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Mark L Dell'Acqua

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM - Pharmacology
Phone303/724-3616

    Collapse Research 
    Collapse research activities and funding
    R56NS040701     (DELL'ACQUA, MARK L)Dec 1, 2000 - Apr 30, 2014
    NIH/NINDS
    Regulation of AKAP79 Postsynaptic Targeting and Signaling
    Role: Principal Investigator

    R01NS040701     (DELL'ACQUA, MARK L)Dec 1, 2000 - Jul 31, 2018
    NIH/NINDS
    Regulation of AKAP79 Postsynaptic Targeting and Signaling
    Role: Principal Investigator

    R01MH080291     (DELL'ACQUA, MARK L)Aug 1, 2007 - Jul 31, 2014
    NIH/NIMH
    AKAP Anchored PKA and Calcineurin Regulation of Neuronal L-type Calcium Channels
    Role: Principal Investigator

    R01MH102338     (DELL'ACQUA, MARK L)Dec 1, 2013 - Nov 30, 2018
    NIH/NIMH
    Mechanisms of Neuronal Calcineurin-NFAT Synapse-to-Nucleus Signaling
    Role: Principal Investigator

    R21NS094453     (DELL'ACQUA, MARK L)Jul 1, 2016 - Jun 30, 2018
    NIH/NINDS
    Amyloid Beta Postsynaptic Signaling through AKAP-anchored Calcineurin
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dittmer PJ, Wild AR, Dell'Acqua ML, Sather WA. STIM1 Ca2+ Sensor Control of L-type Ca2+-Channel-Dependent Dendritic Spine Structural Plasticity and Nuclear Signaling. Cell Rep. 2017 Apr 11; 19(2):321-334. PMID: 28402855.
      View in: PubMed
    2. Sinnen BL, Bowen AB, Forte JS, Hiester BG, Crosby KC, Gibson ES, Dell'Acqua ML, Kennedy MJ. Optogenetic Control of Synaptic Composition and Function. Neuron. 2017 Feb 08; 93(3):646-660.e5. PMID: 28132827.
      View in: PubMed
    3. Freund RK, Gibson ES, Potter H, Dell'Acqua ML. Inhibition of the Motor Protein Eg5/Kinesin-5 in Amyloid ß-Mediated Impairment of Hippocampal Long-Term Potentiation and Dendritic Spine Loss. Mol Pharmacol. 2016 May; 89(5):552-9. PMID: 26957206; PMCID: PMC4851299 [Available on 05/01/17].
    4. Nieves-Cintrón M, Nystoriak MA, Prada MP, Johnson K, Fayer W, Dell'Acqua ML, Scott JD, Navedo MF. Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes. J Biol Chem. 2016 Mar 04; 291(10):4912. PMID: 26945093; PMCID: PMC4777829.
    5. Sanderson JL, Gorski JA, Dell'Acqua ML. NMDA Receptor-Dependent LTD Requires Transient Synaptic Incorporation of Ca²?-Permeable AMPARs Mediated by AKAP150-Anchored PKA and Calcineurin. Neuron. 2016 Mar 02; 89(5):1000-15. PMID: 26938443; PMCID: PMC4914360 [Available on 03/02/17].
    6. Nieves-Cintrón M, Hirenallur-Shanthappa D, Nygren PJ, Hinke SA, Dell'Acqua ML, Langeberg LK, Navedo M, Santana LF, Scott JD. AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K(+) currents in ventricular myocytes following myocardial infarction. Cell Signal. 2016 07; 28(7):733-40. PMID: 26724383; PMCID: PMC4902329 [Available on 07/01/17].
    7. Woolfrey KM, Dell'Acqua ML. Coordination of Protein Phosphorylation and Dephosphorylation in Synaptic Plasticity. J Biol Chem. 2015 Nov 27; 290(48):28604-12. PMID: 26453308; PMCID: PMC4661375 [Available on 11/27/16].
    8. Yu T, Taussig MD, DiPatrizio NV, Astarita G, Piomelli D, Bergman BC, Dell'Acqua ML, Eckel RH, Wang H. Deficiency of Lipoprotein Lipase in Neurons Decreases AMPA Receptor Phosphorylation and Leads to Neurobehavioral Abnormalities in Mice. PLoS One. 2015; 10(8):e0135113. PMID: 26263173; PMCID: PMC4532501.
