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Jingshi Shen

TitleAssociate Professor
InstitutionUniversity of Colorado Boulder
DepartmentBiology-MCD Instruction

    Collapse Research 
    Collapse research activities and funding
    K99DK080080     (SHEN, JINGSHI)Sep 20, 2007 - Aug 31, 2009
    Regulation of GLUT4 Exocytosis
    Role: Principal Investigator

    R00DK080080     (SHEN, JINGSHI)Feb 15, 2009 - Jan 31, 2012
    Regulation of GLUT4 Exocytosis
    Role: Principal Investigator

    R56DK095367     (SHEN, JINGSHI)Sep 21, 2012 - Mar 31, 2013
    Regulatory Mechanisms of GLUT4 Exocytosis
    Role: Principal Investigator

    R01GM102217     (SHEN, JINGSHI)Apr 1, 2013 - Jan 31, 2018
    Protein-Membrane Interactions in Regulated Exocytosis
    Role: Principal Investigator

    R01DK095367     (SHEN, JINGSHI)Apr 1, 2013 - Mar 31, 2018
    Regulatory Mechanisms of GLUT4 Exocytosis
    Role: Principal Investigator

    R21AI128443     (LI, SUZHAO)Aug 14, 2017 - Jul 31, 2019
    Molecular Mechanisms of Cytokine Induced Insulin Resistance
    Role: Co-Principal Investigator

    R35GM126960     (SHEN, JINGSHI)Apr 1, 2018 - Mar 31, 2023
    Protein-membrane interactions in regulated exocytosis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gulbranson DR, Davis EM, Demmitt BA, Ouyang Y, Ye Y, Yu H, Shen J. RABIF/MSS4 is a Rab-stabilizing holdase chaperone required for GLUT4 exocytosis. Proc Natl Acad Sci U S A. 2017 Sep 26; 114(39):E8224-E8233. PMID: 28894007.
      View in: PubMed
    2. Yu H, Liu Y, Gulbranson DR, Paine A, Rathore SS, Shen J. Extended synaptotagmins are Ca2+-dependent lipid transfer proteins at membrane contact sites. Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16):4362-7. PMID: 27044075; PMCID: PMC4843466 [Available on 10/19/16].
    3. Shen C, Rathore SS, Yu H, Gulbranson DR, Hua R, Zhang C, Schoppa NE, Shen J. The trans-SNARE-regulating function of Munc18-1 is essential to synaptic exocytosis. Nat Commun. 2015 Nov 17; 6:8852. PMID: 26572858; PMCID: PMC4668942 [Available on 11/17/16].
    4. Yu H, Rathore SS, Shen C, Liu Y, Ouyang Y, Stowell MH, Shen J. Reconstituting Intracellular Vesicle Fusion Reactions: The Essential Role of Macromolecular Crowding. J Am Chem Soc. 2015 Oct 14; 137(40):12873-83. PMID: 26431309; PMCID: PMC4638180.
    5. Davis EM, Kim J, Menasche BL, Sheppard J, Liu X, Tan AC, Shen J. Comparative Haploid Genetic Screens Reveal Divergent Pathways in the Biogenesis and Trafficking of Glycophosphatidylinositol-Anchored Proteins. Cell Rep. 2015 Jun 23; 11(11):1727-36. PMID: 26074080; PMCID: PMC4481156.
    6. Zhang C, Lee S, Peng Y, Bunker E, Shen C, Giaime E, Shen J, Shen J, Zhou Z, Liu X. A chemical genetic approach to probe the function of PINK1 in regulating mitochondrial dynamics. Cell Res. 2015 Mar; 25(3):394-7. PMID: 25475060; PMCID: PMC4349247.
    7. Yu H, Rathore SS, Gulbranson DR, Shen J. The N- and C-terminal domains of tomosyn play distinct roles in soluble N-ethylmaleimide-sensitive factor attachment protein receptor binding and fusion regulation. J Biol Chem. 2014 Sep 12; 289(37):25571-80. PMID: 25063806; PMCID: PMC4162162.
    8. Yu H, Rathore SS, Lopez JA, Davis EM, James DE, Martin JL, Shen J. Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):E3271-80. PMID: 23918365; PMCID: PMC3761595.
    9. Yu H, Rathore SS, Shen J. Synip arrests soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-dependent membrane fusion as a selective target membrane SNARE-binding inhibitor. J Biol Chem. 2013 Jun 28; 288(26):18885-93. PMID: 23665562; PMCID: PMC3696664.
    10. Yu H, Rathore SS, Davis EM, Ouyang Y, Shen J. Doc2b promotes GLUT4 exocytosis by activating the SNARE-mediated fusion reaction in a calcium- and membrane bending-dependent manner. Mol Biol Cell. 2013 Apr; 24(8):1176-84. PMID: 23427263; PMCID: PMC3623638.
    11. Rathore SS, Ghosh N, Ouyang Y, Shen J. Topological arrangement of the intracellular membrane fusion machinery. Mol Biol Cell. 2011 Jul 15; 22(14):2612-9. PMID: 21633111; PMCID: PMC3135485.
    12. Rathore SS, Bend EG, Yu H, Hammarlund M, Jorgensen EM, Shen J. Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22399-406. PMID: 21139055; PMCID: PMC3012463.
    13. Shen J, Rathore SS, Khandan L, Rothman JE. SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion. J Cell Biol. 2010 Jul 12; 190(1):55-63. PMID: 20603329; PMCID: PMC2911676.
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