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Lee Niswander

TitlePrincipal Investigator
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
Address2TCH
Children's Hospital
13065 East 17th Avenue

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Parker JJ, Dionne KR, Massarwa R, Klaassen M, Foreman NK, Niswander L, Canoll P, Kleinschmidt-Demasters BK, Waziri A. Gefitinib selectively inhibits tumor cell migration in EGFR-amplified human glioblastoma. Neuro Oncol. 2013 Aug; 15(8):1048-57.
    View in: PubMed
  2. Schnatwinkel C, Niswander L. Multiparametric image analysis of lung-branching morphogenesis. Dev Dyn. 2013 Jun; 242(6):622-37.
    View in: PubMed
  3. Wallingford JB, Niswander LA, Shaw GM, Finnell RH. The continuing challenge of understanding, preventing, and treating neural tube defects. Science. 2013 Mar 1; 339(6123):1222002.
    View in: PubMed
  4. Yates LL, Schnatwinkel C, Hazelwood L, Chessum L, Paudyal A, Hilton H, Romero MR, Wilde J, Bogani D, Sanderson J, Formstone C, Murdoch JN, Niswander LA, Greenfield A, Dean CH. Scribble is required for normal epithelial cell-cell contacts and lumen morphogenesis in the mammalian lung. Dev Biol. 2013 Jan 15; 373(2):267-80.
    View in: PubMed
  5. Massarwa R, Niswander L. In toto live imaging of mouse morphogenesis and new insights into neural tube closure. Development. 2013 Jan; 140(1):226-36.
    View in: PubMed
  6. Schnatwinkel C, Niswander L. Nubp1 is required for lung branching morphogenesis and distal progenitor cell survival in mice. PLoS One. 2012; 7(9):e44871.
    View in: PubMed
  7. Zhang Y, Niswander L. Phactr4: A new integrin modulator required for directional migration of enteric neural crest cells. Cell Adh Migr. 2012 Sep 1; 6(5):419-23.
    View in: PubMed
  8. McKean DM, Niswander L. Defects in GPI biosynthesis perturb Cripto signaling during forebrain development in two new mouse models of holoprosencephaly. Biol Open. 2012 Sep 15; 1(9):874-83.
    View in: PubMed
  9. Ray HJ, Niswander L. Mechanisms of tissue fusion during development. Development. 2012 May; 139(10):1701-11.
    View in: PubMed
  10. Chen J, Lai F, Niswander L. The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling. Genes Dev. 2012 Apr 15; 26(8):803-15.
    View in: PubMed
  11. Zhang Y, Kim TH, Niswander L. Phactr4 regulates directional migration of enteric neural crest through PP1, integrin signaling, and cofilin activity. Genes Dev. 2012 Jan 1; 26(1):69-81.
    View in: PubMed
  12. Marean A, Graf A, Zhang Y, Niswander L. Folic acid supplementation can adversely affect murine neural tube closure and embryonic survival. Hum Mol Genet. 2011 Sep 15; 20(18):3678-83.
    View in: PubMed
  13. Pyrgaki C, Liu A, Niswander L. Grainyhead-like 2 regulates neural tube closure and adhesion molecule expression during neural fold fusion. Dev Biol. 2011 May 1; 353(1):38-49.
    View in: PubMed
  14. Becker-Heck A, Zohn IE, Okabe N, Pollock A, Lenhart KB, Sullivan-Brown J, McSheene J, Loges NT, Olbrich H, Haeffner K, Fliegauf M, Horvath J, Reinhardt R, Nielsen KG, Marthin JK, Baktai G, Anderson KV, Geisler R, Niswander L, Omran H, Burdine RD. The coiled-coil domain containing protein CCDC40 is essential for motile cilia function and left-right axis formation. Nat Genet. 2011 Jan; 43(1):79-84.
    View in: PubMed
  15. Mao J, McKean DM, Warrier S, Corbin JG, Niswander L, Zohn IE. The iron exporter ferroportin 1 is essential for development of the mouse embryo, forebrain patterning and neural tube closure. Development. 2010 Sep; 137(18):3079-88.
    View in: PubMed
  16. Hubler M, Niswander LA, Peters J, Sears KE. The developmental reduction of the marsupial coracoid: a case study in Monodelphis domestica. J Morphol. 2010 Jul; 271(7):769-76.
