 Superantigens
"Superantigens" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions.
| Descriptor ID |
D018089
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| MeSH Number(s) |
D23.050.820
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Superantigens".
Below are MeSH descriptors whose meaning is more specific than "Superantigens".
This graph shows the total number of publications written about "Superantigens" by people in this website by year, and whether "Superantigens" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 5 | 1 | 6 | | 1995 | 2 | 1 | 3 | | 1996 | 1 | 1 | 2 | | 1997 | 2 | 1 | 3 | | 1998 | 1 | 0 | 1 | | 1999 | 1 | 4 | 5 | | 2000 | 1 | 1 | 2 | | 2001 | 0 | 2 | 2 | | 2002 | 0 | 2 | 2 | | 2003 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 2 | 0 | 2 | | 2013 | 3 | 0 | 3 | | 2015 | 0 | 1 | 1 | | 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Superantigens" by people in Profiles.
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Marrack P. Obsessive-Compulsive Behavior Isn't Necessarily a Bad Thing. Annu Rev Immunol. 2020 04 26; 38:1-21.
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Vickery TW, Ramakrishnan VR, Suh JD. The Role of Staphylococcus aureus in Patients with Chronic Sinusitis and Nasal Polyposis. Curr Allergy Asthma Rep. 2019 03 11; 19(4):21.
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Trikha A, Kingdom T. Chronic Rhinosinusitis. J Allergy Clin Immunol Pract. 2015 Sep-Oct; 3(5):821-2; quiz 823.
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Salgado-Pab?n W, Breshears L, Spaulding AR, Merriman JA, Stach CS, Horswill AR, Peterson ML, Schlievert PM. Superantigens are critical for Staphylococcus aureus Infective endocarditis, sepsis, and acute kidney injury. mBio. 2013 Aug 20; 4(4).
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Spaulding AR, Salgado-Pab?n W, Kohler PL, Horswill AR, Leung DY, Schlievert PM. Staphylococcal and streptococcal superantigen exotoxins. Clin Microbiol Rev. 2013 Jul; 26(3):422-47.
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Yomogida K, Chou YK, Chu CQ. Superantigens induce IL-17 production from polarized Th1 clones. Cytokine. 2013 Jul; 63(1):6-9.
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Lin YC, Anderson MJ, Kohler PL, Strandberg KL, Olson ME, Horswill AR, Schlievert PM, Peterson ML. Proinflammatory exoprotein characterization of toxic shock syndrome Staphylococcus aureus. Biochemistry. 2011 Aug 23; 50(33):7157-67.
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Benson MA, Lilo S, Wasserman GA, Thoendel M, Smith A, Horswill AR, Fraser J, Novick RP, Shopsin B, Torres VJ. Staphylococcus aureus regulates the expression and production of the staphylococcal superantigen-like secreted proteins in a Rot-dependent manner. Mol Microbiol. 2011 Aug; 81(3):659-75.
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Xu Q, Zhang X, Yue J, Liu C, Cao C, Zhong H, Ma Q. Human TGFalpha-derived peptide TGFalphaL3 fused with superantigen for immunotherapy of EGFR-expressing tumours. BMC Biotechnol. 2010 Dec 22; 10:91.
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Duong BH, Ota T, A?t-Azzouzene D, Aoki-Ota M, Vela JL, Huber C, Walsh K, Gavin AL, Nemazee D. Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen. J Immunol. 2010 Apr 15; 184(8):4143-58.
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