 Arachidonate 12-Lipoxygenase
"Arachidonate 12-Lipoxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the oxidation of arachidonic acid to yield 12-hydroperoxyarachidonate (12-HPETE) which is itself rapidly converted by a peroxidase to 12-hydroxy-5,8,10,14-eicosatetraenoate (12-HETE). The 12-hydroperoxides are preferentially formed in PLATELETS.
| Descriptor ID |
D001092
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| MeSH Number(s) |
D08.811.682.690.416.583.500.060 D12.776.556.579.374.568.500.025
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| Concept/Terms |
Arachidonate 12-Lipoxygenase- Arachidonate 12-Lipoxygenase
- 12-Lipoxygenase, Arachidonate
- Arachidonate 12 Lipoxygenase
- Arachidonic Acid 12-Lipoxygenase
- 12-Lipoxygenase, Arachidonic Acid
- Arachidonic Acid 12 Lipoxygenase
- 12-Lipoxygenase
- 12 Lipoxygenase
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Below are MeSH descriptors whose meaning is more general than "Arachidonate 12-Lipoxygenase".
Below are MeSH descriptors whose meaning is more specific than "Arachidonate 12-Lipoxygenase".
This graph shows the total number of publications written about "Arachidonate 12-Lipoxygenase" by people in this website by year, and whether "Arachidonate 12-Lipoxygenase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 | | 2009 | 2 | 0 | 2 | | 2013 | 0 | 1 | 1 | | 2014 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Arachidonate 12-Lipoxygenase" by people in Profiles.
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Montford JR, Bauer C, Rahkola J, Reisz JA, Floyd D, Hopp K, Soranno DE, Klawitter J, Weiser-Evans MCM, Nemenoff R, Faubel S, Furgeson SB. 15-Lipoxygenase worsens renal fibrosis, inflammation, and metabolism in a murine model of ureteral obstruction. Am J Physiol Renal Physiol. 2022 01 01; 322(1):F105-F119.
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Connor AE, Baumgartner RN, Baumgartner KB, Pinkston CM, Boone SD, John EM, Torres-Mej?a G, Hines LM, Giuliano AR, Wolff RK, Slattery ML. Associations between ALOX, COX, and CRP polymorphisms and breast cancer among Hispanic and non-Hispanic white women: The breast cancer health disparities study. Mol Carcinog. 2015 Dec; 54(12):1541-53.
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Klawitter J, Klawitter J, McFann K, Pennington AT, Abebe KZ, Brosnahan G, Cadnapaphornchai MA, Chonchol M, Gitomer B, Christians U, Schrier RW. Bioactive lipid mediators in polycystic kidney disease. J Lipid Res. 2014 06; 55(6):1139-49.
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Rong S, Cao Q, Liu M, Seo J, Jia L, Boudyguina E, Gebre AK, Colvin PL, Smith TL, Murphy RC, Mishra N, Parks JS. Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis. J Lipid Res. 2012 Apr; 53(4):686-95.
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Thomas CP, Morgan LT, Maskrey BH, Murphy RC, K?hn H, Hazen SL, Goodall AH, Hamali HA, Collins PW, O'Donnell VB. Phospholipid-esterified eicosanoids are generated in agonist-activated human platelets and enhance tissue factor-dependent thrombin generation. J Biol Chem. 2010 Mar 05; 285(10):6891-903.
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Kim S, Choi IF, Quante JR, Zhang L, Roop DR, Koster MI. p63 directly induces expression of Alox12, a regulator of epidermal barrier formation. Exp Dermatol. 2009 Dec; 18(12):1016-21.
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Zarbock A, Distasi MR, Smith E, Sanders JM, Kronke G, Harry BL, von Vietinghoff S, Buscher K, Nadler JL, Ley K. Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI). J Immunol. 2009 Oct 01; 183(7):4715-22.
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Poeckel D, Zemski Berry KA, Murphy RC, Funk CD. Dual 12/15- and 5-lipoxygenase deficiency in macrophages alters arachidonic acid metabolism and attenuates peritonitis and atherosclerosis in ApoE knock-out mice. J Biol Chem. 2009 Jul 31; 284(31):21077-89.
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Owens JM, Shroyer KR, Kingdom TT. Expression of cyclooxygenase and lipoxygenase enzymes in sinonasal mucosa of patients with cystic fibrosis. Arch Otolaryngol Head Neck Surg. 2008 Aug; 134(8):825-31.
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Liu Y, Freedman BI, Burdon KP, Langefeld CD, Howard T, Herrington D, Goff DC, Bowden DW, Wagenknecht LE, Hedrick CC, Rich SS. Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes. Am J Kidney Dis. 2008 Aug; 52(2):242-50.
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