    View in: PubMed
  17. Pyrgaki C, Trainor P, Hadjantonakis AK, Niswander L. Dynamic imaging of mammalian neural tube closure. Dev Biol. 2010 Aug 15; 344(2):941-7.
    View in: PubMed
  18. Yates LL, Schnatwinkel C, Murdoch JN, Bogani D, Formstone CJ, Townsend S, Greenfield A, Niswander LA, Dean CH. The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis. Hum Mol Genet. 2010 Jun 1; 19(11):2251-67.
    View in: PubMed
  19. Weatherbee SD, Niswander LA, Anderson KV. A mouse model for Meckel syndrome reveals Mks1 is required for ciliogenesis and Hedgehog signaling. Hum Mol Genet. 2009 Dec 1; 18(23):4565-75.
    View in: PubMed
  20. Hoover AN, Wynkoop A, Zeng H, Jia J, Niswander LA, Liu A. C2cd3 is required for cilia formation and Hedgehog signaling in mouse. Development. 2008 Dec; 135(24):4049-58.
    View in: PubMed
  21. Niswander L. Methods in avian embryology experimental and molecular manipulation of the embryonic chick limb. Methods Cell Biol. 2008; 87:135-52.
    View in: PubMed
  22. Kim TH, Goodman J, Anderson KV, Niswander L. Phactr4 regulates neural tube and optic fissure closure by controlling PP1-, Rb-, and E2F1-regulated cell-cycle progression. Dev Cell. 2007 Jul; 13(1):87-102.
    View in: PubMed
  23. Barna M, Niswander L. Visualization of cartilage formation: insight into cellular properties of skeletal progenitors and chondrodysplasia syndromes. Dev Cell. 2007 Jun; 12(6):931-41.
    View in: PubMed
  24. Zohn IE, Anderson KV, Niswander L. The Hectd1 ubiquitin ligase is required for development of the head mesenchyme and neural tube closure. Dev Biol. 2007 Jun 1; 306(1):208-21.
    View in: PubMed
  25. Zohn IE, De Domenico I, Pollock A, Ward DM, Goodman JF, Liang X, Sanchez AJ, Niswander L, Kaplan J. The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease. Blood. 2007 May 15; 109(10):4174-80.
    View in: PubMed
  26. Weatherbee SD, Anderson KV, Niswander LA. LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junction. Development. 2006 Dec; 133(24):4993-5000.
    View in: PubMed
  27. Sears KE, Behringer RR, Rasweiler JJ, Niswander LA. The evolutionary and developmental basis of parallel reduction in mammalian zeugopod elements. Am Nat. 2007 Jan; 169(1):105-17.
    View in: PubMed
  28. Weatherbee SD, Behringer RR, Rasweiler JJ, Niswander LA. Interdigital webbing retention in bat wings illustrates genetic changes underlying amniote limb diversification. Proc Natl Acad Sci U S A. 2006 Oct 10; 103(41):15103-7.
    View in: PubMed
  29. Zohn IE, Li Y, Skolnik EY, Anderson KV, Han J, Niswander L. p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation. Cell. 2006 Jun 2; 125(5):957-69.
    View in: PubMed
  30. Atit R, Sgaier SK, Mohamed OA, Taketo MM, Dufort D, Joyner AL, Niswander L, Conlon RA. Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse. Dev Biol. 2006 Aug 1; 296(1):164-76.
    View in: PubMed
  31. Sears KE, Behringer RR, Rasweiler JJ, Niswander LA. Development of bat flight: morphologic and molecular evolution of bat wing digits. Proc Natl Acad Sci U S A. 2006 Apr 25; 103(17):6581-6.
    View in: PubMed
  32. Liu A, Niswander LA. Bone morphogenetic protein signalling and vertebrate nervous system development. Nat Rev Neurosci. 2005 Dec; 6(12):945-54.
    View in: PubMed
  33. Dean CH, Miller LA, Smith AN, Dufort D, Lang RA, Niswander LA. Canonical Wnt signaling negatively regulates branching morphogenesis of the lung and lacrimal gland. Dev Biol. 2005 Oct 1; 286(1):270-86.
    View in: PubMed
  34. DiPaola CP, Farmer JC, Manova K, Niswander LA. Molecular signaling in intervertebral disk development. J Orthop Res. 2005 Sep; 23(5):1112-9.
