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Lee Niswander

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
Address2TCH
Children's Hospital
13065 East 17th Avenue
Aurora CO 80045
Phone303 7243790

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wilde JJ, Petersen JR, Niswander L. Genetic, epigenetic, and environmental contributions to neural tube closure. Annu Rev Genet. 2014 Nov 23; 48:583-611.
      View in: PubMed
    2. Hanson MG, Niswander LA. An explant muscle model to examine the refinement of the synaptic landscape. J Neurosci Methods. 2014 Dec 30; 238:95-104.
      View in: PubMed
    3. Hanson MG, Fregoso VL, Vrana JD, Tucker CL, Niswander LA. Peripheral nervous system defects in a mouse model for peroxisomal biogenesis disorders. Dev Biol. 2014 Nov 1; 395(1):84-95.
      View in: PubMed
    4. Apkon SD, Grady R, Hart S, Lee A, McNalley T, Niswander L, Petersen J, Remley S, Rotenstein D, Shurtleff H, Warner M, Walker WO. Advances in the care of children with spina bifida. Adv Pediatr. 2014 Aug; 61(1):33-74.
      View in: PubMed
    5. Chen JF, Zhang Y, Wilde J, Hansen KC, Lai F, Niswander L. Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain size. Nat Commun. 2014; 5:3885.
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    6. Harmacek L, Watkins-Chow DE, Chen J, Jones KL, Pavan WJ, Salbaum JM, Niswander L. A unique missense allele of BAF155, a core BAF chromatin remodeling complex protein, causes neural tube closure defects in mice. Dev Neurobiol. 2014 May; 74(5):483-97.
      View in: PubMed
    7. Feng W, Choi I, Clouthier DE, Niswander L, Williams T. The Ptch1(DL) mouse: a new model to study lambdoid craniosynostosis and basal cell nevus syndrome-associated skeletal defects. Genesis. 2013 Oct; 51(10):677-89.
      View in: PubMed
    8. Parker JJ, Dionne KR, Massarwa R, Klaassen M, Foreman NK, Niswander L, Canoll P, Kleinschmidt-Demasters BK, Waziri A. Gefitinib selectively inhibits tumor cell migration in EGFR-amplified human glioblastoma. Neuro Oncol. 2013 Aug; 15(8):1048-57.
      View in: PubMed
    9. Massarwa R, Ray HJ, Niswander L. Morphogenetic movements in the neural plate and neural tube: mouse. Wiley Interdiscip Rev Dev Biol. 2014 Jan; 3(1):59-68.
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    10. Schnatwinkel C, Niswander L. Multiparametric image analysis of lung-branching morphogenesis. Dev Dyn. 2013 Jun; 242(6):622-37.
      View in: PubMed
    11. Wallingford JB, Niswander LA, Shaw GM, Finnell RH. The continuing challenge of understanding, preventing, and treating neural tube defects. Science. 2013 Mar 1; 339(6123):1222002.
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    12. Zhang Y, Niswander L. Zic2 is required for enteric nervous system development and neurite outgrowth: a mouse model of enteric hyperplasia and dysplasia. Neurogastroenterol Motil. 2013 Jun; 25(6):538-41.
      View in: PubMed
    13. Yates LL, Schnatwinkel C, Hazelwood L, Chessum L, Paudyal A, Hilton H, Romero MR, Wilde J, Bogani D, Sanderson J, Formstone C, Murdoch JN, Niswander LA, Greenfield A, Dean CH. Scribble is required for normal epithelial cell-cell contacts and lumen morphogenesis in the mammalian lung. Dev Biol. 2013 Jan 15; 373(2):267-80.
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    14. Massarwa R, Niswander L. In toto live imaging of mouse morphogenesis and new insights into neural tube closure. Development. 2013 Jan 1; 140(1):226-36.
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    15. Schnatwinkel C, Niswander L. Nubp1 is required for lung branching morphogenesis and distal progenitor cell survival in mice. PLoS One. 2012; 7(9):e44871.
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    16. Zhang Y, Niswander L. Phactr4: a new integrin modulator required for directional migration of enteric neural crest cells. Cell Adh Migr. 2012 Sep-Oct; 6(5):419-23.
