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Meredith D Betterton

TitleProfessor
InstitutionUniversity of Colorado Boulder
DepartmentBiology-MCD Instruction
Phone303/735-6135

    Collapse Research 
    Collapse research activities and funding
    R01GM124371     (BETTERTON, MEREDITH)Aug 1, 2018 - Jul 31, 2022
    NIH
    Mechanisms of Kinesin-5 Motors in Mitotic Spindle Assembly
    Role: Principal Investigator
    K25GM110486     (BETTERTON, MEREDITH)Jun 1, 2014 - Dec 31, 2018
    NIH
    Assessing the Contributions of Microtubule Dynamic Instability and Microtubule Ro
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Allgood SC, Su C-C, Crooks AL, Meyer CT, Zhou B, Betterton MD, Barbachyn MR, Yu EW, Detweiler CS. Bacterial efflux pump modulators prevent bacterial growth in macrophages and under broth conditions that mimic the host environment. mBio. 2023 Dec 19; 14(6):e0249223. PMID: 37921493.
      View in: PubMed
    2. Allgood SC, Su CC, Crooks AL, Meyer CT, Zhou B, Betterton MD, Barbachyn MR, Yu EW, Detweiler CS. Bacterial Efflux Pump Modulators Prevent Bacterial Growth in Macrophages and Under Broth Conditions that Mimic the Host Environment. bioRxiv. 2023 Sep 20. PMID: 37786697.
      View in: PubMed
    3. Gergely ZR, Jones MH, Zhou B, Cash C, McIntosh JR, Betterton MD. Distinct regions of the kinesin-5 C-terminal tail are essential for mitotic spindle midzone localization and sliding force. Proc Natl Acad Sci U S A. 2023 09 26; 120(39):e2306480120. PMID: 37725645.
      View in: PubMed
    4. Gergely Z, Jones MH, Zhou B, Cash C, McIntosh R, Betterton M. Distinct regions of the kinesin-5 C-terminal tail are essential for mitotic spindle midzone localization and sliding force. bioRxiv. 2023 Jun 27. PMID: 37205432.
      View in: PubMed
    5. Ansari S, Gergely ZR, Flynn P, Li G, Moore JK, Betterton MD. Quantifying Yeast Microtubules and Spindles Using the Toolkit for Automated Microtubule Tracking (TAMiT). Biomolecules. 2023 06 04; 13(6). PMID: 37371519.
      View in: PubMed
    6. Avinery R, Aina KO, Dyson CJ, Kuan HS, Betterton MD, Goodisman MAD, Goldman DI. Agitated ants: regulation and self-organization of incipient nest excavation via collisional cues. J R Soc Interface. 2023 05; 20(202):20220597. PMID: 37194494.
      View in: PubMed
    7. Gergely ZR, Ansari S, Jones MH, Zhou B, Cash C, McIntosh R, Betterton MD. The kinesin-5 protein Cut7 moves bidirectionally on fission yeast spindles with activity that increases in anaphase. J Cell Sci. 2023 03 01; 136(5). PMID: 36655493.
      View in: PubMed
    8. Ansari S, Gergely ZR, Flynn P, Li G, Moore JK, Betterton MD. Quantifying yeast microtubules and spindles using the Toolkit for Automated Microtubule Tracking (TAMiT). bioRxiv. 2023 Feb 08. PMID: 36798368.
      View in: PubMed
    9. Wijeratne SS, Fiorenza SA, Neary AE, Subramanian R, Betterton MD. Motor guidance by long-range communication on the microtubule highway. Proc Natl Acad Sci U S A. 2022 07 12; 119(28):e2120193119. PMID: 35867749.
      View in: PubMed
    10. Ansari S, Yan W, Lamson A, Shelley MJ, Glaser MA, Betterton MD. Active condensation of filaments under spatial confinement. Front Phys. 2022; 10. PMID: 38116396.
      View in: PubMed
    11. Yan W, Ansari S, Lamson A, Glaser MA, Blackwell R, Betterton MD, Shelley M. Toward the cellular-scale simulation of motor-driven cytoskeletal assemblies. Elife. 2022 05 26; 11. PMID: 35617115.
      View in: PubMed
    12. Betterton MD. A new view of how cytoplasmic viscosity affects microtubule dynamics. Dev Cell. 2022 02 28; 57(4):419-420. PMID: 35231424.
      View in: PubMed
    13. Fiorenza SA, Steckhahn DG, Betterton MD. Modeling spatiotemporally varying protein-protein interactions in CyLaKS, the Cytoskeleton Lattice-based Kinetic Simulator. Eur Phys J E Soft Matter. 2021 Aug 18; 44(8):105. PMID: 34406510.
      View in: PubMed
    14. Moore JM, Glaser MA, Betterton MD. Chiral self-sorting of active semiflexible filaments with intrinsic curvature. Soft Matter. 2021 May 05; 17(17):4559-4565. PMID: 33949407.