    View in: PubMed
  35. Zohn IE, Anderson KV, Niswander L. Using genomewide mutagenesis screens to identify the genes required for neural tube closure in the mouse. Birth Defects Res A Clin Mol Teratol. 2005 Sep; 73(9):583-90.
    View in: PubMed
  36. Timmer J, Chesnutt C, Niswander L. The activin signaling pathway promotes differentiation of dI3 interneurons in the spinal neural tube. Dev Biol. 2005 Sep 1; 285(1):1-10.
    View in: PubMed
  37. Timmer JR, Mak TW, Manova K, Anderson KV, Niswander L. Tissue morphogenesis and vascular stability require the Frem2 protein, product of the mouse myelencephalic blebs gene. Proc Natl Acad Sci U S A. 2005 Aug 16; 102(33):11746-50.
    View in: PubMed
  38. Barna M, Pandolfi PP, Niswander L. Gli3 and Plzf cooperate in proximal limb patterning at early stages of limb development. Nature. 2005 Jul 14; 436(7048):277-81.
    View in: PubMed
  39. Cretekos CJ, Weatherbee SD, Chen CH, Badwaik NK, Niswander L, Behringer RR, Rasweiler JJ. Embryonic staging system for the short-tailed fruit bat, Carollia perspicillata, a model organism for the mammalian order Chiroptera, based upon timed pregnancies in captive-bred animals. Dev Dyn. 2005 Jul; 233(3):721-38.
    View in: PubMed
  40. Liu A, Wang B, Niswander LA. Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development. 2005 Jul; 132(13):3103-11.
    View in: PubMed
  41. Chesnutt C, Burrus LW, Brown AM, Niswander L. Coordinate regulation of neural tube patterning and proliferation by TGFbeta and WNT activity. Dev Biol. 2004 Oct 15; 274(2):334-47.
    View in: PubMed
  42. Chesnutt C, Niswander L. Plasmid-based short-hairpin RNA interference in the chicken embryo. Genesis. 2004 Jun; 39(2):73-8.
    View in: PubMed
  43. Niemann S, Zhao C, Pascu F, Stahl U, Aulepp U, Niswander L, Weber JL, Müller U. Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family. Am J Hum Genet. 2004 Mar; 74(3):558-63.
    View in: PubMed
  44. Rouzankina I, Abate-Shen C, Niswander L. Dlx genes integrate positive and negative signals during feather bud development. Dev Biol. 2004 Jan 1; 265(1):219-33.
    View in: PubMed
  45. Holmes G, Crooijmans R, Groenen M, Niswander L. ALC (adjacent to LMX1 in chick) is a novel dorsal limb mesenchyme marker. Gene Expr Patterns. 2003 Dec; 3(6):735-41.
    View in: PubMed
  46. Huangfu D, Liu A, Rakeman AS, Murcia NS, Niswander L, Anderson KV. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature. 2003 Nov 6; 426(6962):83-7.
    View in: PubMed
  47. Liu A, Li JY, Bromleigh C, Lao Z, Niswander LA, Joyner AL. FGF17b and FGF18 have different midbrain regulatory properties from FGF8b or activated FGF receptors. Development. 2003 Dec; 130(25):6175-85.
    View in: PubMed
  48. Zohn IE, Chesnutt CR, Niswander L. Cell polarity pathways converge and extend to regulate neural tube closure. Trends Cell Biol. 2003 Sep; 13(9):451-4.
    View in: PubMed
  49. Atit R, Conlon RA, Niswander L. EGF signaling patterns the feather array by promoting the interbud fate. Dev Cell. 2003 Feb; 4(2):231-40.
    View in: PubMed
  50. Niswander L. Pattern formation: old models out on a limb. Nat Rev Genet. 2003 Feb; 4(2):133-43.
    View in: PubMed
  51. Niswander L, Anderson KV. Hopeful monsters and morphogens at the beach. Nat Cell Biol. 2002 Nov; 4(11):E259-62.
    View in: PubMed
  52. Timmer JR, Wang C, Niswander L. BMP signaling patterns the dorsal and intermediate neural tube via regulation of homeobox and helix-loop-helix transcription factors. Development. 2002 May; 129(10):2459-72.
    View in: PubMed
  53. Niswander L. Interplay between the molecular signals that control vertebrate limb development. Int J Dev Biol. 2002; 46(7):877-81.
    View in: PubMed
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