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    17. McKean DM, Niswander L. Defects in GPI biosynthesis perturb Cripto signaling during forebrain development in two new mouse models of holoprosencephaly. Biol Open. 2012 Sep 15; 1(9):874-83.
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    18. Ray HJ, Niswander L. Mechanisms of tissue fusion during development. Development. 2012 May; 139(10):1701-11.
      View in: PubMed
    19. Chen J, Lai F, Niswander L. The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling. Genes Dev. 2012 Apr 15; 26(8):803-15.
      View in: PubMed
    20. Zhang Y, Kim TH, Niswander L. Phactr4 regulates directional migration of enteric neural crest through PP1, integrin signaling, and cofilin activity. Genes Dev. 2012 Jan 1; 26(1):69-81.
      View in: PubMed
    21. Marean A, Graf A, Zhang Y, Niswander L. Folic acid supplementation can adversely affect murine neural tube closure and embryonic survival. Hum Mol Genet. 2011 Sep 15; 20(18):3678-83.
      View in: PubMed
    22. Pyrgaki C, Liu A, Niswander L. Grainyhead-like 2 regulates neural tube closure and adhesion molecule expression during neural fold fusion. Dev Biol. 2011 May 1; 353(1):38-49.
      View in: PubMed
    23. Becker-Heck A, Zohn IE, Okabe N, Pollock A, Lenhart KB, Sullivan-Brown J, McSheene J, Loges NT, Olbrich H, Haeffner K, Fliegauf M, Horvath J, Reinhardt R, Nielsen KG, Marthin JK, Baktai G, Anderson KV, Geisler R, Niswander L, Omran H, Burdine RD. The coiled-coil domain containing protein CCDC40 is essential for motile cilia function and left-right axis formation. Nat Genet. 2011 Jan; 43(1):79-84.
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    24. Mao J, McKean DM, Warrier S, Corbin JG, Niswander L, Zohn IE. The iron exporter ferroportin 1 is essential for development of the mouse embryo, forebrain patterning and neural tube closure. Development. 2010 Sep; 137(18):3079-88.
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    25. Hubler M, Niswander LA, Peters J, Sears KE. The developmental reduction of the marsupial coracoid: a case study in Monodelphis domestica. J Morphol. 2010 Jul; 271(7):769-76.
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    26. Pyrgaki C, Trainor P, Hadjantonakis AK, Niswander L. Dynamic imaging of mammalian neural tube closure. Dev Biol. 2010 Aug 15; 344(2):941-7.
      View in: PubMed
    27. Yates LL, Schnatwinkel C, Murdoch JN, Bogani D, Formstone CJ, Townsend S, Greenfield A, Niswander LA, Dean CH. The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis. Hum Mol Genet. 2010 Jun 1; 19(11):2251-67.
      View in: PubMed
    28. Weatherbee SD, Niswander LA, Anderson KV. A mouse model for Meckel syndrome reveals Mks1 is required for ciliogenesis and Hedgehog signaling. Hum Mol Genet. 2009 Dec 1; 18(23):4565-75.
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    29. Hoover AN, Wynkoop A, Zeng H, Jia J, Niswander LA, Liu A. C2cd3 is required for cilia formation and Hedgehog signaling in mouse. Development. 2008 Dec; 135(24):4049-58.
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    30. Niswander L. Methods in avian embryology experimental and molecular manipulation of the embryonic chick limb. Methods Cell Biol. 2008; 87:135-52.
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    31. Sears KE, Goswami A, Flynn JJ, Niswander LA. The correlated evolution of Runx2 tandem repeats, transcriptional activity, and facial length in carnivora. Evol Dev. 2007 Nov-Dec; 9(6):555-65.
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    32. Kim TH, Goodman J, Anderson KV, Niswander L. Phactr4 regulates neural tube and optic fissure closure by controlling PP1-, Rb-, and E2F1-regulated cell-cycle progression. Dev Cell. 2007 Jul; 13(1):87-102.
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    33. Barna M, Niswander L. Visualization of cartilage formation: insight into cellular properties of skeletal progenitors and chondrodysplasia syndromes. Dev Cell. 2007 Jun; 12(6):931-41.
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    34. Zohn IE, Anderson KV, Niswander L. The Hectd1 ubiquitin ligase is required for development of the head mesenchyme and neural tube closure. Dev Biol. 2007 Jun 1; 306(1):208-21.
