 Chalcones
"Chalcones" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Derivatives of CHALCONE that are important intermediates in the formation of FLAVONOIDS with anti-fungal, anti-bacterial, anti-inflammatory, and anti-tumor properties.
| Descriptor ID |
D047188
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| MeSH Number(s) |
D02.522.818.222 D03.383.663.283.266.450.221 D03.633.100.150.266.450.221
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| Concept/Terms |
Chalcones- Chalcones
- 1,3-Diphenyl-propenones
- 1,3 Diphenyl propenones
- 1,3-Diphenylpropenones
- 1,3 Diphenylpropenones
- Chalconoids
1,3-Diphenylpropanediones- 1,3-Diphenylpropanediones
- 1,3 Diphenylpropanediones
- 1,3-Diphenyl-propanediones
- 1,3 Diphenyl propanediones
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Below are MeSH descriptors whose meaning is more general than "Chalcones".
Below are MeSH descriptors whose meaning is more specific than "Chalcones".
This graph shows the total number of publications written about "Chalcones" by people in this website by year, and whether "Chalcones" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2010 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2012 | 2 | 0 | 2 | | 2013 | 0 | 1 | 1 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Chalcones" by people in Profiles.
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Kumar V, Dhawan S, Girase PS, Awolade P, Shinde SR, Karpoormath R, Singh P. Recent Advances in Chalcone-Based Anticancer Heterocycles: A Structural and Molecular Target Perspective. Curr Med Chem. 2021 Oct 25; 28(33):6805-6845.
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Wang J, Fujiyoshi T, Kosaka Y, Raybuck JD, Lattal KM, Ikeda M, Herson PS, Koerner IP. Inhibition of soluble epoxide hydrolase after cardiac arrest/cardiopulmonary resuscitation induces a neuroprotective phenotype in activated microglia and improves neuronal survival. J Cereb Blood Flow Metab. 2013 Oct; 33(10):1574-81.
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Valdameri G, Gauthier C, Terreux R, Kachadourian R, Day BJ, Winnischofer SM, Rocha ME, Frachet V, Ronot X, Di Pietro A, Boumendjel A. Investigation of chalcones as selective inhibitors of the breast cancer resistance protein: critical role of methoxylation in both inhibition potency and cytotoxicity. J Med Chem. 2012 Apr 12; 55(7):3193-200.
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Kachadourian R, Day BJ, Pugazhenti S, Franklin CC, Genoux-Bastide E, Mahaffey G, Gauthier C, Di Pietro A, Boumendjel A. A synthetic chalcone as a potent inducer of glutathione biosynthesis. J Med Chem. 2012 Feb 09; 55(3):1382-8.
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Wempe MF, Quade B, Jutabha P, Iwen T, Frick M, Rice PJ, Wakui S, Endou H. Human uric acid transporter 1 (hURAT1): an inhibitor structure-activity relationship (SAR) study. Nucleosides Nucleotides Nucleic Acids. 2011 Dec; 30(12):1312-23.
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Brechbuhl HM, Gould N, Kachadourian R, Riekhof WR, Voelker DR, Day BJ. Glutathione transport is a unique function of the ATP-binding cassette protein ABCG2. J Biol Chem. 2010 May 28; 285(22):16582-7.
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Ruiz-Pern?a JJ, Tu??n I, Moliner V, Hynes JT, Roca M. Dynamic effects on reaction rates in a Michael addition catalyzed by chalcone isomerase. Beyond the frozen environment approach. J Am Chem Soc. 2008 Jun 11; 130(23):7477-88.
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Kachadourian R, Leitner HM, Day BJ. Selected flavonoids potentiate the toxicity of cisplatin in human lung adenocarcinoma cells: a role for glutathione depletion. Int J Oncol. 2007 Jul; 31(1):161-8.
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Kachadourian R, Day BJ. Flavonoid-induced glutathione depletion: potential implications for cancer treatment. Free Radic Biol Med. 2006 Jul 01; 41(1):65-76.
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