 Protein Splicing
"Protein Splicing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The excision of in-frame internal protein sequences (INTEINS) of a precursor protein, coupled with ligation of the flanking sequences (EXTEINS). Protein splicing is an autocatalytic reaction and results in the production of two proteins from a single primary translation product: the intein and the mature protein.
| Descriptor ID |
D019154
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| MeSH Number(s) |
G02.111.660.871.790.600.700 G02.111.691.600.700 G03.734.871.790.600.700 G05.308.670.600.700
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| Concept/Terms |
Protein Splicing- Protein Splicing
- Protein Splicings
- Splicing, Protein
- Splicings, Protein
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Below are MeSH descriptors whose meaning is more general than "Protein Splicing".
Below are MeSH descriptors whose meaning is more specific than "Protein Splicing".
This graph shows the total number of publications written about "Protein Splicing" by people in this website by year, and whether "Protein Splicing" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 | | 1999 | 4 | 0 | 4 | | 2000 | 1 | 0 | 1 | | 2001 | 1 | 1 | 2 | | 2002 | 1 | 0 | 1 | | 2003 | 2 | 1 | 3 | | 2004 | 1 | 0 | 1 | | 2005 | 3 | 0 | 3 | | 2011 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Splicing" by people in Profiles.
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Taliaferro JM, Alvarez N, Green RE, Blanchette M, Rio DC. Evolution of a tissue-specific splicing network. Genes Dev. 2011 Mar 15; 25(6):608-20.
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Sun P, Ye S, Ferrandon S, Evans TC, Xu MQ, Rao Z. Crystal structures of an intein from the split dnaE gene of Synechocystis sp. PCC6803 reveal the catalytic model without the penultimate histidine and the mechanism of zinc ion inhibition of protein splicing. J Mol Biol. 2005 Nov 11; 353(5):1093-105.
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Xu MQ, Evans TC. Recent advances in protein splicing: manipulating proteins in vitro and in vivo. Curr Opin Biotechnol. 2005 Aug; 16(4):440-6.
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Evans TC, Xu MQ, Pradhan S. Protein splicing elements and plants: from transgene containment to protein purification. Annu Rev Plant Biol. 2005; 56:375-92.
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Nichols NM, Evans TC. Mutational analysis of protein splicing, cleavage, and self-association reactions mediated by the naturally split Ssp DnaE intein. Biochemistry. 2004 Aug 10; 43(31):10265-76.
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Nichols NM, Benner JS, Martin DD, Evans TC. Zinc ion effects on individual Ssp DnaE intein splicing steps: regulating pathway progression. Biochemistry. 2003 May 13; 42(18):5301-11.
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Chin HG, Kim GD, Marin I, Mersha F, Evans TC, Chen L, Xu MQ, Pradhan S. Protein trans-splicing in transgenic plant chloroplast: reconstruction of herbicide resistance from split genes. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4510-5.
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Xu MQ, Evans TC. Purification of recombinant proteins from E. coli by engineered inteins. Methods Mol Biol. 2003; 205:43-68.
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Evans TC, Xu MQ. Mechanistic and kinetic considerations of protein splicing. Chem Rev. 2002 12; 102(12):4869-84.
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Martin DD, Xu MQ, Evans TC. Characterization of a naturally occurring trans-splicing intein from Synechocystis sp. PCC6803. Biochemistry. 2001 Feb 06; 40(5):1393-402.
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