 Jingshi Shen
| Title | Professor |
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| Institution | University of Colorado Boulder |
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| Department | Biology-MCD Instruction |
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| Phone | 303/492-6166 |
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 Research DP1DK139964 (SHEN, JINGSHI)Sep 5, 2024 - Aug 31, 2026 NIH
Extracellular vesicle-dependent RNA signaling in metabolism
Role: Principal Investigator |
| R01DK124431 (SHEN, JINGSHI)Apr 1, 2020 - Mar 31, 2024 NIH
Mechanisms of GLUT4 Exocytosis
Role: Principal Investigator |
| RF1AG061829 (SHEN, JINGSHI)Sep 30, 2018 - Mar 31, 2023 NIH
Identifying exosome-mediated cargo transport machinery in Alzheimer's disease
Role: Principal Investigator |
| R03AI135473 (YU, HAIJIA)May 3, 2018 - Apr 30, 2020 NIH/NIAID
Dissect Cytolytic Granule Secretion in Cytotoxic T Lymphocytes Using CRISPR Genetic Screens
Role: Co-Principal Investigator |
| R35GM126960 (SHEN, JINGSHI)Apr 1, 2018 - Feb 28, 2029 NIH
Discovering protein networks underlying regulated exocytosis
Role: Principal Investigator |
| R21AI128443 (LI, SUZHAO)Aug 14, 2017 - Jul 31, 2020 NIH
Molecular Mechanisms of Cytokine Induced Insulin Resistance
Role: Co-Principal Investigator |
| R01DK095367 (SHEN, JINGSHI)Apr 1, 2013 - Sep 19, 2018 NIH
Regulatory Mechanisms of GLUT4 Exocytosis
Role: Principal Investigator |
| R01GM102217 (SHEN, JINGSHI)Apr 1, 2013 - Jan 31, 2018 NIH
Protein-Membrane Interactions in Regulated Exocytosis
Role: Principal Investigator |
| R56DK095367 (SHEN, JINGSHI)Sep 21, 2012 - Aug 31, 2020 NIH
Regulatory Mechanisms of GLUT4 Exocytosis
Role: Principal Investigator |
| R00DK080080 (SHEN, JINGSHI)Feb 15, 2009 - Jan 31, 2012 NIH
Regulation of GLUT4 Exocytosis
Role: Principal Investigator |
| K99DK080080 (SHEN, JINGSHI)Sep 20, 2007 - Aug 31, 2009 NIH
Regulation of GLUT4 Exocytosis
Role: Principal Investigator |
Bibliographic
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Wang S, Chen X, Crisman L, Dou X, Winborn CS, Wan C, Puscher H, Yin Q, Kennedy MJ, Shen J. Regulation of cargo exocytosis by a Reps1-Ralbp1-RalA module. Sci Adv. 2023 02 22; 9(8):eade2540. PMID: 36812304.
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Wan C, Stowell MHB, Shen J. Progress and gaps of extracellular vesicle-mediated intercellular cargo transfer in the central nervous system. Commun Biol. 2022 11 11; 5(1):1223. PMID: 36369335.
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Wan C, Crisman L, Wang B, Tian Y, Wang S, Yang R, Datta I, Nomura T, Li S, Yu H, Yin Q, Shen J. AAGAB is an assembly chaperone regulating AP1 and AP2 clathrin adaptors. J Cell Sci. 2021 10 01; 134(19). PMID: 34494650.
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Liu Y, Wan C, Rathore SS, Stowell MHB, Yu H, Shen J. SNARE Zippering Is Suppressed by a Conformational Constraint that Is Removed by v-SNARE Splitting. Cell Rep. 2021 01 12; 34(2):108611. PMID: 33440145.
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Zhang X, Xu Q, Zi Z, Liu Z, Wan C, Crisman L, Shen J, Liu X. Programmable Extracellular Vesicles for Macromolecule Delivery and Genome Modifications. Dev Cell. 2020 12 21; 55(6):784-801.e9. PMID: 33296682.
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Dombach JL, Quintana JLJ, Nagy TA, Wan C, Crooks AL, Yu H, Su CC, Yu EW, Shen J, Detweiler CS. A small molecule that mitigates bacterial infection disrupts Gram-negative cell membranes and is inhibited by cholesterol and neutral lipids. PLoS Pathog. 2020 12; 16(12):e1009119. PMID: 33290418.
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Menasche BL, Davis EM, Wang S, Ouyang Y, Li S, Yu H, Shen J. PBRM1 and the glycosylphosphatidylinositol biosynthetic pathway promote tumor killing mediated by MHC-unrestricted cytotoxic lymphocytes. Sci Adv. 2020 11; 6(48). PMID: 33246952.
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Wang S, Liu Y, Crisman L, Wan C, Miller J, Yu H, Shen J. Genetic evidence for an inhibitory role of tomosyn in insulin-stimulated GLUT4 exocytosis. Traffic. 2020 10; 21(10):636-646. PMID: 32851733.
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Rathore SS, Liu Y, Yu H, Wan C, Lee M, Yin Q, Stowell MHB, Shen J. Intracellular Vesicle Fusion Requires a Membrane-Destabilizing Peptide Located at the Juxtamembrane Region of the v-SNARE. Cell Rep. 2019 12 24; 29(13):4583-4592.e3. PMID: 31875562.
