 Protein Kinase C-alpha
"Protein Kinase C-alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cytoplasmic serine threonine kinase involved in regulating CELL DIFFERENTIATION and CELLULAR PROLIFERATION. Overexpression of this enzyme has been shown to promote PHOSPHORYLATION of BCL-2 PROTO-ONCOGENE PROTEINS and chemoresistance in human acute leukemia cells.
| Descriptor ID |
D051571
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| MeSH Number(s) |
D08.811.913.696.620.682.700.725.100
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| Concept/Terms |
Protein Kinase C-alpha- Protein Kinase C-alpha
- Protein Kinase C(alpha)
- PKC-alpha Serine-Threonine Kinase
- PKC alpha Serine Threonine Kinase
- Serine-Threonine Kinase, PKC-alpha
- Protein Kinase C alpha
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Below are MeSH descriptors whose meaning is more general than "Protein Kinase C-alpha".
Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C-alpha".
This graph shows the total number of publications written about "Protein Kinase C-alpha" by people in this website by year, and whether "Protein Kinase C-alpha" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1996 | 0 | 1 | 1 | | 1997 | 0 | 2 | 2 | | 1998 | 0 | 2 | 2 | | 1999 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2003 | 0 | 3 | 3 | | 2005 | 1 | 1 | 2 | | 2006 | 1 | 0 | 1 | | 2007 | 2 | 2 | 4 | | 2008 | 1 | 1 | 2 | | 2009 | 3 | 0 | 3 | | 2010 | 2 | 3 | 5 | | 2011 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2014 | 2 | 0 | 2 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2021 | 1 | 1 | 2 | | 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Kinase C-alpha" by people in Profiles.
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Black JD, Affandi T, Black AR, Reyland ME. PKCa and PKCd: Friends and Rivals. J Biol Chem. 2022 Aug; 298(8):102194.
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Kakadia J, Biggar K, Jain B, Chen AW, Nygard K, Li C, Nathanielsz PW, Jansson T, Gupta MB. Mechanisms linking hypoxia to phosphorylation of insulin-like growth factor binding protein-1 in baboon fetuses with intrauterine growth restriction and in cell culture. FASEB J. 2021 09; 35(9):e21788.
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Chen AW, Biggar K, Nygard K, Singal S, Zhao T, Li C, Nathanielsz PW, Jansson T, Gupta MB. IGFBP-1 hyperphosphorylation in response to nutrient deprivation is mediated by activation of protein kinase Ca (PKCa). Mol Cell Endocrinol. 2021 10 01; 536:111400.
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Vang A, Clements RT, Chichger H, Kue N, Allawzi A, O'Connell K, Jeong EM, Dudley SC, Sakhatskyy P, Lu Q, Zhang P, Rounds S, Choudhary G. Effect of a7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure. Am J Physiol Lung Cell Mol Physiol. 2017 05 01; 312(5):L748-L759.
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Ziemba BP, Burke JE, Masson G, Williams RL, Falke JJ. Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway. Biophys J. 2016 04 26; 110(8):1811-1825.
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Blount MA, Cipriani P, Redd SK, Ordas RJ, Black LN, Gumina DL, Hoban CA, Klein JD, Sands JM. Activation of protein kinase Ca increases phosphorylation of the UT-A1 urea transporter at serine 494 in the inner medullary collecting duct. Am J Physiol Cell Physiol. 2015 Nov 01; 309(9):C608-15.
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Morrison MM, Young CD, Wang S, Sobolik T, Sanchez VM, Hicks DJ, Cook RS, Brantley-Sieders DM. mTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling Axis. PLoS Genet. 2015 Jul; 11(7):e1005291.
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Li J, Ziemba BP, Falke JJ, Voth GA. Interactions of protein kinase C-a C1A and C1B domains with membranes: a combined computational and experimental study. J Am Chem Soc. 2014 Aug 20; 136(33):11757-66.
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Ziemba BP, Li J, Landgraf KE, Knight JD, Voth GA, Falke JJ. Single-molecule studies reveal a hidden key step in the activation mechanism of membrane-bound protein kinase C-a. Biochemistry. 2014 Mar 18; 53(10):1697-713.
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Griner EM, Churchill ME, Brautigan DL, Theodorescu D. PKCa phosphorylation of RhoGDI2 at Ser31 disrupts interactions with Rac1 and decreases GDI activity. Oncogene. 2013 Feb 21; 32(8):1010-7.
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