SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage.

Hong X, Liu W, Song R, Shah JJ, Feng X, Tsang CK, Morgan KM, Bunting SF, Inuzuka H, Zheng XF, Shen Z, Sabaawy HE, Liu L, Pine SR. SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage. Nucleic Acids Res. 2016 Oct 14; 44(18):8855-8869.

View in: PubMed

subject areas

Antineoplastic Agents
Cell Cycle Proteins
Cell Death
Cell Line, Tumor
DNA Damage
F-Box Proteins
F-Box-WD Repeat-Containing Protein 7
Glycogen Synthase Kinase 3 beta
Humans
Models, Biological
Phosphorylation
Proteasome Endopeptidase Complex
Protein Binding
Protein Interaction Domains and Motifs
Proteolysis
SOX9 Transcription Factor
Ubiquitination
Ubiquitin-Protein Ligases
Ultraviolet Rays

authors with profiles

Hatim Sabaawy
Sharon Pine