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Mark L Dell'Acqua

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM - Pharmacology
Phone303/724-3616

    Collapse Research 
    Collapse research activities and funding
    R56NS040701     (DELL'ACQUA, MARK L)Dec 1, 2000 - Apr 30, 2014
    NIH/NINDS
    Regulation of AKAP79 Postsynaptic Targeting and Signaling
    Role: Principal Investigator

    R01NS040701     (DELL'ACQUA, MARK L)Dec 1, 2000 - Jul 31, 2018
    NIH/NINDS
    Regulation of AKAP79 Postsynaptic Targeting and Signaling
    Role: Principal Investigator

    R01MH080291     (DELL'ACQUA, MARK L)Aug 1, 2007 - Jul 31, 2014
    NIH/NIMH
    AKAP Anchored PKA and Calcineurin Regulation of Neuronal L-type Calcium Channels
    Role: Principal Investigator

    R01MH102338     (DELL'ACQUA, MARK L)Dec 1, 2013 - Nov 30, 2018
    NIH/NIMH
    Mechanisms of Neuronal Calcineurin-NFAT Synapse-to-Nucleus Signaling
    Role: Principal Investigator

    R21NS094453     (DELL'ACQUA, MARK L)Jul 1, 2016 - Jun 30, 2018
    NIH/NINDS
    Amyloid Beta Postsynaptic Signaling through AKAP-anchored Calcineurin
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sinnen BL, Bowen AB, Forte JS, Hiester BG, Crosby KC, Gibson ES, Dell'Acqua ML, Kennedy MJ. Optogenetic Control of Synaptic Composition and Function. Neuron. 2017 Feb 08; 93(3):646-660.e5. PMID: 28132827.
      View in: PubMed
    2. Freund RK, Gibson ES, Potter H, Dell'Acqua ML. Inhibition of the Motor Protein Eg5/Kinesin-5 in Amyloid ß-Mediated Impairment of Hippocampal Long-Term Potentiation and Dendritic Spine Loss. Mol Pharmacol. 2016 May; 89(5):552-9. PMID: 26957206.
      View in: PubMed
    3. Nieves-Cintrón M, Nystoriak MA, Prada MP, Johnson K, Fayer W, Dell'Acqua ML, Scott JD, Navedo MF. Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes. J Biol Chem. 2016 Mar 04; 291(10):4912. PMID: 26945093.
      View in: PubMed
    4. Corser-Jensen CE, Goodell DJ, Freund RK, Serbedzija P, Murphy RC, Farias SE, Dell'Acqua ML, Frey LC, Serkova N, Heidenreich KA. Blocking leukotriene synthesis attenuates the pathophysiology of traumatic brain injury and associated cognitive deficits. Exp Neurol. 2014 Jun; 256:7-16. PMID: 24681156.
      View in: PubMed
    5. Oliveria SF, Dittmer PJ, Youn DH, Dell'Acqua ML, Sather WA. Localized calcineurin confers Ca2+-dependent inactivation on neuronal L-type Ca2+ channels. J Neurosci. 2012 Oct 31; 32(44):15328-37. PMID: 23115171.
      View in: PubMed
    6. Sanderson JL, Gorski JA, Gibson ES, Lam P, Freund RK, Chick WS, Dell'Acqua ML. AKAP150-anchored calcineurin regulates synaptic plasticity by limiting synaptic incorporation of Ca2+-permeable AMPA receptors. J Neurosci. 2012 Oct 24; 32(43):15036-52. PMID: 23100425.
      View in: PubMed
    7. Hinke SA, Navedo MF, Ulman A, Whiting JL, Nygren PJ, Tian G, Jimenez-Caliani AJ, Langeberg LK, Cirulli V, Tengholm A, Dell'Acqua ML, Santana LF, Scott JD. Anchored phosphatases modulate glucose homeostasis. EMBO J. 2012 Oct 17; 31(20):3991-4004. PMID: 22940692.
      View in: PubMed
    8. Keith DJ, Sanderson JL, Gibson ES, Woolfrey KM, Robertson HR, Olszewski K, Kang R, El-Husseini A, Dell'acqua ML. Palmitoylation of A-kinase anchoring protein 79/150 regulates dendritic endosomal targeting and synaptic plasticity mechanisms. J Neurosci. 2012 May 23; 32(21):7119-36. PMID: 22623657.
      View in: PubMed
    9. Li H, Pink MD, Murphy JG, Stein A, Dell'Acqua ML, Hogan PG. Balanced interactions of calcineurin with AKAP79 regulate Ca2+-calcineurin-NFAT signaling. Nat Struct Mol Biol. 2012 Feb 19; 19(3):337-45. PMID: 22343722.
      View in: PubMed
    10. Brandao KE, Dell'Acqua ML, Levinson SR. A-kinase anchoring protein 150 expression in a specific subset of TRPV1- and CaV 1.2-positive nociceptive rat dorsal root ganglion neurons. J Comp Neurol. 2012 Jan 01; 520(1):81-99. PMID: 21674494.
      View in: PubMed
    11. Sanderson JL, Dell'Acqua ML. AKAP signaling complexes in regulation of excitatory synaptic plasticity. Neuroscientist. 2011 Jun; 17(3):321-36. PMID: 21498812.
