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David L Bain

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOP-Administration
Phone303/724-6118

    Collapse Research 
    Collapse research activities and funding
    R01DK088843     (BAIN, DAVID L)Jul 1, 2010 - Apr 30, 2016
    NIH
    Quantitative Dissection of Steroid Receptor Function
    Role: Principal Investigator
    R21DK071652     (BAIN, DAVID L)Jul 1, 2007 - Jun 30, 2010
    NIH
    Quantitative Analysis of AIB-1 Recruitment
    Role: Principal Investigator
    R01DK061933     (BAIN, DAVID L)Mar 15, 2003 - Jan 31, 2013
    NIH
    Mechanistic Studies of Progesterone Receptor Function
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hopkins MM, Antonopoulos IH, Parupudi A, Bee JS, Bain DL. Comparative Thermodynamics of the Reversible Self-Association of Therapeutic mAbs Reveal Opposing Roles for Linked Proton- and Ion-Binding Events. Pharm Res. 2023 Jun; 40(6):1383-1397. PMID: 36869246.
      View in: PubMed
    2. Hopkins MM, Parupudi A, Bee JS, Bain DL. Energetic Dissection of Mab-Specific Reversible Self-Association Reveals Unique Thermodynamic Signatures. Pharm Res. 2021 Feb; 38(2):243-255. PMID: 33604786.
      View in: PubMed
    3. Hudson WH, Vera IMS, Nwachukwu JC, Weikum ER, Herbst AG, Yang Q, Bain DL, Nettles KW, Kojetin DJ, Ortlund EA. Cryptic glucocorticoid receptor-binding sites pervade genomic NF-?B response elements. Nat Commun. 2018 04 06; 9(1):1337. PMID: 29626214.
      View in: PubMed
    4. Hopkins MM, Lambert CL, Bee JS, Parupudi A, Bain DL. Determination of Interaction Parameters for Reversibly Self-Associating Antibodies: A Comparative Analysis. J Pharm Sci. 2018 07; 107(7):1820-1830. PMID: 29571738.
      View in: PubMed
    5. Quirk S, Hopkins MM, Bureau H, Lusk RJ, Allen C, Hernandez R, Bain DL. Mutational Analysis of Neuropeptide Y Reveals Unusual Thermal Stability Linked to Higher-Order Self-Association. ACS Omega. 2018 Feb 28; 3(2):2141-2154. PMID: 29619413.
      View in: PubMed
    6. Gandhi AV, Pothecary MR, Bain DL, Carpenter JF. Some Lessons Learned From a Comparison Between Sedimentation Velocity Analytical Ultracentrifugation and Size Exclusion Chromatography to Characterize and Quantify Protein Aggregates. J Pharm Sci. 2017 08; 106(8):2178-2186. PMID: 28479353.
      View in: PubMed
    7. Bain DL, Brenowitz M, Roberts CJ. An Opportunity for Industry-Academia Partnership: Training the Next Generation of Industrial Researchers in Characterizing Higher Order Protein Structure. J Pharm Sci. 2016 12; 105(12):3483-3486. PMID: 27671238.
      View in: PubMed
    8. De Angelis RW, Maluf NK, Yang Q, Lambert JR, Bain DL. Glucocorticoid Receptor-DNA Dissociation Kinetics Measured in Vitro Reveal Exchange on the Second Time Scale. Biochemistry. 2015 Sep 01; 54(34):5306-14. PMID: 26267475.
      View in: PubMed
    9. Bain DL, De Angelis RW, Connaghan KD, Yang Q, Degala GD, Lambert JR. Dissecting Steroid Receptor Function by Analytical Ultracentrifugation. Methods Enzymol. 2015; 562:363-89. PMID: 26412661.