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Wang S, Crisman L, Miller J, Datta I, Gulbranson DR, Tian Y, Yin Q, Yu H, Shen J. Inducible Exoc7/Exo70 knockout reveals a critical role of the exocyst in insulin-regulated GLUT4 exocytosis. J Biol Chem. 2019 Dec 27; 294(52):19988-19996. PMID: 31740584.
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Gulbranson DR, Crisman L, Lee M, Ouyang Y, Menasche BL, Demmitt BA, Wan C, Nomura T, Ye Y, Yu H, Shen J. AAGAB Controls AP2 Adaptor Assembly in Clathrin-Mediated Endocytosis. Dev Cell. 2019 08 19; 50(4):436-446.e5. PMID: 31353312.
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Shen C, Liu Y, Yu H, Gulbranson DR, Kogut I, Bilousova G, Zhang C, Stowell MHB, Shen J. The N-peptide-binding mode is critical to Munc18-1 function in synaptic exocytosis. J Biol Chem. 2018 11 23; 293(47):18309-18317. PMID: 30275014.
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Menasche BL, Crisman L, Gulbranson DR, Davis EM, Yu H, Shen J. Fluorescence Activated Cell Sorting (FACS) in Genome-Wide Genetic Screening of Membrane Trafficking. Curr Protoc Cell Biol. 2019 03; 82(1):e68. PMID: 30265447.
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Guan X, Chaffey PK, Wei X, Gulbranson DR, Ruan Y, Wang X, Li Y, Ouyang Y, Chen L, Zeng C, Koelsch TN, Tran AH, Liang W, Shen J, Tan Z. Chemically Precise Glycoengineering Improves Human Insulin. ACS Chem Biol. 2018 01 19; 13(1):73-81. PMID: 29090903.
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Gulbranson DR, Davis EM, Demmitt BA, Ouyang Y, Ye Y, Yu H, Shen J. RABIF/MSS4 is a Rab-stabilizing holdase chaperone required for GLUT4 exocytosis. Proc Natl Acad Sci U S A. 2017 09 26; 114(39):E8224-E8233. PMID: 28894007.
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Yu H, Liu Y, Gulbranson DR, Paine A, Rathore SS, Shen J. Extended synaptotagmins are Ca2+-dependent lipid transfer proteins at membrane contact sites. Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16):4362-7. PMID: 27044075.
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Shen C, Rathore SS, Yu H, Gulbranson DR, Hua R, Zhang C, Schoppa NE, Shen J. The trans-SNARE-regulating function of Munc18-1 is essential to synaptic exocytosis. Nat Commun. 2015 Nov 17; 6:8852. PMID: 26572858.
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Yu H, Rathore SS, Shen C, Liu Y, Ouyang Y, Stowell MH, Shen J. Reconstituting Intracellular Vesicle Fusion Reactions: The Essential Role of Macromolecular Crowding. J Am Chem Soc. 2015 Oct 14; 137(40):12873-83. PMID: 26431309.
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Davis EM, Kim J, Menasche BL, Sheppard J, Liu X, Tan AC, Shen J. Comparative Haploid Genetic Screens Reveal Divergent Pathways in the Biogenesis and Trafficking of Glycophosphatidylinositol-Anchored Proteins. Cell Rep. 2015 Jun 23; 11(11):1727-36. PMID: 26074080.
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Zhang C, Lee S, Peng Y, Bunker E, Shen C, Giaime E, Shen J, Shen J, Zhou Z, Liu X. A chemical genetic approach to probe the function of PINK1 in regulating mitochondrial dynamics. Cell Res. 2015 Mar; 25(3):394-7. PMID: 25475060.
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Yu H, Rathore SS, Gulbranson DR, Shen J. The N- and C-terminal domains of tomosyn play distinct roles in soluble N-ethylmaleimide-sensitive factor attachment protein receptor binding and fusion regulation. J Biol Chem. 2014 Sep 12; 289(37):25571-80. PMID: 25063806.
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Yu H, Rathore SS, Lopez JA, Davis EM, James DE, Martin JL, Shen J. Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):E3271-80. PMID: 23918365.
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Yu H, Rathore SS, Shen J. Synip arrests soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-dependent membrane fusion as a selective target membrane SNARE-binding inhibitor. J Biol Chem. 2013 Jun 28; 288(26):18885-93. PMID: 23665562.
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Yu H, Rathore SS, Davis EM, Ouyang Y, Shen J. Doc2b promotes GLUT4 exocytosis by activating the SNARE-mediated fusion reaction in a calcium- and membrane bending-dependent manner. Mol Biol Cell. 2013 Apr; 24(8):1176-84. PMID: 23427263.
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Rathore SS, Ghosh N, Ouyang Y, Shen J. Topological arrangement of the intracellular membrane fusion machinery. Mol Biol Cell. 2011 Jul 15; 22(14):2612-9. PMID: 21633111.
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Rathore SS, Bend EG, Yu H, Hammarlund M, Jorgensen EM, Shen J. Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22399-406. PMID: 21139055.
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Shen J, Rathore SS, Khandan L, Rothman JE. SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion. J Cell Biol. 2010 Jul 12; 190(1):55-63. PMID: 20603329.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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| Year | Publications |
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| 2010 | 2 | | 2011 | 1 | | 2013 | 3 | | 2014 | 2 | | 2015 | 3 | | 2016 | 1 | | 2017 | 2 | | 2018 | 2 | | 2019 | 3 | | 2020 | 4 | | 2021 | 2 | | 2022 | 1 | | 2023 | 1 |
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