 Arachidonate 5-Lipoxygenase
"Arachidonate 5-Lipoxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the oxidation of arachidonic acid to yield 5-hydroperoxyarachidonate (5-HPETE) which is rapidly converted by a peroxidase to 5-hydroxy-6,8,11,14-eicosatetraenoate (5-HETE). The 5-hydroperoxides are preferentially formed in leukocytes.
| Descriptor ID |
D001094
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| MeSH Number(s) |
D08.811.682.690.416.583.500.055 D12.776.556.579.374.568.500.020
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| Concept/Terms |
Arachidonate 5-Lipoxygenase- Arachidonate 5-Lipoxygenase
- 5-Lipoxygenase, Arachidonate
- Arachidonate 5 Lipoxygenase
- Arachidonic Acid 5-Lipoxygenase
- 5-Lipoxygenase, Arachidonic Acid
- Arachidonic Acid 5 Lipoxygenase
- LTA4 Synthase
- Synthase, LTA4
- Leukotriene A4 Synthase
- Synthase, Leukotriene A4
- Leukotriene A4 Synthetase
- Synthetase, Leukotriene A4
- 5-Lipoxygenase
- 5 Lipoxygenase
- Leukotriene A Synthase
- Synthase, Leukotriene A
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Below are MeSH descriptors whose meaning is more general than "Arachidonate 5-Lipoxygenase".
Below are MeSH descriptors whose meaning is more specific than "Arachidonate 5-Lipoxygenase".
This graph shows the total number of publications written about "Arachidonate 5-Lipoxygenase" by people in this website by year, and whether "Arachidonate 5-Lipoxygenase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1994 | 2 | 1 | 3 | | 1995 | 1 | 0 | 1 | | 1996 | 2 | 0 | 2 | | 1997 | 0 | 1 | 1 | | 1998 | 1 | 2 | 3 | | 2003 | 0 | 1 | 1 | | 2004 | 1 | 1 | 2 | | 2005 | 0 | 1 | 1 | | 2006 | 2 | 2 | 4 | | 2008 | 0 | 2 | 2 | | 2009 | 1 | 2 | 3 | | 2012 | 1 | 0 | 1 | | 2014 | 1 | 1 | 2 | | 2015 | 1 | 1 | 2 | | 2016 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2018 | 1 | 0 | 1 | | 2019 | 0 | 1 | 1 | | 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Arachidonate 5-Lipoxygenase" by people in Profiles.
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Almodovar S, Wade BE, Porter KM, Smith JM, Lopez-Astacio RA, Bijli K, Kang BY, Cribbs SK, Guidot DM, Molehin D, McNair BK, Pumarejo-Gomez L, Perez Hernandez J, Salazar EA, Martinez EG, Huang L, Kessing CF, Suarez-Martinez EB, Pruitt K, Hsue PY, Tyor WR, Flores SC, Sutliff RL. HIV X4 Variants Increase Arachidonate 5-Lipoxygenase in the Pulmonary Microenvironment and are associated with Pulmonary Arterial Hypertension. Sci Rep. 2020 07 16; 10(1):11696.
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Montford JR, Bauer C, Dobrinskikh E, Hopp K, Levi M, Weiser-Evans M, Nemenoff R, Furgeson SB. Inhibition of 5-lipoxygenase decreases renal fibrosis and progression of chronic kidney disease. Am J Physiol Renal Physiol. 2019 04 01; 316(4):F732-F742.
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Brandt SL, Klopfenstein N, Wang S, Winfree S, McCarthy BP, Territo PR, Miller L, Serezani CH. Macrophage-derived LTB4 promotes abscess formation and clearance of Staphylococcus aureus skin infection in mice. PLoS Pathog. 2018 08; 14(8):e1007244.
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Nunns GR, Stringham JR, Gamboni F, Moore EE, Fragoso M, Stettler GR, Silliman CC, Banerjee A. Trauma and hemorrhagic shock activate molecular association of 5-lipoxygenase and 5-lipoxygenase-Activating protein in lung tissue. J Surg Res. 2018 09; 229:262-270.
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Sorgi CA, Zarini S, Martin SA, Sanchez RL, Scandiuzzi RF, Gij?n MA, Guijas C, Flamand N, Murphy RC, Faccioli LH. Dormant 5-lipoxygenase in inflammatory macrophages is triggered by exogenous arachidonic acid. Sci Rep. 2017 09 08; 7(1):10981.
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Zemski Berry KA, Murphy RC. Phospholipid Ozonation Products Activate the 5-Lipoxygenase Pathway in Macrophages. Chem Res Toxicol. 2016 08 15; 29(8):1355-64.
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Poczobutt JM, Nguyen TT, Hanson D, Li H, Sippel TR, Weiser-Evans MC, Gijon M, Murphy RC, Nemenoff RA. Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment. J Immunol. 2016 Jan 15; 196(2):891-901.
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Qian J, Tian W, Jiang X, Tamosiuniene R, Sung YK, Shuffle EM, Tu AB, Valenzuela A, Jiang S, Zamanian RT, Fiorentino DF, Voelkel NF, Peters-Golden M, Stenmark KR, Chung L, Rabinovitch M, Nicolls MR. Leukotriene B4 Activates Pulmonary Artery Adventitial Fibroblasts in Pulmonary Hypertension. Hypertension. 2015 Dec; 66(6):1227-1239.
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Takahashi H, Riether D, Bartolozzi A, Bosanac T, Berger V, Binetti R, Broadwater J, Chen Z, Crux R, De Lombaert S, Dave R, Dines JA, Fadra-Khan T, Flegg A, Garrigou M, Hao MH, Huber J, Hutzler JM, Kerr S, Kotey A, Liu W, Lo HY, Loke PL, Mahaney PE, Morwick TM, Napier S, Olague A, Pack E, Padyana AK, Thomson DS, Tye H, Wu L, Zindell RM, Abeywardane A, Simpson T. Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915). J Med Chem. 2015 Feb 26; 58(4):1669-90.
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Fang WF, Douglas IS, Wang CC, Kao HC, Chang YT, Tseng CC, Huang KT, Chang HC, Lin MC. 5-Lipoxygenase activating protein (FLAP) dependent leukotriene biosynthesis inhibition (MK591) attenuates Lipid A endotoxin-induced inflammation. PLoS One. 2014; 9(7):e102622.
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