 Arachidonate 15-Lipoxygenase
"Arachidonate 15-Lipoxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the oxidation of arachidonic acid to yield 15-hydroperoxyarachidonate (15-HPETE) which is rapidly converted to 15-hydroxy-5,8,11,13-eicosatetraenoate (15-HETE). The 15-hydroperoxides are preferentially formed in NEUTROPHILS and LYMPHOCYTES.
| Descriptor ID |
D001093
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| MeSH Number(s) |
D08.811.682.690.416.583.500.065 D12.776.556.579.374.568.500.030
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| Concept/Terms |
Arachidonate 15-Lipoxygenase- Arachidonate 15-Lipoxygenase
- 15-Lipoxygenase, Arachidonate
- Arachidonate 15 Lipoxygenase
- Arachidonic Acid 15-Lipoxygenase
- 15-Lipoxygenase, Arachidonic Acid
- Arachidonic Acid 15 Lipoxygenase
- 15-Lipoxygenase
- 15 Lipoxygenase
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Below are MeSH descriptors whose meaning is more general than "Arachidonate 15-Lipoxygenase".
Below are MeSH descriptors whose meaning is more specific than "Arachidonate 15-Lipoxygenase".
This graph shows the total number of publications written about "Arachidonate 15-Lipoxygenase" by people in this website by year, and whether "Arachidonate 15-Lipoxygenase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 | | 2002 | 1 | 0 | 1 | | 2003 | 1 | 0 | 1 | | 2005 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2009 | 1 | 0 | 1 | | 2013 | 0 | 1 | 1 | | 2019 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 | | 2024 | 1 | 1 | 2 |
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Below are the most recent publications written about "Arachidonate 15-Lipoxygenase" by people in Profiles.
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Nemri J, Morales C, Gilbert NC, Majewski J, Newcomer ME, Vander Zanden CM. Structure of a model lipid membrane oxidized by human 15-lipoxygenase-2. Biochem Biophys Res Commun. 2024 12 10; 737:150533.
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Greuter T, Straumann A, Fernandez-Marrero Y, Germic N, Hosseini A, Chanwangpong A, Yousefi S, Simon D, Collins MH, Bussmann C, Chehade M, Dellon ES, Furuta GT, Gonsalves N, Hirano I, Moawad FJ, Biedermann L, Safroneeva E, Schoepfer AM, Simon HU. A Multicenter Long-Term Cohort Study of Eosinophilic Esophagitis Variants and Their Progression to Eosinophilic Esophagitis Over Time. Clin Transl Gastroenterol. 2024 Apr 01; 15(4):e00664.
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Montford JR, Bauer C, Rahkola J, Reisz JA, Floyd D, Hopp K, Soranno DE, Klawitter J, Weiser-Evans MCM, Nemenoff R, Faubel S, Furgeson SB. 15-Lipoxygenase worsens renal fibrosis, inflammation, and metabolism in a murine model of ureteral obstruction. Am J Physiol Renal Physiol. 2022 01 01; 322(1):F105-F119.
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Li Z, Zeng M, Deng Y, Zhao J, Zhou X, Trudeau JB, Goldschmidt E, Moore JA, Chu H, Zhang W, Yin S, Liu Z, Di YP, Lee SE, Wenzel SE. 15-Lipoxygenase 1 in nasal polyps promotes CCL26/eotaxin 3 expression through extracellular signal-regulated kinase activation. J Allergy Clin Immunol. 2019 11; 144(5):1228-1241.e9.
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Bender G, Schexnaydre EE, Murphy RC, Uhlson C, Newcomer ME. Membrane-dependent Activities of Human 15-LOX-2 and Its Murine Counterpart: IMPLICATIONS FOR MURINE MODELS OF ATHEROSCLEROSIS. J Biol Chem. 2016 09 09; 291(37):19413-24.
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Klawitter J, Klawitter J, McFann K, Pennington AT, Abebe KZ, Brosnahan G, Cadnapaphornchai MA, Chonchol M, Gitomer B, Christians U, Schrier RW. Bioactive lipid mediators in polycystic kidney disease. J Lipid Res. 2014 06; 55(6):1139-49.
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Hutchins PM, Murphy RC. Cholesteryl ester acyl oxidation and remodeling in murine macrophages: formation of oxidized phosphatidylcholine. J Lipid Res. 2012 Aug; 53(8):1588-97.
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Rong S, Cao Q, Liu M, Seo J, Jia L, Boudyguina E, Gebre AK, Colvin PL, Smith TL, Murphy RC, Mishra N, Parks JS. Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis. J Lipid Res. 2012 Apr; 53(4):686-95.
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Hutchins PM, Moore EE, Murphy RC. Electrospray MS/MS reveals extensive and nonspecific oxidation of cholesterol esters in human peripheral vascular lesions. J Lipid Res. 2011 Nov; 52(11):2070-83.
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Zarbock A, Distasi MR, Smith E, Sanders JM, Kronke G, Harry BL, von Vietinghoff S, Buscher K, Nadler JL, Ley K. Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI). J Immunol. 2009 Oct 01; 183(7):4715-22.
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