    9. Samelson BK, Gore BB, Whiting JL, Nygren PJ, Purkey AM, Colledge M, Langeberg LK, Dell'Acqua ML, Zweifel LS, Scott JD. A-kinase Anchoring Protein 79/150 Recruits Protein Kinase C to Phosphorylate Roundabout Receptors. J Biol Chem. 2015 May 29; 290(22):14107-19. PMID: 25882844; PMCID: PMC4447981.
    10. Nieves-Cintrón M, Nystoriak MA, Prada MP, Johnson K, Fayer W, Dell'Acqua ML, Scott JD, Navedo MF. Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes. J Biol Chem. 2015 Mar 20; 290(12):7918-29. PMID: 25670860; PMCID: PMC4367290.
    11. Woolfrey KM, Sanderson JL, Dell'Acqua ML. The palmitoyl acyltransferase DHHC2 regulates recycling endosome exocytosis and synaptic potentiation through palmitoylation of AKAP79/150. J Neurosci. 2015 Jan 14; 35(2):442-56. PMID: 25589740; PMCID: PMC4293401.
    12. Murphy JG, Sanderson JL, Gorski JA, Scott JD, Catterall WA, Sather WA, Dell'Acqua ML. AKAP-anchored PKA maintains neuronal L-type calcium channel activity and NFAT transcriptional signaling. Cell Rep. 2014 Jun 12; 7(5):1577-1588. PMID: 24835999; PMCID: PMC4136445.
    13. Dittmer PJ, Dell'Acqua ML, Sather WA. Ca2+/calcineurin-dependent inactivation of neuronal L-type Ca2+ channels requires priming by AKAP-anchored protein kinase A. Cell Rep. 2014 Jun 12; 7(5):1410-1416. PMID: 24835998; PMCID: PMC4164350.
    14. Corser-Jensen CE, Goodell DJ, Freund RK, Serbedzija P, Murphy RC, Farias SE, Dell'Acqua ML, Frey LC, Serkova N, Heidenreich KA. Blocking leukotriene synthesis attenuates the pathophysiology of traumatic brain injury and associated cognitive deficits. Exp Neurol. 2014 Jun; 256:7-16. PMID: 24681156; PMCID: PMC4731038.
    15. Coultrap SJ, Freund RK, O'Leary H, Sanderson JL, Roche KW, Dell'Acqua ML, Bayer KU. Autonomous CaMKII mediates both LTP and LTD using a mechanism for differential substrate site selection. Cell Rep. 2014 Feb 13; 6(3):431-7. PMID: 24485660; PMCID: PMC3930569.
    16. Nystoriak MA, Nieves-Cintrón M, Nygren PJ, Hinke SA, Nichols CB, Chen CY, Puglisi JL, Izu LT, Bers DM, Dell'acqua ML, Scott JD, Santana LF, Navedo MF. AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus. Circ Res. 2014 Feb 14; 114(4):607-15. PMID: 24323672; PMCID: PMC3954117.
    17. Oliveria SF, Dittmer PJ, Youn DH, Dell'Acqua ML, Sather WA. Localized calcineurin confers Ca2+-dependent inactivation on neuronal L-type Ca2+ channels. J Neurosci. 2012 Oct 31; 32(44):15328-37. PMID: 23115171; PMCID: PMC3593728.
    18. Sanderson JL, Gorski JA, Gibson ES, Lam P, Freund RK, Chick WS, Dell'Acqua ML. AKAP150-anchored calcineurin regulates synaptic plasticity by limiting synaptic incorporation of Ca2+-permeable AMPA receptors. J Neurosci. 2012 Oct 24; 32(43):15036-52. PMID: 23100425; PMCID: PMC3504485.
    19. Hinke SA, Navedo MF, Ulman A, Whiting JL, Nygren PJ, Tian G, Jimenez-Caliani AJ, Langeberg LK, Cirulli V, Tengholm A, Dell'Acqua ML, Santana LF, Scott JD. Anchored phosphatases modulate glucose homeostasis. EMBO J. 2012 Oct 17; 31(20):3991-4004. PMID: 22940692; PMCID: PMC3474922.