      View in: PubMed
    35. Zohn IE, De Domenico I, Pollock A, Ward DM, Goodman JF, Liang X, Sanchez AJ, Niswander L, Kaplan J. The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease. Blood. 2007 May 15; 109(10):4174-80.
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    36. Weatherbee SD, Anderson KV, Niswander LA. LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junction. Development. 2006 Dec; 133(24):4993-5000.
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    37. Sears KE, Behringer RR, Rasweiler JJ, Niswander LA. The evolutionary and developmental basis of parallel reduction in mammalian zeugopod elements. Am Nat. 2007 Jan; 169(1):105-17.
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    38. Weatherbee SD, Behringer RR, Rasweiler JJ, Niswander LA. Interdigital webbing retention in bat wings illustrates genetic changes underlying amniote limb diversification. Proc Natl Acad Sci U S A. 2006 Oct 10; 103(41):15103-7.
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    39. Zohn IE, Li Y, Skolnik EY, Anderson KV, Han J, Niswander L. p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation. Cell. 2006 Jun 2; 125(5):957-69.
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    40. Atit R, Sgaier SK, Mohamed OA, Taketo MM, Dufort D, Joyner AL, Niswander L, Conlon RA. Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse. Dev Biol. 2006 Aug 1; 296(1):164-76.
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    41. Sears KE, Behringer RR, Rasweiler JJ, Niswander LA. Development of bat flight: morphologic and molecular evolution of bat wing digits. Proc Natl Acad Sci U S A. 2006 Apr 25; 103(17):6581-6.
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    42. Liu A, Niswander LA. Bone morphogenetic protein signalling and vertebrate nervous system development. Nat Rev Neurosci. 2005 Dec; 6(12):945-54.
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    43. Dean CH, Miller LA, Smith AN, Dufort D, Lang RA, Niswander LA. Canonical Wnt signaling negatively regulates branching morphogenesis of the lung and lacrimal gland. Dev Biol. 2005 Oct 1; 286(1):270-86.
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    44. DiPaola CP, Farmer JC, Manova K, Niswander LA. Molecular signaling in intervertebral disk development. J Orthop Res. 2005 Sep; 23(5):1112-9.
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    45. Timmer J, Chesnutt C, Niswander L. The activin signaling pathway promotes differentiation of dI3 interneurons in the spinal neural tube. Dev Biol. 2005 Sep 1; 285(1):1-10.
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    46. Zohn IE, Anderson KV, Niswander L. Using genomewide mutagenesis screens to identify the genes required for neural tube closure in the mouse. Birth Defects Res A Clin Mol Teratol. 2005 Sep; 73(9):583-90.
      View in: PubMed
    47. Timmer JR, Mak TW, Manova K, Anderson KV, Niswander L. Tissue morphogenesis and vascular stability require the Frem2 protein, product of the mouse myelencephalic blebs gene. Proc Natl Acad Sci U S A. 2005 Aug 16; 102(33):11746-50.
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    48. Barna M, Pandolfi PP, Niswander L. Gli3 and Plzf cooperate in proximal limb patterning at early stages of limb development. Nature. 2005 Jul 14; 436(7048):277-81.
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    49. Cretekos CJ, Weatherbee SD, Chen CH, Badwaik NK, Niswander L, Behringer RR, Rasweiler JJ. Embryonic staging system for the short-tailed fruit bat, Carollia perspicillata, a model organism for the mammalian order Chiroptera, based upon timed pregnancies in captive-bred animals. Dev Dyn. 2005 Jul; 233(3):721-38.
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    50. Liu A, Wang B, Niswander LA. Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development. 2005 Jul; 132(13):3103-11.
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    51. Chesnutt C, Burrus LW, Brown AM, Niswander L. Coordinate regulation of neural tube patterning and proliferation by TGFbeta and WNT activity. Dev Biol. 2004 Oct 15; 274(2):334-47.
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    52. Chesnutt C, Niswander L. Plasmid-based short-hairpin RNA interference in the chicken embryo. Genesis. 2004 Jun; 39(2):73-8.