      View in: PubMed
    15. Lamson AR, Moore JM, Fang F, Glaser MA, Shelley MJ, Betterton MD. Comparison of explicit and mean-field models of cytoskeletal filaments with crosslinking motors. Eur Phys J E Soft Matter. 2021 Mar 29; 44(3):45. PMID: 33779863.
      View in: PubMed
    16. Moore JM, Thompson TN, Glaser MA, Betterton MD. Collective motion of driven semiflexible filaments tuned by soft repulsion and stiffness. Soft Matter. 2020 Oct 28; 16(41):9436-9442. PMID: 32959862.
      View in: PubMed
    17. Maguire L, Betterton MD, Hough LE. Bound-State Diffusion due to Binding to Flexible Polymers in a Selective Biofilter. Biophys J. 2020 Jul 07; 119(1):232. PMID: 32553127.
      View in: PubMed
    18. Edelmaier C, Lamson AR, Gergely ZR, Ansari S, Blackwell R, McIntosh JR, Glaser MA, Betterton MD. Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling. Elife. 2020 02 13; 9. PMID: 32053104.
      View in: PubMed
    19. Maguire L, Betterton MD, Hough LE. Bound-State Diffusion due to Binding to Flexible Polymers in a Selective Biofilter. Biophys J. 2020 01 21; 118(2):376-385. PMID: 31858976.
      View in: PubMed
    20. Maguire L, Stefferson M, Betterton MD, Hough LE. Design principles of selective transport through biopolymer barriers. Phys Rev E. 2019 Oct; 100(4-1):042414. PMID: 31770897.
      View in: PubMed
    21. Lamson AR, Edelmaier CJ, Glaser MA, Betterton MD. Theory of Cytoskeletal Reorganization during Cross-Linker-Mediated Mitotic Spindle Assembly. Biophys J. 2019 05 07; 116(9):1719-1731. PMID: 31010665.
      View in: PubMed
    22. Aguilar J, Monaenkova D, Linevich V, Savoie W, Dutta B, Kuan HS, Betterton MD, Goodisman MAD, Goldman DI. Collective clog control: Optimizing traffic flow in confined biological and robophysical excavation. Science. 2018 08 17; 361(6403):672-677. PMID: 30115804.
      View in: PubMed
    23. Stefferson MW, Norris SL, Vernerey FJ, Betterton MD, Hough LE. Effects of soft interactions and bound mobility on diffusion in crowded environments: a model of sticky and slippery obstacles. Phys Biol. 2017 06 29; 14(4):045008. PMID: 28597848.
      View in: PubMed
    24. Rincon SA, Lamson A, Blackwell R, Syrovatkina V, Fraisier V, Paoletti A, Betterton MD, Tran PT. Kinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker Ase1 in fission yeast. Nat Commun. 2017 05 17; 8:15286. PMID: 28513584.
      View in: PubMed
    25. Blackwell R, Edelmaier C, Sweezy-Schindler O, Lamson A, Gergely ZR, O'Toole E, Crapo A, Hough LE, McIntosh JR, Glaser MA, Betterton MD. Physical determinants of bipolar mitotic spindle assembly and stability in fission yeast. Sci Adv. 2017 Jan; 3(1):e1601603. PMID: 28116355.
      View in: PubMed
    26. Blackwell R, Sweezy-Schindler O, Edelmaier C, Gergely ZR, Flynn PJ, Montes S, Crapo A, Doostan A, McIntosh JR, Glaser MA, Betterton MD. Contributions of Microtubule Dynamic Instability and Rotational Diffusion to Kinetochore Capture. Biophys J. 2017 Feb 07; 112(3):552-563. PMID: 27692365.
      View in: PubMed
    27. Kuan HS, Betterton MD. Phase-plane analysis of the totally asymmetric simple exclusion process with binding kinetics and switching between antiparallel lanes. Phys Rev E. 2016 Aug; 94(2-1):022419. PMID: 27627345.
      View in: PubMed
    28. Kuan HS, Betterton MD. Motor Protein Accumulation on Antiparallel Microtubule Overlaps. Biophys J. 2016 05 10; 110(9):2034-43. PMID: 27166811.
      View in: PubMed
    29. Gergely ZR, Crapo A, Hough LE, McIntosh JR, Betterton MD. Kinesin-8 effects on mitotic microtubule dynamics contribute to spindle function in fission yeast. Mol Biol Cell. 2016 11 07; 27(22):3490-3514. PMID: 27146110.
      View in: PubMed
    30. Blackwell R, Sweezy-Schindler O, Baldwin C, Hough LE, Glaser MA, Betterton MD. Microscopic origins of anisotropic active stress in motor-driven nematic liquid crystals. Soft Matter. 2016 Mar 14; 12(10):2676-87. PMID: 26742483.
