 Cathepsins
"Cathepsins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of lysosomal proteinases or endopeptidases found in aqueous extracts of a variety of animal tissues. They function optimally within an acidic pH range. The cathepsins occur as a variety of enzyme subtypes including SERINE PROTEASES; ASPARTIC PROTEINASES; and CYSTEINE PROTEASES.
| Descriptor ID |
D002403
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| MeSH Number(s) |
D08.811.277.656.224
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Cathepsins".
Below are MeSH descriptors whose meaning is more specific than "Cathepsins".
This graph shows the total number of publications written about "Cathepsins" by people in this website by year, and whether "Cathepsins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 1 | 2 | | 1996 | 0 | 1 | 1 | | 1999 | 1 | 0 | 1 | | 2001 | 0 | 2 | 2 | | 2002 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cathepsins" by people in Profiles.
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Reed B, Crawford F, Hill RC, Jin N, White J, Krovi SH, Marrack P, Hansen K, Kappler JW. Lysosomal cathepsin creates chimeric epitopes for diabetogenic CD4 T cells via transpeptidation. J Exp Med. 2021 02 01; 218(2).
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Andrault PM, Schamberger AC, Chazeirat T, Sizaret D, Renault J, Staab-Weijnitz CA, Hennen E, Petit-Courty A, Wartenberg M, Saidi A, Baranek T, Guyetant S, Courty Y, Eickelberg O, Lalmanach G, Lecaille F. Cigarette smoke induces overexpression of active human cathepsin S in lungs from current smokers with or without COPD. Am J Physiol Lung Cell Mol Physiol. 2019 11 01; 317(5):L625-L638.
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Chabaud M, Heuzé ML, Bretou M, Vargas P, Maiuri P, Solanes P, Maurin M, Terriac E, Le Berre M, Lankar D, Piolot T, Adelstein RS, Zhang Y, Sixt M, Jacobelli J, Bénichou O, Voituriez R, Piel M, Lennon-Duménil AM. Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells. Nat Commun. 2015 Jun 25; 6:7526.
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Chuong EB, Tong W, Hoekstra HE. Maternal-fetal conflict: rapidly evolving proteins in the rodent placenta. Mol Biol Evol. 2010 Jun; 27(6):1221-5.
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Harman AN, Kraus M, Bye CR, Byth K, Turville SG, Tang O, Mercier SK, Nasr N, Stern JL, Slobedman B, Driessen C, Cunningham AL. HIV-1-infected dendritic cells show 2 phases of gene expression changes, with lysosomal enzyme activity decreased during the second phase. Blood. 2009 Jul 02; 114(1):85-94.
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Pham L, Purcell P, Morse L, Stashenko P, Battaglino RA. Expression analysis of nha-oc/NHA2: a novel gene selectively expressed in osteoclasts. Gene Expr Patterns. 2007 Oct; 7(8):846-51.
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Vandivier RW, Fadok VA, Ogden CA, Hoffmann PR, Brain JD, Accurso FJ, Fisher JH, Greene KE, Henson PM. Impaired clearance of apoptotic cells from cystic fibrosis airways. Chest. 2002 Mar; 121(3 Suppl):89S.
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Fadok VA, Bratton DL, Guthrie L, Henson PM. Differential effects of apoptotic versus lysed cells on macrophage production of cytokines: role of proteases. J Immunol. 2001 Jun 1; 166(11):6847-54.
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Ebert DH, Wetzel JD, Brumbaugh DE, Chance SR, Stobie LE, Baer GS, Dermody TS. Adaptation of reovirus to growth in the presence of protease inhibitor E64 segregates with a mutation in the carboxy terminus of viral outer-capsid protein sigma3. J Virol. 2001 Apr; 75(7):3197-206.
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Cha JN, Shimizu K, Zhou Y, Christiansen SC, Chmelka BF, Stucky GD, Morse DE. Silicatein filaments and subunits from a marine sponge direct the polymerization of silica and silicones in vitro. Proc Natl Acad Sci U S A. 1999 Jan 19; 96(2):361-5.
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