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Johannes Rudolph

TitleSr Research Associate
InstitutionUniversity of Colorado Boulder
DepartmentBiochemistry
Phone303/492-3545

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rudolph J, Luger K. PARP1 and HPF1 team up to flag down DNA-repair machinery. Nat Struct Mol Biol. 2023 05; 30(5):568-569. PMID: 37161004.
      View in: PubMed
    2. Rudolph J, Luger K. Analyzing PARP1 Activity: Small Molecule Reactants and Attached Chains of Poly (ADP-Ribose). Methods Mol Biol. 2023; 2609:61-73. PMID: 36515829.
      View in: PubMed
    3. Bennett JA, Steward LR, Rudolph J, Voss AP, Aydin H. The structure of the human LACTB filament reveals the mechanisms of assembly and membrane binding. PLoS Biol. 2022 12; 20(12):e3001899. PMID: 36534696.
      View in: PubMed
    4. Mahadevan J, Jha A, Rudolph J, Bowerman S, Narducci D, Hansen AS, Luger K. Dynamics of endogenous PARP1 and PARP2 during DNA damage revealed by live-cell single-molecule imaging. iScience. 2023 Jan 20; 26(1):105779. PMID: 36594010.
      View in: PubMed
    5. Bowerman S, Mahadevan J, Benson P, Rudolph J, Luger K. Automated modeling of protein accumulation at DNA damage sites using qFADD.py. Biol Imaging. 2022; 2. PMID: 36424940.
      View in: PubMed
    6. Lin X, Jiang W, Rudolph J, Lee BJ, Luger K, Zha S. PARP inhibitors trap PARP2 and alter the mode of recruitment of PARP2 at DNA damage sites. Nucleic Acids Res. 2022 04 22; 50(7):3958-3973. PMID: 35349716.
      View in: PubMed
    7. Rudolph J, Jung K, Luger K. Inhibitors of PARP: Number crunching and structure gazing. Proc Natl Acad Sci U S A. 2022 03 15; 119(11):e2121979119. PMID: 35259019.
      View in: PubMed
    8. Rudolph J, Muthurajan UM, Palacio M, Mahadevan J, Roberts G, Erbse AH, Dyer PN, Luger K. The BRCT domain of PARP1 binds intact DNA and mediates intrastrand transfer. Mol Cell. 2021 12 16; 81(24):4994-5006.e5. PMID: 34919819.
      View in: PubMed
    9. Rudolph J, Roberts G, Muthurajan UM, Luger K. HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase. Elife. 2021 03 08; 10. PMID: 33683197.
      View in: PubMed
    10. Rudolph J, Roberts G, Luger K. Histone Parylation factor 1 contributes to the inhibition of PARP1 by cancer drugs. Nat Commun. 2021 02 02; 12(1):736. PMID: 33531508.
      View in: PubMed
    11. Gaullier G, Roberts G, Muthurajan UM, Bowerman S, Rudolph J, Mahadevan J, Jha A, Rae PS, Luger K. Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1. PLoS One. 2020; 15(11):e0240932. PMID: 33141820.
      View in: PubMed
    12. Rudolph J, Luger K. The secret life of histones. Science. 2020 07 03; 369(6499):33. PMID: 32631882.
      View in: PubMed
    13. Rudolph J, Mahadevan J, Luger K. Probing the Conformational Changes Associated with DNA Binding to PARP1. Biochemistry. 2020 06 02; 59(21):2003-2011. PMID: 32357296.
      View in: PubMed
    14. Nakamoto MY, Rudolph J, Wuttke DS, Luger K. Nonspecific Binding of RNA to PARP1 and PARP2 Does Not Lead to Catalytic Activation. Biochemistry. 2019 12 24; 58(51):5107-5111. PMID: 31829559.
