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Thomas C Evans

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Cell and Devopmental Bio
Phone303/724-3414

    Collapse Research 
    Collapse research activities and funding
    F32GM013288     (EVANS, THOMAS C)Feb 28, 1990
    NIH/NIGMS
    REGULATION AND FUNCTION OF THE C ELEGANS FEM-3 GENE
    Role: Principal Investigator

    R01GM079682     (EVANS, THOMAS C)Aug 1, 2007 - May 31, 2012
    NIH/NIGMS
    Regulation of mRNPs during early C. elegans development
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chen L, Liu P, Evans TC, Ettwiller LM. DNA damage is a pervasive cause of sequencing errors, directly confounding variant identification. Science. 2017 Feb 17; 355(6326):752-756. PMID: 28209900.
      View in: PubMed
    2. Bauer RJ, Jurkiw TJ, Evans TC, Lohman GJ. Rapid Time Scale Analysis of T4 DNA Ligase-DNA Binding. Biochemistry. 2017 Feb 28; 56(8):1117-1129. PMID: 28165732.
      View in: PubMed
    3. Poole CB, Li Z, Alhassan A, Guelig D, Diesburg S, Tanner NA, Zhang Y, Evans TC, LaBarre P, Wanji S, Burton RA, Carlow CK. Colorimetric tests for diagnosis of filarial infection and vector surveillance using non-instrumented nucleic acid loop-mediated isothermal amplification (NINA-LAMP). PLoS One. 2017; 12(2):e0169011. PMID: 28199317.
      View in: PubMed
    4. Bauer RJ, Evans TC, Lohman GJ. The Inhibitory Effect of Non-Substrate and Substrate DNA on the Ligation and Self-Adenylylation Reactions Catalyzed by T4 DNA Ligase. PLoS One. 2016; 11(3):e0150802. PMID: 26954034.
      View in: PubMed
    5. Hubstenberger A, Cameron C, Noble SL, Keenan S, Evans TC. Modifiers of solid RNP granules control normal RNP dynamics and mRNA activity in early development. J Cell Biol. 2015 Nov 09; 211(3):703-16. PMID: 26527741.
      View in: PubMed
    6. Poole CB, Ettwiller L, Tanner NA, Evans TC, Wanji S, Carlow CK. Genome Filtering for New DNA Biomarkers of Loa loa Infection Suitable for Loop-Mediated Isothermal Amplification. PLoS One. 2015; 10(9):e0139286. PMID: 26414073.
      View in: PubMed
    7. Lohman GJ, Bauer RJ, Nichols NM, Mazzola L, Bybee J, Rivizzigno D, Cantin E, Evans TC. A high-throughput assay for the comprehensive profiling of DNA ligase fidelity. Nucleic Acids Res. 2016 Jan 29; 44(2):e14. PMID: 26365241.
      View in: PubMed
    8. Tanner NA, Zhang Y, Evans TC. Visual detection of isothermal nucleic acid amplification using pH-sensitive dyes. Biotechniques. 2015 Feb; 58(2):59-68. PMID: 25652028.
      View in: PubMed
    9. Tanner NA, Evans TC. Loop-mediated isothermal amplification for detection of nucleic acids. Curr Protoc Mol Biol. 2014 Jan 06; 105:Unit 15.14.. PMID: 24510439.
      View in: PubMed
    10. Lohman GJ, Zhang Y, Zhelkovsky AM, Cantor EJ, Evans TC. Efficient DNA ligation in DNA-RNA hybrid helices by Chlorella virus DNA ligase. Nucleic Acids Res. 2014 Feb; 42(3):1831-44. PMID: 24203707.
      View in: PubMed
    11. Hubstenberger A, Noble SL, Cameron C, Evans TC. Translation repressors, an RNA helicase, and developmental cues control RNP phase transitions during early development. Dev Cell. 2013 Oct 28; 27(2):161-73. PMID: 24176641.
      View in: PubMed
    12. Poole CB, Tanner NA, Zhang Y, Evans TC, Carlow CK. Diagnosis of brugian filariasis by loop-mediated isothermal amplification. PLoS Negl Trop Dis. 2012; 6(12):e1948. PMID: 23272258.
