 Synapses
"Synapses" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.
| Descriptor ID |
D013569
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| MeSH Number(s) |
A08.850 A11.284.149.165.420.780
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Synapses".
Below are MeSH descriptors whose meaning is more specific than "Synapses".
This graph shows the total number of publications written about "Synapses" by people in this website by year, and whether "Synapses" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1993 | 1 | 1 | 2 | | 1994 | 1 | 1 | 2 | | 1995 | 0 | 4 | 4 | | 1996 | 1 | 2 | 3 | | 1997 | 1 | 0 | 1 | | 1998 | 2 | 1 | 3 | | 1999 | 1 | 1 | 2 | | 2000 | 4 | 1 | 5 | | 2001 | 2 | 2 | 4 | | 2002 | 1 | 2 | 3 | | 2003 | 5 | 4 | 9 | | 2004 | 6 | 2 | 8 | | 2005 | 6 | 0 | 6 | | 2006 | 12 | 4 | 16 | | 2007 | 7 | 4 | 11 | | 2008 | 3 | 2 | 5 | | 2009 | 6 | 3 | 9 | | 2010 | 9 | 1 | 10 | | 2011 | 8 | 4 | 12 | | 2012 | 6 | 2 | 8 | | 2013 | 1 | 3 | 4 | | 2014 | 7 | 7 | 14 | | 2015 | 5 | 9 | 14 | | 2016 | 8 | 6 | 14 | | 2017 | 4 | 5 | 9 | | 2018 | 10 | 3 | 13 | | 2019 | 8 | 5 | 13 | | 2020 | 2 | 3 | 5 | | 2021 | 2 | 8 | 10 | | 2022 | 6 | 3 | 9 | | 2023 | 0 | 2 | 2 |
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Below are the most recent publications written about "Synapses" by people in Profiles.
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Rumian NL, Freund RK, Dell'Acqua ML, Coultrap SJ, Bayer KU. Decreased nitrosylation of CaMKII causes aging-associated impairments in memory and synaptic plasticity in mice. Sci Signal. 2023 07 25; 16(795):eade5892.
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Larsen ME, Buonarati OR, Qian H, Hell JW, Bayer KU. Stimulating ?-adrenergic receptors promotes synaptic potentiation by switching CaMKII movement from LTD to LTP mode. J Biol Chem. 2023 06; 299(6):104706.
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Kleinjan MS, Buchta WC, Ogelman R, Hwang IW, Kuwajima M, Hubbard DD, Kareemo DJ, Prikhodko O, Olah SL, Gomez Wulschner LE, Abraham WC, Franco SJ, Harris KM, Oh WC, Kennedy MJ. Dually innervated dendritic spines develop in the absence of excitatory activity and resist plasticity through tonic inhibitory crosstalk. Neuron. 2023 02 01; 111(3):362-371.e6.
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Sanderson JL, Freund RK, Castano AM, Benke TA, Dell'Acqua ML. The CaV1.2 G406R mutation decreases synaptic inhibition and alters L-type Ca2+ channel-dependent LTP at hippocampal synapses in a mouse model of Timothy Syndrome. Neuropharmacology. 2022 12 01; 220:109271.
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Liu X, Hua F, Yang D, Lin Y, Zhang L, Ying J, Sheng H, Wang X. Roles of neuroligins in central nervous system development: focus on glial neuroligins and neuron neuroligins. J Transl Med. 2022 09 10; 20(1):418.
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Thompson SM. Plasticity of synapses and reward circuit function in the genesis and treatment of depression. Neuropsychopharmacology. 2023 Jan; 48(1):90-103.
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Martin SC, Gay SM, Armstrong ML, Pazhayam NM, Reisdorph N, Diering GH. Tonic endocannabinoid signaling supports sleep through development in both sexes. Sleep. 2022 08 11; 45(8).
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Ball JB, Green-Fulgham SM, Watkins LR. Mechanisms of microglia-mediated synapse turnover and synaptogenesis. Prog Neurobiol. 2022 11; 218:102336.
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Cook SG, Rumian NL, Bayer KU. CaMKII T286 phosphorylation has distinct essential functions in three forms of long-term plasticity. J Biol Chem. 2022 09; 298(9):102299.
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Burlingham SR, Wong NF, Peterkin L, Lubow L, Dos Santos Passos C, Benner O, Ghebrial M, Cast TP, Xu-Friedman MA, S?dhof TC, Chanda S. Induction of synapse formation by de novo neurotransmitter synthesis. Nat Commun. 2022 06 01; 13(1):3060.
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