 Frailty
"Frailty" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A state of increased vulnerability to stressors, following declines in function and reserves across multiple physiologic systems, characterized by MUSCLE WEAKNESS; FATIGUE; slowed motor performance; low physical activity; and unintentional weight loss.
| Descriptor ID |
D000073496
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| MeSH Number(s) |
C23.550.359
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Frailty".
Below are MeSH descriptors whose meaning is more specific than "Frailty".
This graph shows the total number of publications written about "Frailty" by people in this website by year, and whether "Frailty" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 0 | 1 | 1 | | 2017 | 2 | 2 | 4 | | 2018 | 11 | 1 | 12 | | 2019 | 11 | 3 | 14 | | 2020 | 9 | 3 | 12 | | 2021 | 10 | 0 | 10 | | 2022 | 16 | 1 | 17 | | 2023 | 19 | 0 | 19 | | 2024 | 11 | 7 | 18 | | 2025 | 2 | 1 | 3 |
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Below are the most recent publications written about "Frailty" by people in Profiles.
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Peters BA, Xue X, Hanna DB, Wang Y, Wang Z, Sharma A, Floris-Moore M, Konkle-Parker D, Alcaide ML, Sheth AN, Topper EF, Weber KM, Tien PC, Merenstein D, V?squez E, Chen Y, Mimiaga MJ, Stosor V, Brown TT, Erlandson KM, Dillon SM, Elsayed NS, Usyk M, Sollecito CC, Kaplan RC, Burk RD, Qi Q. Healthy Aging and the Gut Microbiome in People With and Without HIV. J Infect Dis. 2025 Apr 15; 231(4):981-992.
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Witham MD, McDonald C, Wilson N, Rennie KJ, Bardgett M, Bradley P, Clegg AP, Connolly S, Hancock H, Hiu S, Nicholson K, Robertson L, Simms L, Steel AJ, Steves CJ, Storey B, Wason J, von Zglinicki T, Sayer AA. Metformin and physical performance in older people with probable sarcopenia and physical prefrailty or frailty in England?(MET-PREVENT): a double-blind, randomised, placebo-controlled trial. Lancet Healthy Longev. 2025 Mar; 6(3):100695.
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Wanigatunga AA, Dong Y, Jin M, Leroux A, Cui E, Zhou X, Zhao A, Schrack JA, Bandeen-Roche K, Walston JD, Xue QL, Lindquist MA, Crainiceanu CM. Moderate-to-Vigorous Physical Activity at any Dose Reduces All-Cause Dementia Risk Regardless of Frailty Status. J Am Med Dir Assoc. 2025 Mar; 26(3):105456.
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Baim-Lance A, Cooley S, Yoo-Jeong M, Ances B, Duque G, Ellis RJ, Flexner C, Pence BW, Plankey M, Mullins JD, Sun J, Thames AD, Margolick JB, Moore DJ, Erlandson KM. Current Challenges, Solutions, and Novel Directions in Research and Clinical Care: Proceedings From the 14th Annual International Workshop on HIV and Aging. J Gerontol A Biol Sci Med Sci. 2024 Dec 11; 80(1).
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Iriarte E, Smyth HL, Schmiege S, Tassiopoulos K, Jankowski CM, Erlandson KM. Predictors of frailty trajectories among people with HIV. AIDS. 2025 Mar 15; 39(4):373-380.
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Yaussy SL, Marklein KE, DeWitte SN, Crews DE. Frailty or resilience? Hazard-based and cumulative phenotype approaches to discerning signals of health inequality in medieval London. Sci Adv. 2024 Nov 15; 10(46):eadq5703.
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Darrah MA, Longtine AG, Greenberg NT, Mahoney SA, Venkatasubramanian R, VanDongen NS, Reisz JA, D'Alessandro A, Seals DR, de Quiros Miranda YB, Clayton ZS. The influence of a human macronutrient-matched diet on phenotypes in old mice. Geroscience. 2025 Apr; 47(2):2293-2308.
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Debroy P, Barrett BW, Erlandson KM, Budoff M, Brown TT, Price JC, Post WS, Stosor V, Skavarca C, D'Souza G, Lake JE. Relationships Between Hepatic Steatosis and Frailty Differ by HIV Serostatus. J Acquir Immune Defic Syndr. 2024 Oct 01; 97(2):165-171.
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Canonico ME, Low Wang CC, Hsia J, Debus ES, Nehler MR, Patel MR, Anand SS, Ycas J, Capell WH, Muehlhofer E, Haskell LP, Berkowitz SD, Bauersachs R, Bonaca MP. Low-Dose Rivaroxaban Plus Aspirin in?Fragile Patients After Lower Extremity?Revascularization. J Am Coll Cardiol. 2024 Aug 27; 84(9):801-811.
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Iriarte E, Cooley S, Wisch J, Erlandson KM, Ances BM, Jankowski C. Area Deprivation Index and Frailty Among Older People With HIV. J Appl Gerontol. 2025 Jan; 44(1):44-51.
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