    20. Keith DJ, Sanderson JL, Gibson ES, Woolfrey KM, Robertson HR, Olszewski K, Kang R, El-Husseini A, Dell'acqua ML. Palmitoylation of A-kinase anchoring protein 79/150 regulates dendritic endosomal targeting and synaptic plasticity mechanisms. J Neurosci. 2012 May 23; 32(21):7119-36. PMID: 22623657; PMCID: PMC3367663.
    21. Li H, Pink MD, Murphy JG, Stein A, Dell'Acqua ML, Hogan PG. Balanced interactions of calcineurin with AKAP79 regulate Ca2+-calcineurin-NFAT signaling. Nat Struct Mol Biol. 2012 Feb 19; 19(3):337-45. PMID: 22343722; PMCID: PMC3294036.
    22. Brandao KE, Dell'Acqua ML, Levinson SR. A-kinase anchoring protein 150 expression in a specific subset of TRPV1- and CaV 1.2-positive nociceptive rat dorsal root ganglion neurons. J Comp Neurol. 2012 Jan 01; 520(1):81-99. PMID: 21674494; PMCID: PMC4807902.
    23. Sanderson JL, Dell'Acqua ML. AKAP signaling complexes in regulation of excitatory synaptic plasticity. Neuroscientist. 2011 Jun; 17(3):321-36. PMID: 21498812; PMCID: PMC3126619.
    24. Lin L, Sun W, Kung F, Dell'Acqua ML, Hoffman DA. AKAP79/150 impacts intrinsic excitability of hippocampal neurons through phospho-regulation of A-type K+ channel trafficking. J Neurosci. 2011 Jan 26; 31(4):1323-32. PMID: 21273417; PMCID: PMC3035425.
    25. Buard I, Coultrap SJ, Freund RK, Lee YS, Dell'Acqua ML, Silva AJ, Bayer KU. CaMKII "autonomy" is required for initiating but not for maintaining neuronal long-term information storage. J Neurosci. 2010 Jun 16; 30(24):8214-20. PMID: 20554872; PMCID: PMC2891520.
    26. Coultrap SJ, Buard I, Kulbe JR, Dell'Acqua ML, Bayer KU. CaMKII autonomy is substrate-dependent and further stimulated by Ca2+/calmodulin. J Biol Chem. 2010 Jun 04; 285(23):17930-7. PMID: 20353941; PMCID: PMC2878555.
    27. Clapp P, Gibson ES, Dell'acqua ML, Hoffman PL. Phosphorylation regulates removal of synaptic N-methyl-D-aspartate receptors after withdrawal from chronic ethanol exposure. J Pharmacol Exp Ther. 2010 Mar; 332(3):720-9. PMID: 20008487; PMCID: PMC2835432.
    28. Robertson HR, Gibson ES, Benke TA, Dell'Acqua ML. Regulation of postsynaptic structure and function by an A-kinase anchoring protein-membrane-associated guanylate kinase scaffolding complex. J Neurosci. 2009 Jun 17; 29(24):7929-43. PMID: 19535604; PMCID: PMC2716089.
    29. Oliveria SF, Dell'Acqua ML, Sather WA. AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling. Neuron. 2007 Jul 19; 55(2):261-75. PMID: 17640527; PMCID: PMC2698451.
    30. Horne EA, Dell'Acqua ML. Phospholipase C is required for changes in postsynaptic structure and function associated with NMDA receptor-dependent long-term depression. J Neurosci. 2007 Mar 28; 27(13):3523-34. PMID: 17392468.
      View in: PubMed
    31. Shcherbakova OG, Hurt CM, Xiang Y, Dell'Acqua ML, Zhang Q, Tsien RW, Kobilka BK. Organization of beta-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes. J Cell Biol. 2007 Feb 12; 176(4):521-33. PMID: 17296797; PMCID: PMC2063986.
    32. Altamura C, Dell'Acqua ML, Moessner R, Murphy DL, Lesch KP, Persico AM. Altered neocortical cell density and layer thickness in serotonin transporter knockout mice: a quantitation study. Cereb Cortex. 2007 Jun; 17(6):1394-401. PMID: 16905592.