      View in: PubMed
    10. Zhao H, Ghirlando R, Alfonso C, Arisaka F, Attali I, Bain DL, Bakhtina MM, Becker DF, Bedwell GJ, Bekdemir A, Besong TM, Birck C, Brautigam CA, Brennerman W, Byron O, Bzowska A, Chaires JB, Chaton CT, C?lfen H, Connaghan KD, Crowley KA, Curth U, Daviter T, Dean WL, D?ez AI, Ebel C, Eckert DM, Eisele LE, Eisenstein E, England P, Escalante C, Fagan JA, Fairman R, Finn RM, Fischle W, de la Torre JG, Gor J, Gustafsson H, Hall D, Harding SE, Cifre JG, Herr AB, Howell EE, Isaac RS, Jao SC, Jose D, Kim SJ, Kokona B, Kornblatt JA, Kosek D, Krayukhina E, Krzizike D, Kusznir EA, Kwon H, Larson A, Laue TM, Le Roy A, Leech AP, Lilie H, Luger K, Luque-Ortega JR, Ma J, May CA, Maynard EL, Modrak-Wojcik A, Mok YF, M?cke N, Nagel-Steger L, Narlikar GJ, Noda M, Nourse A, Obsil T, Park CK, Park JK, Pawelek PD, Perdue EE, Perkins SJ, Perugini MA, Peterson CL, Peverelli MG, Piszczek G, Prag G, Prevelige PE, Raynal BD, Rezabkova L, Richter K, Ringel AE, Rosenberg R, Rowe AJ, Rufer AC, Scott DJ, Seravalli JG, Solovyova AS, Song R, Staunton D, Stoddard C, Stott K, Strauss HM, Streicher WW, Sumida JP, Swygert SG, Szczepanowski RH, Tessmer I, Toth RT, Tripathy A, Uchiyama S, Uebel SF, Unzai S, Gruber AV, von Hippel PH, Wandrey C, Wang SH, Weitzel SE, Wielgus-Kutrowska B, Wolberger C, Wolff M, Wright E, Wu YS, Wubben JM, Schuck P. A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation. PLoS One. 2015; 10(5):e0126420. PMID: 25997164.
      View in: PubMed
    11. Connaghan KD, Yang Q, Miura MT, Moody AD, Bain DL. Homologous steroid receptors assemble at identical promoter architectures with unique energetics of cooperativity. Proteins. 2014 Sep; 82(9):2078-87. PMID: 24648119.
      View in: PubMed
    12. Bain DL, Connaghan KD, Maluf NK, Yang Q, Miura MT, De Angelis RW, Degala GD, Lambert JR. Steroid receptor-DNA interactions: toward a quantitative connection between energetics and transcriptional regulation. Nucleic Acids Res. 2014 Jan; 42(2):691-700. PMID: 24064251.
      View in: PubMed
    13. De Angelis RW, Yang Q, Miura MT, Bain DL. Dissection of androgen receptor-promoter interactions: steroid receptors partition their interaction energetics in parallel with their phylogenetic divergence. J Mol Biol. 2013 Nov 15; 425(22):4223-35. PMID: 23917122.
      View in: PubMed
    14. Connaghan KD, Miura MT, Maluf NK, Lambert JR, Bain DL. Analysis of a glucocorticoid-estrogen receptor chimera reveals that dimerization energetics are under ionic control. Biophys Chem. 2013 Feb; 172:8-17. PMID: 23333595.
      View in: PubMed
    15. Bain DL, Yang Q, Connaghan KD, Robblee JP, Miura MT, Degala GD, Lambert JR, Maluf NK. Glucocorticoid receptor-DNA interactions: binding energetics are the primary determinant of sequence-specific transcriptional activity. J Mol Biol. 2012 Sep 07; 422(1):18-32. PMID: 22698871.
      View in: PubMed
    16. Robblee JP, Miura MT, Bain DL. Glucocorticoid receptor-promoter interactions: energetic dissection suggests a framework for the specificity of steroid receptor-mediated gene regulation. Biochemistry. 2012 Jun 05; 51(22):4463-72. PMID: 22587663.
