 Sep; 5(3). PMID: 29057214.
      View in: PubMed
    21. Estrem C, Fees CP, Moore JK. Dynein is regulated by the stability of its microtubule track. J Cell Biol. 2017 07 03; 216(7):2047-2058. PMID: 28572117.
      View in: PubMed
    22. Fees CP, Estrem C, Moore JK. High-resolution Imaging and Analysis of Individual Astral Microtubule Dynamics in Budding Yeast. J Vis Exp. 2017 04 20; (122). PMID: 28448000.
      View in: PubMed
    23. Mangan AJ, Sietsema DV, Li D, Moore JK, Citi S, Prekeris R. Cingulin and actin mediate midbody-dependent apical lumen formation during polarization of epithelial cells. Nat Commun. 2016 08 03; 7:12426. PMID: 27484926.
      View in: PubMed
    24. Fees CP, Aiken J, O'Toole ET, Giddings TH, Moore JK. The negatively charged carboxy-terminal tail of ?-tubulin promotes proper chromosome segregation. Mol Biol Cell. 2016 06 01; 27(11):1786-96. PMID: 27053662.
      View in: PubMed
    25. Gartz Hanson M, Aiken J, Sietsema DV, Sept D, Bates EA, Niswander L, Moore JK. Novel a-tubulin mutation disrupts neural development and tubulin proteostasis. Dev Biol. 2016 Jan 15; 409(2):406-19. PMID: 26658218.
      View in: PubMed
    26. Aiken J, Sept D, Costanzo M, Boone C, Cooper JA, Moore JK. Genome-wide analysis reveals novel and discrete functions for tubulin carboxy-terminal tails. Curr Biol. 2014 Jun 16; 24(12):1295-1303. PMID: 24835459.
      View in: PubMed
    27. Moore JK. Stopped in its tracks: negative regulation of the dynein motor by the yeast protein She1. Bioessays. 2013 Aug; 35(8):677-82. PMID: 23666903.
      View in: PubMed
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