 Cyclophilins
"Cyclophilins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of peptidyl-prolyl cis-trans isomerases that bind to CYCLOSPORINS and regulate the IMMUNE SYSTEM. EC 5.2.1.-
| Descriptor ID |
D021983
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| MeSH Number(s) |
D08.811.399.325.500.400.300 D12.776.543.750.705.400.300 D12.776.827.275.300
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| Concept/Terms |
Cyclophilins- Cyclophilins
- Cyclosporin-Binding Proteins
- Cyclosporin Binding Proteins
- Proteins, Cyclosporin-Binding
- Cyclophilin
- Cyclosporin-Binding Protein
- Cyclosporin Binding Protein
- Protein, Cyclosporin-Binding
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Below are MeSH descriptors whose meaning is more general than "Cyclophilins".
Below are MeSH descriptors whose meaning is more specific than "Cyclophilins".
This graph shows the total number of publications written about "Cyclophilins" by people in this website by year, and whether "Cyclophilins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 | | 2004 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2008 | 0 | 1 | 1 | | 2010 | 4 | 0 | 4 | | 2013 | 1 | 0 | 1 | | 2014 | 0 | 1 | 1 | | 2015 | 2 | 1 | 3 | | 2017 | 1 | 0 | 1 | | 2018 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 | | 2022 | 0 | 1 | 1 | | 2023 | 0 | 1 | 1 | | 2024 | 0 | 1 | 1 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cyclophilins" by people in Profiles.
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Flick H, Venbakkam A, Singh PK, Layish B, Huang S-W, Radhakrishnan R, Kvaratskhelia M, Engelman AN, Kane M. Interplay between the cyclophilin homology domain of RANBP2 and MX2 regulates HIV-1 capsid dependencies on nucleoporins. mBio. 2025 Mar 12; 16(3):e0264624.
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Delaunay M, Jebessa ZH, McKinsey TA. Cyclophilin(g) a Knowledge Gap in Heart Failure Pathogenesis. Circ Res. 2024 Sep 13; 135(7):774-776.
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Lee E, Redzic JS, Saviola AJ, Li X, Ebmeier CC, Kutateladze TG, Hansen KC, Zhao R, Ahn N, Sluchanko NN, Eisenmesser E. Molecular insight into the specific interactions of the SARS-Coronavirus-2 nucleocapsid with RNA and host protein. Protein Sci. 2023 04; 32(4):e4603.
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Berthold EJ, Ma-Lauer Y, Chakraborty A, von Brunn B, Hilgendorff A, Hatz R, Behr J, Hausch F, Staab-Weijnitz CA, von Brunn A. Effects of immunophilin inhibitors and non-immunosuppressive analogs on coronavirus replication in human infection models. Front Cell Infect Microbiol. 2022; 12:958634.
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Lloyd NR, Wuttke DS. Cyp33 binds AU-rich RNA motifs via an extended interface that competitively disrupts the gene repressive Cyp33-MLL1 interaction in vitro. PLoS One. 2021; 16(2):e0237956.
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Keogh RA, Zapf RL, Wiemels RE, Wittekind MA, Carroll RK. The Intracellular Cyclophilin PpiB Contributes to the Virulence of Staphylococcus aureus Independently of Its Peptidyl-Prolyl cis/trans Isomerase Activity. Infect Immun. 2018 11; 86(11).
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Klawitter J, Pennington A, Klawitter J, Thurman JM, Christians U. Mitochondrial cyclophilin D ablation is associated with the activation of Akt/p70S6K pathway in the mouse kidney. Sci Rep. 2017 09 05; 7(1):10540.
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Klawitter J, Seres T, Pennington A, Beatty JT, Klawitter J, Christians U. Ablation of Cyclophilin D Results in an Activation of FAK, Akt, and ERK Pathways in the Mouse Heart. J Cell Biochem. 2017 09; 118(9):2933-2940.
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Holliday MJ, Armstrong GS, Eisenmesser EZ. Determination of the Full Catalytic Cycle among Multiple Cyclophilin Family Members and Limitations on the Application of CPMG-RD in Reversible Catalytic Systems. Biochemistry. 2015 Sep 29; 54(38):5815-27.
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Holliday MJ, Camilloni C, Armstrong GS, Isern NG, Zhang F, Vendruscolo M, Eisenmesser EZ. Structure and Dynamics of GeoCyp: A Thermophilic Cyclophilin with a Novel Substrate Binding Mechanism That Functions Efficiently at Low Temperatures. Biochemistry. 2015 May 26; 54(20):3207-17.
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