      View in: PubMed
    12. Lin L, Sun W, Kung F, Dell'Acqua ML, Hoffman DA. AKAP79/150 impacts intrinsic excitability of hippocampal neurons through phospho-regulation of A-type K+ channel trafficking. J Neurosci. 2011 Jan 26; 31(4):1323-32. PMID: 21273417.
      View in: PubMed
    13. Buard I, Coultrap SJ, Freund RK, Lee YS, Dell'Acqua ML, Silva AJ, Bayer KU. CaMKII "autonomy" is required for initiating but not for maintaining neuronal long-term information storage. J Neurosci. 2010 Jun 16; 30(24):8214-20. PMID: 20554872.
      View in: PubMed
    14. Coultrap SJ, Buard I, Kulbe JR, Dell'Acqua ML, Bayer KU. CaMKII autonomy is substrate-dependent and further stimulated by Ca2+/calmodulin. J Biol Chem. 2010 Jun 04; 285(23):17930-7. PMID: 20353941.
      View in: PubMed
    15. Clapp P, Gibson ES, Dell'acqua ML, Hoffman PL. Phosphorylation regulates removal of synaptic N-methyl-D-aspartate receptors after withdrawal from chronic ethanol exposure. J Pharmacol Exp Ther. 2010 Mar; 332(3):720-9. PMID: 20008487.
      View in: PubMed
    16. Robertson HR, Gibson ES, Benke TA, Dell'Acqua ML. Regulation of postsynaptic structure and function by an A-kinase anchoring protein-membrane-associated guanylate kinase scaffolding complex. J Neurosci. 2009 Jun 17; 29(24):7929-43. PMID: 19535604.
      View in: PubMed
    17. Oliveria SF, Dell'Acqua ML, Sather WA. AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling. Neuron. 2007 Jul 19; 55(2):261-75. PMID: 17640527.
      View in: PubMed
    18. Horne EA, Dell'Acqua ML. Phospholipase C is required for changes in postsynaptic structure and function associated with NMDA receptor-dependent long-term depression. J Neurosci. 2007 Mar 28; 27(13):3523-34. PMID: 17392468.
      View in: PubMed
    19. Altamura C, Dell'Acqua ML, Moessner R, Murphy DL, Lesch KP, Persico AM. Altered neocortical cell density and layer thickness in serotonin transporter knockout mice: a quantitation study. Cereb Cortex. 2007 Jun; 17(6):1394-401. PMID: 16905592.
      View in: PubMed
    20. Smith KE, Gibson ES, Dell'Acqua ML. cAMP-dependent protein kinase postsynaptic localization regulated by NMDA receptor activation through translocation of an A-kinase anchoring protein scaffold protein. J Neurosci. 2006 Mar 01; 26(9):2391-402. PMID: 16510716.
      View in: PubMed
    21. Dell'Acqua ML, Smith KE, Gorski JA, Horne EA, Gibson ES, Gomez LL. Regulation of neuronal PKA signaling through AKAP targeting dynamics. Eur J Cell Biol. 2006 Jul; 85(7):627-33. PMID: 16504338.
      View in: PubMed
    22. Gorski JA, Gomez LL, Scott JD, Dell'Acqua ML. Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells. Mol Biol Cell. 2005 Aug; 16(8):3574-90. PMID: 15930126.
      View in: PubMed
    23. Oliveria SF, Gomez LL, Dell'Acqua ML. Imaging kinase--AKAP79--phosphatase scaffold complexes at the plasma membrane in living cells using FRET microscopy. J Cell Biol. 2003 Jan 06; 160(1):101-12. PMID: 12507994.
      View in: PubMed
    24. Dell'Acqua ML, Dodge KL, Tavalin SJ, Scott JD. Mapping the protein phosphatase-2B anchoring site on AKAP79. Binding and inhibition of phosphatase activity are mediated by residues 315-360. J Biol Chem. 2002 Dec 13; 277(50):48796-802. PMID: 12354762.
      View in: PubMed
    25. Gomez LL, Alam S, Smith KE, Horne E, Dell'Acqua ML. Regulation of A-kinase anchoring protein 79/150-cAMP-dependent protein kinase postsynaptic targeting by NMDA receptor activation of calcineurin and remodeling of dendritic actin. J Neurosci. 2002 Aug 15; 22(16):7027-44. PMID: 12177200.
      View in: PubMed
    26. Dell'Acqua ML, Faux MC, Thorburn J, Thorburn A, Scott JD. Membrane-targeting sequences on AKAP79 bind phosphatidylinositol-4, 5-bisphosphate. EMBO J. 1998 Apr 15; 17(8):2246-60. PMID: 9545238.
      View in: PubMed
    27. Dell'Acqua ML, Scott JD. Protein kinase A anchoring. J Biol Chem. 1997 May 16; 272(20):12881-4. PMID: 9190362.
      View in: PubMed
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