      View in: PubMed
    15. Pegram LM, Liddle JC, Xiao Y, Hoh M, Rudolph J, Iverson DB, Vigers GP, Smith D, Zhang H, Wang W, Moffat JG, Ahn NG. Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2. Proc Natl Acad Sci U S A. 2019 07 30; 116(31):15463-15468. PMID: 31311868.
      View in: PubMed
    16. Rudolph J, Luger K. Kinetics of DNA-protein association and dissociation by stopped-flow spectroscopy. Methods Enzymol. 2019; 625:135-156. PMID: 31455524.
      View in: PubMed
    17. Mahadevan J, Rudolph J, Jha A, Tay JW, Dragavon J, Grumstrup EM, Luger K. Q-FADD: A Mechanistic Approach for Modeling the Accumulation of Proteins at Sites of DNA Damage. Biophys J. 2019 06 04; 116(11):2224-2233. PMID: 31109734.
      View in: PubMed
    18. Rudolph J, Mahadevan J, Dyer P, Luger K. Poly(ADP-ribose) polymerase 1 searches DNA via a 'monkey bar' mechanism. Elife. 2018 08 08; 7. PMID: 30088474.
      View in: PubMed
    19. Kitevski-LeBlanc JL, Yuwen T, Dyer PN, Rudolph J, Luger K, Kay LE. Investigating the Dynamics of Destabilized Nucleosomes Using Methyl-TROSY NMR. J Am Chem Soc. 2018 04 11; 140(14):4774-4777. PMID: 29589929.
      View in: PubMed
    20. Rudolph J, Xiao Y, Pardi A, Ahn NG. Slow inhibition and conformation selective properties of extracellular signal-regulated kinase 1 and 2 inhibitors. Biochemistry. 2015 Jan 13; 54(1):22-31. PMID: 25350931.
      View in: PubMed
    21. Rudolph J, Erbse AH, Behlen LS, Copley SD. A radical intermediate in the conversion of pentachlorophenol to tetrachlorohydroquinone by Sphingobium chlorophenolicum. Biochemistry. 2014 Oct 21; 53(41):6539-49. PMID: 25238136.
      View in: PubMed
    22. Yadid I, Rudolph J, Hlouchova K, Copley SD. Sequestration of a highly reactive intermediate in an evolving pathway for degradation of pentachlorophenol. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):E2182-90. PMID: 23676275.
      View in: PubMed
    23. Hlouchova K, Rudolph J, Pietari JM, Behlen LS, Copley SD. Pentachlorophenol hydroxylase, a poorly functioning enzyme required for degradation of pentachlorophenol by Sphingobium chlorophenolicum. Biochemistry. 2012 May 08; 51(18):3848-60. PMID: 22482720.
      View in: PubMed
    24. Rudolph J, Kim J, Copley SD. Multiple turnovers of the nicotino-enzyme PdxB require a-keto acids as cosubstrates. Biochemistry. 2010 Nov 02; 49(43):9249-55. PMID: 20831184.
      View in: PubMed
    25. Chen CY, Willard D, Rudolph J. Redox regulation of SH2-domain-containing protein tyrosine phosphatases by two backdoor cysteines. Biochemistry. 2009 Feb 17; 48(6):1399-409. PMID: 19166311.
      View in: PubMed
    26. Sohn J, Rudolph J. The energetic network of hotspot residues between Cdc25B phosphatase and its protein substrate. J Mol Biol. 2006 Oct 06; 362(5):1060-71. PMID: 16950393.
      View in: PubMed
    27. Kwiek JJ, Haystead TA, Rudolph J. Kinetic mechanism of quinone oxidoreductase 2 and its inhibition by the antimalarial quinolines. Biochemistry. 2004 Apr 20; 43(15):4538-47. PMID: 15078100.
      View in: PubMed
    28. Sohn J, Rudolph J. Catalytic and chemical competence of regulation of cdc25 phosphatase by oxidation/reduction. Biochemistry. 2003 Sep 02; 42(34):10060-70. PMID: 12939134.
      View in: PubMed
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