      View in: PubMed
    17. Cochrane DR, Jacobsen BM, Connaghan KD, Howe EN, Bain DL, Richer JK. Progestin regulated miRNAs that mediate progesterone receptor action in breast cancer. Mol Cell Endocrinol. 2012 May 15; 355(1):15-24. PMID: 22330642.
      View in: PubMed
    18. Moody AD, Miura MT, Connaghan KD, Bain DL. Thermodynamic dissection of estrogen receptor-promoter interactions reveals that steroid receptors differentially partition their self-association and promoter binding energetics. Biochemistry. 2012 Jan 24; 51(3):739-49. PMID: 22201220.
      View in: PubMed
    19. Moody AD, Robblee JP, Bain DL. Dissecting the linkage between transcription factor self-assembly and site-specific DNA binding: the role of the analytical ultracentrifuge. Methods Mol Biol. 2012; 796:187-204. PMID: 22052491.
      View in: PubMed
    20. Connaghan KD, Moody AD, Robblee JP, Lambert JR, Bain DL. From steroid receptors to cytokines: the thermodynamics of self-associating systems. Biophys Chem. 2011 Nov; 159(1):24-32. PMID: 21696881.
      View in: PubMed
    21. Connaghan KD, Heneghan AF, Miura MT, Bain DL. Na(+) and K(+) allosterically regulate cooperative DNA binding by the human progesterone receptor. Biochemistry. 2010 Jan 26; 49(3):422-31. PMID: 20000807.
      View in: PubMed
    22. Connaghan-Jones KD, Bain DL. Using thermodynamics to understand progesterone receptor function: method and theory. Methods Enzymol. 2009; 455:41-70. PMID: 19289202.
      View in: PubMed
    23. Connaghan-Jones KD, Heneghan AF, Miura MT, Bain DL. Thermodynamic dissection of progesterone receptor interactions at the mouse mammary tumor virus promoter: monomer binding and strong cooperativity dominate the assembly reaction. J Mol Biol. 2008 Apr 04; 377(4):1144-60. PMID: 18313072.
      View in: PubMed
    24. Connaghan-Jones KD, Moody AD, Bain DL. Quantitative DNase footprint titration: a tool for analyzing the energetics of protein-DNA interactions. Nat Protoc. 2008; 3(5):900-14. PMID: 18451798.
      View in: PubMed
    25. Heneghan AF, Connaghan-Jones KD, Miura MT, Bain DL. Coactivator assembly at the promoter: efficient recruitment of SRC2 is coupled to cooperative DNA binding by the progesterone receptor. Biochemistry. 2007 Oct 02; 46(39):11023-32. PMID: 17845055.
      View in: PubMed
    26. Connaghan-Jones KD, Heneghan AF, Miura MT, Bain DL. Thermodynamic analysis of progesterone receptor-promoter interactions reveals a molecular model for isoform-specific function. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2187-92. PMID: 17277083.
      View in: PubMed
    27. Bain DL, Heneghan AF, Connaghan-Jones KD, Miura MT. Nuclear receptor structure: implications for function. Annu Rev Physiol. 2007; 69:201-20. PMID: 17137423.
      View in: PubMed
    28. Connaghan-Jones KD, Heneghan AF, Miura MT, Bain DL. Hydrodynamic analysis of the human progesterone receptor A-isoform reveals that self-association occurs in the micromolar range. Biochemistry. 2006 Oct 03; 45(39):12090-9. PMID: 17002309.
      View in: PubMed
    29. Heneghan AF, Connaghan-Jones KD, Miura MT, Bain DL. Cooperative DNA binding by the B-isoform of human progesterone receptor: thermodynamic analysis reveals strongly favorable and unfavorable contributions to assembly. Biochemistry. 2006 Mar 14; 45(10):3285-96. PMID: 16519523.
      View in: PubMed
    30. Heneghan AF, Berton N, Miura MT, Bain DL. Self-association energetics of an intact, full-length nuclear receptor: the B-isoform of human progesterone receptor dimerizes in the micromolar range. Biochemistry. 2005 Jul 12; 44(27):9528-37. PMID: 15996107.