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    53. Niemann S, Zhao C, Pascu F, Stahl U, Aulepp U, Niswander L, Weber JL, Müller U. Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family. Am J Hum Genet. 2004 Mar; 74(3):558-63.
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    54. Rouzankina I, Abate-Shen C, Niswander L. Dlx genes integrate positive and negative signals during feather bud development. Dev Biol. 2004 Jan 1; 265(1):219-33.
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    55. Holmes G, Crooijmans R, Groenen M, Niswander L. ALC (adjacent to LMX1 in chick) is a novel dorsal limb mesenchyme marker. Gene Expr Patterns. 2003 Dec; 3(6):735-41.
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    56. Huangfu D, Liu A, Rakeman AS, Murcia NS, Niswander L, Anderson KV. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature. 2003 Nov 6; 426(6962):83-7.
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    57. Liu A, Li JY, Bromleigh C, Lao Z, Niswander LA, Joyner AL. FGF17b and FGF18 have different midbrain regulatory properties from FGF8b or activated FGF receptors. Development. 2003 Dec; 130(25):6175-85.
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    58. Zohn IE, Chesnutt CR, Niswander L. Cell polarity pathways converge and extend to regulate neural tube closure. Trends Cell Biol. 2003 Sep; 13(9):451-4.
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    59. Niswander L. Pattern formation: old models out on a limb. Nat Rev Genet. 2003 Feb; 4(2):133-43.
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    60. Atit R, Conlon RA, Niswander L. EGF signaling patterns the feather array by promoting the interbud fate. Dev Cell. 2003 Feb; 4(2):231-40.
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    61. Niswander L, Anderson KV. Hopeful monsters and morphogens at the beach. Nat Cell Biol. 2002 Nov; 4(11):E259-62.
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    62. Timmer JR, Wang C, Niswander L. BMP signaling patterns the dorsal and intermediate neural tube via regulation of homeobox and helix-loop-helix transcription factors. Development. 2002 May; 129(10):2459-72.
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    63. Niswander L. Interplay between the molecular signals that control vertebrate limb development. Int J Dev Biol. 2002; 46(7):877-81.
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    64. Pizette S, Abate-Shen C, Niswander L. BMP controls proximodistal outgrowth, via induction of the apical ectodermal ridge, and dorsoventral patterning in the vertebrate limb. Development. 2001 Nov; 128(22):4463-74.
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    65. Holmes G, Niswander L. Expression of slit-2 and slit-3 during chick development. Dev Dyn. 2001 Oct; 222(2):301-7.
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    66. Timmer J, Johnson J, Niswander L. The use of in ovo electroporation for the rapid analysis of neural-specific murine enhancers. Genesis. 2001 Mar; 29(3):123-32.
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    67. Pizette S, Niswander L. Early steps in limb patterning and chondrogenesis. Novartis Found Symp. 2001; 232:23-36; discussion 36-46.
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    68. Barna M, Hawe N, Niswander L, Pandolfi PP. Plzf regulates limb and axial skeletal patterning. Nat Genet. 2000 Jun; 25(2):166-72.
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    69. Pizette S, Niswander L. BMPs are required at two steps of limb chondrogenesis: formation of prechondrogenic condensations and their differentiation into chondrocytes. Dev Biol. 2000 Mar 15; 219(2):237-49.
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    70. Niswander L. Developmental biology. Legs to wings and back again. Nature. 1999 Apr 29; 398(6730):751-2.
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    71. Obara-Ishihara T, Kuhlman J, Niswander L, Herzlinger D. The surface ectoderm is essential for nephric duct formation in intermediate mesoderm. Development. 1999 Mar; 126(6):1103-8.
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    72. Pizette S, Niswander L. BMPs negatively regulate structure and function of the limb apical ectodermal ridge. Development. 1999 Feb; 126(5):883-94.
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    73. Crowe R, Zikherman J, Niswander L. Delta-1 negatively regulates the transition from prehypertrophic to hypertrophic chondrocytes during cartilage formation. Development. 1999 Feb; 126(5):987-98.
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    74. Gibson-Brown JJ, Agulnik SI, Silver LM, Niswander L, Papaioannou VE. Involvement of T-box genes Tbx2-Tbx5 in vertebrate limb specification and development. Development. 1998 Jul; 125(13):2499-509.
