Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution
Menu

Contact Us
If you have any questions or feedback please contact us.

Joseph Brzezinski

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-OP General Operations
Phone303/724-6959

    Collapse Research 
    Collapse research activities and funding
    R01EY024272     (BRZEZINSKI, JOSEPH A)Apr 1, 2014 - Apr 30, 2028
    NIH
    Mechanisms of cell fate specification and competence regulation in photoreceptors
    Role: Principal Investigator
    F32EY019227     (BRZEZINSKI, JOSEPH ALLAN)Sep 30, 2008 - Sep 29, 2010
    NIH
    Visual regeneration by cone photoreceptor replacement
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Bosze B, Suarez-Navarro J, Cajias I, Brzezinski JA, Brown NL. Not all Notch pathway mutations are equal in the embryonic mouse retina. bioRxiv. 2023 Jan 12. PMID: 36711950.
      View in: PubMed
    2. Bachu VS, Kandoi S, Park KU, Kaufman ML, Schwanke M, Lamba DA, Brzezinski JA. An enhancer located in a Pde6c intron drives transient expression in the cone photoreceptors of developing mouse and human retinas. Dev Biol. 2022 08; 488:131-150. PMID: 35644251.
      View in: PubMed
    3. Kaufman ML, Goodson NB, Park KU, Schwanke M, Office E, Schneider SR, Abraham J, Hensley A, Jones KL, Brzezinski JA. Initiation of Otx2 expression in the developing mouse retina requires a unique enhancer and either Ascl1 or Neurog2 activity. Development. 2021 06 15; 148(12). PMID: 34143204.
      View in: PubMed
    4. Goodson NB, Kaufman MA, Park KU, Brzezinski JA. Simultaneous deletion of Prdm1 and Vsx2 enhancers in the retina alters photoreceptor and bipolar cell fate specification, yet differs from deleting both genes. Development. 2020 07 03; 147(13). PMID: 32541005.
      View in: PubMed
    5. Goodson NB, Park KU, Silver JS, Chiodo VA, Hauswirth WW, Brzezinski JA. Prdm1 overexpression causes a photoreceptor fate-shift in nascent, but not mature, bipolar cells. Dev Biol. 2020 08 15; 464(2):111-123. PMID: 32562755.
      View in: PubMed
    6. Nam MH, Smith AJO, Pantcheva MB, Park KU, Brzezinski JA, Galligan JJ, Fritz K, Wormstone IM, Nagaraj RH. Aspirin inhibits TGF?2-induced epithelial to mesenchymal transition of lens epithelial cells: selective acetylation of K56 and K122 in histone H3. Biochem J. 2020 01 17; 477(1):75-97. PMID: 31815277.
      View in: PubMed
    7. Kaufman ML, Park KU, Goodson NB, Chew S, Bersie S, Jones KL, Lamba DA, Brzezinski JA. Transcriptional profiling of murine retinas undergoing semi-synchronous cone photoreceptor differentiation. Dev Biol. 2019 09 15; 453(2):155-167. PMID: 31163126.
      View in: PubMed
    8. Goodson NB, Nahreini J, Randazzo G, Uruena A, Johnson JE, Brzezinski JA. Prdm13 is required for Ebf3+ amacrine cell formation in the retina. Dev Biol. 2018 02 01; 434(1):149-163. PMID: 29258872.
      View in: PubMed
    9. Groman-Lupa S, Adewumi J, Park KU, Brzezinski JA. The Transcription Factor Prdm16 Marks a Single Retinal Ganglion Cell Subtype in the Mouse Retina. Invest Ophthalmol Vis Sci. 2017 10 01; 58(12):5421-5433. PMID: 29053761.
      View in: PubMed
    10. Mills TS, Eliseeva T, Bersie SM, Randazzo G, Nahreini J, Park KU, Brzezinski JA. Combinatorial regulation of a Blimp1 (Prdm1) enhancer in the mouse retina. PLoS One. 2017; 12(8):e0176905. PMID: 28829770.
      View in: PubMed
    11. O'Sullivan ML, Pu?al VM, Kerstein PC, Brzezinski JA, Glaser T, Wright KM, Kay JN. Astrocytes follow ganglion cell axons to establish an angiogenic template during retinal development. Glia. 2017 10; 65(10):1697-1716. PMID: 28722174.
      View in: PubMed