      View in: PubMed
    13. Tanner NA, Zhang Y, Evans TC. Simultaneous multiple target detection in real-time loop-mediated isothermal amplification. Biotechniques. 2012 Aug; 53(2):81-9. PMID: 23030060.
      View in: PubMed
    14. Hubstenberger A, Cameron C, Shtofman R, Gutman S, Evans TC. A network of PUF proteins and Ras signaling promote mRNA repression and oogenesis in C. elegans. Dev Biol. 2012 Jun 15; 366(2):218-31. PMID: 22542599.
      View in: PubMed
    15. Lohman GJ, Chen L, Evans TC. Kinetic characterization of single strand break ligation in duplex DNA by T4 DNA ligase. J Biol Chem. 2011 Dec 23; 286(51):44187-96. PMID: 22027837.
      View in: PubMed
    16. Ward MM, Clabaugh G, Evans TC, Herwaldt L. A successful, voluntary, multicomponent statewide effort to reduce health care-associated infections. Am J Med Qual. 2012 Jan-Feb; 27(1):66-73. PMID: 21551323.
      View in: PubMed
    17. Helms C, Polgreen P, Polgreen L, Evans T, Roberts LL, Clabaugh G, Quinlisk P. Voluntary reporting of employee influenza vaccination rates by acute care hospitals in Iowa: the impact of a four year provider-based statewide performance improvement project. Vaccine. 2011 Apr 18; 29(18):3483-8. PMID: 21439317.
      View in: PubMed
    18. Ghosh I, Considine N, Maunus E, Sun L, Zhang A, Buswell J, Evans TC, Xu MQ. Site-specific protein labeling by intein-mediated protein ligation. Methods Mol Biol. 2011; 705:87-107. PMID: 21125382.
      View in: PubMed
    19. Mauris J, Evans TC. A human PMS2 homologue from Aquifex aeolicus stimulates an ATP-dependent DNA helicase. J Biol Chem. 2010 Apr 09; 285(15):11087-92. PMID: 20129926.
      View in: PubMed
    20. Mauris J, Evans TC. Adenosine triphosphate stimulates Aquifex aeolicus MutL endonuclease activity. PLoS One. 2009 Sep 24; 4(9):e7175. PMID: 19777055.
      View in: PubMed
    21. Polgreen PM, Polgreen LA, Evans T, Helms C. A statewide system for improving influenza vaccination rates in hospital employees. Infect Control Hosp Epidemiol. 2009 May; 30(5):474-8. PMID: 19327039.
      View in: PubMed
    22. Zimmermann J, Hajibabaei M, Blackburn DC, Hanken J, Cantin E, Posfai J, Evans TC. DNA damage in preserved specimens and tissue samples: a molecular assessment. Front Zool. 2008 Oct 23; 5:18. PMID: 18947416.
      View in: PubMed
    23. Evans TC, Nichols NM. DNA repair enzymes. Curr Protoc Mol Biol. 2008 Oct; Chapter 3:Unit3.9. PMID: 18972391.
      View in: PubMed
    24. Noble SL, Allen BL, Goh LK, Nordick K, Evans TC. Maternal mRNAs are regulated by diverse P body-related mRNP granules during early Caenorhabditis elegans development. J Cell Biol. 2008 Aug 11; 182(3):559-72. PMID: 18695046.
      View in: PubMed
    25. Dun BQ, Wang XJ, Lu W, Zhao ZL, Hou SN, Zhang BM, Li GY, Evans TC, Xu MQ, Lin M. Reconstitution of glyphosate resistance from a split 5-enolpyruvyl shikimate-3-phosphate synthase gene in Escherichia coli and transgenic tobacco. Appl Environ Microbiol. 2007 Dec; 73(24):7997-8000. PMID: 17951442.
      View in: PubMed
    26. Lublin AL, Evans TC. The RNA-binding proteins PUF-5, PUF-6, and PUF-7 reveal multiple systems for maternal mRNA regulation during C. elegans oogenesis. Dev Biol. 2007 Mar 15; 303(2):635-49. PMID: 17234175.
      View in: PubMed
    27. Ward MM, Evans TC, Spies AJ, Roberts LL, Wakefield DS. National Quality Forum 30 safe practices: priority and progress in Iowa hospitals. Am J Med Qual. 2006 Mar-Apr; 21(2):101-8. PMID: 16533901.