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    75. Bushdid PB, Brantley DM, Yull FE, Blaeuer GL, Hoffman LH, Niswander L, Kerr LD. Inhibition of NF-kappaB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis. Nature. 1998 Apr 9; 392(6676):615-8.
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    76. Varley JE, McPherson CE, Zou H, Niswander L, Maxwell GD. Expression of a constitutively active type I BMP receptor using a retroviral vector promotes the development of adrenergic cells in neural crest cultures. Dev Biol. 1998 Apr 1; 196(1):107-18.
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    77. Crowe R, Niswander L. Disruption of scale development by Delta-1 misexpression. Dev Biol. 1998 Mar 1; 195(1):70-4.
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    78. Crowe R, Henrique D, Ish-Horowicz D, Niswander L. A new role for Notch and Delta in cell fate decisions: patterning the feather array. Development. 1998 Feb; 125(4):767-75.
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    79. Yang Y, Drossopoulou G, Chuang PT, Duprez D, Marti E, Bumcrot D, Vargesson N, Clarke J, Niswander L, McMahon A, Tickle C. Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb. Development. 1997 Nov; 124(21):4393-404.
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    80. Zou H, Wieser R, Massagué J, Niswander L. Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage. Genes Dev. 1997 Sep 1; 11(17):2191-203.
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    81. Niswander L. Limb mutants: what can they tell us about normal limb development? Curr Opin Genet Dev. 1997 Aug; 7(4):530-6.
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    82. Zou H, Choe KM, Lu Y, Massagué J, Niswander L. BMP signaling and vertebrate limb development. Cold Spring Harb Symp Quant Biol. 1997; 62:269-72.
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    83. Kuhlman J, Niswander L. Limb deformity proteins: role in mesodermal induction of the apical ectodermal ridge. Development. 1997 Jan; 124(1):133-9.
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    84. Niswander L. Growth factor interactions in limb development. Ann N Y Acad Sci. 1996 Jun 8; 785:23-6.
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    85. Zou H, Niswander L. Requirement for BMP signaling in interdigital apoptosis and scale formation. Science. 1996 May 3; 272(5262):738-41.
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    86. Vogel A, Roberts-Clarke D, Niswander L. Effect of FGF on gene expression in chick limb bud cells in vivo and in vitro. Dev Biol. 1995 Oct; 171(2):507-20.
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    87. Yang Y, Niswander L. Interaction between the signaling molecules WNT7a and SHH during vertebrate limb development: dorsal signals regulate anteroposterior patterning. Cell. 1995 Mar 24; 80(6):939-47.
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    88. Niswander L, Jeffrey S, Martin GR, Tickle C. A positive feedback loop coordinates growth and patterning in the vertebrate limb. Nature. 1994 Oct 13; 371(6498):609-12.
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    89. Niswander L, Tickle C, Vogel A, Booth I, Martin GR. FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb. Cell. 1993 Nov 5; 75(3):579-87.
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    90. Niswander L, Martin GR. FGF-4 regulates expression of Evx-1 in the developing mouse limb. Development. 1993 Sep; 119(1):287-94.
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    91. Niswander L, Martin GR. FGF-4 and BMP-2 have opposite effects on limb growth. Nature. 1993 Jan 7; 361(6407):68-71.
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    92. Niswander L, Martin GR. Mixed signals from the AER: FGF-4 and Bmp-2 have opposite effects on limb growth. Prog Clin Biol Res. 1993; 383B:625-33.
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    93. Hollingsworth RE, Ostroff RM, Klein MB, Niswander LA, Sclafani RA. Molecular genetic studies of the Cdc7 protein kinase and induced mutagenesis in yeast. Genetics. 1992 Sep; 132(1):53-62.
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    94. Niswander L, Martin GR. Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse. Development. 1992 Mar; 114(3):755-68.
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    95. Niswander L, Yee D, Rinchik EM, Russell LB, Magnuson T. The albino-deletion complex in the mouse defines genes necessary for development of embryonic and extraembryonic ectoderm. Development. 1989 Jan; 105(1):175-82.
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    96. Niswander L, Yee D, Rinchik EM, Russell LB, Magnuson T. The albino deletion complex and early postimplantation survival in the mouse. Development. 1988 Jan; 102(1):45-53.
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