      View in: PubMed
    33. Smith KE, Gibson ES, Dell'Acqua ML. cAMP-dependent protein kinase postsynaptic localization regulated by NMDA receptor activation through translocation of an A-kinase anchoring protein scaffold protein. J Neurosci. 2006 Mar 01; 26(9):2391-402. PMID: 16510716.
      View in: PubMed
    34. Dell'Acqua ML, Smith KE, Gorski JA, Horne EA, Gibson ES, Gomez LL. Regulation of neuronal PKA signaling through AKAP targeting dynamics. Eur J Cell Biol. 2006 Jul; 85(7):627-33. PMID: 16504338.
      View in: PubMed
    35. Gorski JA, Gomez LL, Scott JD, Dell'Acqua ML. Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells. Mol Biol Cell. 2005 Aug; 16(8):3574-90. PMID: 15930126; PMCID: PMC1182299.
    36. Uhlik MT, Abell AN, Johnson NL, Sun W, Cuevas BD, Lobel-Rice KE, Horne EA, Dell'Acqua ML, Johnson GL. Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock. Nat Cell Biol. 2003 Dec; 5(12):1104-10. PMID: 14634666.
      View in: PubMed
    37. Oliveria SF, Gomez LL, Dell'Acqua ML. Imaging kinase--AKAP79--phosphatase scaffold complexes at the plasma membrane in living cells using FRET microscopy. J Cell Biol. 2003 Jan 06; 160(1):101-12. PMID: 12507994; PMCID: PMC2172743.
    38. Dell'Acqua ML, Dodge KL, Tavalin SJ, Scott JD. Mapping the protein phosphatase-2B anchoring site on AKAP79. Binding and inhibition of phosphatase activity are mediated by residues 315-360. J Biol Chem. 2002 Dec 13; 277(50):48796-802. PMID: 12354762; PMCID: PMC3923414.
    39. Gomez LL, Alam S, Smith KE, Horne E, Dell'Acqua ML. Regulation of A-kinase anchoring protein 79/150-cAMP-dependent protein kinase postsynaptic targeting by NMDA receptor activation of calcineurin and remodeling of dendritic actin. J Neurosci. 2002 Aug 15; 22(16):7027-44. PMID: 12177200.
      View in: PubMed
    40. Scott JD, Dell'Acqua ML, Fraser ID, Tavalin SJ, Lester LB. Coordination of cAMP signaling events through PKA anchoring. Adv Pharmacol. 2000; 47:175-207. PMID: 10582087.
      View in: PubMed
    41. Dell'Acqua ML, Faux MC, Thorburn J, Thorburn A, Scott JD. Membrane-targeting sequences on AKAP79 bind phosphatidylinositol-4, 5-bisphosphate. EMBO J. 1998 Apr 15; 17(8):2246-60. PMID: 9545238; PMCID: PMC1170569.
    42. Gao T, Yatani A, Dell'Acqua ML, Sako H, Green SA, Dascal N, Scott JD, Hosey MM. cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits. Neuron. 1997 Jul; 19(1):185-96. PMID: 9247274.
      View in: PubMed
    43. Dell'Acqua ML, Scott JD. Protein kinase A anchoring. J Biol Chem. 1997 May 16; 272(20):12881-4. PMID: 9190362.
      View in: PubMed
    44. Hausken ZE, Dell'Acqua ML, Coghlan VM, Scott JD. Mutational analysis of the A-kinase anchoring protein (AKAP)-binding site on RII. Classification Of side chain determinants for anchoring and isoform selective association with AKAPs. J Biol Chem. 1996 Nov 15; 271(46):29016-22. PMID: 8910553.
      View in: PubMed
    45. Dell'Acqua ML, Carroll RC, Peralta EG. Transfected m2 muscarinic acetylcholine receptors couple to G alpha i2 and G alpha i3 in Chinese hamster ovary cells. Activation and desensitization of the phospholipase C signaling pathway. J Biol Chem. 1993 Mar 15; 268(8):5676-85. PMID: 8449930.
      View in: PubMed
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