      View in: PubMed
    28. Barbee SA, Evans TC. The Sm proteins regulate germ cell specification during early C. elegans embryogenesis. Dev Biol. 2006 Mar 01; 291(1):132-43. PMID: 16413530.
      View in: PubMed
    29. Evans TC, Hunter CP. Translational control of maternal RNAs. WormBook. 2005 Nov 10; 1-11. PMID: 18050410.
      View in: PubMed
    30. Chin HG, Pradhan M, Estève PO, Patnaik D, Evans TC, Pradhan S. Sequence specificity and role of proximal amino acids of the histone H3 tail on catalysis of murine G9A lysine 9 histone H3 methyltransferase. Biochemistry. 2005 Oct 04; 44(39):12998-3006. PMID: 16185068.
      View in: PubMed
    31. Sun P, Ye S, Ferrandon S, Evans TC, Xu MQ, Rao Z. Crystal structures of an intein from the split dnaE gene of Synechocystis sp. PCC6803 reveal the catalytic model without the penultimate histidine and the mechanism of zinc ion inhibition of protein splicing. J Mol Biol. 2005 Nov 11; 353(5):1093-105. PMID: 16219320.
      View in: PubMed
    32. Xu MQ, Evans TC. Recent advances in protein splicing: manipulating proteins in vitro and in vivo. Curr Opin Biotechnol. 2005 Aug; 16(4):440-6. PMID: 16026977.
      View in: PubMed
    33. Evans TC, Xu MQ, Pradhan S. Protein splicing elements and plants: from transgene containment to protein purification. Annu Rev Plant Biol. 2005; 56:375-92. PMID: 15862101.
      View in: PubMed
    34. Ghosh I, Sun L, Evans TC, Xu MQ. An improved method for utilization of peptide substrates for antibody characterization and enzymatic assays. J Immunol Methods. 2004 Oct; 293(1-2):85-95. PMID: 15541279.
      View in: PubMed
    35. Nichols NM, Evans TC. Mutational analysis of protein splicing, cleavage, and self-association reactions mediated by the naturally split Ssp DnaE intein. Biochemistry. 2004 Aug 10; 43(31):10265-76. PMID: 15287754.
      View in: PubMed
    36. Bull SS, Posner SF, Ortiz C, Evans T. Knowledge of, attitudes toward, and stage of change for female and male condoms among Denver inner-city women. J Urban Health. 2003 Dec; 80(4):658-66. PMID: 14709713.
      View in: PubMed
    37. Zhang MY, Shu Y, Phogat S, Xiao X, Cham F, Bouma P, Choudhary A, Feng YR, Sanz I, Rybak S, Broder CC, Quinnan GV, Evans T, Dimitrov DS. Broadly cross-reactive HIV neutralizing human monoclonal antibody Fab selected by sequential antigen panning of a phage display library. J Immunol Methods. 2003 Dec; 283(1-2):17-25. PMID: 14659896.
      View in: PubMed
    38. Marin VA, Evans TC. Translational repression of a C. elegans Notch mRNA by the STAR/KH domain protein GLD-1. Development. 2003 Jun; 130(12):2623-32. PMID: 12736207.
      View in: PubMed
    39. Nichols NM, Benner JS, Martin DD, Evans TC. Zinc ion effects on individual Ssp DnaE intein splicing steps: regulating pathway progression. Biochemistry. 2003 May 13; 42(18):5301-11. PMID: 12731871.
      View in: PubMed
    40. Chin HG, Kim GD, Marin I, Mersha F, Evans TC, Chen L, Xu MQ, Pradhan S. Protein trans-splicing in transgenic plant chloroplast: reconstruction of herbicide resistance from split genes. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4510-5. PMID: 12671070.
      View in: PubMed
    41. Xu MQ, Evans TC. Purification of recombinant proteins from E. coli by engineered inteins. Methods Mol Biol. 2003; 205:43-68. PMID: 12491879.
      View in: PubMed
    42. Barbee SA, Lublin AL, Evans TC. A novel function for the Sm proteins in germ granule localization during C. elegans embryogenesis. Curr Biol. 2002 Sep 03; 12(17):1502-6. PMID: 12225665.
      View in: PubMed
    43. Xu MQ, Evans TC. Intein-mediated ligation and cyclization of expressed proteins. Methods. 2001 Jul; 24(3):257-77. PMID: 11403575.