      View in: PubMed
    31. Kuan HS, Blackwell R, Hough LE, Glaser MA, Betterton MD. Hysteresis, reentrance, and glassy dynamics in systems of self-propelled rods. Phys Rev E Stat Nonlin Soft Matter Phys. 2015; 92(6):060501. PMID: 26764616.
      View in: PubMed
    32. Gao T, Blackwell R, Glaser MA, Betterton MD, Shelley MJ. Multiscale modeling and simulation of microtubule-motor-protein assemblies. Phys Rev E Stat Nonlin Soft Matter Phys. 2015; 92(6):062709. PMID: 26764729.
      View in: PubMed
    33. Gao T, Blackwell R, Glaser MA, Betterton MD, Shelley MJ. Multiscale polar theory of microtubule and motor-protein assemblies. Phys Rev Lett. 2015 Jan 30; 114(4):048101. PMID: 25679909.
      View in: PubMed
    34. Betterton MD, McIntosh JR. Regulation of chromosome speeds in mitosis. Cell Mol Bioeng. 2013 Dec; 6(4):418-430. PMID: 26405462.
      View in: PubMed
    35. Kuan HS, Betterton MD. Biophysics of filament length regulation by molecular motors. Phys Biol. 2013 Jun; 10(3):036004. PMID: 23587993.
      View in: PubMed
    36. Hough LE, Schwabe A, Glaser MA, McIntosh JR, Betterton MD. Microtubule depolymerization by the Kinesin-8 motor Kip3p: a mathematical model. Biophys J. 2009 Apr 22; 96(8):3050-64. PMID: 19383451.
      View in: PubMed
    37. McDonald D, Waterbury L, Knight R, Betterton MD. Activating and inhibiting connections in biological network dynamics. Biol Direct. 2008 Dec 04; 3:49. PMID: 19055800.
      View in: PubMed
    38. Garai A, Chowdhury D, Betterton MD. Two-state model for helicase translocation and unwinding of nucleic acids. Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Jun; 77(6 Pt 1):061910. PMID: 18643303.
      View in: PubMed
    39. Seol Y, Li J, Nelson PC, Perkins TT, Betterton MD. Elasticity of short DNA molecules: theory and experiment for contour lengths of 0.6-7 microm. Biophys J. 2007 Dec 15; 93(12):4360-73. PMID: 17766363.
      View in: PubMed
    40. Lladser ME, Betterton MD, Knight R. Multiple pattern matching: a Markov chain approach. J Math Biol. 2008 Jan; 56(1-2):51-92. PMID: 17668213.
      View in: PubMed
    41. Hieb AR, Halsey WA, Betterton MD, Perkins TT, Kugel JF, Goodrich JA. TFIIA changes the conformation of the DNA in TBP/TATA complexes and increases their kinetic stability. J Mol Biol. 2007 Sep 21; 372(3):619-32. PMID: 17681538.
      View in: PubMed
    42. Clarke DC, Betterton MD, Liu X. Systems theory of Smad signalling. Syst Biol (Stevenage). 2006 Nov; 153(6):412-24. PMID: 17186703.
      View in: PubMed
    43. Hamady M, Betterton MD, Knight R. Using the nucleotide substitution rate matrix to detect horizontal gene transfer. BMC Bioinformatics. 2006 Oct 26; 7:476. PMID: 17067382.
      View in: PubMed
    44. Downer J, Sevinsky JR, Ahn NG, Resing KA, Betterton MD. Incorporating expression data in metabolic modeling: a case study of lactate dehydrogenase. J Theor Biol. 2006 Jun 07; 240(3):464-74. PMID: 16325864.
      View in: PubMed
    45. Betterton MD, J?licher F. Velocity and processivity of helicase unwinding of double-stranded nucleic acids. J Phys Condens Matter. 2005 Nov 30; 17(47):S3851-69. PMID: 21690729.
      View in: PubMed
    46. Betterton MD, J?licher F. Opening of nucleic-acid double strands by helicases: active versus passive opening. Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Jan; 71(1 Pt 1):011904. PMID: 15697627.
      View in: PubMed
    47. Betterton MD, J?licher F. A motor that makes its own track: helicase unwinding of DNA. Phys Rev Lett. 2003 Dec 19; 91(25):258103. PMID: 14754162.
      View in: PubMed
    48. Betterton MD, Brenner MP. Collapsing bacterial cylinders. Phys Rev E Stat Nonlin Soft Matter Phys. 2001 Dec; 64(6 Pt 1):061904. PMID: 11736207.
      View in: PubMed
    49. Betterton MD. Theory of structure formation in snowfields motivated by penitentes, suncups, and dirt cones. Phys Rev E Stat Nonlin Soft Matter Phys. 2001 May; 63(5 Pt 2):056129. PMID: 11414983.
      View in: PubMed
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