      View in: PubMed
    31. Martin SL, Branciforte D, Keller D, Bain DL. Trimeric structure for an essential protein in L1 retrotransposition. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):13815-20. PMID: 14615577.
      View in: PubMed
    32. Takimoto GS, Tung L, Abdel-Hafiz H, Abel MG, Sartorius CA, Richer JK, Jacobsen BM, Bain DL, Horwitz KB. Functional properties of the N-terminal region of progesterone receptors and their mechanistic relationship to structure. J Steroid Biochem Mol Biol. 2003 Jun; 85(2-5):209-19. PMID: 12943706.
      View in: PubMed
    33. McManaman JL, Bain DL. Structural and conformational analysis of the oxidase to dehydrogenase conversion of xanthine oxidoreductase. J Biol Chem. 2002 Jun 14; 277(24):21261-8. PMID: 11914370.
      View in: PubMed
    34. Bain DL, Franden MA, McManaman JL, Takimoto GS, Horwitz KB. The N-terminal region of human progesterone B-receptors: biophysical and biochemical comparison to A-receptors. J Biol Chem. 2001 Jun 29; 276(26):23825-31. PMID: 11328821.
      View in: PubMed
    35. Bain DL, Berton N, Ortega M, Baran J, Yang Q, Catalano CE. Biophysical characterization of the DNA binding domain of gpNu1, a viral DNA packaging protein. J Biol Chem. 2001 Jun 08; 276(23):20175-81. PMID: 11279084.
      View in: PubMed
    36. Graham JD, Bain DL, Richer JK, Jackson TA, Tung L, Horwitz KB. Thoughts on tamoxifen resistant breast cancer. Are coregulators the answer or just a red herring? J Steroid Biochem Mol Biol. 2000 Nov 30; 74(5):255-9. PMID: 11162933.
      View in: PubMed
    37. Graham JD, Bain DL, Richer JK, Jackson TA, Tung L, Horwitz KB. Nuclear receptor conformation, coregulators, and tamoxifen-resistant breast cancer. Steroids. 2000 Oct-Nov; 65(10-11):579-84. PMID: 11108862.
      View in: PubMed
    38. Bain DL, Franden MA, McManaman JL, Takimoto GS, Horwitz KB. The N-terminal region of the human progesterone A-receptor. Structural analysis and the influence of the DNA binding domain. J Biol Chem. 2000 Mar 10; 275(10):7313-20. PMID: 10702302.
      View in: PubMed
    39. Bain DL, Ackers GK. A quantitative cryogenic gel-shift technique for analysis of protein-DNA binding. Anal Biochem. 1998 May 01; 258(2):240-5. PMID: 9570836.
      View in: PubMed
    40. Jackson TA, Richer JK, Bain DL, Takimoto GS, Tung L, Horwitz KB. The partial agonist activity of antagonist-occupied steroid receptors is controlled by a novel hinge domain-binding coactivator L7/SPA and the corepressors N-CoR or SMRT. Mol Endocrinol. 1997 Jun; 11(6):693-705. PMID: 9171233.
      View in: PubMed
    41. Horwitz KB, Jackson TA, Bain DL, Richer JK, Takimoto GS, Tung L. Nuclear receptor coactivators and corepressors. Mol Endocrinol. 1996 Oct; 10(10):1167-77. PMID: 9121485.
      View in: PubMed
    42. Bain DL, Ackers GK. Self-association and DNA binding of lambda cI repressor N-terminal domains reveal linkage between sequence-specific binding and the C-terminal cooperativity domain. Biochemistry. 1994 Dec 13; 33(49):14679-89. PMID: 7993896.
      View in: PubMed
    43. Koblan KS, Bain DL, Beckett D, Shea MA, Ackers GK. Analysis of site-specific interaction parameters in protein-DNA complexes. Methods Enzymol. 1992; 210:405-25. PMID: 1584044.
      View in: PubMed
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