      View in: PubMed
    44. Martin DD, Xu MQ, Evans TC. Characterization of a naturally occurring trans-splicing intein from Synechocystis sp. PCC6803. Biochemistry. 2001 Feb 06; 40(5):1393-402. PMID: 11170467.
      View in: PubMed
    45. Chen L, Pradhan S, Evans TC. Herbicide resistance from a divided EPSPS protein: the split Synechocystis DnaE intein as an in vivo affinity domain. Gene. 2001 Jan 24; 263(1-2):39-48. PMID: 11223241.
      View in: PubMed
    46. Evans TC, Martin D, Kolly R, Panne D, Sun L, Ghosh I, Chen L, Benner J, Liu XQ, Xu MQ. Protein trans-splicing and cyclization by a naturally split intein from the dnaE gene of Synechocystis species PCC6803. J Biol Chem. 2000 Mar 31; 275(13):9091-4. PMID: 10734038.
      View in: PubMed
    47. Southworth MW, Amaya K, Evans TC, Xu MQ, Perler FB. Purification of proteins fused to either the amino or carboxy terminus of the Mycobacterium xenopi gyrase A intein. Biotechniques. 1999 Jul; 27(1):110-4, 116, 118-20. PMID: 10407673.
      View in: PubMed
    48. Evans TC, Benner J, Xu MQ. The cyclization and polymerization of bacterially expressed proteins using modified self-splicing inteins. J Biol Chem. 1999 Jun 25; 274(26):18359-63. PMID: 10373440.
      View in: PubMed
    49. Mathys S, Evans TC, Chute IC, Wu H, Chong S, Benner J, Liu XQ, Xu MQ. Characterization of a self-splicing mini-intein and its conversion into autocatalytic N- and C-terminal cleavage elements: facile production of protein building blocks for protein ligation. Gene. 1999 Apr 29; 231(1-2):1-13. PMID: 10231563.
      View in: PubMed
    50. Evans TC, Benner J, Xu MQ. The in vitro ligation of bacterially expressed proteins using an intein from Methanobacterium thermoautotrophicum. J Biol Chem. 1999 Feb 12; 274(7):3923-6. PMID: 9933578.
      View in: PubMed
    51. Evans TC, Xu MQ. Intein-mediated protein ligation: harnessing nature's escape artists. Biopolymers. 1999; 51(5):333-42. PMID: 10685044.
      View in: PubMed
    52. Evans TC, Benner J, Xu MQ. Semisynthesis of cytotoxic proteins using a modified protein splicing element. Protein Sci. 1998 Nov; 7(11):2256-64. PMID: 9827992.
      View in: PubMed
    53. McDonald JF, Evans TC, Emeagwali DB, Hariharan M, Allewell NM, Pusey ML, Shah AM, Nelsestuen GL. Ionic properties of membrane association by vitamin K-dependent proteins: the case for univalency. Biochemistry. 1997 Dec 16; 36(50):15589-98. PMID: 9398287.
      View in: PubMed
    54. Crittenden SL, Rudel D, Binder J, Evans TC, Kimble J. Genes required for GLP-1 asymmetry in the early Caenorhabditis elegans embryo. Dev Biol. 1997 Jan 01; 181(1):36-46. PMID: 9015263.
      View in: PubMed
    55. Evans TC, Nelsestuen GL. Importance of cis-proline 22 in the membrane-binding conformation of bovine prothrombin. Biochemistry. 1996 Jun 25; 35(25):8210-5. PMID: 8679575.
      View in: PubMed
    56. Crittenden SL, Troemel ER, Evans TC, Kimble J. GLP-1 is localized to the mitotic region of the C. elegans germ line. Development. 1994 Oct; 120(10):2901-11. PMID: 7607080.
      View in: PubMed
    57. Evans TC, Crittenden SL, Kodoyianni V, Kimble J. Translational control of maternal glp-1 mRNA establishes an asymmetry in the C. elegans embryo. Cell. 1994 Apr 22; 77(2):183-94. PMID: 8168128.
      View in: PubMed
    58. Goodwin EB, Okkema PG, Evans TC, Kimble J. Translational regulation of tra-2 by its 3' untranslated region controls sexual identity in C. elegans. Cell. 1993 Oct 22; 75(2):329-39. PMID: 8402916.
      View in: PubMed
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