    12. Park KU, Randazzo G, Jones KL, Brzezinski JA. Gsg1, Trnp1, and Tmem215 Mark Subpopulations of Bipolar Interneurons in the Mouse Retina. Invest Ophthalmol Vis Sci. 2017 02 01; 58(2):1137-1150. PMID: 28199486.
      View in: PubMed
    13. Brzezinski JA, Reh TA. Photoreceptor cell fate specification in vertebrates. Development. 2015 Oct 01; 142(19):3263-73. PMID: 26443631.
      View in: PubMed
    14. Wilken MS, Brzezinski JA, La Torre A, Siebenthall K, Thurman R, Sabo P, Sandstrom RS, Vierstra J, Canfield TK, Hansen RS, Bender MA, Stamatoyannopoulos J, Reh TA. DNase I hypersensitivity analysis of the mouse brain and retina identifies region-specific regulatory elements. Epigenetics Chromatin. 2015; 8:8. PMID: 25972927.
      View in: PubMed
    15. Vincent SD, Mayeuf-Louchart A, Watanabe Y, Brzezinski JA, Miyagawa-Tomita S, Kelly RG, Buckingham M. Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryo. Hum Mol Genet. 2014 Oct 01; 23(19):5087-101. PMID: 24821700.
      View in: PubMed
    16. Brzezinski JA, Uoon Park K, Reh TA. Blimp1 (Prdm1) prevents re-specification of photoreceptors into retinal bipolar cells by restricting competence. Dev Biol. 2013 Dec 15; 384(2):194-204. PMID: 24125957.
      View in: PubMed
    17. Hufnagel RB, Riesenberg AN, Quinn M, Brzezinski JA, Glaser T, Brown NL. Heterochronic misexpression of Ascl1 in the Atoh7 retinal cell lineage blocks cell cycle exit. Mol Cell Neurosci. 2013 May; 54:108-20. PMID: 23481413.
      View in: PubMed
    18. Brzezinski JA, Prasov L, Glaser T. Math5 defines the ganglion cell competence state in a subpopulation of retinal progenitor cells exiting the cell cycle. Dev Biol. 2012 May 15; 365(2):395-413. PMID: 22445509.
      View in: PubMed
    19. Brzezinski JA, Kim EJ, Johnson JE, Reh TA. Ascl1 expression defines a subpopulation of lineage-restricted progenitors in the mammalian retina. Development. 2011 Aug; 138(16):3519-31. PMID: 21771810.
      View in: PubMed
    20. Ghiasvand NM, Rudolph DD, Mashayekhi M, Brzezinski JA, Goldman D, Glaser T. Deletion of a remote enhancer near ATOH7 disrupts retinal neurogenesis, causing NCRNA disease. Nat Neurosci. 2011 May; 14(5):578-86. PMID: 21441919.
      View in: PubMed
    21. Brzezinski JA, Lamba DA, Reh TA. Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development. Development. 2010 Feb; 137(4):619-29. PMID: 20110327.
      View in: PubMed
    22. Saul SM, Brzezinski JA, Altschuler RA, Shore SE, Rudolph DD, Kabara LL, Halsey KE, Hufnagel RB, Zhou J, Dolan DF, Glaser T. Math5 expression and function in the central auditory system. Mol Cell Neurosci. 2008 Jan; 37(1):153-69. PMID: 17977745.
      View in: PubMed
    23. Akimoto M, Cheng H, Zhu D, Brzezinski JA, Khanna R, Filippova E, Oh EC, Jing Y, Linares JL, Brooks M, Zareparsi S, Mears AJ, Hero A, Glaser T, Swaroop A. Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors. Proc Natl Acad Sci U S A. 2006 Mar 07; 103(10):3890-5. PMID: 16505381.
      View in: PubMed
    24. Brzezinski JA, Brown NL, Tanikawa A, Bush RA, Sieving PA, Vitaterna MH, Takahashi JS, Glaser T. Loss of circadian photoentrainment and abnormal retinal electrophysiology in Math5 mutant mice. Invest Ophthalmol Vis Sci. 2005 Jul; 46(7):2540-51. PMID: 15980246.
      View in: PubMed
    Brzezinski's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    See all (156) concept(s)
    _
    Co-Authors Expand Description
    See all (3) people
    _
    Similar People Expand Description
    See all (60) people
    _
    Same Department Expand Description
    Search Department

    Copyright © 2025 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.11.1)